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plasmoDJ1

Victor ID 5133
Gene Name plasmoDJ1
Sequence Strain (Species/Organism) Plasmodium falciparum 3D7
NCBI Gene ID 3885695
NCBI Protein GI 86171677
Locus Tag PFF1335c
Genbank Accession AL844505
Protein Accession XP_966258
Taxonomy ID 36329
Chromosome No 6
Gene Starting Position 1101734
Gene Ending Position 1102852
Gene Strand (Orientation) -
Protein Name 4-methyl-5(B-hydroxyethyl)-thiazol monophosphate biosynthesis enzyme
Protein pI 7.46
Protein Weight 17812.72
Protein Length 189
DNA Sequence 
>gi|86176855:1101734-1102852 Plasmodium falciparum 3D7 chromosome 6
ATTAAAATGTAACTGCTGGATGTAAAAGAAAACCTGAAGCAAGGCTTAGTGCTACTTGCCTTCCTAATAA
ATGTTCAACAATTTTAAGACCAAATTCAACAGCTGAACCTGGTCCTACAGAAGTTATACAATTTTTAGAA
ACACATACTCTTCCTTTTCCAATGTGTTTAAAATTTCTTTCAAAAGAAGGATAAGCCACAGCTTCTACAT
CATCAATTAACGAGTGTCGATCTAAAACAGTTTCGGGGGCAGCACATATAGCTGCATATAATCTGTTATT
AGCTTTTTGTTCTTTTAACATGTCAATAAATTCTGAACACTCCGATATAGTATTAGATCCTTTCATACCT
CCTGGTATGACTAAAACATCATAAATATTATTTCGTACCTTACTAATAGTTGTGTCAGCTAACACGACAT
TTTTTGATTGTAAGCAGACTTGCTCACTCTTTTCAACAGATGCTGTTGTTACATGTACACCTTATAAAAA
ATTAAAAAAAAAAAAAAAAAAAAAATATATATATATAAATATACATATATGTATGTTATTTCATTTTTTT
TTTTTTATATATTATATATTTATATCATTAAACGAAATTAAAATGAAAGACCTGAATTTTTTAACTTTCT
CATTTAAAAGTAAAATGAATATACATATATATATATATATATATATATATATATATATATATATATATAT
ATTATGGTTATTTTTTCTTTCTTTCACATATATATTATTATATGATAATGTAATATTATAATTGGTGAAG
TATCCCAAATTACACAAAAATATTATACGTATATAAAAATGTCATATGTTTATATTTTTATTTTTATATT
TATTTACCTGCTCTCCTTAAAACGTCAACAACAGTAATATATTCGACATCTTCAGATCCAGAAGCCTTAA
AAAAAAAAAAAATTAAAAGAGCAATTTTTTATATGTATAAATAAAGCAAAAATATGTATGTATATATATA
TATATATGTATAGTATTACATAATATATTGATACTACAGAATTATTTATGGGTATATATTAATAAATCAT
AACAGATGTATTATTTTTATTTATTTGTATGCCTCACCACTGCAACTAATGCTGTTTTTTTTCCACTCA
Protein Sequence 
>gi|86171677|ref|XP_966258.1| 4-methyl-5(B-hydroxyethyl)-thiazol monophosphate biosynthesis enzyme [Plasmodium falciparum 3D7]
MSGKKTALVAVASGSEDVEYITVVDVLRRAGVHVTTASVEKSEQVCLQSKNVVLADTTISKVRNNIYDVL
VIPGGMKGSNTISECSEFIDMLKEQKANNRLYAAICAAPETVLDRHSLIDDVEAVAYPSFERNFKHIGKG
RVCVSKNCITSVGPGSAVEFGLKIVEHLLGRQVALSLASGFLLHPAVTF
Molecule Role Virulence factor
Molecule Role Annotation To investigate the effect of the loss of DJ-1 in insect stage development, mosquitoes were fed on wild-type- or plasmoDJ1 knockout-parasite-infected BALB/c mice, and infectivity was determined by counting the number of oocysts in the mosquito mid-guts. The knockout parasites showed almost 50% reduction in both infectivity to mosquitoes and the number of oocysts. The results suggested that plasmoDJ1 plays a major role for in parasite development and virulence (Singhal et al., 2014).
References
Singhal et al., 2014: Singhal N, Atul, Mastan BS, Kumar KA, Sijwali PS. Genetic ablation of plasmoDJ1, a multi-activity enzyme, attenuates parasite virulence and reduces oocyst production. The Biochemical journal. 2014; 461(2); 189-203. [PubMed: 25097910].