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ciaR from Streptococcus agalactiae 2603V/R

Victor ID 4337
Gene Name ciaR from Streptococcus agalactiae 2603V/R
Sequence Strain (Species/Organism) Streptococcus agalactiae 2603V/R
NCBI Gene ID 1013789
NCBI Protein GI 22537145
Locus Tag SAG0985
Protein Accession NP_687996.1
Other Database IDs UniProtKB-ID: Q8DZW1_STRA5
UniRef100: UniRef100_Q3D2L1
UniRef90: UniRef90_Q3D2L1
UniRef50: UniRef50_Q03V75
UniParc: UPI0000053A20
EMBL: AE009948
EMBL-CDS: AAM99868.1
RefSeq_NT: NC_004116.1
HSSP: Q9WYN0
EnsemblGenome: EBSTRG00000007298.
EnsemblGenome_TRS: EBSTRT00000007298
EnsemblGenome_PRO: EBSTRP00000006965
GenomeReviews: AE009948_GR
KEGG: sag:SAG0985
TIGR: SAG0985
HOGENOM: HBG753323
OMA: VILPKEQ
ProtClustDB: CLSK876907
BioCyc: SAGA208435:SAG_0985-MONOMER
Taxonomy ID 208435
Gene Starting Position 993613
Gene Ending Position 994293
Gene Strand (Orientation) -
Protein Name DNA-binding response regulator CiaR
DNA Sequence 
>gi|22536185:993613-994293 Streptococcus agalactiae 2603V/R, complete genome
CTTAATCGGTTTCGACATGCTTTAAAATATATCCTACACTACGCAAAGTTTGAAGGTTTTCTGAAAAAAG
TGTTCCTTTTAATTTTTTCCGAACCTTAGAGACATAGACTTCTACAACTGAAATCGTTGTATCACTATCA
AATCCCCAAATACGATCAAAGATTTGAGATTTCGGTAAGATAACATTTTGATTTTGAAGGAAATAGACTA
AAAGATCAAACTCTTTACCTAAGAGCTCAACTTCTGTTTGATTAACAAAGGTTGAGTTAGTAGACATGTC
TACGCGAATATCACCATAAATTAGGCTGTTATCATTAAATTTTCCAGAACGCTTTAAAAGAGCCTGAATT
CGCATTTTTAGTTCTTCTAGGTAAAAAGGTTTTGTTAGATAATCATCAGCACCTAAGTCGAAACCTTGTC
CCTTATCATCAATGCTTTCTTTAGCGGTCATTATTAATACAGGGGTTGTAATACCTTTTTCACGTAGCTC
TTTCAACACTTGGAAGCCGTTTTTTTCAGGTAACATGAGATCTAGAAGAATCAGATCATAGACTCCACTT
TCGGCTTCGTAAAGACCCTCTTCTCCATCAAAAATTTGCATGACATCGGCAAAGTCATCAAGGAAATCAA
AAACGGAATTGGAAAGACTCAAGTCATCTTCAATTAATAAAATTTTTATCA
Protein Sequence 
>gi|22537145|ref|NP_687996.1| DNA-binding response regulator CiaR [Streptococcus agalactiae 2603V/R] MIKILLIEDDLSLSNSVFDFLDDFADVMQIFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTAKESIDDKGQGFDLGADDYLTKPFYLEELKMRIQALLKRSGKFNDNSLIYGDIRVDMSTNSTFVNQTEVELLGKEFDLLVYFLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKVRKKLKGTLFSENLQTLRSVGYILKHVETD
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ciaR mutant had a significant decrease in intracellular survival within neutrophils, murine macrophages, and human BMEC (Quach et al., 2009).
COG COG0745TK, under T: Signal transduction mechanisms; K: Transcription
References
Quach et al., 2009: Quach D, van Sorge NM, Kristian SA, Bryan JD, Shelver DW, Doran KS. The CiaR response regulator in group B Streptococcus promotes intracellular survival and resistance to innate immune defenses. Journal of bacteriology. 2009; 191(7); 2023-2032. [PubMed: 19114476].