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brkA

Victor ID 3954
Gene Name brkA
Sequence Strain (Species/Organism) Bordetella pertussis Tohama I
NCBI Gene ID 2664892
NCBI Protein GI 33594369
Locus Tag BP3494
Genbank Accession BX640421
Protein Accession NP_882013
Other Database IDs UniProtKB-ID: BRKA_BORPE
UniRef100: UniRef100_Q45340
UniRef90: UniRef90_Q45340
UniRef50: UniRef50_Q45340
UniParc: UPI00000BB9D4
EMBL: U12276
EMBL: BX640421
EMBL-CDS: AAA51646.1
EMBL-CDS: CAE43755.1
RefSeq_NT: NC_002929.2
HSSP: P14283
TCDB: 1.B.12.2.3
GenomeReviews: BX470248_GR
KEGG: bpe:BP3494
NMPDR: fig|257313.1.peg.3083
OMA: YASYMAH
BioCyc: BPER257313:BP3494-MONOMER
Taxonomy ID 257313
Gene Starting Position 3703056
Gene Ending Position 3706088
Gene Strand (Orientation) +
Protein Name serum resistance protein
Protein pI 7.12
Protein Weight 95737.8
Protein Length 1010
Protein Note Previously sequenced as Bordetella pertussis serum resistance protein BrkA TR:Q45340 (EMBL: U12276) (1010 aa) fasta scores: E(): 0, 100% id in 1010 aa. Similar to Bordetella pertussis pertactin precursor Prn SW:PERT_BORPE (P14283) (910 aa) fasta scores: E(): 4.2e-52, 38.36% id in 915 aa
DNA Sequence 
>gi|33591275:3703056-3706088 Bordetella pertussis Tohama I, complete genome
CATGTATCTCGATAGATTCCGTCAATGTCCGTCTTCCTTGCAGATCCCGCGTTCCGCGTGGCGCCTGCAT
GCGCTGGCCGCAGCTCTGGCGCTGGCCGGCATGGCCCGGCTGGCGCCCGCGGCGGCGCAGGCGCCGCAGC
CGCCCGTGGCCGGCGCGCCGCATGCGCAGGACGCCGGGCAGGAAGGAGAGTTCGACCACCGGGACAACAC
GCTCATTGCAGTCTTTGACGACGGCGTCGGCATCAATCTCGACGACGATCCCGACGAGCTCGGCGAGACG
GCGCCCCCCACGCTCAAGGACATCCACATCTCGGTGGAGCACAAGAACCCGATGAGCAAGCCGGCCATCG
GGGTGCGTGTCAGCGGCGCCGGCCGCGCGCTGACGCTGGCCGGCTCGACCATCGATGCCACCGAGGGCGG
CATTCCCGCAGTGGTACGGCGCGGCGGCACGCTGGAGCTGGATGGCGTCACCGTGGCGGGCGGGGAAGGG
ATGGAGCCGATGACGGTCTCTGACGCCGGCAGCCGCCTGAGCGTGCGCGGCGGCGTGCTGGGCGGCGAAG
CGCCGGGCGTCGGCCTGGTCCGGGCCGCGCAAGGCGGCCAGGCGAGCATCATCGACGCGACGCTGCAGAG
CATCCTCGGGCCCGCGCTCATTGCCGACGGCGGCTCCATTTCCGTCGCCGGCGGTTCGATCGACATGGAC
ATGGGCCCGGGATTCCCGCCGCCGCCTCCACCGCTTCCCGGGGCGCCGCTGGCCGCGCATCCGCCGCTCG
ATCGCGTTGCCGCGGTGCACGCCGGCCAGGACGGCAAGGTGACACTGCGGGAGGTGGCGCTGCGGGCTCA
CGGGCCGCAGGCGACGGGCGTCTATGCGTATATGCCTGGCAGCGAAATCACCCTGCAGGGAGGCACAGTC
AGCGTGCAGGGCGATGACGGGGCCGGCGTGGTCGCCGGCGCGGGCCTGCTCGACGCCTTGCCGCCCGGCG
GCACGGTGCGGCTGGACGGAACCACGGTGTCGACCGATGGCGCCAACACCGATGCCGTGCTGGTTCGCGG
CGACGCGGCGCGCGCCGAGGTCGTCAACACCGTGCTGCGCACCGCCAAGAGCCTGGCCGCCGGCGTATCG
GCCCAGCATGGAGGCCGCGTCACGCTGCGGCAGACCCGCATCGAGACCGCGGGCGCGGGGGCCGAGGGCA
TCTCCGTGCTGGGCTTCGAGCCGCAGTCCGGCTCCGGCCCGGCCAGCGTCGACATGCAGGGCGGCAGCAT
CACCACGACCGGCAACCGCGCCGCCGGCATCGCGCTCACCCACGGCAGCGCCCGCCTGGAAGGCGTGGCG
GTGCGCGCCGAGGGCAGCGGCTCGAGCGCCGCGCAGCTGGCCAACGGCACGCTGGTCGTCAGCGCAGGGT
CGCTGGCCTCGGCCCAGTCCGGCGCGATCAGCGTGACCGACACGCCGCTGAAGCTGATGCCGGGCGCCCT
GGCCAGCAGCACGGTCTCGGTCCGGTTGACCGACGGCGCCACGGCGCAAGGCGGCAATGGCGTGTTCCTC
CAGCAGCATTCCACCATTCCGGTGGCGGTTGCCCTCGAGAGCGGCGCCCTGGCTCGCGGCGATATCGTCG
CCGACGGCAACAAGCCCCTCGATGCCGGGATCTCCCTCAGCGTGGCCAGCGGCGCCGCCTGGCACGGCGC
CACCCAGGTGCTCCAGTCGGCCACGCTGGGCAAGGGCGGAACCTGGGTCGTGAACGCCGACTCCCGGGTG
CAGGACATGTCGATGCGCGGCGGGCGGGTCGAATTCCAGGCGCCCGCGCCCGAGGCCTCTTACAAGACCC
TGACCCTGCAAACCCTGGACGGCAACGGCGTGTTCGTGCTGAACACCAACGTCGCCGCCGGGCAGAACGA
CCAGTTGCGGGTCACCGGCCGCGCCGATGGCCAGCACCGCGTGCTGGTGCGCAATGCCGGAGGCGAGGCC
GACAGCCGGGGCGCCCGCCTGGGCCTGGTGCATACCCAGGGGCAGGGCAACGCCACCTTCCGGCTGGCCA
ACGTCGGCAAGGCGGTTGACCTGGGCACGTGGCGCTACAGCCTGGCGGAGGATCCGAAGACGCATGTCTG
GAGCTTGCAGCGCGCGGGCCAGGCCCTGTCGGGGGCGGCCAATGCCGCCGTGAACGCGGCGGATCTTTCC
AGCATCGCCCTGGCCGAGTCCAACGCGCTGGACAAGCGCCTGGGCGAGCTGCGCCTGCGCGCCGACGCCG
GCGGGCCATGGGCGCGTACGTTCAGCGAGCGCCAGCAGATCAGCAACCGCCACGCCCGCGCCTACGACCA
GACGGTCAGCGGGCTGGAGATCGGCCTGGACCGTGGCTGGAGCGCGTCGGGCGGGCGCTGGTACGCCGGC
GGCCTGCTCGGCTACACCTATGCCGACCGCACCTATCCCGGCGACGGTGGCGGCAAGGTCAAGGGCCTGC
ACGTCGGCGGCTACGCCGCCTATGTCGGCGATGGCGGCTACTATCTCGACACCGTGCTGCGGCTGGGCCG
CTACGATCAGCAATACAACATTGCCGGCACCGATGGCGGCCGCGTCACCGCCGACTACCGCACAAGCGGC
GCCGCATGGTCGCTCGAAGGCGGGCGCCGGTTCGAGCTGCCCAACGACTGGTTCGCCGAACCGCAGGCCG
AGGTCATGCTGTGGCGCACGTCAGGCAAGCGCTATCGCGCCAGCAATGGCCTGCGCGTCAAGGTGGACGC
CAACACCGCCACGCTGGGCCGCCTGGGCTTGCGCTTCGGCCGCCGCATCGCCCTGGCCGGCGGCAACATC
GTGCAGCCCTACGCCAGGCTCGGCTGGACGCAGGAGTTCAAAAGCACGGGCGATGTGCGCACCAATGGCA
TTGGCCATGCCGGCGCAGGCCGCCACGGCCGCGTGGAACTGGGCGCGGGCGTCGACGCCGCGTTGGGCAA
GGGGCACAACCTCTATGCTTCGTACGAGTACGCGGCGGGCGACCGGATCAACATTCCGTGGTCGTTCCAC
GCCGGCTACCGCTACAGCTTCTG
Protein Sequence 
>gi|33594369|ref|NP_882013.1| serum resistance protein [Bordetella pertussis Tohama I]
MYLDRFRQCPSSLQIPRSAWRLHALAAALALAGMARLAPAAAQAPQPPVAGAPHAQDAGQEGEFDHRDNT
LIAVFDDGVGINLDDDPDELGETAPPTLKDIHISVEHKNPMSKPAIGVRVSGAGRALTLAGSTIDATEGG
IPAVVRRGGTLELDGVTVAGGEGMEPMTVSDAGSRLSVRGGVLGGEAPGVGLVRAAQGGQASIIDATLQS
ILGPALIADGGSISVAGGSIDMDMGPGFPPPPPPLPGAPLAAHPPLDRVAAVHAGQDGKVTLREVALRAH
GPQATGVYAYMPGSEITLQGGTVSVQGDDGAGVVAGAGLLDALPPGGTVRLDGTTVSTDGANTDAVLVRG
DAARAEVVNTVLRTAKSLAAGVSAQHGGRVTLRQTRIETAGAGAEGISVLGFEPQSGSGPASVDMQGGSI
TTTGNRAAGIALTHGSARLEGVAVRAEGSGSSAAQLANGTLVVSAGSLASAQSGAISVTDTPLKLMPGAL
ASSTVSVRLTDGATAQGGNGVFLQQHSTIPVAVALESGALARGDIVADGNKPLDAGISLSVASGAAWHGA
TQVLQSATLGKGGTWVVNADSRVQDMSMRGGRVEFQAPAPEASYKTLTLQTLDGNGVFVLNTNVAAGQND
QLRVTGRADGQHRVLVRNAGGEADSRGARLGLVHTQGQGNATFRLANVGKAVDLGTWRYSLAEDPKTHVW
SLQRAGQALSGAANAAVNAADLSSIALAESNALDKRLGELRLRADAGGPWARTFSERQQISNRHARAYDQ
TVSGLEIGLDRGWSASGGRWYAGGLLGYTYADRTYPGDGGGKVKGLHVGGYAAYVGDGGYYLDTVLRLGR
YDQQYNIAGTDGGRVTADYRTSGAAWSLEGGRRFELPNDWFAEPQAEVMLWRTSGKRYRASNGLRVKVDA
NTATLGRLGLRFGRRIALAGGNIVQPYARLGWTQEFKSTGDVRTNGIGHAGAGRHGRVELGAGVDAALGK
GHNLYASYEYAAGDRINIPWSFHAGYRYSF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: attenuated in infant mice (Smith et al., 2001).
References
Smith et al., 2001: Smith AM, Guzmán CA, Walker MJ. The virulence factors of Bordetella pertussis: a matter of control. FEMS microbiology reviews. 2001; 25(3); 309-333. [PubMed: 11348687].