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pbp1A

Victor ID 4336
Gene Name pbp1A
Sequence Strain (Species/Organism) Streptococcus agalactiae 2603V/R
NCBI Gene ID 1013087
NCBI Protein GI 22536482
Locus Tag SAG0298
Protein Accession NP_687333.1
Other Database IDs UniProtKB-ID: Q8E1Q5_STRA5
UniRef100: UniRef100_Q8E1Q5
UniRef90: UniRef90_Q8E1Q5
UniRef50: UniRef50_Q8DR59
UniParc: UPI00000E28B0
EMBL: AE009948
EMBL-CDS: AAM99205.1
RefSeq_NT: NC_004116.1
EnsemblGenome: EBSTRG00000007563.
EnsemblGenome_TRS: EBSTRT00000007563
EnsemblGenome_PRO: EBSTRP00000007230
GenomeReviews: AE009948_GR
KEGG: sag:SAG0298
TIGR: SAG0298
HOGENOM: HBG672432
OMA: LYDWDRQ
ProtClustDB: CLSK877241
BioCyc: SAGA208435:SAG_0298-MONOMER
Taxonomy ID 208435
Gene Starting Position 307764
Gene Ending Position 310016
Gene Strand (Orientation) -
Protein Name penicillin-binding protein 1A
DNA Sequence 
>gi|22536185:307764-310016 Streptococcus agalactiae 2603V/R, complete genome
TTTAATTACCGTTAGGTACTGTATTGTTGTTACCATTACCATTACCATTACCATGTCCAGTTCCTGGCAC
AGTTTGATTGGAATTATTAGGGGTAGTAGCATTACCATTATTAGGTGTTTCGACTTGTGGGGATGATGAA
TTGGCATCATTTGCTGTATTCTTATCCTCTTTTTGTTTCTCAGAGGATGTTGAACTACTGCTTTGACTTG
ACTGTCCAGAATTTTGATAGATATTCTTATAGACAGAAGAAGAGTAAGTGCCGGTTGTAGTTGTCCCATT
GATATACAAGTAGCTTCCGCTTCGATAGAGCCCTTCTGGCATTGTCCAATCTGCACTGTATCCGCCAGTT
AGGTAGGACATCATTGCACGATAAACCTCAGTAGCAATATCCAGTTGGCTACCATAAAGTGGTGTAAGGC
GATTTTTATAACCAGTCCAAATTGCCATTGTGTACTTAGAAGTATAGCCGACAAAGTTTTCATCAGGAGC
CATTGTACCAACGGCGCTATTGTAGATACCAGTAGTTGCTTCAATTTTAGCTAACTCATCTTCCGTATAG
TTGGAAGTACCAGTCTTACCAGCTTGTGCAACACCAGGGATAGCTGCTTTAGTACCAGTACCAAATGTTA
GTACTGTTTTCAGCATATCCGTCATCATGTAGGCAGTAGTCTCTTTCATCGCACGGCTACCAGACGCTGC
ATAAGTATCATTGGTTCCATCGCTAAATTCAATTTTATTAACATATTGCGGTTTATAGTAAGTTCCGCCG
TTTGCAAAAGCCGAGTAAGCCGCTGCCATTTTCTCACTACTTGCACCATATTTTGCATCACTGCTACTGT
TGTTACTTGAAATAGCATTTGAATAGTTCATTTCTGGATAGTATATGCCTAATTTTTCAAGGAAAGATTT
TGCTTCGTCTAATCCAGCGGCTTCAAGTGCTCTGACAGCAGGGACGTTACGTGATTGTTGAATAGCGGTC
TGCATACTCATCCAACCCATATATTGACGATCCCAGTCATATAGTTGAGTAGAAGTACCAGGCCAGTAGT
AAACTGAGTCGTTTAATGATTGACCTGTTGAATTATAGACACCACTATCAATAGCAGGTGCATAAGCTGA
GATAGGTTTCATTGTAGAACCCCAATCGCGGTCTGTTAAGACAGATTGATTTGTCCCAAATGAAATATTT
TCATTCTGATGACGCCCGCCTAATTGTGCAATGACTTTACCATTAGTCGCATCCATGATGGTAGATGCTA
TTTGTAATTCATTGTTTGGATAAGCGATGTAAGTGTCACTGTTGTAGATGTCATATAGTTGTTTTTGTGC
ATCAGTGTTGATATTAGTATACACTTTTAGCCCAGCAGTAAAGATATCTTTACCAGTTTTTTGTTTAACT
TCACTAATAACTTGTTTTAAGTAGTTATCCATATATTTTGGATAAGTAGATTTTTGCTTTAATTCTTTTA
AGCCATCAGTTACTGGAGTTGCAACAGCTTGGTCGTATTCCTTTTTAGAAATGTTTTTATCTTGATACAT
CTGCTGAAGAACGGTATTACGTCTTGTTTGAGCAGATTCTGGGTTTTTATAAGGGTCATATTGTGTAGGT
GCTTGAGGAATACCAGCGAGCAAAGCAAGTTGTGCAATAGATAATTCCTTTAGGTCTTTACCAAAGTATG
ATTTAGCTGTTGTTCTCATACCATAATTCCCATTTCCCATATAAACTTTATTAATATAGAAAGTAAGAAT
TTCTTCTTTGGTGTATTTACGCTCCATTTGAAGCGCAAGCCAAACTTCCTGTGATTTACGTTTTAACGTT
TGGTCAGATTTATTGGTAGAAAAGTAAGCCAGTTTAATCAACTGTTGATCAAGGGTTGAACCACCTTGCG
TATTACTACTAACAAGATTATGCCAAGCTGCACCTAAAATACGATAAATATCGACACCTCTATGTTTAAA
GAAACGTTTATCTTCGATAGAAGTGATAGCGTTAACCAAATTTAGTGGAATGCTATCCGCACTAACACTT
TCACGCTTTTCTGAGCCTAAATCGGCAATAAGTTTATTATTACCATCATAAACCAAACTAGAGTTAACGG
ATTTTAAAGCTTGATCGGTTAATTTCGGAGAACGACTAACGTAGTATGCAAATAGGAGCCCACCTATTAC
AATAGCTAAGATAATAAATCCCATTATAATGCCAAAAGCATACTTCAATAGTTTGATAACAGATTCCTTT
TTAATTGTAATCA
Protein Sequence 
>gi|22536482|ref|NP_687333.1| penicillin-binding protein 1A [Streptococcus agalactiae 2603V/R] MITIKKESVIKLLKYAFGIIMGFIILAIVIGGLLFAYYVSRSPKLTDQALKSVNSSLVYDGNNKLIADLGSEKRESVSADSIPLNLVNAITSIEDKRFFKHRGVDIYRILGAAWHNLVSSNTQGGSTLDQQLIKLAYFSTNKSDQTLKRKSQEVWLALQMERKYTKEEILTFYINKVYMGNGNYGMRTTAKSYFGKDLKELSIAQLALLAGIPQAPTQYDPYKNPESAQTRRNTVLQQMYQDKNISKKEYDQAVATPVTDGLKELKQKSTYPKYMDNYLKQVISEVKQKTGKDIFTAGLKVYTNINTDAQKQLYDIYNSDTYIAYPNNELQIASTIMDATNGKVIAQLGGRHQNENISFGTNQSVLTDRDWGSTMKPISAYAPAIDSGVYNSTGQSLNDSVYYWPGTSTQLYDWDRQYMGWMSMQTAIQQSRNVPAVRALEAAGLDEAKSFLEKLGIYYPEMNYSNAISSNNSSSDAKYGASSEKMAAAYSAFANGGTYYKPQYVNKIEFSDGTNDTYAASGSRAMKETTAYMMTDMLKTVLTFGTGTKAAIPGVAQAGKTGTSNYTEDELAKIEATTGIYNSAVGTMAPDENFVGYTSKYTMAIWTGYKNRLTPLYGSQLDIATEVYRAMMSYLTGGYSADWTMPEGLYRSGSYLYINGTTTTGTYSSSVYKNIYQNSGQSSQSSSSTSSEKQKEDKNTANDANSSSPQVETPNNGNATTPNNSNQTVPGTGHGNGNGNGNNNTVPNGN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pbp1A mutant is attenuated in rats (Jones et al., 2000).
COG COG0744M, under M: Cell wall/membrane/envelope biogenesis
References
Jones et al., 2000: Jones AL, Knoll KM, Rubens CE. Identification of Streptococcus agalactiae virulence genes in the neonatal rat sepsis model using signature-tagged mutagenesis. Molecular microbiology. 2000; 37(6); 1444-1455. [PubMed: 10998175].