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PM4

Victor ID 5175
Gene Name PM4
NCBI Protein GI 675227064
Other Database IDs CDD:140051
CDD:133138
Taxonomy ID 5823
Gene Strand (Orientation) ?
Protein Name plasmepsin IV
Protein Length 450
Protein Note plasmepsin 4 (PM4); Provisional
Protein Sequence 
>gi|675227064|emb|CDU21415.1| plasmepsin IV [Plasmodium berghei ANKA]
MEYSEKESNYSNGLMRNGSAFGHLKFDNIKSFKIQKKFQALYFIIFICIIGSIFAYMVGTNYYSTKTIDI
DKIIANSEYLTIRAKIERPRDKLFKKVMNKNVSNYIKESFKLLKSGLLKKEHLTKYEDSIELDQSLGLSF
IGTAELGNNKQSFSFILDTGSANLWVPSKECKSGGCAYKHRYDSSASNTYEKDGTPVSILYGSGGIKGFF
SNDMFTIGHHTIPYKFIEVTETDDLEPIYTASPFDGILGLGWKSLAVGNVEPVIVEMKKTGQIENAVFSF
YLPEADDSVGYFTIGGIEESFYTGDVTYEKLTNESYWQINLDVDFGIVALNNANAIVDSGTSAITAPSDF
LNKFLNSIMSIPVPFIPLRIVLCHDTNLPTLKFRSKSTEYTIEPKHYLIELDPVGGICAISLIDVDIDAN
TFILGDVFFKKYYTIFDYDNSRVGFAVAKN
Molecule Role Virulence factor
Molecule Role Annotation PM4 deficiency in the rodent malaria parasite Plasmodium berghei results in significantly less virulence than that for the parental parasite. P. berghei Deltapm4 parasites failed to induce experimental cerebral malaria (ECM) in ECM-susceptible mice, and ECM-resistant mice were able to clear infections. Furthermore, after a single infection, all convalescent mice were protected against subsequent parasite challenge for at least 1 year.(Spaccapelo et al., 2010)
References