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US11

Victor ID 5107
Gene Name US11
Sequence Strain (Species/Organism) Human herpesvirus 1
NCBI Gene ID 2703439
NCBI Protein GI 9629453
Locus Tag HHV1gp107
Genbank Accession X02138
Protein Accession NP_044674
Taxonomy ID 10298
Gene Starting Position 144118
Gene Ending Position 145489
Gene Strand (Orientation) -
Protein Name tegument protein US11
Protein pI 12.25
Protein Weight 16665.63
Protein Length 161
DNA Sequence 
>gi|9629378:144118-145489 Human herpesvirus 1, complete genome
AAAATCTGTTTGTAAAATTTATTAAGGGTACAAATTGCCCTAGCACAGGGGTGGGGTTAGGGCCGGGTCC
CCACACCCAAACGCACCAAACAGATGCAGGCAGTGGGTCGAGTACAGCCCCGCGTACGAACACGTCGATG
CGTGTGTCAGACAGCACCAGAAAGCACAGGCCATCAACAGGTCGTGCATGTGTCGGTGGGTTTGGACGCG
GGGGGCCATGGTGGTGATAAAGTTAATGGCCGCCGTCCGCCAGGGCCACAGGGGCGACGTCTCTTGGTTG
GCCCGGAGCCACTGGGTGTGGACCAGCCGCGCGTGGCGGCCCAACATGGCCCCTGTAGCCGGGGGCGGGG
GATCGCGCACGTTTGCAGCGCACATGCGAGACACCTCGACCACGGTTCGAAAGAAGGCCCGGTGGTCCGC
GGGCAACATCACCAGGTGCGCAAGCGCCCGGGCGTCCAGAGGGTAGAGCCCTGAGTCATCCGAGGTTGGC
TCATCGCCCGGGTCTTGCCGCAAGTGCGTGTGGGTTGGGCTTCCGGTGGGCGGGACGCGAACCGCGGTGT
GGATCCCGACGCGGGCCCGAGCGTATGCTCCATGTTGTGGGGAGAAGGGGTCTGGGCTCGCCAGGGGGGC
ATACTTGCCCGGGCTATACAGACCCGCGAGCCGTACGTGGTTCGCGGGGGGTGCGTGGGGTCCGGGGCTC
CCGGGGAGACCGGGGCTCCCGGGGAGACCGGGGCTCCCTGGGAGACCGGGGTTGTCGTGGATCCCTGGGG
TCACGCGGTACCCTGGGGTCTCTGGGAGCTCGCGGTACTCTGGGTTCCCTAGGTTCTCGGGGTGGTCGCG
GAACCCGGGGCTCCCGGGGAACACGCGGTGTCCTGGGGATTGTTGGCGGTCGGACGGCTTCAGATGGCTT
CGAGATCGTAGTGTCCGCACCGACTCGTAGTAGACCCGAATCTCCACATTGCCCCGCCGCTTGATCATTA
TCACCCCGTTGCGGGGGTCCGGAGATCATGCGCGGGTGTCCTCGAGGTGCGTGAACACCTCTGGGGTGCA
TGCCGGCGGACGGCACGCCTTTTAAGTAAACATCTGGGTCGCCCGGCCCAACTGGGGCCGGGGGTTGGGT
CTGGCTCATCTCGAGAGCCACGGGGGGGAACCACCCTCCGCCCAGAGACTCGGGTGATGGTCGTACCCGG
GACTCAACGGGTTACCGGATTACGGGGACTGTCGGTCACGGTCCCGCCGGTTCTTCGATGTGCCACACCC
AAGGATGCGTTGGGGGCGATTTCGGGCAGCAGCCCGGGAGAGCGCAGCAGGGGACGCTCCGGGTCGTGCA
CGGCGGTTCTGGCCGCCTCCCGGTCCTCACGCCCCCTTTTAT
Protein Sequence 
>gi|9629453|ref|NP_044674.1| tegument protein US11 [Human herpesvirus 1]
MSQTQPPAPVGPGDPDVYLKGVPSAGMHPRGVHAPRGHPRMISGPPQRGDNDQAAGQCGDSGLLRVGADT
TISKPSEAVRPPTIPRTPRVPREPRVPRPPREPREPRVPRAPRDPRVPRDPRDPRQPRSPREPRSPREPR
SPREPRTPRTPREPRTARGSV
Molecule Role Virulence factor
Molecule Role Annotation Mutants exhibited a significantly reduced virulence (106 to 107 PFU/LD50), the LD50 of wild-type HSV-1(F) is 102 PFU. (Meignier et al., 1988)
References
Meignier et al., 1988: Meignier B, Longnecker R, Mavromara-Nazos P, Sears AE, Roizman B. Virulence of and establishment of latency by genetically engineered deletion mutants of herpes simplex virus 1. Virology. 1988; 162(1); 251-254. [PubMed: 2827384].