Protegen ID Gene Name Sequence Strain (Species/Organism) NCBI Gene ID NCBI Nucleotide GI NCBI Protein GI Locus Tag Genbank Accession Protein Accession Protein Name Protein Annotation Molecule Role Molecule Role Annotation COG PMID 3949 bhuR Bordetella pertussis Tohama I 2664030 33591576 BP0347 BX640412 NP_879220 outer membrane heme receptor Virulence factor MUTATION: attenuated in mice [Ref6846:Brickman et al., 2006]. COG4771P, under P: Inorganic ion transport and metabolism 16495546 3950 prn Bordetella pertussis Tohama I 2664290 33592195 BP1054 BX640414 NP_879839 pertactin precursor Virulence factor MUTATION: mutant was 30% to 40% less efficient at adhering to CHO cells and to human HeLa cells compared to parent [Ref6847:Leininger et al., 1991]. COG3468MU, under M: Cell wall/membrane/envelope biogenesis; U: Intracellular trafficking, secretion, and vesicular transport 1988935 3951 cyaC Bordetella pertussis Tohama I 2664491 33591933 BP0758 BX640413 NP_879577 cyclolysin-activating lysine-acyltransferase Virulence factor MUTATION: cyaC mutant had toxin activities less than 1% of the wild type [Ref6848:Barry et al., 1991]. COG2994O, under O: Posttranslational modification, protein turnover, chaperones 1987161 3952 cyaA Bordetella pertussis Tohama I 2664492 33591934 BP0760 BX640413 NP_879578 bifunctional hemolysin-adenylate cyclase precursor Virulence factor MUTATION: mutant strain was unable to multiply as fast and is avirulent in murine respiratory models [Ref6849:Khelef et al., 1992]. COG2931Q, under Q: Secondary metabolites biosynthesis, transport and catabolism 1614333 3953 brkB Bordetella pertussis Tohama I 2664891 33594368 BP3493 BX640421 NP_882012 serum resistance protein Virulence factor MUTATION: attenuated in infant mice [Ref6850:Smith et al., 2001]. COG1295S, under S: Function unknown 11348687 3954 brkA Bordetella pertussis Tohama I 2664892 33594369 BP3494 BX640421 NP_882013 serum resistance protein Virulence factor MUTATION: attenuated in infant mice [Ref6850:Smith et al., 2001]. 11348687 3955 tonB Bordetella pertussis Tohama I 2664931 33594402 BP3531 BX640421 NP_882046 siderophore-mediated iron transport protein Virulence factor MUTATION: tonB exb double mutant is attenuated in mice [Ref6851:Pradel et al., 2000]. COG0810M, under M: Cell wall/membrane/envelope biogenesis 10722583 3956 exbB Bordetella pertussis Tohama I 2664932 33594403 BP3532 BX640421 NP_882047 MotA/TolQ/ExbB proton channel family protein Virulence factor MUTATION: tonB exbB double mutant is attenuated in mice [Ref6851:Pradel et al., 2000]. COG0811U, under U: Intracellular trafficking, secretion, and vesicular transport 10722583 3957 ptxA Bordetella pertussis 2665068 33594638 BP3783 NP_882282.1 toxin subunit 1 Virulence factor MUTATION: deletion mutant displayed a significant defect in respiratory tract colonization in mice [Ref6852:Carbonetti et al., 2004]. 15155640 3958 ptxB Bordetella pertussis 2665069 33594639 BP3784 NP_882283.1 toxin subunit 2 Virulence factor MUTATION: deletion mutant displayed a significant defect in respiratory tract colonization in mice [Ref6852:Carbonetti et al., 2004]. 15155640 3959 BP0123 Bordetella pertussis Tohama I 2665353 33591381 BP0123 BX640411 NP_879025 putative cAMP phosphodiesterase Virulence factor MUTATION: deletion mutant avirulent in the infant mouse model [Ref6853:Weiss and Hewlett, 1986]. COG1409R, under R: General function prediction only 2877614 3960 fim3 Bordetella pertussis Tohama I 2665596 33592658 BP1568 BX640415 NP_880302 serotype 3 fimbrial subunit precursor Virulence factor MUTATION: deletion mutant showed significantly reduced ability to colonize in the trachea of a mouse respiratory infection model [Ref6854:Mooi et al., 1992]. COG3539NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport 1350044 3961 BP3072 Bordetella pertussis Tohama I 2666331 33593999 BP3072 BX640420 NP_881643 lipid A biosynthesis lauroyl acyltransferase Virulence factor MUTATION: lpxL1 deficient mutant displayed defect in infection of human macrophages [Ref6855:Geurtsen et al., 2007]. COG1560M, under M: Cell wall/membrane/envelope biogenesis 17967899 3962 tcfA Bordetella pertussis Tohama I 2666888 33592330 BP1201 BX640414 NP_879974 tracheal colonization factor precursor Virulence factor MUTATION: TcfA mutation reduced bacteria by 10 fold compared to parent strain [Ref6856:Finn and Stevens, 1995]. COG3468MU, under M: Cell wall/membrane/envelope biogenesis; U: Intracellular trafficking, secretion, and vesicular transport 7476158 3963 dnt Bordetella pertussis Tohama I 2666936 33594321 BP3439 BX640421 NP_881965 dermonecrotic toxin Virulence factor MUTATION: deletion mutant attenuated in mice [Ref6857:Feunou et al., 2008]. 18762220 3964 bvgR Bordetella pertussis Tohama I 2667056 33592924 BP1876 AF071567 NP_880568 regulatory protein BvgR Virulence factor MUTATION: mutant showed reduced colonization in mice compared to wild-type [Ref6850:Smith et al., 2001]. COG2200T, under T: Signal transduction mechanisms 11348687 3965 bvgS Bordetella pertussis Tohama I 2667057 33592925 BP1877 BX640416 NP_880569 virulence sensor protein Virulence factor MUTATION: mutant displayed reduced virulence, and lost ability to express some Bvg+-phase factors [Ref6858:Cotter and Miller, 1997]. COG0642T, under T: Signal transduction mechanisms 9194696 3966 bvgA Bordetella pertussis Tohama I 2667058 33592926 BP1878 BX640416 NP_880570 virulence factors transcription regulator Virulence factor MUTATION: mutant strain showed growth inhibition and reduced colonization [Ref6859:Stibitz, 1998]. COG2197TK, under T: Signal transduction mechanisms; K: Transcription 9573202 3967 fhaB Bordetella pertussis 2667059 33592927 BP1879 NP_880571.1 filamentous hemagglutinin/adhesin Virulence factor MUTATION: FhaB mutation abolished bacterial adhesion to Chinese Hamster Ovary cells [Ref6860:Aricò et al., 1993]. 8415678 3968 bscN Bordetella pertussis Tohama I 2667132 33593244 BP2245 BX640417 NP_880888 type III secretion system ATPase Virulence factor MUTATION: deletion mutant showed a decrease in cytotoxicity and secretion of proteins in vitro as well as reduced colonization in the trachea of a rat infection model [Ref6861:Yuk et al., 1998]. COG1157NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport 9663681 3969 fimD Bordetella pertussis Tohama I 2667435 33592930 BP1883 BX640416 NP_880574 fimbrial adhesin Virulence factor MUTATION: FimD mutant strain showed reduced colonization in the lungs and trachea of mice [Ref6850:Smith et al., 2001]. COG3539NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport 11348687 3970 fhaC Bordetella pertussis Tohama I 2667436 33592931 BP1884 BX640416 NP_880575 hemolysin activator-like protein Virulence factor MUTATION: mutation strongly reduced binding to CHO cells [Ref6860:Aricò et al., 1993]. COG2831U, under U: Intracellular trafficking, secretion, and vesicular transport 8415678 3971 fauA Bordetella pertussis Tohama I 2667469 33593446 BP2463 BX640418 NP_881090 ferric alcaligin siderophore receptor Virulence factor MUTATION: fauA mutant is attenuated in mice [Ref6862:Brickman and Armstrong, 2007]. COG4773P, under P: Inorganic ion transport and metabolism 17724074 4950 aroA Bordetella pertussis 144037 Virulence factor MUTATION: An aroA mutant is highly attenuated in mice [Ref7369:Roberts et al., 1990]. 2407655 4951 fla