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GRA4

Victor ID 5213
Gene Name GRA4
NCBI Protein GI 527309516
Taxonomy ID 508771
Gene Strand (Orientation) ?
Protein Name dense granule protein GRA4
Protein Length 345
Protein Note encoded by transcript TGME49_310780; Signal peptide predicted by SignalP 2.0 HMM (probability 0.996) with cleavage site probability 0.558 at residue 24; Predicted trans-membrane domain (TMHMM2.0):4-27; GO_component: GO:0020003 - symbiont-containing vacuole;ev_code=EXP; GO_component: GO:0045177 - apical part of cell;ev_code=EXP
Protein Sequence 
>gi|527309516|gb|EPT26152.1| dense granule protein GRA4 [Toxoplasma gondii ME49]
MQGTWFSLFVVVMVSHLAFGGECSFGSYLADMAGLTGREDKEHHAAKKRYYHSMYGNKTPYPYADGQQGS
PPPQGQLLIIQNPDGSFMIVDQQGVPQAPQAAGGPGSPMNGGYYMPAGVYTAQVVPGTPGHPVQAIPQQP
LRTQATATYYHPAAAPPPGPSVFVFTPSSVQPGAEVTPGYSGLQLRQQSQYDYSYPGTTSTPTPPRPASY
GYPAFPAFPRLPAFSDSVSVSTEDSGLTVVRDSSSSESTVTPADEAASESEEGDKTSRKSKVKKGVLTGL
GVAATLAAAAAAAKAVKGFGGTRTSTAPAEAGKTELDDGYRPPPFNPRPSPYAELLKDLERMRKE
Molecule Role Virulence factor
Molecule Role Annotation the dense granule proteins GRA4 and GRA6 in cyst development since brain tissue cyst burdens were drastically reduced specifically in mutant strains with GRA4 and/or GRA6 deleted. Complementation of the Ãˇâ€¯gra4 and Ãˇâ€¯gra6 mutant strains using a functional allele of the deleted GRA coding region placed under the control of the endogenous UPRT locus was found to significantly restore brain cyst burdens.(Fox et al., 2011)
References