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ROP2

Victor ID 4477
Gene Name ROP2
Sequence Strain (Species/Organism) Toxoplasma gondii
NCBI Protein GI 563627
Other Database IDs CDD:186871
CDD:173623
GOA:Q27007
InterPro: IPR000719
InterPro: IPR011009
UniProtKB/TrEMBL: Q27007
Taxonomy ID 5811
Gene Strand (Orientation) ?
Protein Name ROP 2
Protein Length 561
Protein Note Protein Kinases, catalytic domain; cl09925
Protein Sequence 
>gi|563627|emb|CAA85377.1| ROP 2 [Toxoplasma gondii]
MENCASVRSSSCLIWLAAAFFVSALGHVQQGAGVVRPRHWQNSEAAVSVRPPGGASPRHFHSPIEPVAFI
DGEHVEDKHGGSWLEQEAAEEVTPLLNSHTETPTQSPSAFRRLLRRLRFWRRGRTGGSDGGGEPPQTPRP
SLPTRLFQHLRRAAAAIPAAASRFFRRFRRVQEPVFPPDEFPEDVDTNPMYFRGTDPGDVVIEELFNRIP
ETSVWNENERVLSNANHLVSTALWRNEQSFRVESELGERPRTLVRGPVLRDDGSYICLEATDQETGEPLE
VHVPYFTERPPSNAIKQLSEQVLRLRLLRGIKNQRQAKAYLRFIFPIDLVKDPKKRKMIRVRLDERDMWV
LSRFFLYPRMQSNLHILGDVLLSHSSTHKSLVHHARLQLTLQLIRLAASLQHYGLVHADFQVRNILLDQR
GGVFLTGFEHLVRDGASAVSPIGRGFAPPETTAERMLPYRQHHPTLMTFPFDTWTLGLAIYWIWCADLPN
TEDAELGGIEWIYRRCKNIPQPVRALLEGFLRYSKEDRLLPLQAMETSEYEQLRTELSAVLPLYQTDGEP
A
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Targeted depletion of ROP2 using a ribozyme-modified antisense RNA strategy resulted in multiple effects on parasite morphology because of a disruption in the formation of mature rhoptries, and an arrest in cytokinesis. The association of host cell mitochondria with the parasitophorous vacuole membrane was abolished and the ROP2-deficient parasites had a reduced uptake of sterol from the host cell. Furthermore, these parasites invaded human fibroblasts poorly and had markedly attenuated virulence in mice (Nakaar et al., 2003).
References
Nakaar et al., 2003: Nakaar V, Ngô HM, Aaronson EP, Coppens I, Stedman TT, Joiner KA. Pleiotropic effect due to targeted depletion of secretory rhoptry protein ROP2 in Toxoplasma gondii. Journal of cell science. 2003; 116(Pt 11); 2311-2320. [PubMed: 12711703].