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nt1

Victor ID 5206
Gene Name nt1
Sequence Strain (Species/Organism) Plasmodium falciparum 3D7
NCBI Gene ID 814217
NCBI Protein GI 124513660
Locus Tag PF13_0252
Genbank Accession AL844509
Protein Accession XP_001350186
Taxonomy ID 36329
Chromosome No 13
Gene Starting Position 1886183
Gene Ending Position 1887451
Gene Strand (Orientation) -
Protein pI 8.19
Protein Weight 44653.78
Protein Length 422
Protein Note Nucleoside transporter 1
DNA Sequence 
>gi|296005645:1886183-1887451 Plasmodium falciparum 3D7 chromosome 13
TTTATTGTGTTACATCGATGGGTGGTAAATCTGGCTTTGGTAAAACTATATTGAATAAGTTATAAATGTA
TGTAGTCCATATACCACAGAATAATCCAACAAACATAGCAATAACTAAGAATGTGGATATAATTTCGATT
TCTTTCTTTTTCTTGGCTTTTTTTAATTCTTTAACAAATACAAGGAATGGTACAGTATTAAACCAACCAT
TTGTAAAAGCTAACATAGCCATACATACACATTGTTGTACAATGTTTTTGAAAAATGGATGATCAACACA
TGCATTTAAAATAAACCATGGAATGAATAATAATCTCAATGAATTGGCAACCAATAATTTATTTAAAGAG
AAAGTAAAATTTTTAAAGATTTTAATATGTGTAAGATTTGGTGGATATCTACTGAGAAAATCAAAAACTT
GAAACATACCAACAATAATGGTAACATTATAATCGGAGATATTATGACTTTCTTGCCATTTTTTGTGTCC
AACACCTGGAAATAATTGTAAAGTTAACCAGTTTACAAGAAACATAGTTAATATAGCTTTGTAACTATCT
TTAAATAATTCCATATAAGATAATGTGGCATTGTTTTCTTTATTTTCTTCATCTTTTTTATTATTCTTGT
TTGTTAAATCTAAATTACATACACAAAATACTATAGCTAATATTAAACAAAGTTCACAGATTATATATAA
ATATAATAACTTTGCTTTATTAACACCATAATGTTTTTCGGGAGATACGAATTGATCAAGTAATAAATTA
ATAACAAAAATAAATACTCCTGATATACCAATACCTGCTGACATATAACCACCCATATTATCTTCCATGG
TTGATCCTATATTAAATGCAATGGTTTGAGCTAATCCTGCCACTACACCAATAACAATAAAAGCTACTAA
ACAATATGTATCAAATTGTGTATCTGTAAAAAAACTGTGAGATATTTGAAAACCTGCACATAAAATTGAT
AAACCACCCAAAAGAAATGGTAACATTATTTTGGGAATCTCAACAAATAAAGCTACAATTGAGGAACATA
CTAAACCTGTAATCTGAAAGGTATTATATTTAAAATTTATATTTAATCCTAAGGCTGTATTCCATACATT
CAAAGAACTTAAACCTATTAATATAAAGGTTAAAGATAACATGAAATGTTGTTTACTGCTTAATGTAGAT
CCTTTCTTTCCATCGTCCTTATAATCACCCCTGGATTCTATATCAGCATAAGCTTTAGATGACTCTTTAC
CGGTACTCA
Protein Sequence 
>gi|124513660|ref|XP_001350186.1| nucleoside transporter 1 [Plasmodium falciparum 3D7]
MSTGKESSKAYADIESRGDYKDDGKKGSTLSSKQHFMLSLTFILIGLSSLNVWNTALGLNINFKYNTFQI
TGLVCSSIVALFVEIPKIMLPFLLGGLSILCAGFQISHSFFTDTQFDTYCLVAFIVIGVVAGLAQTIAFN
IGSTMEDNMGGYMSAGIGISGVFIFVINLLLDQFVSPEKHYGVNKAKLLYLYIICELCLILAIVFCVCNL
DLTNKNNKKDEENKENNATLSYMELFKDSYKAILTMFLVNWLTLQLFPGVGHKKWQESHNISDYNVTIIV
GMFQVFDFLSRYPPNLTHIKIFKNFTFSLNKLLVANSLRLLFIPWFILNACVDHPFFKNIVQQCVCMAML
AFTNGWFNTVPFLVFVKELKKAKKKKEIEIISTFLVIAMFVGLFCGIWTTYIYNLFNIVLPKPDLPPIDV
TQ
Molecule Role Virulence factor
Molecule Role Annotation Nucleoside transporter 1 (NT1) plays an important role in purine salvage in Plasmodium berghei (pb). The rapid increase of wild-type pb-ANKA in mice early in infection was significantly inhibited by disruption of pbnt1. Moreover, mice infected with Ãâpbnt1 parasite showed neither cerebral paralysis nor cerebral haemorrhage, and all mice spontaneously recovered from infection. The results showed that the pbnt1 gene act as an important virulence factor in Pb ANKA in the asexual.(Niikura et al., 2013)
References