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tcfA

Victor ID 3962
Gene Name tcfA
Sequence Strain (Species/Organism) Bordetella pertussis Tohama I
NCBI Gene ID 2666888
NCBI Protein GI 33592330
Locus Tag BP1201
Genbank Accession BX640414
Protein Accession NP_879974
Other Database IDs UniProtKB-ID: O86135_BORPE
UniRef100: UniRef100_O86135
UniRef90: UniRef90_Q8GB90
UniRef50: UniRef50_Q7WHU6
UniParc: UPI00000B0658
EMBL: AJ009785
EMBL: BX640414
EMBL: AM238668
EMBL-CDS: CAA08832.2
EMBL-CDS: CAE41497.1
EMBL-CDS: CAJ87644.1
RefSeq_NT: NC_002929.2
GenomeReviews: BX470248_GR
KEGG: bpe:BP1201
NMPDR: fig|257313.1.peg.1052
OMA: GNGETEK
ProtClustDB: CLSK266100
BioCyc: BPER257313:BP1201-MONOMER
Taxonomy ID 257313
Gene Starting Position 1264435
Gene Ending Position 1266378
Gene Strand (Orientation) +
Protein Name tracheal colonization factor precursor
Protein pI 5.91
Protein Weight 62423.78
Protein Length 647
Protein Note Identical to the previously sequenced Bordetella pertussis tracheal colonization factor precursor Tcfa2 TR:O86135 (EMBL: AJ009785) (647 aa) fasta scores: E(): 1.7e-171, 99.84% id in 647 aa
DNA Sequence 
>gi|33591275:1264435-1266378 Bordetella pertussis Tohama I, complete genome
TATGCACATTTACGGAAATATGAATCGAGCAACACCTTGCCGCGGTGCGGTGCGTGCCCTTGCGCTTGCC
CTGCTGGGAGCGGGTATGTGGACACTTTCTCCTCCCTCGGCATGGGCGCTTAAGCTCCCGTCGCTGCTGA
CGGACGACGAGCTGAAGCTGGTTCTGCCGACTGGCATGTCTCTGGAGGATTTCAAGCGCAGCCTTCAGGA
GTCCGCGCCGAGCGCGCTGGCAACGCCGCCGTCGTCTTCGCCTCCGGTTGCGAAGCCAGGTCCGGGCTCC
GTTGCCGAGGCTCCGTCGGGGTCGGGCCACAAGGACAACCCATCCCCTCCCGTCGTCGGCGTCGGTCCAG
GTATGGCGGAGTCGTCTGGCGGACATAACCCCGGCGTGGGGGGGGGCACGCATGAAAATGGGTTGCCCGG
TATAGGAAAGGTCGGCGGGTCTGCGCCCGGACCGGATACCAGTACGGGCTCGGGTCCCGACGCCGGCATG
GCGTCCGGAGCGGGTTCGACGTCGCCCGGCGCATCGGGTGGGGCGGGCAAGGATGCGATGCCGCCCTCGG
AAGGCGAGAGGCCGGACTCCGGTATGTCCGATTCGGGGCGGGGTGGCGAATCGTCGGCTGGAGGCTTGAA
TCCGGACGGCGCTGGCAAGCCACCGCGGGAGGAAGGCGAGCCGGGTTCCAAGTCTCCTGCGGACGGTGGC
CAGGACGGGCCGCCGCCGCCCCGGGACGGCGGCGATGCGGATCCGCAACCTCCGCGGGACGATGGCAATG
GGGAACAGCAGCCGCCCAAGGGCGGCGGGGATGAGGGGCAGCGCCCGCCGCCTGCCGCCGGAAACGGTGG
CAACGGTGGCAACGGGAACGCGCAGCTTCCCGAGCGCGGCGACGACGCGGGTCCGAAGCCTCCCGAGGGA
GAGGGCGGCGATGAAGGTCCGCAACCGCCGCAGGGCGGCGGCGAGCAGGACGCGCCGGAGGTTCCTCCCG
TCGCGCCGGCGCCGCCCGCGGGCAACGGTGTCTATGACCCGGGCACGCATACCTTGACCACGCCGGCCTC
TGCGGCGGTGAGCCTGGCCAGCAGTTCGCATGGCGTATGGCAGGCCGAGATGAACGCGTTGAGCAAGCGC
ATGGGCGAGTTGCGCCTGACGCCGGTTGCGGGCGGCGTATGGGGCCGCGCTTTTGGCCGGCGCCAGGACG
TCGACAACCGCGTGTCGCGCGAGTTCCGCCAGACCATCAGCGGTTTCGAACTGGGCGCCGATACCGCCTT
GCCGGTGGCCGACGGGCGCTGGCACGTGGGCGCGGTGGCTGGCTACACCAACGGCCGCATCAAGTTCGAC
CGGGGCGGCACGGGCGATGACGACAGCGTGCACGTGGGCGCTTACGCTACCTACATCGAGGACGGCGGTT
TCTATATGGATGGCATCGTGCGGGTCAGCCGCATTCGCCACGCGTTCAAGGTGGACGACGCCAAGGGCCG
GCGCGTGCGCGGCCAGTACCGCGGCAATGGCGTGGGCGCGTCGCTGGAACTGGGCAAGCGCTTCACGTGG
CCCGGCGCCTGGTACGTGGAGCCGCAGCTGGAGGTGGCCGCCTTCCATGCGCAAGGGGCCGACTACACCG
CCAGCAACGGCCTGCGCATCAAGGACGACGGCACGAACTCCATGCTGGGCCGCCTGGGCCTGCACGTGGG
GCGGCAGTTCGACCTGGGCGATGGCCGCGTGGTGCAGCCCTACATGAAGCTGAGCTGGGTGCAGGAGTTC
GACGGCAAGGGCACGGTGCGCACCAACGACATCCGGCACAAGGTGCGGCTCGATGGCGGCCGCACCGAAC
TGGCCGTAGGGGTGGCTTCGCAACTGGGCAAGCACGGCAGCCTGTTCGGCTCGTACGAGTACGCCAAGGG
CAGCCGCCAGACCATGCCGTGGACCTTCCACGTCGGCTATCGCTACGCCTGGTA
Protein Sequence 
>gi|33592330|ref|NP_879974.1| tracheal colonization factor precursor [Bordetella pertussis Tohama I]
MHIYGNMNRATPCRGAVRALALALLGAGMWTLSPPSAWALKLPSLLTDDELKLVLPTGMSLEDFKRSLQE
SAPSALATPPSSSPPVAKPGPGSVAEAPSGSGHKDNPSPPVVGVGPGMAESSGGHNPGVGGGTHENGLPG
IGKVGGSAPGPDTSTGSGPDAGMASGAGSTSPGASGGAGKDAMPPSEGERPDSGMSDSGRGGESSAGGLN
PDGAGKPPREEGEPGSKSPADGGQDGPPPPRDGGDADPQPPRDDGNGEQQPPKGGGDEGQRPPPAAGNGG
NGGNGNAQLPERGDDAGPKPPEGEGGDEGPQPPQGGGEQDAPEVPPVAPAPPAGNGVYDPGTHTLTTPAS
AAVSLASSSHGVWQAEMNALSKRMGELRLTPVAGGVWGRAFGRRQDVDNRVSREFRQTISGFELGADTAL
PVADGRWHVGAVAGYTNGRIKFDRGGTGDDDSVHVGAYATYIEDGGFYMDGIVRVSRIRHAFKVDDAKGR
RVRGQYRGNGVGASLELGKRFTWPGAWYVEPQLEVAAFHAQGADYTASNGLRIKDDGTNSMLGRLGLHVG
RQFDLGDGRVVQPYMKLSWVQEFDGKGTVRTNDIRHKVRLDGGRTELAVGVASQLGKHGSLFGSYEYAKG
SRQTMPWTFHVGYRYAW
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: TcfA mutation reduced bacteria by 10 fold compared to parent strain (Finn and Stevens, 1995).
COG COG3468MU, under M: Cell wall/membrane/envelope biogenesis; U: Intracellular trafficking, secretion, and vesicular transport
References
Finn and Stevens, 1995: Finn TM, Stevens LA. Tracheal colonization factor: a Bordetella pertussis secreted virulence determinant. Molecular microbiology. 1995; 16(4); 625-634. [PubMed: 7476158].