Protegen ID Gene Name Sequence Strain (Species/Organism) NCBI Gene ID NCBI Nucleotide GI NCBI Protein GI Locus Tag Genbank Accession Protein Accession Protein Name Protein Annotation Molecule Role Molecule Role Annotation COG PMID 1977 PFB0100c Plasmodium falciparum 812616 124800689 PFB0100c XP_001349534.1 knob associated histidine-rich protein Virulence factor MUTATION: KAHRP mutant has reduced adherence to CD36 when tested under flow conditions that mimic those of postcapillary venules [Ref6617:Crabb et al., 1997]. 9108483 1978 PFD0215c Plasmodium falciparum 812450 124505229 PFD0215c XP_001351356.1 pbs36 homologue Virulence factor MUTATION: pbs36 had arrested intracellular growth in liver HC-04 cells [Ref6618:VanBuskirk et al., 2009]. 19625622 1979 PFL0800c Plasmodium falciparum 811213 124805898 PFL0800c XP_001350569.1 hypothetical protein Virulence factor MUTATION: CelTOS mutant has reduced infectivity in rat liver and almost abolished its cell-passage ability [Ref6619:Kariu et al., 2006].; 16468982 2017 PF13_0201 Plasmodium falciparum 814170 124513464 PF13_0201 XP_001350088.1 sporozoite surface protein 2 Virulence factor MUTATION: TRAP mutant is attenuated for sporozoite infection of rat liver [Ref6635:Sultan et al., 1997]. 9267031 2018 PF13_0197 Plasmodium falciparum 814166 124513450 PF13_0197 XP_001350081.1 merozoite surface protein 7 Virulence factor MUTATION: msp7 mutant is attenuated for invasion of erythrocytes compared to the wild type [Ref6636:Kadekoppala et al., 2008]. 18820076 4465 SAP1 Plasmodium yoelii yoelii str. 17XNL 3926325 Record to support submission of GeneRIFs for a gene not in Entrez Gene. Virulence factor MUTATION: Targeted deletion of SAP1 in the rodent malaria parasite Plasmodium yoelii generated mutant parasites that traverse and invade hepatocytes normally but cannot initiate liver-stage development in vitro and in vivo [Ref7003:Aly et al., 2008]. 18466298 4987 FabB/FabF Plasmodium falciparum 3D7 3885996 296004726 PFF1275c AL844505 XP_966246 Virulence factor MUTATION: A genetically attenuated parasite (GAP) with a mutation in the FabB/FabF gene is attenuated in mice by arresting in the late liver stage [Ref7402:Butler et al., 2011]. 21669394 4988 P36p Plasmodium berghei str. ANKA 3424772 68068733 PB000799.01.0 CAAI01001447 XP_676277 Virulence factor MUTATION: P36p-deficient Plasmodium berghei is attenuated in mice [Ref7403:Douradinha et al., 2007]. 17604034 4989 PY04725 (Py36) Plasmodium yoelii 17XNL 23479924 p36 protein Virulence factor MUTATION: A genetically attenuated parasite (GAP) with deletions in p52 and p36 are attenuated in mice [Ref7404:Labaied et al., 2007]. 17517871 4990 Py52 Plasmodium yoelii 17XNL 15193061 15193062 AAK91678.1 Py52 Virulence factor MUTATION: A genetically attenuated parasite (GAP) with deletions in p52 and p36 are attenuated in mice [Ref7404:Labaied et al., 2007]. 17517871 4991 UIS3 Plasmodium yoelii yoelii str. 17XNL 3830198 83315853 PY03011 AABL01000850 XP_730972 Virulence factor MUTATION: Deletion of UIS3 in Plasmodium yoelii provided attenuation and full protection in mice [Ref7405:Tarun et al., 2007]. 17624848 5133 plasmoDJ1 Plasmodium falciparum 3D7 3885695 86171677 PFF1335c AL844505 XP_966258 4-methyl-5(B-hydroxyethyl)-thiazol monophosphate biosynthesis enzyme Virulence factor To investigate the effect of the loss of DJ-1 in insect stage development, mosquitoes were fed on wild-type- or plasmoDJ1 knockout-parasite-infected BALB/c mice, and infectivity was determined by counting the number of oocysts in the mosquito mid-guts. The knockout parasites showed almost 50% reduction in both infectivity to mosquitoes and the number of oocysts. The results suggested that plasmoDJ1 plays a major role for in parasite development and virulence [Ref7533:Singhal et al., 2014].; 25097910 5170 Sir2 Plasmodium falciparum 3D7 812071 124809723 PF14_0489 AE014187 XP_001348663 Virulence factor histone deacetylase 2 (PfHda2), is a global silencer of virulence gene expression and controls the frequency of switching from the asexual cycle to sexual development. PfHda2 depletion leads to dysregulated expression of both virulence-associated var genes and PfAP2-g, a transcription factor controlling sexual conversion, and is accompanied by increases in gametocytogenesis. [Ref7569:Coleman et al., 2014]; 25121747 5171 PF13_0133 Plasmodium falciparum 3D7 814104 124513238 PF13_0133 AL844509 XP_001349975 Virulence factor PMV activity is essential for protein export in Plasmodium spp. and for parasite survival in human erythrocytes and validates PMV as an antimalarial drug target.; [Ref7570:Sleebs et al., 2014] 24983235 5172 FIKK4.1 Plasmodium falciparum 3D7 812596 124505613 PFD1165w AL844503 XP_001351548 Virulence factor targeted disruption of the gene encoding FIKK4.2 (fikk4.2) dramatically alters the parasites ability to modify and remodel the red blood cells in which it multiplies.; [Ref7571:Kats et al., 2014] 24530877 5173 DegP Plasmodium falciparum 3D7 2655249 124512626 MAL8P1.126 AL844507 XP_001349446 Virulence factor To determine the molecular identity and functions of the parasite-encoded DegP, we complemented the Escherichia coli degP null mutant with a putative PfdegP gene, and the results showed that PfDegP complements the growth defect of the temperature sensitive DegP-deficient mutant and imparts resistance to non-permissive temperatures and oxidative stress. Our data suggest that the PfDegP protein may play a role in the growth and development of P. falciparum through its ability to confer protection against thermal/oxidative stress.[Ref7572:Sharma et al., 2014]; 24494818 5174 PfEMP1 Plasmodium falciparum 3D7 810160 124801837 PF10_0001 AE014185 XP_001347288 Virulence factor The variant antigen Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), which is expressed on the surface of P. falciparum-infected red blood cells, is a critical virulence factor for malaria.[Ref7573:Jiang et al., 2013]; 23823717 5175 PM4 675227064 plasmepsin IV Virulence factor PM4 deficiency in the rodent malaria parasite Plasmodium berghei results in significantly less virulence than that for the parental parasite. P. berghei Deltapm4 parasites failed to induce experimental cerebral malaria (ECM) in ECM-susceptible mice, and ECM-resistant mice were able to clear infections. Furthermore, after a single infection, all convalescent mice were protected against subsequent parasite challenge for at least 1 year.[Ref7575:Spaccapelo et al., 2010]; 20019192 5206 nt1 Plasmodium falciparum 3D7 814217 124513660 PF13_0252 AL844509 XP_001350186 Virulence factor Nucleoside transporter 1 (NT1) plays an important role in purine salvage in Plasmodium berghei (pb). The rapid increase of wild-type pb-ANKA in mice early in infection was significantly inhibited by disruption of pbnt1. Moreover, mice infected with Δpbnt1 parasite showed neither cerebral paralysis nor cerebral haemorrhage, and all mice spontaneously recovered from infection. The results showed that the pbnt1 gene act as an important virulence factor in Pb ANKA in the asexual.[Ref7604:Niikura et al., 2013] 23402751 5227 PkNBPXa 213950524 EU867791 normocyte binding protein Xa Virulence factor Our study strongly suggests that P. knowlesi invasion gene variants contribute to parasite virulence. We focused on two invasion genes, and we anticipate that additional virulent loci will be identified in pathogen genome-wide studies. [Ref7621:Ahmed et al., 2014]; 25121807 5228 PkNBPXb 213950526 ACJ54536 normocyte binding protein Xb Virulence factor Our study strongly suggests that P. knowlesi invasion gene variants contribute to parasite virulence. We focused on two invasion genes, and we anticipate that additional virulent loci will be identified in pathogen genome-wide studies. [Ref7621:Ahmed et al., 2014]; 25121807 5229 HP1