| Victors ID |
Gene Name |
Sequence Strain (Species/Organism) |
NCBI Gene ID |
NCBI Nucleotide GI |
NCBI Protein GI |
Locus Tag |
Genbank Accession |
Protein Accession |
Protein Name |
Molecule Role |
Molecule Role Annotation |
PMID |
|
|
ORF10 |
Varicella-zoster virus |
1487675
|
|
9625885
|
HHV3_gp12 |
|
NP_040133.1 |
transactivates immediate early genes |
Virulence factor |
MUTATION: deletion of ORF10 reduced viral titers and the extent of cutaneous lesions significantly in SCIDhu skin xenografts in vivo [Ref6798:Che et al., 2006]. |
16537591
|
|
|
ICP0 |
Human herpesvirus 1 |
2703390
|
|
9629439
|
HHV1gp082 |
X14112 |
NP_044660 |
mRNA |
Virulence factor |
MUTATION: ICP0 null HSV-1 mutant is avirulent in mice [Ref7033:Halford et al., 2006].
|
16764725
|
|
|
gD |
Human herpesvirus 1 |
2703406
|
|
9629447
|
HHV1gp094 |
L00036 |
NP_044668 |
mRNA |
Virulence factor |
MUTATION: A HSV-1 strain with mutatinos in the gD gene is attenuated for virulence in mice [Ref7034:Awasthi et al., 2008].
|
18243431
|
|
|
ICP34.5 |
Human herpesvirus 1 |
2703396
|
|
9629440
|
HHV1gp083 |
X14112 |
NP_044661 |
neurovirulence protein ICP34.5 |
Virulence factor |
MUTATION: ICP34.5 mutant virus is avirulent in mice [Ref7035:Ward et al., 2003].
|
12663769
|
|
|
UL41 |
Human herpesvirus 1 |
2703365
|
|
9629422
|
HHV1gp060 |
X14112 |
NP_044643 |
tegument host shutoff protein |
Virulence factor |
MUTATION: Viruses lacking UL41 (vhs) are attenuated in mice [Ref7036:Smith et al., 2000].
|
10729135
|
|
|
US8 |
Human herpesvirus 1 |
2703448
|
|
9629449
|
HHV1gp101 |
X02138 |
NP_044670 |
mRNA |
Virulence factor |
MUTATION: An HSV-1 gE (US8) deletion strain is attenuated in mice [Ref7390:Brittle et al., 2008]. |
18562543
|
|
|
UL29 |
Human herpesvirus 1 |
2703458
|
|
9629410
|
HHV1gp41.5 |
X14112 |
NP_044631 |
single-stranded DNA-binding protein |
Virulence factor |
MUTATION: A UL29 mutant is attenuated in mice [Ref7391:Morrison and Knipe, 1994]. |
8289372
|
|
|
UL23 |
Human herpesvirus 1 |
2703374
|
|
9629403
|
HHV1gp034 |
X14112 |
NP_044624 |
thymidine kinase |
Virulence factor |
MUTATION: A thymidine kinase-deficient (UL23) mutant was found to be attenuated in mice [Ref7392:Field and Wildy, 1978]. |
212476
|
|
|
gH |
Herpes simplex virus (type 1 / strain 17) |
|
|
138315
|
|
|
|
Envelope glycoprotein H |
Virulence factor |
MUTATION: A gH mutant is attenuated in mice [Ref7393:Farrell et al., 1994]. |
8289395
|
|
|
US3 |
Human herpesvirus 2 |
1487355
|
|
9629333
|
HHV2gp66 |
Z86099 |
NP_044533 |
serine/threonine protein kinase US3 |
Virulence factor |
The mutant, L1BR1, could replicate in Vero cells as efficiently as the parental virus. L1BR1 were examined in mice by using four routes (footpad, intraperitoneal, corneal, and intracerebral) of infection, the mutant displayed the route-dependent reduction of virulence. After inoculation by footpad and intraperitoneal routes, the mutant was more than 10,000-fold less virulent than the parental virus. [Ref7430:Nishiyama et al., 1992] |
1326804
|
|
|
UL39 |
Human herpesvirus 1 |
2703361
|
|
9629420
|
HHV1gp057 |
X14112 |
NP_044641 |
ribonucleotide reductase subunit 1 |
Virulence factor |
The RR mutant was extremely impaired in its ability to induce external vaginal lesions or to cause death in mice following intracerebral, intraperitoneal, or intravaginal inoculation, or in guinea pigs following intraperitoneal or intravaginal inoculation. The RR mutant replicated poorly in the vagina of mice and guinea pigs. [Ref7431:Idowu et al., 1992] |
1313220
|
|
|
gC |
|
|
|
330092
|
|
|
|
|
Virulence factor |
A previous study from our laboratory showed that a mutant of herpes simplex virus type 1 (HSV-1), strain KOS-321, carrying a deletion in the structural gene for glycoprotein C (gC) had reduced pathogenicity for the mouse central nervous system when compared to the wild-type virus (Kümel et al., 1985). In this study, eight additional gC negative (gC-) mutants derived from KOS-321 were shown to vary widely in their ability to induce lethal encephalitis in female DBA/2 mice following intracerebral inoculation. [Ref7432:Sunstrum et al., 1988] |
2845681
|
|
|
infected-cell protein (ICP34.5) |
|
|
330116
|
330117
|
|
|
AAA45791.1 |
|
Virulence factor |
All rabbits infected with the ICP34.5 mutant virus (d34.5) survived, even at challenge doses greater than 4 x 10(7) PFU per eye. In contrast, a 200-fold-lower challenge dose of 2 x 10(5) PFU per eye was lethal for approximately 50% of rabbits infected with either the wild-type McKrae parental virus or a rescued ICP34.5 mutant in which both copies of the ICP34.5 gene were restored. [Ref7463:Perng et al., 1995] |
7707530
|
|
|
LAT |
|
|
3002817
|
|
|
|
|
|
Virulence factor |
These results suggest for the first time (i) that regions past the first 1.5 kb of LAT can compensate for deletions in the first 1.5kb of LAT and may therefore play a role in LAT dependent spontaneous reactivation and (ii) that regions of LAT affect viral virulence. [Ref7464:Perng et al., 1999] |
9882292
|
|
|
UL13 |
Human herpesvirus 1 |
2703383
|
|
9629393
|
HHV1gp018 |
AX164125 |
NP_044614 |
tegument serine/threonine protein kinase |
Virulence factor |
We isolated a UL13 gene-deleted mutant of the herpes simplex virus type 1 (HSV-1) strain VR3 (VRDelta13) and its revertant virus (VRDelta13R). VRDelta13 was cleared in the early period of intraperitoneal infection. VRDelta13 had a higher sensitivity to the mouse type I interferon (IFN) and showed a higher level of IFN induction in the study period of infection than did VR3 and VRDelta13R. These results suggest that a nonspecific antiviral response (i.e., the IFN system) may contribute to this rapid inhibition of viral replication in vivo. [Ref7465:Shibaki et al., 2001] |
11429158
|
|
|
LAT-2 |
|
|
330128
|
330129
|
|
|
AAA45796.1 |
|
Virulence factor |
dLAT1.5, a mutant with LAT nucleotides 76 to 1667 deleted. dLAT1.5 had similar or slightly reduced virulence in rabbits (based on survival following ocular infection). In contrast, in mice, dLAT1.5 had increased virulence (P < 0.0001). Thus, deletion of LAT nucleotides 76 to 1667 increased viral virulence in mice but not in rabbits. [Ref7466:Perng et al., 2001] |
11533165
|
|
|
UL24 |
Human herpesvirus 2 |
1487308
|
|
9629293
|
HHV2gp26 |
Z86099 |
NP_044493 |
nuclear protein UL24 |
Virulence factor |
UL24-betagluc was not virulent after intravaginal inoculation of BALB/c mice in that all inoculated animals survived doses up to 400 times the 50% lethal dose (LD50) of the parental virus. Furthermore, few UL24-betagluc-inoculated mice developed any vaginal lesions. Although genital lesions developed in some UL24-betagluc-inoculated guinea pigs, both the overall number of lesions and the severity of disease were far less than that observed for animals infected with parental strain 186. [Ref7467:Blakeney et al., 2005] |
16051842
|
|
|
US6 |
Human herpesvirus 1 |
2703444
|
|
|
HHV1gp096 |
|
|
mRNA |
Virulence factor |
mutations in the gD gene at amino acid residues 3 and 38 by changing alanine to cysteine and tyrosine to cysteine, respectively (A3C/Y38C). When tested in the murine flank model, the mutant virus was markedly attenuated for virulence and caused only mild disease, while the parental and rescued viruses produced much more severe disease. Therefore, this gD mutant virus impaired in entry may represent a novel candidate for an attenuated live HSV-1 vaccine. [Ref7034:Awasthi et al., 2008] |
18243431
|
|
|
US11 |
Human herpesvirus 1 |
2703439
|
|
9629453
|
HHV1gp107 |
X02138 |
NP_044674 |
tegument protein US11 |
Virulence factor |
Mutants exhibited a significantly reduced virulence (106 to 107 PFU/LD50), the LD50 of wild-type HSV-1(F) is 102 PFU. [Ref7504:Meignier et al., 1988] |
2827384
|
|
|
US2 |
Human herpesvirus 1 |
2703399
|
|
9629443
|
HHV1gp087 |
HM585513 |
NP_044664 |
mRNA |
Virulence factor |
Mutants exhibited a significantly reduced virulence (106 to 107 PFU/LD50), the LD50 of wild-type HSV-1(F) is 102 PFU.
[Ref7504:Meignier et al., 1988] |
2827384
|
|
|
US7 |
Human herpesvirus 1 |
2703446
|
|
9629448
|
HHV1gp098 |
JN555585 |
NP_044669 |
mRNA |
Virulence factor |
Mutants exhibited a significantly reduced virulence (106 to 107 PFU/LD50), the LD50 of wild-type HSV-1(F) is 102 PFU.
|
|
|
|
RL1 |
Human herpesvirus 1 |
2703396
|
|
9629440
|
HHV1gp083 |
X14112 |
NP_044661 |
neurovirulence protein ICP34.5 |
Virulence factor |
Mutants exhibited a significantly reduced virulence (106 to 107 PFU/LD50), the LD50 of wild-type HSV-1(F) is 102 PFU.
[Ref7504:Meignier et al., 1988] |
2827384
|
