| Victors ID |
Gene Name |
Sequence Strain (Species/Organism) |
NCBI Gene ID |
NCBI Nucleotide GI |
NCBI Protein GI |
Locus Tag |
Genbank Accession |
Protein Accession |
Protein Name |
Molecule Role |
Molecule Role Annotation |
PMID |
|
|
PFB0100c |
Plasmodium falciparum |
812616
|
|
124800689
|
PFB0100c |
|
XP_001349534.1 |
knob associated histidine-rich protein |
Virulence factor |
MUTATION: KAHRP mutant has reduced adherence to CD36 when tested under flow conditions that mimic those of postcapillary venules [Ref6617:Crabb et al., 1997]. |
9108483
|
|
|
PFD0215c |
Plasmodium falciparum |
812450
|
|
124505229
|
PFD0215c |
|
XP_001351356.1 |
pbs36 homologue |
Virulence factor |
MUTATION: pbs36 had arrested intracellular growth in liver HC-04 cells [Ref6618:VanBuskirk et al., 2009]. |
19625622
|
|
|
PFL0800c |
Plasmodium falciparum |
811213
|
|
124805898
|
PFL0800c |
|
XP_001350569.1 |
hypothetical protein |
Virulence factor |
MUTATION: CelTOS mutant has reduced infectivity in rat liver and almost abolished its cell-passage ability [Ref6619:Kariu et al., 2006].
|
16468982
|
|
|
PF13_0201 |
Plasmodium falciparum |
814170
|
|
124513464
|
PF13_0201 |
|
XP_001350088.1 |
sporozoite surface protein 2 |
Virulence factor |
MUTATION: TRAP mutant is attenuated for sporozoite infection of rat liver [Ref6635:Sultan et al., 1997]. |
9267031
|
|
|
PF13_0197 |
Plasmodium falciparum |
814166
|
|
124513450
|
PF13_0197 |
|
XP_001350081.1 |
merozoite surface protein 7 |
Virulence factor |
MUTATION: msp7 mutant is attenuated for invasion of erythrocytes compared to the wild type [Ref6636:Kadekoppala et al., 2008]. |
18820076
|
|
|
SAP1 |
Plasmodium yoelii yoelii str. 17XNL |
3926325
|
|
|
|
|
|
Record to support submission of GeneRIFs for a gene not in Entrez Gene. |
Virulence factor |
MUTATION: Targeted deletion of SAP1 in the rodent malaria parasite Plasmodium yoelii generated mutant parasites that traverse and invade hepatocytes normally but cannot initiate liver-stage development in vitro and in vivo [Ref7003:Aly et al., 2008]. |
18466298
|
|
|
FabB/FabF |
Plasmodium falciparum 3D7 |
3885996
|
|
296004726
|
PFF1275c |
AL844505 |
XP_966246 |
|
Virulence factor |
MUTATION: A genetically attenuated parasite (GAP) with a mutation in the FabB/FabF gene is attenuated in mice by arresting in the late liver stage [Ref7402:Butler et al., 2011]. |
21669394
|
|
|
P36p |
Plasmodium berghei str. ANKA |
3424772
|
|
68068733
|
PB000799.01.0 |
CAAI01001447 |
XP_676277 |
|
Virulence factor |
MUTATION: P36p-deficient Plasmodium berghei is attenuated in mice [Ref7403:Douradinha et al., 2007]. |
17604034
|
|
|
PY04725 (Py36) |
Plasmodium yoelii 17XNL |
|
|
23479924
|
|
|
|
p36 protein |
Virulence factor |
MUTATION: A genetically attenuated parasite (GAP) with deletions in p52 and p36 are attenuated in mice [Ref7404:Labaied et al., 2007]. |
17517871
|
|
|
Py52 |
Plasmodium yoelii 17XNL |
|
15193061
|
15193062
|
|
|
AAK91678.1 |
Py52 |
Virulence factor |
MUTATION: A genetically attenuated parasite (GAP) with deletions in p52 and p36 are attenuated in mice [Ref7404:Labaied et al., 2007]. |
17517871
|
|
|
UIS3 |
Plasmodium yoelii yoelii str. 17XNL |
3830198
|
|
83315853
|
PY03011 |
AABL01000850 |
XP_730972 |
|
Virulence factor |
MUTATION: Deletion of UIS3 in Plasmodium yoelii provided attenuation and full protection in mice [Ref7405:Tarun et al., 2007]. |
17624848
|
|
|
plasmoDJ1 |
Plasmodium falciparum 3D7 |
3885695
|
|
86171677
|
PFF1335c |
AL844505 |
XP_966258 |
4-methyl-5(B-hydroxyethyl)-thiazol monophosphate biosynthesis enzyme |
Virulence factor |
To investigate the effect of the loss of DJ-1 in insect stage development, mosquitoes were fed on wild-type- or plasmoDJ1 knockout-parasite-infected BALB/c mice, and infectivity was determined by counting the number of oocysts in the mosquito mid-guts. The knockout parasites showed almost 50% reduction in both infectivity to mosquitoes and the number of oocysts. The results suggested that plasmoDJ1 plays a major role for in parasite development and virulence [Ref7533:Singhal et al., 2014].
|
25097910
|
|
|
Sir2 |
Plasmodium falciparum 3D7 |
812071
|
|
124809723
|
PF14_0489 |
AE014187 |
XP_001348663 |
|
Virulence factor |
histone deacetylase 2 (PfHda2), is a global silencer of virulence gene expression and controls the frequency of switching from the asexual cycle to sexual development. PfHda2 depletion leads to dysregulated expression of both virulence-associated var genes and PfAP2-g, a transcription factor controlling sexual conversion, and is accompanied by increases in gametocytogenesis. [Ref7569:Coleman et al., 2014]
|
25121747
|
|
|
PF13_0133 |
Plasmodium falciparum 3D7 |
814104
|
|
124513238
|
PF13_0133 |
AL844509 |
XP_001349975 |
|
Virulence factor |
PMV activity is essential for protein export in Plasmodium spp. and for parasite survival in human erythrocytes and validates PMV as an antimalarial drug target.
[Ref7570:Sleebs et al., 2014] |
24983235
|
|
|
FIKK4.1 |
Plasmodium falciparum 3D7 |
812596
|
|
124505613
|
PFD1165w |
AL844503 |
XP_001351548 |
|
Virulence factor |
targeted disruption of the gene encoding FIKK4.2 (fikk4.2) dramatically alters the parasites ability to modify and remodel the red blood cells in which it multiplies.
[Ref7571:Kats et al., 2014] |
24530877
|
|
|
DegP |
Plasmodium falciparum 3D7 |
2655249
|
|
124512626
|
MAL8P1.126 |
AL844507 |
XP_001349446 |
|
Virulence factor |
To determine the molecular identity and functions of the parasite-encoded DegP, we complemented the Escherichia coli degP null mutant with a putative PfdegP gene, and the results showed that PfDegP complements the growth defect of the temperature sensitive DegP-deficient mutant and imparts resistance to non-permissive temperatures and oxidative stress. Our data suggest that the PfDegP protein may play a role in the growth and development of P. falciparum through its ability to confer protection against thermal/oxidative stress.[Ref7572:Sharma et al., 2014]
|
24494818
|
|
|
PfEMP1 |
Plasmodium falciparum 3D7 |
810160
|
|
124801837
|
PF10_0001 |
AE014185 |
XP_001347288 |
|
Virulence factor |
The variant antigen Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), which is expressed on the surface of P. falciparum-infected red blood cells, is a critical virulence factor for malaria.[Ref7573:Jiang et al., 2013]
|
23823717
|
|
|
PM4 |
|
|
|
675227064
|
|
|
|
plasmepsin IV |
Virulence factor |
PM4 deficiency in the rodent malaria parasite Plasmodium berghei results in significantly less virulence than that for the parental parasite. P. berghei Deltapm4 parasites failed to induce experimental cerebral malaria (ECM) in ECM-susceptible mice, and ECM-resistant mice were able to clear infections. Furthermore, after a single infection, all convalescent mice were protected against subsequent parasite challenge for at least 1 year.[Ref7575:Spaccapelo et al., 2010]
|
20019192
|
|
|
nt1 |
Plasmodium falciparum 3D7 |
814217
|
|
124513660
|
PF13_0252 |
AL844509 |
XP_001350186 |
|
Virulence factor |
Nucleoside transporter 1 (NT1) plays an important role in purine salvage in Plasmodium berghei (pb). The rapid increase of wild-type pb-ANKA in mice early in infection was significantly inhibited by disruption of pbnt1. Moreover, mice infected with Δpbnt1 parasite showed neither cerebral paralysis nor cerebral haemorrhage, and all mice spontaneously recovered from infection. The results showed that the pbnt1 gene act as an important virulence factor in Pb ANKA in the asexual.[Ref7604:Niikura et al., 2013] |
23402751
|
|
|
PkNBPXa |
|
|
|
213950524
|
|
|
EU867791 |
normocyte binding protein Xa |
Virulence factor |
Our study strongly suggests that P. knowlesi invasion gene variants contribute to parasite virulence. We focused on two invasion genes, and we anticipate that additional virulent loci will be identified in pathogen genome-wide studies. [Ref7621:Ahmed et al., 2014]
|
25121807
|
|
|
PkNBPXb |
|
|
|
213950526
|
|
|
ACJ54536 |
normocyte binding protein Xb |
Virulence factor |
Our study strongly suggests that P. knowlesi invasion gene variants contribute to parasite virulence. We focused on two invasion genes, and we anticipate that additional virulent loci will be identified in pathogen genome-wide studies. [Ref7621:Ahmed et al., 2014]
|
25121807
|
