| Victors ID |
Gene Name |
Sequence Strain (Species/Organism) |
NCBI Gene ID |
NCBI Nucleotide GI |
NCBI Protein GI |
Locus Tag |
Genbank Accession |
Protein Accession |
Protein Name |
Molecule Role |
Molecule Role Annotation |
PMID |
|
|
bhuR |
Bordetella pertussis Tohama I |
2664030
|
|
33591576
|
BP0347 |
BX640412 |
NP_879220 |
outer membrane heme receptor |
Virulence factor |
MUTATION: attenuated in mice [Ref6846:Brickman et al., 2006]. |
16495546
|
|
|
prn |
Bordetella pertussis Tohama I |
2664290
|
|
33592195
|
BP1054 |
BX640414 |
NP_879839 |
pertactin precursor |
Virulence factor |
MUTATION: mutant was 30% to 40% less efficient at adhering to CHO cells and to human HeLa cells compared to parent [Ref6847:Leininger et al., 1991]. |
1988935
|
|
|
cyaC |
Bordetella pertussis Tohama I |
2664491
|
|
33591933
|
BP0758 |
BX640413 |
NP_879577 |
cyclolysin-activating lysine-acyltransferase |
Virulence factor |
MUTATION: cyaC mutant had toxin activities less than 1% of the wild type [Ref6848:Barry et al., 1991]. |
1987161
|
|
|
cyaA |
Bordetella pertussis Tohama I |
2664492
|
|
33591934
|
BP0760 |
BX640413 |
NP_879578 |
bifunctional hemolysin-adenylate cyclase precursor |
Virulence factor |
MUTATION: mutant strain was unable to multiply as fast and is avirulent in murine respiratory models [Ref6849:Khelef et al., 1992]. |
1614333
|
|
|
brkB |
Bordetella pertussis Tohama I |
2664891
|
|
33594368
|
BP3493 |
BX640421 |
NP_882012 |
serum resistance protein |
Virulence factor |
MUTATION: attenuated in infant mice [Ref6850:Smith et al., 2001]. |
11348687
|
|
|
brkA |
Bordetella pertussis Tohama I |
2664892
|
|
33594369
|
BP3494 |
BX640421 |
NP_882013 |
serum resistance protein |
Virulence factor |
MUTATION: attenuated in infant mice [Ref6850:Smith et al., 2001]. |
11348687
|
|
|
tonB |
Bordetella pertussis Tohama I |
2664931
|
|
33594402
|
BP3531 |
BX640421 |
NP_882046 |
siderophore-mediated iron transport protein |
Virulence factor |
MUTATION: tonB exb double mutant is attenuated in mice [Ref6851:Pradel et al., 2000]. |
10722583
|
|
|
exbB |
Bordetella pertussis Tohama I |
2664932
|
|
33594403
|
BP3532 |
BX640421 |
NP_882047 |
MotA/TolQ/ExbB proton channel family protein |
Virulence factor |
MUTATION: tonB exbB double mutant is attenuated in mice [Ref6851:Pradel et al., 2000]. |
10722583
|
|
|
ptxA |
Bordetella pertussis |
2665068
|
|
33594638
|
BP3783 |
|
NP_882282.1 |
toxin subunit 1 |
Virulence factor |
MUTATION: deletion mutant displayed a significant defect in respiratory tract colonization in mice [Ref6852:Carbonetti et al., 2004]. |
15155640
|
|
|
ptxB |
Bordetella pertussis |
2665069
|
|
33594639
|
BP3784 |
|
NP_882283.1 |
toxin subunit 2 |
Virulence factor |
MUTATION: deletion mutant displayed a significant defect in respiratory tract colonization in mice [Ref6852:Carbonetti et al., 2004]. |
15155640
|
|
|
BP0123 |
Bordetella pertussis Tohama I |
2665353
|
|
33591381
|
BP0123 |
BX640411 |
NP_879025 |
putative cAMP phosphodiesterase |
Virulence factor |
MUTATION: deletion mutant avirulent in the infant mouse model [Ref6853:Weiss and Hewlett, 1986]. |
2877614
|
|
|
fim3 |
Bordetella pertussis Tohama I |
2665596
|
|
33592658
|
BP1568 |
BX640415 |
NP_880302 |
serotype 3 fimbrial subunit precursor |
Virulence factor |
MUTATION: deletion mutant showed significantly reduced ability to colonize in the trachea of a mouse respiratory infection model [Ref6854:Mooi et al., 1992]. |
1350044
|
|
|
BP3072 |
Bordetella pertussis Tohama I |
2666331
|
|
33593999
|
BP3072 |
BX640420 |
NP_881643 |
lipid A biosynthesis lauroyl acyltransferase |
Virulence factor |
MUTATION: lpxL1 deficient mutant displayed defect in infection of human macrophages [Ref6855:Geurtsen et al., 2007]. |
17967899
|
|
|
tcfA |
Bordetella pertussis Tohama I |
2666888
|
|
33592330
|
BP1201 |
BX640414 |
NP_879974 |
tracheal colonization factor precursor |
Virulence factor |
MUTATION: TcfA mutation reduced bacteria by 10 fold compared to parent strain [Ref6856:Finn and Stevens, 1995]. |
7476158
|
|
|
dnt |
Bordetella pertussis Tohama I |
2666936
|
|
33594321
|
BP3439 |
BX640421 |
NP_881965 |
dermonecrotic toxin |
Virulence factor |
MUTATION: deletion mutant attenuated in mice [Ref6857:Feunou et al., 2008]. |
18762220
|
|
|
bvgR |
Bordetella pertussis Tohama I |
2667056
|
|
33592924
|
BP1876 |
AF071567 |
NP_880568 |
regulatory protein BvgR |
Virulence factor |
MUTATION: mutant showed reduced colonization in mice compared to wild-type [Ref6850:Smith et al., 2001]. |
11348687
|
|
|
bvgS |
Bordetella pertussis Tohama I |
2667057
|
|
33592925
|
BP1877 |
BX640416 |
NP_880569 |
virulence sensor protein |
Virulence factor |
MUTATION: mutant displayed reduced virulence, and lost ability to express some Bvg+-phase factors [Ref6858:Cotter and Miller, 1997]. |
9194696
|
|
|
bvgA |
Bordetella pertussis Tohama I |
2667058
|
|
33592926
|
BP1878 |
BX640416 |
NP_880570 |
virulence factors transcription regulator |
Virulence factor |
MUTATION: mutant strain showed growth inhibition and reduced colonization [Ref6859:Stibitz, 1998]. |
9573202
|
|
|
fhaB |
Bordetella pertussis |
2667059
|
|
33592927
|
BP1879 |
|
NP_880571.1 |
filamentous hemagglutinin/adhesin |
Virulence factor |
MUTATION: FhaB mutation abolished bacterial adhesion to Chinese Hamster Ovary cells [Ref6860:Aricò et al., 1993]. |
8415678
|
|
|
bscN |
Bordetella pertussis Tohama I |
2667132
|
|
33593244
|
BP2245 |
BX640417 |
NP_880888 |
type III secretion system ATPase |
Virulence factor |
MUTATION: deletion mutant showed a decrease in cytotoxicity and secretion of proteins in vitro as well as reduced colonization in the trachea of a rat infection model [Ref6861:Yuk et al., 1998]. |
9663681
|
|
|
fimD |
Bordetella pertussis Tohama I |
2667435
|
|
33592930
|
BP1883 |
BX640416 |
NP_880574 |
fimbrial adhesin |
Virulence factor |
MUTATION: FimD mutant strain showed reduced colonization in the lungs and trachea of mice [Ref6850:Smith et al., 2001]. |
11348687
|
|
|
fhaC |
Bordetella pertussis Tohama I |
2667436
|
|
33592931
|
BP1884 |
BX640416 |
NP_880575 |
hemolysin activator-like protein |
Virulence factor |
MUTATION: mutation strongly reduced binding to CHO cells [Ref6860:Aricò et al., 1993]. |
8415678
|
|
|
fauA |
Bordetella pertussis Tohama I |
2667469
|
|
33593446
|
BP2463 |
BX640418 |
NP_881090 |
ferric alcaligin siderophore receptor |
Virulence factor |
MUTATION: fauA mutant is attenuated in mice [Ref6862:Brickman and Armstrong, 2007]. |
17724074
|
|
|
aroA |
Bordetella pertussis |
|
|
144037
|
|
|
|
|
Virulence factor |
MUTATION: An aroA mutant is highly attenuated in mice [Ref7369:Roberts et al., 1990]. |
2407655
|
|
|
fla |
|
|
|
|
|
|
|
|
|
|
|
