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gbs1020

Victor ID 4341
Gene Name gbs1020
Sequence Strain (Species/Organism) Streptococcus agalactiae NEM316
NCBI Gene ID 1030007
NCBI Protein GI 25011074
Locus Tag gbs1020
Protein Accession NP_735469.1
Other Database IDs UniProtKB-ID: Q8E5K9_STRA3
UniRef100: UniRef100_Q3D2L1
UniRef90: UniRef90_Q3D2L1
UniRef50: UniRef50_Q03V75
UniParc: UPI0000053A20
EMBL: AL766848
EMBL-CDS: CAD46679.1
RefSeq_NT: NC_004368.1
HSSP: Q9WYN0
EnsemblGenome: EBSTRG00000001956.
EnsemblGenome_TRS: EBSTRT00000001956
EnsemblGenome_PRO: EBSTRP00000001874
GenomeReviews: AL732656_GR
KEGG: san:gbs1020
GenoList: gbs1020
HOGENOM: HBG753323
OMA: VILPKEQ
ProtClustDB: CLSK876907
BioCyc: SAGA211110:GBS1020-MONOMER
Taxonomy ID 211110
Gene Starting Position 1063402
Gene Ending Position 1064092
Gene Strand (Orientation) -
Protein Name DNA-binding response regulator CiaR
DNA Sequence 
>gi|25010075:1063402-1064092 Streptococcus agalactiae NEM316, complete genome
CTTAATCGGTTTCGACATGCTTTAAAATATATCCTACACTACGCAAAGTTTGAAGGTTTTCTGAAAAAAG
TGTTCCTTTTAATTTTTTCCGAACCTTAGAGACATAGACTTCTACAACTGAAATCGTTGTATCACTATCA
AATCCCCAAATACGATCAAAGATTTGAGATTTCGGTAAGATAACATTTTGATTTTGAAGGAAATAGACTA
AAAGATCAAACTCTTTACCTAAGAGCTCAACTTCTGTTTGATTAACAAAGGTTGAGTTAGTAGACATGTC
TACGCGAATATCACCATAAATTAGGCTGTTATCATTAAATTTTCCAGAACGCTTTAAAAGAGCCTGAATT
CGCATTTTTAGTTCTTCTAGGTAAAAAGGTTTTGTTAGATAATCATCAGCACCTAAGTCGAAACCTTGTC
CCTTATCATCAATGCTTTCTTTAGCGGTCATTATTAATACAGGGGTTGTAATACCTTTTTCACGTAGCTC
TTTCAACACTTGGAAGCCGTTTTTTTCAGGTAACATGAGATCTAGAAGAATCAGATCATAGACTCCACTT
TCGGCTTCGTAAAGACCCTCTTCTCCATCAAAAATTTGCATGACATCGGCAAAGTCATCAAGGAAATCAA
AAACGGAATTGGAAAGACTCAAGTCATCTTCAATTAATAAAATTTTTATCATAGTATATCC
Protein Sequence 
>gi|25011074|ref|NP_735469.1| DNA-binding response regulator CiaR [Streptococcus agalactiae NEM316] MIKILLIEDDLSLSNSVFDFLDDFADVMQIFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTAKESIDDKGQGFDLGADDYLTKPFYLEELKMRIQALLKRSGKFNDNSLIYGDIRVDMSTNSTFVNQTEVELLGKEFDLLVYFLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKVRKKLKGTLFSENLQTLRSVGYILKHVETD
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: gbs1020 (CiaR) mutant had a significant decrease in intracellular survival within neutrophils, murine macrophages, and human BMEC (Quach et al., 2009).
COG COG0745TK, under T: Signal transduction mechanisms; K: Transcription
References
Quach et al., 2009: Quach D, van Sorge NM, Kristian SA, Bryan JD, Shelver DW, Doran KS. The CiaR response regulator in group B Streptococcus promotes intracellular survival and resistance to innate immune defenses. Journal of bacteriology. 2009; 191(7); 2023-2032. [PubMed: 19114476].