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scpB from Streptococcus agalactiae NEM316

Victor ID 4344
Gene Name scpB from Streptococcus agalactiae NEM316
Sequence Strain (Species/Organism) Streptococcus agalactiae NEM316
NCBI Gene ID 1030336
NCBI Protein GI 25011354
Locus Tag gbs1308
Protein Accession NP_735749.1
Other Database IDs UniProtKB-ID: Q8E4T9_STRA3
UniRef100: UniRef100_Q3K0M1
UniRef90: UniRef90_Q5X9R0
UniRef50: UniRef50_Q5X9R0
UniParc: UPI00000E27BC
EMBL: AL766850
EMBL-CDS: CAD46967.1
RefSeq_NT: NC_004368.1
HSSP: Q45670
MEROPS: S08.020
EnsemblGenome: EBSTRG00000003484.
EnsemblGenome_TRS: EBSTRT00000003484
EnsemblGenome_PRO: EBSTRP00000003402
GenomeReviews: AL732656_GR
KEGG: san:gbs1308
GenoList: gbs1308
HOGENOM: HBG694572
OMA: TKPEQDG
ProtClustDB: CLSK698937
BioCyc: SAGA211110:GBS1308-MONOMER
Taxonomy ID 211110
Gene Starting Position 1351655
Gene Ending Position 1355174
Gene Strand (Orientation) -
Protein Name streptococcal C5a peptidase
DNA Sequence 
>gi|25010075:1351655-1355174 Streptococcus agalactiae NEM316, complete genome
TAGAGAGAACCAAATTGGTTCTCTCTATTAAATAAGCTCTTATCAGTTTAAGTAATACTATTTTTTAGTT
TCTTTTTGGCGTTTTGTTTTAAATATATGAGCTACTAATCCCAAGAAGAAAGTGGTCATAACTAACTTAA
GGAGATGTAAACGATTTGTATCCTTGTCATTAGTCGTTGGTAACTGATCTCTTGTTGATGCTTTTGTAGC
TAAAGCACGCTTAGAAGATCGTTTCTCTAGAGTACGAGAAGGTTGACCTTTTTGAGGAGTTTTACCTGGT
GTTTGACCTGAACTATCTTTTTCTGGTTTAGTTTCTGTTTTTTTATCTGGTGTTTGACCTGAACCGTCTT
GTTCTGGTTTAGCTTCTGGTTTTTTGTCTGGTGCTTGATCTGAACCGTCTTGTTCTGGCTTATTAGAGTG
GCCCTCCAATAGCTTAGTCACTGGTGTATAAGTGATGTTACCAGCCATATCTTCAACAACATAAGTAAAG
TCTGACATTTTCAATGGAACAGTAGCGCCTTCCATTGTTTCAGCCTCTTCAGGAAGAGTAAAGGTACCAT
CTTCATTTGGAGAAATATACTCTGTTGTTGGCAGATCCTCATCCATGTAAGTATAAGCAATACGCTCACG
GTAAACCGGTTGGCTGGTTTTTGGTTTAGATGCAAGTGTCAAACGACGATCTTCTGTTGAGAATGTTGCC
GATGTTGCGACTTCAGGTGTCGTATTGTCTACAATCACATCAAAATCAGTGTGTTGTTCTTTTGCACCTG
AGCTAATCGGAGTGTAGCGGACACGATAGGTGTAGGTTCCGTTAGCAACAACTTTGCCGTCTTTATCTTT
ACCGTCCCAACGCGTTTTTTCAAAACGGGTTGAACCAAGTGTGCTTGCCAAGTCATTGTTGTAGTTTTTA
ACAACTTGCTCGGTTACCTCACTTGTCCAAACAACATTTCCTTCTTTGTCCAAGACTTCAGCCACAAGGT
TTTTAGCATTACGCAAGAAAGTACCTTGGAATTGGACATAATCTCTGTTACCGTCCCCATTTGGAGAGAT
CGCAGCATATGGCTTGCCATTAGCGTGACGGTGGATATAGTAGTGGCTATCATCGTCTTGTTTTGCAAAA
GTACCTGCAAAAATGGTTTCTGTGATCTCTGAAGATTCGATATCCTCTATGTTTTCAACCCCTTCTTTGA
CAGCTTTAATAATCGTCCACGGGTTAGACTCTGTGGTAAGTGCTGTAAAGTTATTTTTCAGAGCGTAAAA
CTGTAATCCATCACCATCTAATTGGTCTTTGGCATCACTATTTGCTTCATGATAGTAGCTGCTACCGTCT
TTGCTATCATAGATTGGTTTTTCTAAGGCTGACAGATTGCCAAAATCACCTCGGAAACCAATATATGGAA
TGCTCATAAGCTCTTCTTTTTTAGGATCTTGTTTGAAACGAACAAAACCTTCTAAGAAATAGCCATTTTT
CATTTGGGCAAGCAAGTCCTTGCTAAATCGACTAGCATCGATTGGAACGGTGACTTGTTTGCTGCTATTG
GCTGGAATTGTGATTTTTTGCCATGATGTCTCATACAATGCTTTAGGAGCCAAGGCAAAGTGTTTTCCAT
CTACTTTATCTGTTTGAACAGTTGCTTGGTAATACAACTCTTGAGGTTTATCAGATTTGTTGTGAACTGT
TACTGTTACTTCAAATTTATCAGAAACATTGTTCAGGTGAACCTTGCTTGAGGTATTATCCTTATCTGTC
ACATACATCGTTGCTGCTGAAGCTTTTTTAGCATCGACTGCTCCTGCTCCTTGTTGGCGAGGAGAAAAAT
AAGCTTTTTCATCTTCATCATATAAGGCAGTTGCTGAGCTCATCAATACTTTTTTAGCTAAATCAAGACG
CTCTGATGGTGTCATATCAGGATACTGTGTCTCATACTGCTTTTGCAACAGTCCCATGATACCCGCTACT
AATGGCGCAGACATACTAGTTCCAGAAAGTTTGGCATACTTGTTGTTAGCCACTGATGACAAAATATCTT
GGCCGGGTGCTGCAATATCTGGCTTAATATTACCGTCAGCTGTCAGACCCCAGCTTGAGAAGCGGCTTAG
TTTGGTGCCACTTGCTGTTGGCAATACCTTAGGTGTCGCATTGAAGGTGATGGTTTTTTGGGGATTGTCT
TTTAATAAGAGACCATCTTTTCGACTGATAAAGGCCGCAGGCATCTGATCAACATTTGGCAATTCAATCG
GGAAGCCCTTGTCCTGATTGTCATAGATCAAGACTCCTACAGCACCAGCTTTTTTAGCTTTTGCAATCTT
ATCTTTGAAATCAATATCGCCACGTTCAATAAGGGCAATCTTACCTTTGACATCCTTAAAATCATCCTCT
TTCGTCCCTCGATTAGCATAAGCATAGTCGTAAGCCTTGTTTGGCTCAAAACGGTTTGTTGAAAGAACAG
GCATTTCTTTATCTTGCTGATCGGCTGTTTTGACCGTAGCAGTTTCAGTGAGCTGTTTATCTGGGCTGTA
AGAAGCAACTGTCAATGTTGAGTCTGCCGCTGCAGGTGTCCCAACCACCCCATAATCAGGATGATCTGCT
AGAGGTAGACGGGTCTTGCCCCCAAAGCTACTATCATTACCAGCTGAGGTCACAATGCTAACACCTTTTG
ATTTGGCATAGTCAAAGGCTTTTTTGGTTTCGTCTGGAAGGTTGGCGTAAGCTAGTGCAGCATTACCAAA
GCTCATATTAATCACCTTAGCTCCCAAGTTGATAGCATCTCTGATAGCTTGAGCGTAGTTACGAGCATAG
TCTGCTAGTCCATTTACAATTTCGACACGCATCAAAAGCAATTGAGCCTCAGGCATCGCACCTTCTAGGC
GGTAAGGTTCTTTCGTTTCAGATGGAGCATTTCCTGACAAGATTCCTGACACGTGTGTGCCGTGCTCTTG
ATCGACAGCGGTTTTACCATCTTTACTATAGTCATGGTAGTAAGCAACCTTATCATTGACCCACTCGCCA
TAGGTAATACCGTGCTCTTTTTTAGCTTTTTCAAGATCTTCTTTTGATTGGTAACGTGCTTTGGCTTTGT
CTGTTAAGCGCCACGCTTCATGATTTTTATCAAAACCAGCATCAATCACTGCAACAACAGTCCCAGCTCC
CTTGCCTGCTTTTTCCTGCAGGGTTTTGACCTGAGAAGGGTCGTTCAAATCCCTAATAGTCGCTTTTGAG
GTTGCTGGTGTATCAGCAGTTTTAGCAGGAGCTTGAGGGGCTAGATCATTAGCGTCATCTGCTACTGTTT
CTCCTGCATCACTAGGAGTTTGTGGGGTTTTAGTTTCCTTTGATGATGGTGCTTCCTCAGAAACCGCTGT
TGGTTGTGGAGTTTCTACGGTTTGTTCGGTAGCAGGAGTGTCTTCTGTCACAGTATTTGCTTTGATGTCT
GATTGTGCATTGAGCAAGATGCTCGTAGACATAAGCGCAATGGCAAGTTTATCAAATGGTAGTTTCTGTT
TTTTACGCAATGTGTCGTCC
Protein Sequence 
>gi|25011354|ref|NP_735749.1| streptococcal C5a peptidase [Streptococcus agalactiae NEM316] MRKKQKLPFDKLAIALMSTSILLNAQSDIKANTVTEDTPATEQTVETPQPTAVSEEAPSSKETKTPQTPSDAGETVADDANDLAPQAPAKTADTPATSKATIRDLNDPSQVKTLQEKAGKGAGTVVAVIDAGFDKNHEAWRLTDKAKARYQSKEDLEKAKKEHGITYGEWVNDKVAYYHDYSKDGKTAVDQEHGTHVSGILSGNAPSETKEPYRLEGAMPEAQLLLMRVEIVNGLADYARNYAQAIRDAINLGAKVINMSFGNAALAYANLPDETKKAFDYAKSKGVSIVTSAGNDSSFGGKTRLPLADHPDYGVVGTPAAADSTLTVASYSPDKQLTETATVKTADQQDKEMPVLSTNRFEPNKAYDYAYANRGTKEDDFKDVKGKIALIERGDIDFKDKIAKAKKAGAVGVLIYDNQDKGFPIELPNVDQMPAAFISRKDGLLLKDNPQKTITFNATPKVLPTASGTKLSRFSSWGLTADGNIKPDIAAPGQDILSSVANNKYAKLSGTSMSAPLVAGIMGLLQKQYETQYPDMTPSERLDLAKKVLMSSATALYDEDEKAYFSPRQQGAGAVDAKKASAATMYVTDKDNTSSKVHLNNVSDKFEVTVTVHNKSDKPQELYYQATVQTDKVDGKHFALAPKALYETSWQKITIPANSSKQVTVPIDASRFSKDLLAQMKNGYFLEGFVRFKQDPKKEELMSIPYIGFRGDFGNLSALEKPIYDSKDGSSYYHEANSDAKDQLDGDGLQFYALKNNFTALTTESNPWTIIKAVKEGVENIEDIESSEITETIFAGTFAKQDDDSHYYIHRHANGKPYAAISPNGDGNRDYVQFQGTFLRNAKNLVAEVLDKEGNVVWTSEVTEQVVKNYNNDLASTLGSTRFEKTRWDGKDKDGKVVANGTYTYRVRYTPISSGAKEQHTDFDVIVDNTTPEVATSATFSTEDRRLTLASKPKTSQPVYRERIAYTYMDEDLPTTEYISPNEDGTFTLPEEAETMEGATVPLKMSDFTYVVEDMAGNITYTPVTKLLEGHSNKPEQDGSDQAPDKKPEAKPEQDGSGQTPDKKTETKPEKDSSGQTPGKTPQKGQPSRTLEKRSSKRALATKASTRDQLPTTNDKDTNRLHLLKLVMTTFFLGLVAHIFKTKRQKETKK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: scpB mutant has significantly reduced invasion of HEp2 and A549 human cell lines (Cheng et al., 2002).
COG COG1404O, under O: Posttranslational modification, protein turnover, chaperones
References
Cheng et al., 2002: Cheng Q, Stafslien D, Purushothaman SS, Cleary P. The group B streptococcal C5a peptidase is both a specific protease and an invasin. Infection and immunity. 2002; 70(5); 2408-2413. [PubMed: 11953377].