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DegP

Victor ID 5173
Gene Name DegP
Sequence Strain (Species/Organism) Plasmodium falciparum 3D7
NCBI Gene ID 2655249
NCBI Protein GI 124512626
Locus Tag MAL8P1.126
Genbank Accession AL844507
Protein Accession XP_001349446
Taxonomy ID 36329
Chromosome No 8
Gene Starting Position 396769
Gene Ending Position 399908
Gene Strand (Orientation) -
Protein pI 9.84
Protein Weight 96926.54
Protein Length 870
DNA Sequence 
>gi|296005143:396769-399908 Plasmodium falciparum 3D7 chromosome 8
ACTAATATACATATCTATCACGTGTAATAGAATAAATCTTTTTAATTTCTTCATTATATTTTTCAACATC
TCTTTTATTTAACACTATAGGTACTTTTTGCCCAGAAGTTGTTAAAATTAAGATATGAATAATTGTATTT
ATATTTAATGATGTTATCTTTGTATTATAATAATTTATATAACTCTGAAGAGTATGTTTATTATTTTTTA
AATACATAAGTCTGTTGGTATATTTTGTCATTTCAATTAATTCAATCAAGTGTTTTAAATTTTTTACTTT
TATATTATTTACTCTAAGTACAATAGAATCAGTATAATAATATCCTGTTGTTATTTTTGTTGGTAATATA
TTTTTTAATACAACTATTTCATCTTTACTTTTTTTTTTAAAATTATTATATAACATTAATTTATTAATTT
CTGGATTTTGTGTATACACATATAAACTTCTTGTTAATATAGAAAAAACAATTCCACCGTATATAAAATA
TTTATTTCGTTTGTCCCAATTATGTTGATTTAATAAATATTTTACTTTATATAATTTTACCATAACACTT
TTTATTTTTTTATTTCTTACTATTTTAATTATACATAAATCGTTTATAAATTTCTCATTAAATAAATGTT
GAAAACCTACCGTTTCGTTGTCCCTTAGTATTACGGATCCATCGTTGTTGATATCCTTACCATCTACCCT
CAGAATTATGTCGTTCTTTTTTAGACCATAGCAACTTTGTTCATCCTCACCATGCATATTATAATAATAA
TTAAAATTATTATTATTATTATTATTATCACTATATATTTTTTTTTTTTTTTTATCACTATATATATTTT
TTTTATCACTCGTAATAATGTTTGAGTTCAAAATATATGTGCAATAGTCTGTATCCCCCTGAAGGTTATC
TGTATGATCATCACCAACATTGTGGTGTGTATCACCAACATTGTGGTGTGTATCACCAACATTGTGGTGT
TTATTATCCATATCATGATATTTATCATCTTGTTTACTCATATGACCTTCAAATACCTCCGTTATCAATA
TCCCAACGTTTTTTTTTATTATTTTTTTTCTTTCCATTTCTTCTAACCCTAAGGCTTCACGTAGGGAAGG
GTTTTCCAGAGGTTCGTACTTGACTCCCAAAAAAGCGTATCCTGTATAGTCTTTATTTTTATGTATATCT
AAAAGAAAGTGACTAATTATAGTACTAGGTATAATGTAAGATATATTATTAGAAACCTTGTAGGATTGAA
AGCATATACCTACAACTTTCCCTCTGACAAGAGCTGGACCTCCGCTATTTCCTGGGTTCAGAGGGGCATC
TATTTGGGTTAACAAAAATCTTGTCGAAGAAATGTGAATAAAAATAAATAAATATAAAAATAAATATATG
CATAAATATATATACACATATATATATATTATTATTTTTTGTGTTGTCTATACTTATAATTTGAATGTTT
ATAATACTGCACGTCTATTCTACTTACAATACCTTCTGTTACACTTAACTTATCCCCCCCCGCTGGATAA
CCGATAGTTATAATTTCATCTTTTAATGAAGGGAGAGCTCCAAAATGAAGAGCATACACATCATCAAAAA
AAGTTTTATCGTCAGTAGTAAGGATTGCTATATCTACATCATGAGCAACGTACAAAATCTTCGCCTCATA
TTTTCCGGAATTTCTACAAGGAAAAAGATGATATTTTTTTTAAAACAAAAATATTCATGGTATATTATAA
TATTCACACATATGTATATAGACATGTGCAAATGTATGAATGTACACACGTGCATTTTTATATGTTTATA
TGTTTATTTAACCCGTGCTTTCTTATTAATATCCTGGTACTATAGGAAATATTGTGAGCATTGGTTATAA
TTAGATGACCCTCAATAATAAACCCCGATCTGTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
TATAAATATATATATATATAACTTTATGTATATATTAACATTATAATTCTTATATGTAAAATTTTCTTTC
AAATTCAAATAATACATATATATACACCCATATATATATATATATATATATATATATATGTGATAACCCT
GTTATGCTTTTAGGTGGATAATTCTGCCATATCATTTCAAGGTTAGGTTCTGTTATATCCACATATAATT
TTACAACACCTTTGAAATATTTTTTAAATGAATTACCTTCCTCTTTTATATTATTATCTTCTTCTTTTAC
TTTTCTTTCATTTCCTTCTTCCCCTCGGATATCTTTTATGGTACGACTCAAAGATATGTTTTCTAAATTT
TCTAAAAGTCTTTCATTTATTATAGACTCTTCTTTATTATTCTTCTTTGTGGCCATTTTGTCTTTCTTTT
CATGTGTCGATGAGTGTAGGAAATATTCCTCTACAAAAAGAAAAAAATATATACACACATATATATATAT
GTATATATATATATATATATATATATATATATATATGTATATCTTTTATGTTTTATTTTTTCTTACTTGG
AAAAAAGGGCAAGACTCTCCCATTAGACATATTTACATTTACATTTGTTTTTTTATTTTTGTTCATTAAA
CGCTTTTGAATTGAACTTATCATAGAAGGTGTAAGATATTTCGTTATTTTTTTTTTATCATAACCAACAA
TATGAAATTTAATTTGTCCAATTTTGTTTTTGTTCTTTTTATTATTTGGAGAATGCTTTCTTAATTTTGG
GTTTTTAAAGTTATCATTTAATGGATTCTTTTTTTTTTCATTTAATATATTTTCTTTAACATTAAAATGT
TGTACTGAATTAATTTCATTTATTTTATTATTACTTTTTTTTTTCCTATATATATATTTTTTTTTTTTTT
TTTTTTTTTTTTTATCATCATATTCATTTTGTAACATTTCTACAATGTCAGTTATTTTTATATTTCTTTC
ATCATTCAATATACGACCTAATATGTTCATATCATCATTTATCCTTTTTAAATTAGTCGATATAATTTCT
TCTTCTCCTTCTTCTTTTTCTACTGAACAATTCAGAAAATTGTTCGTATCACATCGGGTCCTTAAAGAAA
TTAACATTATTATCATTAACATGATTTTACAATATGTAGGTGTACAAAAAATAATATCCA
Protein Sequence 
>gi|124512626|ref|XP_001349446.1| serine protease, putative [Plasmodium falciparum 3D7]
MDIIFCTPTYCKIMLMIIMLISLRTRCDTNNFLNCSVEKEEGEEEIISTNLKRINDDMNILGRILNDERN
IKITDIVEMLQNEYDDKKKKKKKKKYIYRKKKSNNKINEINSVQHFNVKENILNEKKKNPLNDNFKNPKL
RKHSPNNKKNKNKIGQIKFHIVGYDKKKITKYLTPSMISSIQKRLMNKNKKTNVNVNMSNGRVLPFFPKE
YFLHSSTHEKKDKMATKKNNKEESIINERLLENLENISLSRTIKDIRGEEGNERKVKEEDNNIKEEGNSF
KKYFKGVVKLYVDITEPNLEMIWQNYPPKSITGSGFIIEGHLIITNAHNISYSTRILIRKHGNSGKYEAK
ILYVAHDVDIAILTTDDKTFFDDVYALHFGALPSLKDEIITIGYPAGGDKLSVTEGIVSRIDVQYYKHSN
YKFLLTQIDAPLNPGNSGGPALVRGKVVGICFQSYKVSNNISYIIPSTIISHFLLDIHKNKDYTGYAFLG
VKYEPLENPSLREALGLEEMERKKIIKKNVGILITEVFEGHMSKQDDKYHDMDNKHHNVGDTHHNVGDTH
HNVGDDHTDNLQGDTDYCTYILNSNIITSDKKNIYSDKKKKKIYSDNNNNNNNFNYYYNMHGEDEQSCYG
LKKNDIILRVDGKDINNDGSVILRDNETVGFQHLFNEKFINDLCIIKIVRNKKIKSVMVKLYKVKYLLNQ
HNWDKRNKYFIYGGIVFSILTRSLYVYTQNPEINKLMLYNNFKKKSKDEIVVLKNILPTKITTGYYYTDS
IVLRVNNIKVKNLKHLIELIEMTKYTNRLMYLKNNKHTLQSYINYYNTKITSLNINTIIHILILTTSGQK
VPIVLNKRDVEKYNEEIKKIYSITRDRYVY
Molecule Role Virulence factor
Molecule Role Annotation To determine the molecular identity and functions of the parasite-encoded DegP, we complemented the Escherichia coli degP null mutant with a putative PfdegP gene, and the results showed that PfDegP complements the growth defect of the temperature sensitive DegP-deficient mutant and imparts resistance to non-permissive temperatures and oxidative stress. Our data suggest that the PfDegP protein may play a role in the growth and development of P. falciparum through its ability to confer protection against thermal/oxidative stress.(Sharma et al., 2014)
References