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ciaR from Streptococcus agalactiae A909

Victor ID 4373
Gene Name ciaR from Streptococcus agalactiae A909
Sequence Strain (Species/Organism) Streptococcus agalactiae A909
NCBI Gene ID 3685802
NCBI Protein GI 76787511
Locus Tag SAK_1080
Protein Accession YP_329701.1
Other Database IDs UniProtKB-ID: Q3K1A2_STRA1
UniRef100: UniRef100_Q3D2L1
UniRef90: UniRef90_Q3D2L1
UniRef50: UniRef50_Q03V75
UniParc: UPI0000053A20
EMBL: CP000114
EMBL-CDS: ABA45152.1
RefSeq_NT: NC_007432.1
EnsemblGenome: EBSTRG00000004657.
EnsemblGenome_TRS: EBSTRT00000004657
EnsemblGenome_PRO: EBSTRP00000004430
GenomeReviews: CP000114_GR
KEGG: sak:SAK_1080
TIGR: SAK_1080
HOGENOM: HBG753323
OMA: VILPKEQ
ProtClustDB: CLSK876907
BioCyc: SAGA205921:SAK_1080-MONOMER
Taxonomy ID 205921
Gene Starting Position 1051799
Gene Ending Position 1052479
Gene Strand (Orientation) -
Protein Name DNA-binding response regulator CiaR
DNA Sequence 
>gi|76786714:1051799-1052479 Streptococcus agalactiae A909, complete genome
CTTAATCGGTTTCGACATGCTTTAAAATATATCCTACACTACGCAAAGTTTGAAGGTTTTCTGAAAAAAG
TGTTCCTTTTAATTTTTTCCGAACCTTAGAGACATAGACTTCTACAACTGAAATCGTTGTATCACTATCA
AATCCCCAAATACGATCAAAGATTTGAGATTTCGGTAAGATAACATTTTGATTTTGAAGGAAATAGACTA
AAAGATCAAACTCTTTACCTAAGAGCTCAACTTCTGTTTGATTAACAAAGGTTGAGTTAGTAGACATGTC
TACGCGAATATCACCATAAATTAGGCTGTTATCATTAAATTTTCCAGAACGCTTTAAAAGAGCCTGAATT
CGCATTTTTAGTTCTTCTAGGTAAAAAGGTTTTGTTAGATAATCATCAGCACCTAAGTCGAAACCTTGTC
CCTTATCATCAATGCTTTCTTTAGCGGTCATTATTAATACAGGGGTTGTAATACCTTTTTCACGTAGCTC
TTTCAACACTTGGAAGCCGTTTTTTTCAGGTAACATGAGATCTAGAAGAATCAGATCATAGACTCCACTT
TCGGCTTCGTAAAGACCCTCTTCTCCATCAAAAATTTGCATGACATCGGCAAAGTCATCAAGGAAATCAA
AAACGGAATTGGAAAGACTCAAGTCATCTTCAATTAATAAAATTTTTATCA
Protein Sequence 
>gi|76787511|ref|YP_329701.1| DNA-binding response regulator CiaR [Streptococcus agalactiae A909] MIKILLIEDDLSLSNSVFDFLDDFADVMQIFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTAKESIDDKGQGFDLGADDYLTKPFYLEELKMRIQALLKRSGKFNDNSLIYGDIRVDMSTNSTFVNQTEVELLGKEFDLLVYFLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKVRKKLKGTLFSENLQTLRSVGYILKHVETD
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ciaR mutant had a significant decrease in intracellular survival within neutrophils, murine macrophages, and human BMEC (Quach et al., 2009).
COG COG0745TK, under T: Signal transduction mechanisms; K: Transcription
References
Quach et al., 2009: Quach D, van Sorge NM, Kristian SA, Bryan JD, Shelver DW, Doran KS. The CiaR response regulator in group B Streptococcus promotes intracellular survival and resistance to innate immune defenses. Journal of bacteriology. 2009; 191(7); 2023-2032. [PubMed: 19114476].