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PFB0100c

Victor ID 1977
Gene Name PFB0100c
Sequence Strain (Species/Organism) Plasmodium falciparum
NCBI Gene ID 812616
NCBI Protein GI 124800689
Locus Tag PFB0100c
Protein Accession XP_001349534.1
Other Database IDs UniProtKB-ID: Q9TY99_PLAF7
UniRef100: UniRef100_Q9TY99
UniRef90: UniRef90_P06719
UniRef50: UniRef50_P06719
UniParc: UPI0000076F25
EMBL: AE001362
EMBL-CDS: AAC71810.1
RefSeq_NT: XM_001349498.2
MINT: MINT-1562358
EnsemblGenome: PFB0100c.
KEGG: pfa:PFB0100c
NMPDR: fig|36329.1.peg.260
EuPathDB: PlasmoDB:PFB0100c
OMA: NEDAESV
Taxonomy ID 36329
Chromosome No 2
Gene Starting Position 103384
Gene Ending Position 105795
Gene Strand (Orientation) -
Protein Name knob associated histidine-rich protein
DNA Sequence 
>gi|23593254:103384-105795 Plasmodium falciparum 3D7 chromosome 2, complete sequence
TTTAACCACAGCATCCTCTTTTCTTCTTTTTCTTTCCTGCTTCTTGTAATTGTGCTTGTCCTCTTGACAT
TACTTGTTCACCATTATTTGCAGCATTTTTATCGGCAGTTTCATCTTTAGATTGTACTGCATTAGCTCCT
GTAGTTGCTCCTGTAGTTGAACCTGCAGTAGTACTTGCTCCTTTAGTTGCTCCTTCAGTAGTACTTGCTT
CTTTAGTTGCTCCTTTAGAAGTACTTGCTTCTTTTGTTGCTTCTTTAGAAGTACTTGCTTCTTTTGTTGC
TTCTTTAGAAGTACTTGCTTCTTTTGTTGCTTCTTTAGAAGTACTTGCTTCTTTAGTTGCTCCCTTAGTT
GCTCCTTCAGCAGCACATTGTCCTTTATTTGTTGCGGCATTAGTACTTGCTCCTGTTTTGTCAGTTTTTC
CTCCTTGAGTTTTATCTTTTGCGCCTGGTGTAGCAGCATTTGTTGATTTATTATCAGCTGAAGTAGAATC
TACTTTTTTATTTTCTCCAGCGGTGTTTTTTGTTTCATTTTCTTTTTTTTCATGAGCTTTTGATCCATCT
GATTTTGAATTATTGGTTTTTTCTTTATTTTTATTTTCTTCGTTAGTTTTTTTGCTGCATGGTTTTTTTC
CATTATGCTTTTCTCCCTTTTCTTTAACACTTTTTTTTGATTTTACGCTTTCTGCATCTTCATTGTCTTT
GTGTTTTTTTGATTTTTTCTTTTCACAATCGTGGCTTTTGTGTTTTTTTGATTTTACGCTTTCTGCATCT
TCATTGTCTTTGTGTTTTTTTGATTTTTTCTTTTCTCCATCGTGGTCTTTGTGTTTTTTTGATTTTTTCT
TTTTTTCTCCTTCACCGTCATTTCCTTCATGCTTTTTAGAGGAATGGTGTTTTTCATCACCGTGTTTTCC
ATATTTATTTACGGAACTGAATGAACTATATCTTGAACCATGGGCTGCACCATGTGGAACTCCGTATGGA
GCTGAATAGCCTGCACCATGGGGTGGGACATAATTTTGCATACCATTACTTCCAGGAGCACCATTAAATC
CTGGGTTATATGGAGCTTCATATCCATAACCTTCTGAACCTTTATTATCGTGTCCTCTTAAATTACCGTG
AGAACCATCGTGTGCACTTCCTCCATAAGCATAGCCATTTGGTGCATCTGCTGGAACATAATCTATAGCG
GCAGGTCCACATGTGGTACATGTCTCATTACATATTCCATATAATTGGTTTTGGTATTCATCTAAACCAC
CTGGTAATTTATCTTTTATTGCTAATGCTTCTTTACCTTCTTCATCTTCATCATTCATTCCAAGAGGGAA
TCTTTTTCTTAAGGCAAATATATTTGGACCATTTTCTTGGCTATAATCGTTTACGGTGTATGGGCACTCT
TCGGAGAAAGCATAATTGGCAGCTTCGTATTTTTCATCACAATCTTTTTTACCATCGACAACATTTTCCT
TTAATTTATAGTGTTTTGATTCGTATTTTTCTTCATATGCTTTGAAACCTCCACCTGGTCTTGCTTCCCT
GAATACTTGGGTTTTTACAACTGGTTCATTACTAGGAGGATTAGCAACTGTTCCCTGGGGTTGTTGAGGT
TGTAATTGATGATGGTGGTGATGATGGTGATGGTGTGCTTGGTCTTGACCATGTACTTGTTGGTGAACCT
GTGGTGCTTGGTGATTTACTTCTCCATGATGATGATGGTGGTGTGCTTGGTGTGGAGCTTGGTGTTGGTG
TTGATGTTGATGGTGATGGTGGTGATGGTGTTCATGTTGCTTTTGTGCTAAAGTTCTCTTATTTCTGAAA
TCGAAGGAGTCACCGGATCCGTTTCCATTATTGCACTATATGAAAAAAAAAATAAAATTAAATTAAAATA
AAATAAAATAAAATTAAAATAAAATAAAATAAAATTAAAATAAAATAAAATAAAATTAAAATAAAATAAA
ATTAAAATAAAATTAAAATAAAATTAAAATAAAATTAAAATAAAATTAAAATAAAATAAAATAAAATTAA
AATAAAATAAAATAAAATAAAAATAAAATAAGAAAATAATAATATATAAATATATATTTCATATTTTTTA
AACATCACATATATATATATATATATATATATATATGAAATAAATATATGGAGTAAATATTGTTCAAATA
AACTAATATATAAATATATATATAAAATATTAGGTAAAAAAAATAAAGAATATACACATATGTCAAAGTT
ATAAAATACACATAATTATATATATATATATATATATATATATATATTATTTATGAACTTACGTTATTAG
AGCACTTCAAAACCCATACTAAAAAAGAGACTAAAAGAATTTTAGTAAAAACAGGGAAAGCCTTCTTTCT
CCTCAAAGTATTTTTGTTCTTAAAACTTTTCA
Protein Sequence 
>gi|124800689|ref|XP_001349534.1| knob-associated histidine-rich protein [Plasmodium falciparum 3D7] MKSFKNKNTLRRKKAFPVFTKILLVSFLVWVLKCSNNCNNGNGSGDSFDFRNKRTLAQKQHEHHHHHHHQHQHQHQAPHQAHHHHHHGEVNHQAPQVHQQVHGQDQAHHHHHHHHHQLQPQQPQGTVANPPSNEPVVKTQVFREARPGGGFKAYEEKYESKHYKLKENVVDGKKDCDEKYEAANYAFSEECPYTVNDYSQENGPNIFALRKRFPLGMNDEDEEGKEALAIKDKLPGGLDEYQNQLYGICNETCTTCGPAAIDYVPADAPNGYAYGGSAHDGSHGNLRGHDNKGSEGYGYEAPYNPGFNGAPGSNGMQNYVPPHGAGYSAPYGVPHGAAHGSRYSSFSSVNKYGKHGDEKHHSSKKHEGNDGEGEKKKKSKKHKDHDGEKKKSKKHKDNEDAESVKSKKHKSHDCEKKKSKKHKDNEDAESVKSKKSVKEKGEKHNGKKPCSKKTNEENKNKEKTNNSKSDGSKAHEKKENETKNTAGENKKVDSTSADNKSTNAATPGAKDKTQGGKTDKTGASTNAATNKGQCAAEGATKGATKEASTSKEATKEASTSKEATKEASTSKEATKEASTSKGATKEASTTEGATKGASTTAGSTTGATTGANAVQSKDETADKNAANNGEQVMSRGQAQLQEAGKKKKKRGCCG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: KAHRP mutant has reduced adherence to CD36 when tested under flow conditions that mimic those of postcapillary venules (Crabb et al., 1997).
References
Crabb et al., 1997: Crabb BS, Cooke BM, Reeder JC, Waller RF, Caruana SR, Davern KM, Wickham ME, Brown GV, Coppel RL, Cowman AF. Targeted gene disruption shows that knobs enable malaria-infected red cells to cytoadhere under physiological shear stress. Cell. 1997; 89(2); 287-296. [PubMed: 9108483].