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cpsD

Victor ID 4342
Gene Name cpsD
Sequence Strain (Species/Organism) Streptococcus agalactiae NEM316
NCBI Gene ID 1030264
NCBI Protein GI 25011294
Locus Tag gbs1244
Protein Accession NP_735689.1
Other Database IDs UniProtKB-ID: CPSD_STRA3
UniRef100: UniRef100_Q04663
UniRef90: UniRef90_Q3K0T0
UniRef50: UniRef50_Q3K0T0
UniParc: UPI00000539D7
EMBL: AF163833
EMBL: AL766849
EMBL-CDS: AAB00363.1
EMBL-CDS: CAD46904.1
RefSeq_NT: NC_004368.1
EnsemblGenome: EBSTRG00000003149
EnsemblGenome_TRS: EBSTRT00000003149
EnsemblGenome_PRO: EBSTRP00000003067
GenomeReviews: AL732656_GR
KEGG: san:gbs1245
GenoList: gbs1245
HOGENOM: HBG639890
OMA: PDEIEMI
ProtClustDB: CLSK883944
BioCyc: SAGA211110:GBS1245-MONOMER
Taxonomy ID 211110
Gene Starting Position 1283119
Gene Ending Position 1283828
Gene Strand (Orientation) -
Protein Name capsular polysaccharide chain length regulator/exporter
DNA Sequence 
>gi|25010075:1283119-1283828 Streptococcus agalactiae NEM316, complete genome
CTTACTTCCTTTTTCTATCCCTTTTTCCGTAATTTCCATAATCGCCGTAATCGCCGTAAGTAGCAACAGA
TTCATTAACTTTATTAAGAATAATACCTAAGAACTTTGAACCACTTTGTTCCATCTGTTCTTTTGCTTTT
TCAACATAATTACGTTTTATTCTGCCGGCTTGGGTTACTAAAATAAAACCATCGCAAGCATTAGCGATTA
TTGCGGCATCAACAACTAAACCAATAGGTGGAGTATCGATGATAATATAATCAAATATATTTTTAATAGC
TTCAATCATCTTATTAAAATAAGCGTTCTGAAGTAATGCTGTTGGATTTGGTGGTACTTTCCCTGAAGGA
ACGACCATCAGTCTAGGAACATTGGTTTCACAGATAATATCTCCAAGATCTGCATTACCTGATAAATAAT
TCGTCAAGCCTTTAATAGTTCCAGTTGCTTTAAAGGTTCCAGACATAACAGAGTTCCTAGTATCCGCATC
AATTAATAATGTTTTAAATCCTGCTTGAGCTAAAGATAAAGCTAAACTTGTTGAAGTAGTGGATTTTCCT
TCCCCTTCCCTAACAGAGGTAATTGCAAGAATTTTATTTTCCTTTCCACTAAACTGTATGTTTGTACGGA
TCGCATTGAAGTATTCTTCTGTTTTTTTTGCTTGTCTTAACTTGCTATCAACTATTTCTAAACGAGTCAT
TATATTCTCC
Protein Sequence 
>gi|25011294|ref|NP_735689.1| capsular polysaccharide chain length regulator/exporter [Streptococcus agalactiae NEM316] MTRLEIVDSKLRQAKKTEEYFNAIRTNIQFSGKENKILAITSVREGEGKSTTSTSLALSLAQAGFKTLLIDADTRNSVMSGTFKATGTIKGLTNYLSGNADLGDIICETNVPRLMVVPSGKVPPNPTALLQNAYFNKMIEAIKNIFDYIIIDTPPIGLVVDAAIIANACDGFILVTQAGRIKRNYVEKAKEQMEQSGSKFLGIILNKVNESVATYGDYGDYGNYGKRDRKRK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION:cpsD mutant results in an unencapsulated strain which is avirulent in a neonatal rat model of sepsis compared to the wild type strain, and is also sensitive to killing by human phagocytes in vitro (Rubens et al., 1993).
COG COG0489D, under D: Cell cycle control, cell division, chromosome partitioning
References
Rubens et al., 1993: Rubens CE, Heggen LM, Haft RF, Wessels MR. Identification of cpsD, a gene essential for type III capsule expression in group B streptococci. Molecular microbiology. 1993; 8(5); 843-855. [PubMed: 8355611].