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scpB from Streptococcus agalactiae A909

Victor ID 4377
Gene Name scpB from Streptococcus agalactiae A909
Sequence Strain (Species/Organism) Streptococcus agalactiae A909
NCBI Gene ID 3686098
NCBI Protein GI 76788661
Locus Tag SAK_1320
Protein Accession YP_329932.1
Other Database IDs UniProtKB-ID: Q3K0M1_STRA1
UniRef100: UniRef100_Q3K0M1
UniRef90: UniRef90_Q5X9R0
UniRef50: UniRef50_Q5X9R0
UniParc: UPI00000E27BC
EMBL: CP000114
EMBL-CDS: ABA46302.1
RefSeq_NT: NC_007432.1
MEROPS: S08.020
EnsemblGenome: EBSTRG00000005178.
EnsemblGenome_TRS: EBSTRT00000005178
EnsemblGenome_PRO: EBSTRP00000004951
GenomeReviews: CP000114_GR
KEGG: sak:SAK_1320
TIGR: SAK_1320
HOGENOM: HBG694572
OMA: TKPEQDG
ProtClustDB: CLSK698937
BioCyc: SAGA205921:SAK_1320-MONOMER
Taxonomy ID 205921
Gene Starting Position 1298933
Gene Ending Position 1302385
Gene Strand (Orientation) -
Protein Name C5a peptidase ScpB
DNA Sequence 
>gi|76786714:1298933-1302385 Streptococcus agalactiae A909, complete genome
ACTATTTTTTAGTTTCTTTTTGGCGTTTTGTTTTAAATATATGAGCTACTAATCCCAAGAAGAAAGTGGT
CATAACTAACTTAAGGAGATGTAAACGATTTGTATCCTTGTCATTAGTCGTTGGTAACTGATCTCTTGTT
GATGCTTTTGTAGCTAAAGCACGCTTAGAAGATCGTTTCTCTAGAGTACGAGAAGGTTGACCTTTTTGAG
GAGTTTTACCTGGTGTTTGACCTGAACTATCTTTTTCTGGTTTAGTTTCTGTTTTTTTATCTGGTGTTTG
ACCTGAACCGTCTTGTTCTGGTTTAGCTTCTGGTTTTTTGTCTGGTGCTTGATCTGAACCGTCTTGTTCT
GGCTTATTAGAGTGGCCCTCCAATAGCTTAGTCACTGGTGTATAAGTGATGTTACCAGCCATATCTTCAA
CAACATAAGTAAAGTCTGACATTTTCAATGGAACAGTAGCGCCTTCCATTGTTTCAGCCTCTTCAGGAAG
AGTAAAGGTACCATCTTCATTTGGAGAAATATACTCTGTTGTTGGCAGATCCTCATCCATGTAAGTATAA
GCAATACGCTCACGGTAAACCGGTTGGCTGGTTTTTGGTTTAGATGCAAGTGTCAAACGACGATCTTCTG
TTGAGAATGTTGCCGATGTTGCGACTTCAGGTGTCGTATTGTCTACAATCACATCAAAATCAGTGTGTTG
TTCTTTTGCACCTGAGCTAATCGGAGTGTAGCGGACACGATAGGTGTAGGTTCCGTTAGCAACAACTTTG
CCGTCTTTATCTTTACCGTCCCAACGCGTTTTTTCAAAACGGGTTGAACCAAGTGTGCTTGCCAAGTCAT
TGTTGTAGTTTTTAACAACTTGCTCGGTTACCTCACTTGTCCAAACAACATTTCCTTCTTTGTCCAAGAC
TTCAGCCACAAGGTTTTTAGCATTACGCAAGAAAGTACCTTGGAATTGGACATAATCTCTGTTACCGTCC
CCATTTGGAGAGATCGCAGCATATGGCTTGCCATTAGCGTGACGGTGGATATAGTAGTGGCTATCATCGT
CTTGTTTTGCAAAAGTACCTGCAAAAATGGTTTCTGTGATCTCTGAAGATTCGATATCCTCTATGTTTTC
AACCCCTTCTTTGACAGCTTTAATAATCGTCCACGGGTTAGACTCTGTGGTAAGTGCTGTAAAGTTATTT
TTCAGAGCGTAAAACTGTAATCCATCACCATCTAATTGGTCTTTGGCATCACTATTTGCTTCATGATAGT
AGCTGCTACCGTCTTTGCTATCATAGATTGGTTTTTCTAAGGCTGACAGATTGCCAAAATCACCTCGGAA
ACCAATATATGGAATGCTCATAAGCTCTTCTTTTTTAGGATCTTGTTTGAAACGAACAAAACCTTCTAAG
AAATAGCCATTTTTCATTTGGGCAAGCAAGTCCTTGCTAAATCGACTAGCATCGATTGGAACGGTGACTT
GTTTGCTGCTATTGGCTGGAATTGTGATTTTTTGCCATGATGTCTCATACAATGCTTTAGGAGCCAAGGC
AAAGTGTTTTCCATCTACTTTATCTGTTTGAACAGTTGCTTGGTAATACAACTCTTGAGGTTTATCAGAT
TTGTTGTGAACTGTTACTGTTACTTCAAATTTATCAGAAACATTGTTCAGGTGAACCTTGCTTGAGGTAT
TATCCTTATCTGTCACATACATCGTTGCTGCTGAAGCTTTTTTAGCATCGACTGCTCCTGCTCCTTGTTG
GCGAGGAGAAAAATAAGCTTTTTCATCTTCATCATATAAGGCAGTTGCTGAGCTCATCAATACTTTTTTA
GCTAAATCAAGACGCTCTGATGGTGTCATATCAGGATACTGTGTCTCATACTGCTTTTGCAACAGTCCCA
TGATACCCGCTACTAATGGCGCAGACATACTAGTTCCAGAAAGTTTGGCATACTTGTTGTTAGCCACTGA
TGACAAAATATCTTGGCCGGGTGCTGCAATATCTGGCTTAATATTACCGTCAGCTGTCAGACCCCAGCTT
GAGAAGCGGCTTAGTTTGGTGCCACTTGCTGTTGGCAATACCTTAGGTGTCGCATTGAAGGTGATGGTTT
TTTGGGGATTGTCTTTTAATAAGAGACCATCTTTTCGACTGATAAAGGCCGCAGGCATCTGATCAACATT
TGGCAATTCAATCGGGAAGCCCTTGTCCTGATTGTCATAGATCAAGACTCCTACAGCACCAGCTTTTTTA
GCTTTTGCAATCTTATCTTTGAAATCAATATCGCCACGTTCAATAAGGGCAATCTTACCTTTGACATCCT
TAAAATCATCCTCTTTCGTCCCTCGATTAGCATAAGCATAGTCGTAAGCCTTGTTTGGCTCAAAACGGTT
TGTTGAAAGAACAGGCATTTCTTTATCTTGCTGATCGGCTGTTTTGACCGTAGCAGTTTCAGTGAGCTGT
TTATCTGGGCTGTAAGAAGCAACTGTCAATGTTGAGTCTGCCGCTGCAGGTGTCCCAACCACCCCATAAT
CAGGATGATCTGCTAGAGGTAGACGGGTCTTGCCCCCAAAGCTACTATCATTACCAGCTGAGGTCACAAT
GCTAACACCTTTTGATTTGGCATAGTCAAAGGCTTTTTTGGTTTCGTCTGGAAGGTTGGCGTAAGCTAGT
GCAGCATTACCAAAGCTCATATTAATCACCTTAGCTCCCAAGTTGATAGCATCTCTGATAGCTTGAGCGT
AGTTACGAGCATAGTCTGCTAGTCCATTTACAATTTCGACACGCATCAAAAGCAATTGAGCCTCAGGCAT
CGCACCTTCTAGGCGGTAAGGTTCTTTCGTTTCAGATGGAGCATTTCCTGACAAGATTCCTGACACGTGT
GTGCCGTGCTCTTGATCGACAGCGGTTTTACCATCTTTACTATAGTCATGGTAGTAAGCAACCTTATCAT
TGACCCACTCGCCATAGGTAATACCGTGCTCTTTTTTAGCTTTTTCAAGATCTTCTTTTGATTGGTAACG
TGCTTTGGCTTTGTCTGTTAAGCGCCACGCTTCATGATTTTTATCAAAACCAGCATCAATCACTGCAACA
ACAGTCCCAGCTCCCTTGCCTGCTTTTTCCTGCAGGGTTTTGACCTGAGAAGGGTCGTTCAAATCCCTAA
TAGTCGCTTTTGAGGTTGCTGGTGTATCAGCAGTTTTAGCAGGAGCTTGAGGGGCTAGATCATTAGCGTC
ATCTGCTACTGTTTCTCCTGCATCACTAGGAGTTTGTGGGGTTTTAGTTTCCTTTGATGATGGTGCTTCC
TCAGAAACCGCTGTTGGTTGTGGAGTTTCTACGGTTTGTTCGGTAGCAGGAGTGTCTTCTGTCACAGTAT
TTGCTTTGATGTCTGATTGTGCATTGAGCAAGATGCTCGTAGACATAAGCGCAATGGCAAGTTTATCAAA
TGGTAGTTTCTGTTTTTTACGCA
Protein Sequence 
>gi|76788661|ref|YP_329932.1| C5a peptidase ScpB [Streptococcus agalactiae A909] MRKKQKLPFDKLAIALMSTSILLNAQSDIKANTVTEDTPATEQTVETPQPTAVSEEAPSSKETKTPQTPSDAGETVADDANDLAPQAPAKTADTPATSKATIRDLNDPSQVKTLQEKAGKGAGTVVAVIDAGFDKNHEAWRLTDKAKARYQSKEDLEKAKKEHGITYGEWVNDKVAYYHDYSKDGKTAVDQEHGTHVSGILSGNAPSETKEPYRLEGAMPEAQLLLMRVEIVNGLADYARNYAQAIRDAINLGAKVINMSFGNAALAYANLPDETKKAFDYAKSKGVSIVTSAGNDSSFGGKTRLPLADHPDYGVVGTPAAADSTLTVASYSPDKQLTETATVKTADQQDKEMPVLSTNRFEPNKAYDYAYANRGTKEDDFKDVKGKIALIERGDIDFKDKIAKAKKAGAVGVLIYDNQDKGFPIELPNVDQMPAAFISRKDGLLLKDNPQKTITFNATPKVLPTASGTKLSRFSSWGLTADGNIKPDIAAPGQDILSSVANNKYAKLSGTSMSAPLVAGIMGLLQKQYETQYPDMTPSERLDLAKKVLMSSATALYDEDEKAYFSPRQQGAGAVDAKKASAATMYVTDKDNTSSKVHLNNVSDKFEVTVTVHNKSDKPQELYYQATVQTDKVDGKHFALAPKALYETSWQKITIPANSSKQVTVPIDASRFSKDLLAQMKNGYFLEGFVRFKQDPKKEELMSIPYIGFRGDFGNLSALEKPIYDSKDGSSYYHEANSDAKDQLDGDGLQFYALKNNFTALTTESNPWTIIKAVKEGVENIEDIESSEITETIFAGTFAKQDDDSHYYIHRHANGKPYAAISPNGDGNRDYVQFQGTFLRNAKNLVAEVLDKEGNVVWTSEVTEQVVKNYNNDLASTLGSTRFEKTRWDGKDKDGKVVANGTYTYRVRYTPISSGAKEQHTDFDVIVDNTTPEVATSATFSTEDRRLTLASKPKTSQPVYRERIAYTYMDEDLPTTEYISPNEDGTFTLPEEAETMEGATVPLKMSDFTYVVEDMAGNITYTPVTKLLEGHSNKPEQDGSDQAPDKKPEAKPEQDGSGQTPDKKTETKPEKDSSGQTPGKTPQKGQPSRTLEKRSSKRALATKASTRDQLPTTNDKDTNRLHLLKLVMTTFFLGLVAHIFKTKRQKETKK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: scpB mutant had significantly reduced invasion of HEp2 and A549 human cell lines (Cheng et al., 2002).
COG COG1404O, under O: Posttranslational modification, protein turnover, chaperones
References
Cheng et al., 2002: Cheng Q, Stafslien D, Purushothaman SS, Cleary P. The group B streptococcal C5a peptidase is both a specific protease and an invasin. Infection and immunity. 2002; 70(5); 2408-2413. [PubMed: 11953377].