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fhaC

Victor ID 3970
Gene Name fhaC
Sequence Strain (Species/Organism) Bordetella pertussis Tohama I
NCBI Gene ID 2667436
NCBI Protein GI 33592931
Locus Tag BP1884
Genbank Accession BX640416
Protein Accession NP_880575
Other Database IDs UniProtKB-ID: FHAC_BORPE
UniRef100: UniRef100_P35077
UniRef90: UniRef90_P35077
UniRef50: UniRef50_P35077
UniParc: UPI000012A731
EMBL: X64876
EMBL: BX640416
EMBL-CDS: CAA46092.1
EMBL-CDS: CAE42167.1
RefSeq_NT: NC_002929.2
PDB: 2QDZ
TCDB: 1.B.20.2.1
GenomeReviews: BX470248_GR
KEGG: bpe:BP1884
NMPDR: fig|257313.1.peg.1651
HOGENOM: HBG037605
OMA: WGRIKGW
ProtClustDB: CLSK920530
BioCyc: BPER257313:BP1884-MONOMER
Taxonomy ID 257313
Gene Starting Position 1984837
Gene Ending Position 1986591
Gene Strand (Orientation) +
Protein Name hemolysin activator-like protein
Protein pI 9.87
Protein Weight 60377.29
Protein Length 584
Protein Note Previously sequenced as Bordetella pertussis hemolysin activator-like protein FhaC precursor fhaC SW:FHAC_BORPE (P35077) (584 aa) fasta scores: E(): 0, 100% id in 584 aa, and to Bordetella bronchiseptica FhaC TR:Q9RGR3 (EMBL: AF111795) (583 aa) fasta scores: E(): 0, 97.43% id in 584 aa
DNA Sequence 
>gi|33591275:1984837-1986591 Bordetella pertussis Tohama I, complete genome
TATGACTGACGCAACGAACCGTTTCCGGCCGGGCCTGGTTGGTCGGGCGCTGGTCCGGGCAGGCCTGCTG
TTCGCCGTGGCCGCCTGTGCGCAGGCGCAGCTGCTGCCGGGCGCGCGCGACCTCAACCGTATCGACGATC
GCCAGCGCAAGGAGCAGCTGCAGCGCGATATCGAGCGCGCCTTGACGCGGCCTCCGGTGGAATTGAATCC
GCAGTCCGAGGCCGCTGCGCCGGCGCGCAAGCCGGACGCTACGTCCGGCCACACCGTGACGGTACATGCC
GTGGACCTGGACTTCGGCGTCGAGGGCCGGCTGTTCGACCCCGCGCCGCTGGTTCAGGACTACCTGAACC
GCCCGCTGGACAACGAGCAGCTGTTCCTGCTGGTCAAGGCATTGAGCGCGGCCCTGTACGACCGCGGCTA
CGCGACCAGCATCGTGACGTTCGTGCCGCCAGGCGTGGTGGATGGCGTGCTCAAGCTGAAGGTGGAGTGG
GGCCGCATCAAGGGATGGCTGATCGACGGCAAGCCGCTGGAGGGGACACGCGACCGCATGATGGTGTTCT
CGGCCATGCCGGGCTGGCAGGACAAGGTGCTGAACGTATTCGATATCGACCAGGCGATCTACAACATCAA
CAATGGCGGCAAGACCGGCAACATCACCATCGTTCCCGCGGACGAATACGGCTATTCCTATCTCGATCTG
CAATTGCAGCGGCGCGCGCTGCCCCGCGTCTCGCTGGGCATGGACAATTCCGGCCCCGGCACGCCCGAGA
ACGGCCGCTACAAGTACAACGCCTCGGTGACGGCCAACGACCTGCTGGGCCTCAACGACACGCTGGGCCT
GTATATCGGCAACCGCTACTATCGCGACGCCGGCCATGACGCCGAGCGCAATTACGATCTGATGTACAGC
GTGCCGCTGGGGCGTACGCGCCTGGATCTTCAGACCGGCTACAGTACCTATCGCAATCTGCTCAAGACCC
GCTACGGGCAATACCAGTCCGCCGGAAACTCGCGCAGTTTCGGACTGAAGGCCACCCGCCTGCTTTACCG
CGATACGCGGTCGCAGTTCAGCGTGTATGGCGGTCTCAAGCTGCGCCAGAACAAGAACTATCTGGCCGGC
ACGCGCCTGGACGTCAGCAGCAAGCATTACAGCGACGTCACGGTGGGGATGCAATACTCCACCCAGCGAG
GCGCCAACGCCTATTTCGGCGACCTGTCTTTCACGCGCGGGGTAGGCGTCAACAACGGCAAGTATGCCGC
CTACGATGAGCGCGGCCCGCAGGGCAATGTGTCGCGGTTCAACGGCAGCCTGGCCTGGACGCGCTACATG
GCGTTGGCCGGCCAGCCGATACAGTGGGCGTCGCAACTGGGGTTCCAGTACTCGCGCCAACAGCTGCTCA
ACAGCTACCAGATCACCGTGGGAGACGAGTACACGGTGCGCGGATACAACCTCAGGACGTCGCAAAGCGG
TGACAGCGGCGTGTACCTGAGCAATACGCTGACGGTGCCGGTGCAGTTCAGCCTGCTCGGCAAGCAGGCG
TCGGTGGCGCCGTTCGTGGGCGCGGATGTCGGAGCGCTCAAGAGCAATCATCCCGACGCGCGCACGATAC
GCATGGCGGGCCTGGCGGCCGGCGTGCGGTTCGACCTGCCGTATGCGCGGATGTCGTTCACGTACTCGAA
GCCCGTGGGCGCGCAGCCCGGCGGCGCGCCGCGCGCGCCGGTCTGGTTATACATCAACGCCGGCCTCAGT
TTCTG
Protein Sequence 
>gi|33592931|ref|NP_880575.1| hemolysin activator-like protein [Bordetella pertussis Tohama I]
MTDATNRFRPGLVGRALVRAGLLFAVAACAQAQLLPGARDLNRIDDRQRKEQLQRDIERALTRPPVELNP
QSEAAAPARKPDATSGHTVTVHAVDLDFGVEGRLFDPAPLVQDYLNRPLDNEQLFLLVKALSAALYDRGY
ATSIVTFVPPGVVDGVLKLKVEWGRIKGWLIDGKPLEGTRDRMMVFSAMPGWQDKVLNVFDIDQAIYNIN
NGGKTGNITIVPADEYGYSYLDLQLQRRALPRVSLGMDNSGPGTPENGRYKYNASVTANDLLGLNDTLGL
YIGNRYYRDAGHDAERNYDLMYSVPLGRTRLDLQTGYSTYRNLLKTRYGQYQSAGNSRSFGLKATRLLYR
DTRSQFSVYGGLKLRQNKNYLAGTRLDVSSKHYSDVTVGMQYSTQRGANAYFGDLSFTRGVGVNNGKYAA
YDERGPQGNVSRFNGSLAWTRYMALAGQPIQWASQLGFQYSRQQLLNSYQITVGDEYTVRGYNLRTSQSG
DSGVYLSNTLTVPVQFSLLGKQASVAPFVGADVGALKSNHPDARTIRMAGLAAGVRFDLPYARMSFTYSK
PVGAQPGGAPRAPVWLYINAGLSF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: mutation strongly reduced binding to CHO cells (Aricò et al., 1993).
COG COG2831U, under U: Intracellular trafficking, secretion, and vesicular transport
References
Aricò et al., 1993: Aricò B, Nuti S, Scarlato V, Rappuoli R. Adhesion of Bordetella pertussis to eukaryotic cells requires a time-dependent export and maturation of filamentous hemagglutinin. Proceedings of the National Academy of Sciences of the United States of America. 1993; 90(19); 9204-9208. [PubMed: 8415678].