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Sir2

Victor ID 5170
Gene Name Sir2
Sequence Strain (Species/Organism) Plasmodium falciparum 3D7
NCBI Gene ID 812071
NCBI Protein GI 124809723
Locus Tag PF14_0489
Genbank Accession AE014187
Protein Accession XP_001348663
Taxonomy ID 36329
Chromosome No 14
Gene Starting Position 2108809
Gene Ending Position 2112723
Gene Strand (Orientation) +
Protein pI 8.04
Protein Weight 149551.17
Protein Length 1304
DNA Sequence 
>gi|258549241:2108809-2112723 Plasmodium falciparum 3D7 chromosome 14, complete sequence
CATGAGTTGTATGAACTATGCTTCACGTTTGTCAAAAAATGAATATAAAGGGCCACTAGGTGAAGAAGAA
TTTTTTGAAGATACTGAAGAAGAGAAAAAGAAAGTTAAGGAACTTATAGAGAAAATTAGAAGTAGTGAAT
ATATAGTTGTTCATTCAGGTGCTGGCATATCAACTAGTTCAGGACTGCAAGATTTTAGAGGTCCTACAGG
AATATGGACAAATGAACACCTTAACGAATTAAAGAATAAAAAAAAAAGAAATCATGATTTTAAGGATAAC
AAAAGAAAACTTAAATCTAACGATATAAACTGCAAGAACACTTCAGATATGTGTAGTCCTTCCTTTTTTC
ATAAGGAAAAGAAAGAGAATACATTAAATATTGTAAAAAGGGAAAGGTATTATAATGAAGATAATGTAGA
TATGAATGCGTGTAATGAACGTGTTGTACATCCTAACCATGTATATGTTAATCATGAAGATGATAATAAT
AATAATAATAATAATAATAATAATGATAATAACTTGTACAATAATGTGTACAATTCTGTAGGATCGAATG
ATCATACAAATAAAGAAAGTATTCTTATTAAAAAAGAAAATAATTCAGAAAATGTTAGGAAGGACATACA
TGATAAGGTAAATACAAAAAATGTTAAAAAAATAGATGTTAAGGAAACAAATAATTTAGATCCCGAAAAT
TATGTAATTTTTGGGAAAAGGAAAAAAAAAGTTATAGAACTTCATTTAGCTTTACCATCAAAAACTCATA
TTATGATAAATGAATTAATAAATAAAAATATAATAAAATTTATGATAACTCAAAATATTGATTCTTTGCA
TCATCGATGTGGGAAACACTTTTCTAAAACTGCAGAAATTCATGGAAATATTTTTACAGAAAGATGTGAT
TTTTGTGGTAGAAGATATTTAAGAGATTATCTCATATCTACTATTAGTTTTAAACCAACTGGATCTTTAT
GTTTTTTGTGTTCATTTCCTCCTATTGGAGTATGTACTGATGTTTTATTAGATTGGAATAATTCTTATGA
AGAATTTTTTCATTTAAATTCTATAAAGCATTCTCAAATAGCAGATTTTCATTTTTGCTTGGGTTCTAGT
TTTTACATAGTCCCGGCTAGCTCTTATCCATCTAAAAAAAAATATGCTAATGCAAATTCCTACAGTTGTG
TTATTAATTATCAAAAATCATTTTTATCAAAAGAAGTTAATTTGAATATACATTCAAATGTGAATAATAT
ATCGGATATAATTATTAAAGAGTTTTCTCTTAATCCTTTGTCAATAAGAAGTGCAAGGATAACAATCGTT
AGGTGCCCAATTAATACATTGGATGTAATATGTGATAAATTAATATCAATACACAATATTAAAATGAAGC
ATAAGAGCATGAGACAACATAGTATCGATTATTCTCAAATGGGGAATAAGGATGAAAAATATAATAATGA
AAAATATGTAAAAAGAAATATGACTGAATGTTTATATTATAACAAGGAAGGTGAATGTTATGAAAAAAGG
AAGTATAAACTAATGGAGAAAAAGTTTTTTCCTAATAATCAACAAAATGAATTTATACCAAATAGAATAA
ACATATTTGAACAAAAATTTCACGAGCACAACAACAACAACAACAACAATAACAACAACAACAACAATAA
CAACAACAACAACAACAACAACAACAACAACAATAATAATAATAATAATAATAATAATAATAGTAGCAGT
AGTATTGATAGTAGTTGTAGTATTAATAGTAATTATCATATATCTAAAAATATAAATCCTGATTTTTCTT
TTGTTGAAAATCAGTCCAATATTTATGAGAACTATAAGGAACAAACATTTATACTTATATGTCCCATGAT
AATAAATATCAAAACTGTACGTTTAGAAAGTTTTCATAAAGTATATATAAAACTATTGGATGACATTAAA
GGTTTATGGTTCATAAAAACAAATTTTTCTTGTATTTTAGAAGTAGAATTATGGTATCATTCTTTTATTT
TATTAAAATTAGATTTTAATAAAAGTGATCCTTTTATTCAGTTGAATGCGTGGAATGTAAATGTAGCATA
TACATATGGTGATGACATAGACGATTTCGATTATTTCAAAAATGATGAGAACATTAAGAAACCATTTAAT
TTATATAAAAATAAATATATTTCTAATATGAGAAGAGAAGGGCATGTTAATAATTTGTATACATTGGATA
ATGAAAAGGTAAAAAGTAATACCAGTAATAACAATAATAATAACAATAATAATAATAATAATAATAATAA
TAATAATAATAATAATAATAATAATAATAATAATAATAATAATAATAATAATAATAATAATAATAATAAT
AACAATAATGATAATAATAATAATAATATTAGCGATCATAACATTTATGATGATCATAATAATAATAATA
ATAAAAATCATAATAATTATGATAAAGACAATTCAAATGAATCATATTACTGTTCTGAAATATTAAATGA
ACATGTACATGTAGGTTATAACCCTAATAATTATGAACCCAATTGTAAAGTATATATTTTAGCATATTTG
GATAATTTAAGAACAAGGAATATAAATAATAATGTTAATAATAATAATTTTAGTCGCTTTAATTTAACAC
AATCATGCAAATTGTTATACAACATATATTGTGTGCTTAATAAAGATAATGAACAAAAGAAAAACAGTAC
TATAAAAGAAACATATGATAAACTGGATTATTTTATAAAAAACTTTGATTTCAATAGAGATAGTTGCTTA
TATACAAATAATTTTATAAATATGCTTATACAAAATGAACGTCATGGTAATCAAAGTCGCTATAAATTTA
GAGAAAGAAGAAAGAGACTTTTAAATGATTACAGTTCATGTTCTTCTGATGATGATCAGAGTGGAAAAAA
TATTTTCATTTTTTATAATTTATATATGAATCAATATAAGAAAAAGGAAGATAATGAAATAAATGATATA
TATAAAAAATATGATGTTCATGAGAAAAATATATATGATGAATCAAAACAATATGTGCATAAAGTTAGAG
TGAGAACTGATCTAATTAATCATAAATCTGTTTACAAAATATTAAAGAATAACTATTTGGTGAATATTAA
CAATATGAAACTAATGGAAAAAAAAAATAATTCAGAAAAGTTGTTCTTGATAAATGACAAGGATAATAAT
AGTCTCCTTTCTATTAACAATAAAGAAAATTTTAATTGTATACCCTCTCGTCAAAACAATGTAAAGAAAA
ATAGTGAATACATGCATGAGGAAGAAAATAATAAAACGAATTCTAACGAAAATATAGCACGATTGAATAA
TAATGATTTCATACAGGTTATGGAAACTGAAAAGCAAAAGAAGTACAATTCTTTTGATAAATATAATAGT
GATAGATCTTCAATAAATGATACATTTGATGAAATAAAATATAATAAAAATAATGATAATAATAATGATG
ATAATAATTATGATGATAATAAAAATGATGATGATAATAATAATGATGATAATAATAATAATGATGATAA
TAATAATAATGATGATAATAATAATAATGATGATAATAATAATGGATATATATATTCTCCAGTTCTTTTC
ATAAATAAAAAATTTAAACTCGGAGAATTGGTATATAAAATACCAAAATATGTAAAGCCACAAAAAATTT
ATACTCCTTATAAAAAAATTTCAAGAAATAAAAAATATTCTAATACACTTCAAAAGGATAGATATGAAAA
ATGGAAAATGTTATATGAAGAATTGATTAATAATGAAAATAAAACATATATAATAGATTCAGTTCTCTAT
AAAGAAATAAGTTATTTACCTTATTGGATCCTAAATTATGTAAATGATTTATTTGAATGTATGTA
Protein Sequence 
>gi|124809723|ref|XP_001348663.1| histone deacetylase, putative [Plasmodium falciparum 3D7]
MSCMNYASRLSKNEYKGPLGEEEFFEDTEEEKKKVKELIEKIRSSEYIVVHSGAGISTSSGLQDFRGPTG
IWTNEHLNELKNKKKRNHDFKDNKRKLKSNDINCKNTSDMCSPSFFHKEKKENTLNIVKRERYYNEDNVD
MNACNERVVHPNHVYVNHEDDNNNNNNNNNNDNNLYNNVYNSVGSNDHTNKESILIKKENNSENVRKDIH
DKVNTKNVKKIDVKETNNLDPENYVIFGKRKKKVIELHLALPSKTHIMINELINKNIIKFMITQNIDSLH
HRCGKHFSKTAEIHGNIFTERCDFCGRRYLRDYLISTISFKPTGSLCFLCSFPPIGVCTDVLLDWNNSYE
EFFHLNSIKHSQIADFHFCLGSSFYIVPASSYPSKKKYANANSYSCVINYQKSFLSKEVNLNIHSNVNNI
SDIIIKEFSLNPLSIRSARITIVRCPINTLDVICDKLISIHNIKMKHKSMRQHSIDYSQMGNKDEKYNNE
KYVKRNMTECLYYNKEGECYEKRKYKLMEKKFFPNNQQNEFIPNRINIFEQKFHEHNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNSSSSIDSSCSINSNYHISKNINPDFSFVENQSNIYENYKEQTFILICPMI
INIKTVRLESFHKVYIKLLDDIKGLWFIKTNFSCILEVELWYHSFILLKLDFNKSDPFIQLNAWNVNVAY
TYGDDIDDFDYFKNDENIKKPFNLYKNKYISNMRREGHVNNLYTLDNEKVKSNTSNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNDNNNNNISDHNIYDDHNNNNNKNHNNYDKDNSNESYYCSEILNE
HVHVGYNPNNYEPNCKVYILAYLDNLRTRNINNNVNNNNFSRFNLTQSCKLLYNIYCVLNKDNEQKKNST
IKETYDKLDYFIKNFDFNRDSCLYTNNFINMLIQNERHGNQSRYKFRERRKRLLNDYSSCSSDDDQSGKN
IFIFYNLYMNQYKKKEDNEINDIYKKYDVHEKNIYDESKQYVHKVRVRTDLINHKSVYKILKNNYLVNIN
NMKLMEKKNNSEKLFLINDKDNNSLLSINNKENFNCIPSRQNNVKKNSEYMHEEENNKTNSNENIARLNN
NDFIQVMETEKQKKYNSFDKYNSDRSSINDTFDEIKYNKNNDNNNDDNNYDDNKNDDDNNNDDNNNNDDN
NNNDDNNNNDDNNNGYIYSPVLFINKKFKLGELVYKIPKYVKPQKIYTPYKKISRNKKYSNTLQKDRYEK
WKMLYEELINNENKTYIIDSVLYKEISYLPYWILNYVNDLFECM
Molecule Role Virulence factor
Molecule Role Annotation histone deacetylase 2 (PfHda2), is a global silencer of virulence gene expression and controls the frequency of switching from the asexual cycle to sexual development. PfHda2 depletion leads to dysregulated expression of both virulence-associated var genes and PfAP2-g, a transcription factor controlling sexual conversion, and is accompanied by increases in gametocytogenesis. (Coleman et al., 2014)
References