| Victors ID |
Gene Name |
Sequence Strain (Species/Organism) |
NCBI Gene ID |
NCBI Nucleotide GI |
NCBI Protein GI |
Locus Tag |
Genbank Accession |
Protein Accession |
Protein Name |
Molecule Role |
Molecule Role Annotation |
PMID |
|
|
pbp1A |
Streptococcus agalactiae 2603V/R |
1013087
|
|
22536482
|
SAG0298 |
|
NP_687333.1 |
penicillin-binding protein 1A |
Virulence factor |
MUTATION: pbp1A mutant is attenuated in rats [Ref6958:Jones et al., 2000]. |
10998175
|
|
|
ciaR from Streptococcus agalactiae 2603V/R |
Streptococcus agalactiae 2603V/R |
1013789
|
|
22537145
|
SAG0985 |
|
NP_687996.1 |
DNA-binding response regulator CiaR |
Virulence factor |
MUTATION: ciaR mutant had a significant decrease in intracellular survival within neutrophils, murine macrophages, and human BMEC [Ref6959:Quach et al., 2009]. |
19114476
|
|
|
lmb from Streptococcus agalactiae 2603V/R |
Streptococcus agalactiae 2603V/R |
1014041
|
|
22537388
|
SAG1234 |
|
NP_688239.1 |
laminin-binding surface protein |
Virulence factor |
MUTATION: lmb mutant has reduced invasion of human brain microvascular endothelial cells compared to the wildtype [Ref6960:Tenenbaum et al., 2007]. |
17400016
|
|
|
csrS |
Streptococcus agalactiae 2603V/R |
1014433
|
|
22537764
|
SAG1624 |
|
NP_688615.1 |
sensor histidine kinase CsrS |
Virulence factor |
MUTATION: csrS mutant is attenuated in mice [Ref6961:Jiang et al., 2005]. |
15659687
|
|
|
csrR |
Streptococcus agalactiae 2603V/R |
1014434
|
|
22537765
|
SAG1625 |
|
NP_688616.1 |
DNA-binding response regulator CsrR |
Virulence factor |
MUTATION: csrR mutant is attenuated in mice [Ref6961:Jiang et al., 2005]. |
15659687
|
|
|
gbs1020 |
Streptococcus agalactiae NEM316 |
1030007
|
|
25011074
|
gbs1020 |
|
NP_735469.1 |
DNA-binding response regulator CiaR |
Virulence factor |
MUTATION: gbs1020 (CiaR) mutant had a significant decrease in intracellular survival within neutrophils, murine macrophages, and human BMEC [Ref6959:Quach et al., 2009]. |
19114476
|
|
|
cpsD |
Streptococcus agalactiae NEM316 |
1030264
|
|
25011294
|
gbs1244 |
|
NP_735689.1 |
capsular polysaccharide chain length regulator/exporter |
Virulence factor |
MUTATION:cpsD mutant results in an unencapsulated strain which is avirulent in a neonatal rat model of sepsis compared to the wild type strain, and is also sensitive to killing by human phagocytes in vitro [Ref6962:Rubens et al., 1993]. |
8355611
|
|
|
lmb from Streptococcus agalactiae NEM316 |
Streptococcus agalactiae NEM316 |
1030333
|
|
25011353
|
gbs1307 |
|
NP_735748.1 |
laminin-binding surface protein |
Virulence factor |
MUTATION: lmb mutant has reduced invasion of human brain microvascular endothelial cells compared to wildtype [Ref6960:Tenenbaum et al., 2007]. |
17400016
|
|
|
scpB from Streptococcus agalactiae NEM316 |
Streptococcus agalactiae NEM316 |
1030336
|
|
25011354
|
gbs1308 |
|
NP_735749.1 |
streptococcal C5a peptidase |
Virulence factor |
MUTATION: scpB mutant has significantly reduced invasion of HEp2 and A549 human cell lines [Ref6963:Cheng et al., 2002]. |
11953377
|
|
|
gbs1402 |
Streptococcus agalactiae NEM316 |
1030444
|
|
25011444
|
gbs1402 |
|
NP_735839.1 |
MarR family transcriptional regulator |
Virulence factor |
MUTATION: gbs1402 (pefR) mutant is attenuated in mice [Ref6964:Fernandez et al., 2010]. |
20421944
|
|
|
gbs1477 |
Streptococcus agalactiae NEM316 |
1030552
|
|
25011519
|
gbs1477 |
|
NP_735914.1 |
hypothetical protein |
Virulence factor |
MUTATION: gbs1477 (pilB) mutant had significantly reduced invasion of hBMECs [Ref6965:Maisey et al., 2007]. |
17041051
|
|
|
gbs1529 |
Streptococcus agalactiae NEM316 |
1030619
|
|
25011571
|
gbs1529 |
|
NP_735966.1 |
cell wall surface anchor family protein |
Virulence factor |
MUTATION: Deletion of srr1(gbs1529) in NCTC 10/84 resulted in a significant decrease in adherence to and invasion of hBMECs [Ref6966:van et al., 2009]. |
19392623
|
|
|
pepX |
Streptococcus agalactiae A909 |
3685108
|
|
76786791
|
SAK_1744 |
|
YP_330344.1 |
x-prolyl-dipeptidyl aminopeptidase |
Virulence factor |
MUTATION: pepX mutant is attenuated in rats [Ref6958:Jones et al., 2000]. |
10998175
|
|
|
cydA |
Streptococcus agalactiae A909 |
3685696
|
|
76787464
|
SAK_1750 |
|
YP_330350.1 |
cytochrome d ubiquinol oxidase, subunit II |
Virulence factor |
MUTATION: cydA mutant is attenuated in rats [Ref6973:Yamamoto et al., 2005]. |
15813741
|
|
|
murF |
Streptococcus agalactiae A909 |
3685706
|
|
76788062
|
SAK_0893 |
|
YP_329515.1 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase |
Virulence factor |
MUTATION: murF mutant is attenuated in rats [Ref6958:Jones et al., 2000]. |
10998175
|
|
|
ciaR from Streptococcus agalactiae A909 |
Streptococcus agalactiae A909 |
3685802
|
|
76787511
|
SAK_1080 |
|
YP_329701.1 |
DNA-binding response regulator CiaR |
Virulence factor |
MUTATION: ciaR mutant had a significant decrease in intracellular survival within neutrophils, murine macrophages, and human BMEC [Ref6959:Quach et al., 2009]. |
19114476
|
|
|
SAK_0517 |
Streptococcus agalactiae A909 |
3685804
|
|
76787513
|
SAK_0517 |
|
YP_329152.1 |
C protein alpha-antigen |
Virulence factor |
MUTATION: C protein alpha antigen mutant is attenuated in mice [Ref6974:Li et al., 1997]. |
9371832
|
|
|
lmb from Streptococcus agalactiae A909 |
Streptococcus agalactiae A909 |
3685811
|
|
76787520
|
SAK_1319 |
|
YP_329931.1 |
laminin-binding surface protein |
Virulence factor |
MUTATION: lmb mutant has reduced invasion of human brain microvascular endothelial cells compared to the wildtype [Ref6960:Tenenbaum et al., 2007]. |
17400016
|
|
|
carB |
Streptococcus agalactiae A909 |
3686058
|
|
76788218
|
SAK_1132 |
|
YP_329753.1 |
carbamoyl phosphate synthase large subunit |
Virulence factor |
MUTATION: carB mutant is attenuated in rats [Ref6958:Jones et al., 2000]. |
10998175
|
|
|
scpB from Streptococcus agalactiae A909 |
Streptococcus agalactiae A909 |
3686098
|
|
76788661
|
SAK_1320 |
|
YP_329932.1 |
C5a peptidase ScpB |
Virulence factor |
MUTATION: scpB mutant had significantly reduced invasion of HEp2 and A549 human cell lines [Ref6963:Cheng et al., 2002]. |
11953377
|
|
|
lepA |
Streptococcus agalactiae A909 |
3686142
|
|
76788416
|
SAK_1022 |
|
YP_329644.1 |
GTP-binding protein LepA |
Virulence factor |
MUTATION: lepA mutant is attenuated in rats [Ref6958:Jones et al., 2000]. |
10998175
|
|
|
scrB from Streptococcus agalactiae A909 |
Streptococcus agalactiae A909 |
3686267
|
|
76788376
|
SAK_1703 |
|
YP_330305.1 |
sucrose-6-phosphate hydrolase |
Virulence factor |
MUTATION: scrB mutant is attenuated in rats [Ref6958:Jones et al., 2000]. |
10998175
|
|
|
rpoE |
Streptococcus agalactiae A909 |
3686398
|
|
76787332
|
SAK_0156 |
|
YP_328830.1 |
DNA-directed RNA polymerase subunit delta |
Virulence factor |
MUTATION: rpoE mutant is attenuated in rats [Ref6975:Seepersaud et al., 2006]. |
16513739
|
|
|
cpsY |
Streptococcus agalactiae A909 |
3686453
|
|
76788234
|
SAK_1263 |
|
YP_329877.1 |
transcriptional regulator CpsY |
Virulence factor |
MUTATION: An isogenic strain bearing a kanamycin insertion in mtaR (cpsY) was attenuated for survival in a neonatal-rat model of sepsis and grew poorly in human plasma [Ref6976:Shelver et al., 2003]. |
14594832
|
|
|
pepN |
Streptococcus agalactiae A909 |
3686784
|
|
76788425
|
SAK_1081 |
|
YP_329702.1 |
aminopeptidase N |
Virulence factor |
MUTATION: pepN mutant is attenuated in rats [Ref6958:Jones et al., 2000]. |
10998175
|
|
|
cylE |
Streptococcus agalactiae A909 |
3686789
|
|
76788430
|
SAK_0797 |
|
YP_329421.1 |
CylE protein |
Virulence factor |
MUTATION: cylE mutant has decreased invasion of lung epithelial cells [Ref6977:Doran et al., 2002]. |
11807693
|
|
|
guaA |
Streptococcus agalactiae A909 |
3686928
|
|
76788259
|
SAK_1062 |
|
YP_329683.1 |
glutamine-hydrolyzing |
Virulence factor |
MUTATION: guaA mutant is attenuated in rats [Ref6958:Jones et al., 2000]. |
10998175
|
|
|
lgt |
Streptococcus agalactiae A909 |
3687119
|
|
76788292
|
SAK_0863 |
|
YP_329485.1 |
prolipoprotein diacylglyceryl transferase |
Virulence factor |
MUTATION: lgt mutant has a significant reduction in adherence to human endothelial cells of fetal origin [Ref6978:Bray et al., 2009]. |
19383708
|
|
|
fbsA |
Streptococcus agalactiae 6313 |
|
|
25956188
|
|
|
|
fibrinogen receptor FbsA |
Virulence factor |
MUTATION: fbsA mutant has attenuated growth in human blood [Ref7006:Schubert et al., 2002].
|
12406229
|
|
|
Type III Capsule |
Streptococcus agalactiae |
|
|
|
|
|
|
|
Virulence factor |
MUTATION: a sialic-deficient type 3 capsular polysaccharide mutant was avirulent in in a neonatal rat model of GBS infection and was sensitive to killing by human leukocytes in vitro [Ref7303:Wessels et al., 1992]. |
1309720
|
