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cyaC

Victor ID 3951
Gene Name cyaC
Sequence Strain (Species/Organism) Bordetella pertussis Tohama I
NCBI Gene ID 2664491
NCBI Protein GI 33591933
Locus Tag BP0758
Genbank Accession BX640413
Protein Accession NP_879577
Other Database IDs UniProtKB-ID: CYAC_BORPE
UniRef100: UniRef100_P0A3I6
UniRef90: UniRef90_P0A3I6
UniRef50: UniRef50_P0A3I6
UniParc: UPI00001B6E1A
EMBL: M57286
EMBL: BX640413
EMBL-CDS: AAA22971.1
EMBL-CDS: CAE41065.1
RefSeq_NT: NC_002929.2
GenomeReviews: BX470248_GR
KEGG: bpe:BP0758
HOGENOM: HBG296557
OMA: WALMDAD
ProtClustDB: CLSK920128
BioCyc: BPER257313:BP0758-MONOMER
Taxonomy ID 257313
Gene Starting Position 775191
Gene Ending Position 775748
Gene Strand (Orientation) -
Protein Name cyclolysin-activating lysine-acyltransferase
Protein pI 9.2
Protein Weight 19784.83
Protein Length 185
Protein Note Also known as HlyCIdentical to the previously sequenced Bordetella pertussis cyclolysin-activating lysine-acyltransferase CyaC SW:CYAC_BORPE (Q45359) (185 aa) fasta scores: E(): 2.1e-78, 99.459% id in 185 aa, and to Escherichia coli hemolysin-activating lysine-acyltransferase HlyC SW:HLYC_ECOLI (P06736) (170 aa) fasta scores: E(): 1.5e-24, 40.698% id in 172 aa
DNA Sequence 
>gi|33591275:775191-775748 Bordetella pertussis Tohama I, complete genome
ATCAGGCGGTGCCCCGGCCTCGCGGCGCGTATCCGCCGTTGCTCGCGCGCAGTCCTGCGATCAGTTCGGC
ATGGTAGCGGTCCAGCTGCGCGCGAGCGGCGGCCGCGTCCAGCGCGCGGCCTCGGTACTCCTTGACGCGC
GCGGTGTCGCCGCCGCGCCGAACGCGCAGCGAACGGCCCACGCTGTCGGGGTGCCGTTCGGCCAGCGCGC
GGCGCAGCGCACGATTGTCGTCGCGCGAGAATGGCGCGATCCAGTCGATGATCCACAGTCGGTCGCCGCA
GTTCCAGGCATTCCCGCCCAGCGACGAGGGCGCCATGACATAGGAGAGTTCGGTGTCGGCGTCCATTAGG
GCCCAGCTGCAGTATGCAACCGGCACGTCATTGCATCGCAGCAGAATGTATTGGCCCAGTTGAATCGGCG
CGAGCGTGTTGCGTGCGAGCAGATGCACCGGCCAGTCGCGGTGCATGGGAGAGTTCATCCACAGCCAGGC
AATATTGCCCAGTGCCGCGAAGTCGTCGGTGGGATTGAGGAGGGAGGGCGCTTGGGCGGACGGAAGCA
Protein Sequence 
>gi|33591933|ref|NP_879577.1| cyclolysin-activating lysine-acyltransferase [Bordetella pertussis Tohama I]
MLPSAQAPSLLNPTDDFAALGNIAWLWMNSPMHRDWPVHLLARNTLAPIQLGQYILLRCNDVPVAYCSWA
LMDADTELSYVMAPSSLGGNAWNCGDRLWIIDWIAPFSRDDNRALRRALAERHPDSVGRSLRVRRGGDTA
RVKEYRGRALDAAAARAQLDRYHAELIAGLRASNGGYAPRGRGTA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: cyaC mutant had toxin activities less than 1% of the wild type (Barry et al., 1991).
COG COG2994O, under O: Posttranslational modification, protein turnover, chaperones
References
Barry et al., 1991: Barry EM, Weiss AA, Ehrmann IE, Gray MC, Hewlett EL, Goodwin MS. Bordetella pertussis adenylate cyclase toxin and hemolytic activities require a second gene, cyaC, for activation. Journal of bacteriology. 1991; 173(2); 720-726. [PubMed: 1987161].