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cyaA

Victor ID 3952
Gene Name cyaA
Sequence Strain (Species/Organism) Bordetella pertussis Tohama I
NCBI Gene ID 2664492
NCBI Protein GI 33591934
Locus Tag BP0760
Genbank Accession BX640413
Protein Accession NP_879578
Other Database IDs UniProtKB-ID: CYAA_BORPE
UniRef100: UniRef100_P15318
UniRef90: UniRef90_Q57506
UniRef50: UniRef50_Q57506
UniParc: UPI00001B6E1B
EMBL: Y00545
EMBL: BX640413
EMBL: X14199
EMBL-CDS: CAA68613.1
EMBL-CDS: CAE41066.1
EMBL-CDS: CAA32411.1
RefSeq_NT: NC_002929.2
PDB: 1YRT
PDB: 1YRU
PDB: 1ZOT
PDB: 2COL
TCDB: 1.C.11.1.4
GenomeReviews: BX470248_GR
KEGG: bpe:BP0760
NMPDR: fig|257313.1.peg.657
HOGENOM: HBG353287
OMA: DRGNDGA
ProtClustDB: CLSK265825
BioCyc: BPER257313:BP0760-MONOMER
Taxonomy ID 257313
Gene Starting Position 776227
Gene Ending Position 781347
Gene Strand (Orientation) +
Protein Name bifunctional hemolysin-adenylate cyclase precursor
Protein pI 4.36
Protein Weight 164226.5
Protein Length 1706
Protein Note Also known as cyaIdentical to the previously sequenced Bordetella pertussis bifunctional hemolysin-adenylate cyclase precursor Cya or CyaA SW:CYAA_BORPE (P15318) (1706 aa) fasta scores: E(): 0, 99.941% id in 1706 aa, and to Bordetella parapertussis bifunctional hemolysin-adenylate cyclase precursor CyaA TR:Q9L469 (EMBL: AJ249835) (1706 aa) fasta scores: E(): 0, 97.714% id in 1706 aa
DNA Sequence 
>gi|33591275:776227-781347 Bordetella pertussis Tohama I, complete genome
CATGCAGCAATCGCATCAGGCTGGTTACGCAAACGCCGCCGACCGGGAGTCTGGCATCCCCGCAGCCGTA
CTCGATGGCATCAAGGCCGTGGCGAAGGAAAAAAACGCCACATTGATGTTCCGCCTGGTCAACCCCCATT
CCACCAGCCTGATTGCCGAAGGGGTGGCCACCAAAGGATTGGGCGTGCACGCCAAGTCGTCCGATTGGGG
GTTGCAGGCGGGCTACATTCCCGTCAACCCGAATCTTTCCAAACTGTTCGGCCGTGCGCCCGAGGTGATC
GCGCGGGCCGACAACGACGTCAACAGCAGCCTGGCGCATGGCCATACCGCGGTCGACCTGACGCTGTCGA
AAGAGCGGCTTGACTATCTGCGGCAAGCGGGCCTGGTCACCGGCATGGCCGATGGCGTGGTCGCGAGCAA
CCACGCAGGCTACGAGCAGTTCGAGTTTCGCGTGAAGGAAACCTCGGACGGGCGCTATGCCGTGCAGTAT
CGCCGCAAGGGCGGCGACGATTTCGAGGCGGTCAAGGTGATCGGCAATGCCGCCGGTATTCCACTGACGG
CGGATATCGACATGTTCGCCATTATGCCGCATCTGTCCAACTTCCGCGACTCGGCGCGCAGTTCGGTGAC
CAGCGGCGATTCGGTGACCGATTACCTGGCGCGCACGCGGCGGGCCGCCAGCGAGGCCACGGGCGGCCTG
GATCGCGAACGCATCGACTTGTTGTGGAAAATCGCTCGCGCCGGCGCCCGTTCCGCAGTGGGCACCGAGG
CGCGTCGCCAGTTCCGCTACGACGGCGACATGAATATCGGCGTGATCACCGATTTCGAGCTGGAAGTGCG
CAATGCGCTGAACAGGCGGGCGCACGCCGTCGGCGCGCAGGACGTGGTCCAGCATGGCACTGAGCAGAAC
AATCCTTTCCCGGAGGCAGATGAGAAGATTTTCGTCGTATCGGCCACCGGTGAAAGCCAGATGCTCACGC
GCGGGCAACTGAAGGAATACATTGGCCAGCAGCGCGGCGAGGGCTATGTCTTCTACGAGAACCGTGCATA
CGGCGTGGCGGGGAAAAGCCTGTTCGACGATGGGCTGGGAGCCGCGCCCGGCGTGCCGAGCGGACGTTCG
AAGTTCTCGCCGGATGTACTGGAAACGGTGCCGGCGTCACCCGGATTGCGGCGGCCGTCGCTGGGCGCAG
TGGAACGCCAGGATTCCGGCTATGACAGCCTTGATGGGGTGGGATCGCGATCGTTCTCGTTGGGCGAGGT
GTCCGACATGGCCGCCGTGGAAGCGGCGGAACTGGAAATGACCCGGCAAGTCTTGCACGCCGGGGCGCGG
CAGGACGATGCCGAGCCGGGCGTGAGCGGTGCGTCGGCGCACTGGGGGCAGCGGGCGCTGCAGGGCGCCC
AGGCGGTGGCGGCGGCGCAGCGGCTGGTTCATGCCATTGCCCTGATGACGCAATTCGGCCGGGCCGGTTC
CACCAACACGCCGCAGGAAGCGGCCTCGTTGTCGGCGGCCGTGTTCGGCTTGGGCGAGGCCAGCAGCGCC
GTGGCCGAAACCGTGAGCGGTTTTTTCCGCGGGTCTTCGCGCTGGGCCGGCGGTTTCGGCGTGGCTGGCG
GCGCGATGGCGCTGGGAGGCGGCATCGCCGCGGCCGTTGGCGCCGGGATGTCGTTGACCGATGACGCGCC
GGCCGGACAGAAGGCCGCCGCCGGCGCCGAGATCGCGCTGCAGTTGACAGGTGGAACGGTCGAGCTGGCT
TCTTCCATCGCGTTGGCGCTGGCCGCGGCGCGCGGCGTGACCAGCGGCTTGCAGGTGGCCGGGGCGTCGG
CCGGGGCGGCTGCCGGCGCATTGGCCGCGGCGCTCAGTCCCATGGAGATCTACGGCCTGGTGCAGCAATC
GCACTATGCGGATCAGCTGGACAAGCTGGCGCAGGAATCGAGCGCATACGGTTACGAGGGCGACGCCTTG
CTGGCCCAGCTGTATCGCGACAAGACGGCCGCCGAGGGCGCCGTCGCCGGCGTCTCCGCCGTCCTGAGCA
CGGTGGGGGCGGCGGTGTCGATCGCCGCGGCGGCCAGCGTGGTAGGGGCCCCGGTGGCGGTGGTCACTTC
CTTGCTGACCGGGGCTCTCAACGGCATCCTGCGCGGCGTGCAGCAGCCCATCATCGAAAAGCTGGCCAAC
GATTACGCTCGCAAGATCGACGAGCTGGGCGGGCCGCAAGCGTACTTCGAGAAAAACCTGCAGGCGCGTC
ACGAACAACTGGCCAATTCGGACGGCCTACGGAAAATGCTGGCCGACCTGCAGGCCGGTTGGAACGCCAG
CAGCGTGATCGGGGTGCAGACGACAGAGATCTCCAAGTCGGCGCTCGAACTGGCCGCCATTACCGGCAAC
GCGGACAACCTGAAATCCGTCGACGTGTTCGTGGACCGCTTCGTCCAGGGCGAGCGGGTGGCCGGCCAGC
CGGTGGTCCTCGACGTCGCCGCCGGCGGCATCGATATCGCCAGCCGCAAGGGCGAGCGGCCGGCGCTGAC
GTTCATCACGCCGCTGGCCGCGCCAGGAGAAGAGCAGCGCCGGCGCACGAAAACGGGCAAGAGCGAATTC
ACCACATTCGTCGAGATCGTGGGCAAGCAGGACCGCTGGCGCATCCGGGACGGCGCGGCCGACACCACCA
TCGATCTGGCCAAGGTGGTGTCGCAACTGGTCGACGCCAATGGCGTGCTCAAGCACAGCATCAAACTGGA
TGTGATCGGCGGAGATGGCGATGACGTCGTGCTTGCCAATGCTTCGCGCATCCATTATGACGGCGGCGCG
GGCACCAACACGGTCAGCTATGCCGCCCTGGGTCGACAGGATTCCATTACCGTGTCCGCCGACGGGGAAC
GTTTCAACGTGCGCAAGCAGTTGAACAACGCCAACGTGTATCGCGAAGGCGTGGCTACCCAGACAACCGC
CTACGGCAAGCGCACGGAGAATGTCCAATACCGCCATGTCGAGCTGGCCCGTGTCGGGCAACTGGTGGAG
GTCGACACGCTCGAGCATGTGCAGCACATCATCGGCGGGGCCGGCAACGATTCGATCACCGGCAATGCGC
ACGACAACTTCCTAGCCGGCGGGTCGGGCGACGACAGGCTGGATGGCGGCGCCGGCAACGACACCCTGGT
TGGCGGCGAGGGCCAAAACACGGTCATCGGCGGCGCCGGCGACGACGTATTCCTGCAGGACCTGGGGGTA
TGGAGCAACCAGCTCGATGGCGGCGCGGGCGTCGATACCGTGAAGTACAACGTGCACCAGCCTTCCGAGG
AGCGCCTCGAACGCATGGGCGACACGGGCATCCATGCCGATCTTCAAAAGGGCACGGTCGAGAAGTGGCC
GGCCCTGAACCTGTTCAGCGTCGACCATGTCAAGAATATCGAGAATCTGCACGGCTCCCGCCTGAACGAC
CGCATCGCCGGCGACGACCAGGACAACGAGCTCTGGGGCCACGATGGCAACGACACGATACGCGGCCGGG
GCGGCGACGACATCCTGCGCGGCGGCCTGGGCCTGGACACGCTGTATGGCGAGGACGGCAACGACATCTT
CCTGCAGGACGACGAGACCGTCAGCGATGACATCGACGGCGGCGCGGGGCTGGACACCGTCGACTACTCC
GCCATGATCCATCCAGGCAGGATCGTTGCGCCGCATGAATACGGCTTCGGGATCGAGGCGGACCTGTCCA
GGGAATGGGTGCGCAAGGCGTCCGCGCTGGGCGTGGACTATTACGATAATGTCCGCAATGTCGAAAACGT
CATCGGTACGAGCATGAAGGATGTGCTCATCGGCGACGCGCAAGCCAATACCCTGATGGGCCAGGGCGGC
GACGATACCGTGCGCGGCGGCGACGGCGATGATCTGCTGTTCGGCGGCGACGGCAACGACATGCTGTATG
GCGACGCCGGCAACGACACCCTCTACGGGGGGCTGGGCGACGATACCCTTGAAGGCGGCGCGGGCAACGA
TTGGTTCGGCCAGACGCAGGCGCGCGAGCATGACGTGCTGCGCGGCGGAGATGGGGTGGATACCGTCGAT
TACAGCCAGACCGGCGCGCATGCCGGCATTGCCGCGGGTCGCATCGGGCTGGGCATCCTGGCTGACCTGG
GCGCCGGCCGCGTCGACAAGCTGGGCGAGGCCGGCAGCAGCGCCTACGATACGGTTTCCGGTATCGAGAA
CGTGGTGGGCACGGAACTGGCCGACCGCATCACGGGCGATGCGCAGGCCAACGTGCTGCGCGGCGCGGGT
GGCGCCGACGTGCTTGCGGGCGGCGAGGGCGACGATGTGCTGCTGGGCGGCGACGGCGACGACCAGCTGT
CGGGCGACGCCGGACGCGATCGCTTGTACGGCGAAGCCGGTGACGACTGGTTCTTCCAGGATGCCGCCAA
TGCCGGCAATCTGCTCGACGGCGGCGACGGCCGCGATACCGTGGATTTCAGCGGCCCGGGCCGGGGCCTC
GACGCCGGCGCAAAGGGCGTATTCCTGAGCTTGGGCAAGGGGTTCGCCAGCCTGATGGACGAACCCGAAA
CCAGCAACGTGTTGCGCAATATCGAGAACGCCGTGGGCAGCGCGCGTGATGACGTGCTGATCGGCGACGC
AGGCGCCAACGTCCTCAATGGCCTGGCGGGCAACGACGTGCTGTCCGGCGGCGCTGGCGACGATGTGCTG
CTGGGCGACGAGGGCTCGGACCTGCTCAGCGGCGATGCGGGCAACGACGATCTGTTCGGCGGGCAGGGCG
ATGATACTTATCTGTTCGGGGTCGGGTACGGGCACGACACGATCTACGAATCGGGCGGCGGCCATGACAC
CATCCGCATCAACGCGGGGGCGGACCAGCTGTGGTTCGCGCGCCAGGGCAACGACCTGGAGATCCGCATT
CTCGGCACCGACGATGCACTTACCGTGCACGACTGGTATCGCGACGCCGATCACCGGGTGGAAATCATCC
ATGCCGCCAACCAGGCGGTAGACCAGGCAGGCATCGAAAAGCTGGTCGAGGCAATGGCGCAGTATCCGGA
CCCCGGCGCGGCGGCGGCTGCCCCGCCGGCGGCGCGCGTGCCGGACACGCTGATGCAGTCCCTGGCTGTC
AACTGGCGCTG
Protein Sequence 
>gi|33591934|ref|NP_879578.1| bifunctional hemolysin-adenylate cyclase precursor [Bordetella pertussis Tohama I]
MQQSHQAGYANAADRESGIPAAVLDGIKAVAKEKNATLMFRLVNPHSTSLIAEGVATKGLGVHAKSSDWG
LQAGYIPVNPNLSKLFGRAPEVIARADNDVNSSLAHGHTAVDLTLSKERLDYLRQAGLVTGMADGVVASN
HAGYEQFEFRVKETSDGRYAVQYRRKGGDDFEAVKVIGNAAGIPLTADIDMFAIMPHLSNFRDSARSSVT
SGDSVTDYLARTRRAASEATGGLDRERIDLLWKIARAGARSAVGTEARRQFRYDGDMNIGVITDFELEVR
NALNRRAHAVGAQDVVQHGTEQNNPFPEADEKIFVVSATGESQMLTRGQLKEYIGQQRGEGYVFYENRAY
GVAGKSLFDDGLGAAPGVPSGRSKFSPDVLETVPASPGLRRPSLGAVERQDSGYDSLDGVGSRSFSLGEV
SDMAAVEAAELEMTRQVLHAGARQDDAEPGVSGASAHWGQRALQGAQAVAAAQRLVHAIALMTQFGRAGS
TNTPQEAASLSAAVFGLGEASSAVAETVSGFFRGSSRWAGGFGVAGGAMALGGGIAAAVGAGMSLTDDAP
AGQKAAAGAEIALQLTGGTVELASSIALALAAARGVTSGLQVAGASAGAAAGALAAALSPMEIYGLVQQS
HYADQLDKLAQESSAYGYEGDALLAQLYRDKTAAEGAVAGVSAVLSTVGAAVSIAAAASVVGAPVAVVTS
LLTGALNGILRGVQQPIIEKLANDYARKIDELGGPQAYFEKNLQARHEQLANSDGLRKMLADLQAGWNAS
SVIGVQTTEISKSALELAAITGNADNLKSVDVFVDRFVQGERVAGQPVVLDVAAGGIDIASRKGERPALT
FITPLAAPGEEQRRRTKTGKSEFTTFVEIVGKQDRWRIRDGAADTTIDLAKVVSQLVDANGVLKHSIKLD
VIGGDGDDVVLANASRIHYDGGAGTNTVSYAALGRQDSITVSADGERFNVRKQLNNANVYREGVATQTTA
YGKRTENVQYRHVELARVGQLVEVDTLEHVQHIIGGAGNDSITGNAHDNFLAGGSGDDRLDGGAGNDTLV
GGEGQNTVIGGAGDDVFLQDLGVWSNQLDGGAGVDTVKYNVHQPSEERLERMGDTGIHADLQKGTVEKWP
ALNLFSVDHVKNIENLHGSRLNDRIAGDDQDNELWGHDGNDTIRGRGGDDILRGGLGLDTLYGEDGNDIF
LQDDETVSDDIDGGAGLDTVDYSAMIHPGRIVAPHEYGFGIEADLSREWVRKASALGVDYYDNVRNVENV
IGTSMKDVLIGDAQANTLMGQGGDDTVRGGDGDDLLFGGDGNDMLYGDAGNDTLYGGLGDDTLEGGAGND
WFGQTQAREHDVLRGGDGVDTVDYSQTGAHAGIAAGRIGLGILADLGAGRVDKLGEAGSSAYDTVSGIEN
VVGTELADRITGDAQANVLRGAGGADVLAGGEGDDVLLGGDGDDQLSGDAGRDRLYGEAGDDWFFQDAAN
AGNLLDGGDGRDTVDFSGPGRGLDAGAKGVFLSLGKGFASLMDEPETSNVLRNIENAVGSARDDVLIGDA
GANVLNGLAGNDVLSGGAGDDVLLGDEGSDLLSGDAGNDDLFGGQGDDTYLFGVGYGHDTIYESGGGHDT
IRINAGADQLWFARQGNDLEIRILGTDDALTVHDWYRDADHRVEIIHAANQAVDQAGIEKLVEAMAQYPD
PGAAAAAPPAARVPDTLMQSLAVNWR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: mutant strain was unable to multiply as fast and is avirulent in murine respiratory models (Khelef et al., 1992).
COG COG2931Q, under Q: Secondary metabolites biosynthesis, transport and catabolism
References
Khelef et al., 1992: Khelef N, Sakamoto H, Guiso N. Both adenylate cyclase and hemolytic activities are required by Bordetella pertussis to initiate infection. Microbial pathogenesis. 1992; 12(3); 227-235. [PubMed: 1614333].