Victors

ROP18
Victor ID	4476
Gene Name	ROP18
Sequence Strain (Species/Organism)	Toxoplasma gondii ME49
NCBI Gene ID	7894256
NCBI Protein GI	237840093
Locus Tag	TGME49_052360
Genbank Accession	DS984739
Protein Accession	XP_002369344
Taxonomy ID	508771
Gene Starting Position	143351
Gene Ending Position	145692
Gene Strand (Orientation)	+
Protein pI	9.74
Protein Weight	57024.8
Protein Length	535
DNA Sequence	>gi\|212659401:143351-145692 Toxoplasma gondii ME49 scf_1112359875120, whole genome shotgun sequence CAGTGGTTCGTGGTTTGGATCAATTGTCAGTTCCTCATCGATCCTTAGTCAGTGGTTGTTTTTGTGGGGG CTTCTTGGTGTTGACTGAGAGGAAAAACACTAGAAGATGCACCGGCTGCACCGATGGCAACGCGTTCATT CCTTTTCGTGTTTTTGGCGCTCTCGTCCCTTGGGGGTCTGTGTAGCGAGTATGCTACTCAACGACCACTA GAACCGTACAGAGGTGAAACCGAACGGCCGCTGCCTGAACGCTTGGGCCAAAAGATGTACATTTCAGTAG TGCAACATAAGACACTCTCGTTCAGTCGTAGCTCTGGGGGCCCGTTCCGTCGTCAAAACCCTCAGACGTG GCCGAATTTTGTTCAACTTACCAGCACGTCTGGGGTGCCCCACCGGCGACGCGAAAGGGTAGCCGACGCT GATGAACCGACAACAAGTACGGGCAATCGTCGCGACAGAGCGTTCCCTCTCCGTTCATGGCTTCGACACG CAATACGGCGTTTAGGTGTAGGTGCAAACAACCGGAGACAAGGCGTCCAACATAAGGAGGTCTTGCCGTC TACCGAAGTGGCATCGATAGTGACACTGCTGCAGCAGCTGCAGCAGGAGATCGGGCGGTGCCGCCTGCAA CAACGGACCAATGCACATTTGGAAGACACAGTTACGATACTCTTTTTCCGCCGGGGTTCCACAAGAGTGC TCTTGTCCGATGGCGGGAGACATACGCGAAACATACGCTATGATGGTGAAATTCTCGGCTCGGGGCCGTG GTCCCTTGTCTTGCGCGTGATGGATGTCGACGAGAATCAGGAGTACGCTTTGAAGGTCGCTCGACTGCGT GCTTCGCTATCTGGCGCTGCCGGATACCGGCAACTCTTAAGACAGGGCCTACTCCACCACAGGTTCACAC CGCCTGTTTCTCCGCATCACGCGTTGTGGTGCTTGCAGTTGATGGTCGCTATTGACCTCCTCAAGCTTCC ACGCATTCCCAGGTTCGTCAGAGAACCTAGCTCACGACTAACAATTGCAAACCGTTTCCTCTTGCTGCCG CTCGCGTATACTGACCTTCTGGCAGTACTGCGGGCGCTGTTCACCAGACAGGATGTCAGCGAAAGCCCCG GCGGTTTTCTTGCTCGACTGCACATGACCGCTCAAGTTGTGAAGGCGCTGGCGAGCTACCACAGCCAAGG CTTCGTCCACGGAGACCTAAAGCCACAGAAATTCTTGGTCATGGCAAATGGAAGCCTTGTTCTAGGTGGT TTCACAGAGGTCCGCACCCCCGGCGCACTGCGCTCCGGCGACGTATTCACTGAGTCGTACCTGCCTCCGG AGCATCTAGACCGAAACAGCGTCTACTCATTTGAAAGTGATACCTGGCAGCTGGGCTTGACCATATACCA GATATGGTGTTTGCTGCTACCGTTCGGGCTGATGACACCATTCGTTGCCGAGGGCCCAGAACGCCGTGTT TTTGAAGAAGTCGTGCAGCACCCCGGGGTTCAACCGTCGTTCAACGATCCTGACTGCTTCTCGAATGTTC CGGAGTATATCGAGATGATGGTACATCACATGCTTCAGTTCCATCCAGAAGACCGCCCAAGACCAGCTGA TATCCTCATCAGCGATAACTTCCAGCGACTCCAGGATCACATTCAGCGTTTGGAGCGGTCGCAGGAAGAG GAAGAGTCGGTCCACGGCAGTCCAGCAGGAACACTCTCCCGTAATCCCTGAGGCGCTATGGTGTTGCACG ACAAAACGGGGTCCGAGAGCAGCCACACGAGCATCTAATTGATTTAATTGCTGAACGACACGGGTTGCCA GGGGGACGGACGCTGTGGATGGAAGTTAGTGTGGGACTAATTAGATTGTTGCCATTTCATCCGATTCATC CCGTACACGGGCGACTGCATATCTGAAGTGGCTGTGGGAACCTAGATCCGATCGAGTGATGGAAGGCCGA TATGGAGAAATCACTGGTTCATTCGTTGGCACCGAGAGCCATTCTGTCGAAAACGAACAACACCTGTATC TGTCATGTGCTCGTAGCAAGATGGTAAACGGAAGTTTAAGAAGATTGCTCGGCAGTGACACTGTGTCTCA CGGAAGATGTCAATGACGGCCACAAGAGAAGGCGTTGGGCATCGTATCATTCGTCGTGTGAAGAGCCACT GACGGAACACCGTCCCGGAAAGTATGCTGTGTTTCTTCTGTAGTCTGGAATCGTCGAGCGAACCGTCGCT GGTGGCTGTGATTGTCTACTTGTTCACCGGGAACACACGTCCGTATCCGCGACATACGAGCGAGGACTGA TATCACAAGCAAACCCCAAAATTTGTTGTTTG
Protein Sequence	>gi\|237840093\|ref\|XP_002369344.1\| rhoptry protein, putative [Toxoplasma gondii ME49] MATRSFLFVFLALSSLGGLCSEYATQRPLEPYRGETERPLPERLGQKMYISVVQHKTLSFSRSSGGPFRR QNPQTWPNFVQLTSTSGVPHRRRERVADADEPTTSTGNRRDRAFPLRSWLRHAIRRLGVGANNRRQGVQH KEVLPSTEVASIVTLLQQLQQEIGRCRLQQRTNAHLEDTVTILFFRRGSTRVLLSDGGRHTRNIRYDGEI LGSGPWSLVLRVMDVDENQEYALKVARLRASLSGAAGYRQLLRQGLLHHRFTPPVSPHHALWCLQLMVAI DLLKLPRIPRFVREPSSRLTIANRFLLLPLAYTDLLAVLRALFTRQDVSESPGGFLARLHMTAQVVKALA SYHSQGFVHGDLKPQKFLVMANGSLVLGGFTEVRTPGALRSGDVFTESYLPPEHLDRNSVYSFESDTWQL GLTIYQIWCLLLPFGLMTPFVAEGPERRVFEEVVQHPGVQPSFNDPDCFSNVPEYIEMMVHHMLQFHPED RPRPADILISDNFQRLQDHIQRLERSQEEEESVHGSPAGTLSRNP
Molecule Role	Virulence factor
Molecule Role Annotation	MUTATION: Transfection of the virulent ROP18 allele into a nonpathogenic type III strain increased growth and enhanced mortality by 4 to 5 logs (Taylor et al., 2006).
References	*Taylor et al., 2006:* Taylor S, Barragan A, Su C, Fux B, Fentress SJ, Tang K, Beatty WL, Hajj HE, Jerome M, Behnke MS, White M, Wootton JC, Sibley LD. A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondii. Science (New York, N.Y.). 2006; 314(5806); 1776-1780. [PubMed: 17170305].


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ROP18