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ICP0

Victor ID 4526
Gene Name ICP0
Sequence Strain (Species/Organism) Human herpesvirus 1
NCBI Gene ID 2703390
NCBI Protein GI 9629439
Locus Tag HHV1gp082
Genbank Accession X14112
Protein Accession NP_044660
Taxonomy ID 10298
Gene Starting Position 120672
Gene Ending Position 124284
Gene Strand (Orientation) -
Protein Name mRNA
Protein pI 7.33
Protein Weight 74188.43
Protein Length 775
DNA Sequence 
>gi|9629378:120672-124284 Human herpesvirus 1, complete genome
AAGATACAAAAGTAAACCTTTATTTCCCAACAGACAGCAAAAATCCCCTGAGTTTTTTTTTATTAGGGCC
AACACAAAAGACCCGCTGGTGTGTGGTGCCCGTGTCTTTCACTTTTCCCCTCCCCGACACGGATTGGCTG
GTGTAGTGGGCGCGGCCAGAGACCACCCAGCGCCCGACCCCCCCCTCCCCACAAACACGGGGGGCGTCCC
TTATTGTTTTCCCTCGTCCCGGGTCGACGCCCCCTGCTCCCCGGACCACGGGTGCCGAGACCGCAGGCTG
CGGAAGTCCAGGGCGCCCACTAGGGTGCCCTGGTCGAACAGCATGTTCCCCACGGGGGTCATCCAGAGGC
TGTTCCACTCCGACGCGGGGGCCGTCGGGTACTCGGGGGGCATCACGTGGTTACCCGCGGTCTCGGGGAG
CAGGGTGCGGCGGCTCCAGCCGGGGACCGCGGCCCGCAGCCGGGTCGCCATGTTTCCCGTCTGGTCCACC
AGGACCACGTACGCCCCGATGTTCCCCGTCTCCATGTCCAGGATGGGCAGGCAGTCCCCCGTGATAGTCT
TGTTCACGTAAGGCGACAGGGCGACCACGCTAGAGACCCCCGAGATGGGCAGGTAGCGCGTGAGGCCGCC
CGCGGGGACGGCCCCGGAAGTCTCCGCGTGGCGCGTCTTCCGGGCACACTTCCTCGGCCCCCGCGGCCCA
GAAGCAGCGCGGGGGCCGAGGGAGGTTTCCTCTTGTCTCCCTCCCAGGGCACCGACGGCCCCGCCCGAGG
AGGCGGAAGCGGAGGAGGACGCGGCCCCGGCGGCGGAAGAGGCGGCCCCCGCGGGGGTCGGGGCCGAGGA
GGAAGAGGCAGAGGAGGAAGAGGCGGAGGCCGCCGAGGACGTCAGGGGGGTCCCGGGCCCACCCTGGCCG
CGCCCCCCCGGCCCTGAGTCGGAGGGGGGGTGCGTCGCCGCCCTCTTGGCCCCTGCCGGCGCGAGGGGGG
GACGCGTGGACTGGGGGGAGGGGTTTTCCTGGCCCGACCCGCGCCTCTTCCTCGGACGCACCGCCGCCTC
CTGCTCGACAGAGGCGGCGGAGGGGAGCGGGGCGGCGCCGGAGGGGGCGGCGCCGCGGGAGGGCCCGTGC
CCACCCTCCACGCCCGGCCCCCCCGAGCCGCGCGCCACCGTCGCACGCGCCCGGCACAGACTCTGTTCTT
GGTTCGCGGCCTGAGCCAGGGACGAGTGCGACTGGGGCACACGGCGCGCGTCCGCGGGGCGGGCGGCCGG
CTCCGCCCCGGGGGCCGGGGCGCGGGGGCCGGGCCCCGGAGGCGGCGCTCGCACGCACGGGGCCACGGCC
GCGCGGGGGCGCGCGGGTCCCGACGCGGCCGCGGACGCGGGGGGCCCGGGGCGGGGGGCGGAGCCTGGCA
TGGGCGCCGCGGGGGGCCTGTGGGGAGAGGCCGGGGGGGAGTCGCTGATCACTATGGGGTCTCTGTTGTT
TGCAAGGGGGGCGGGTCTGTTGACAAGGGGGCCCGTCCGGCCCCTCGGCCGCCCCGCCTCCGCTTCAACA
ACCCCAACCCCAACCCCAACCCCCCCGGAGGGGCCAGACGCCCCCCGCGGCGCCGCGGCTCGCGACTGGC
GGGAGCCGCCGCCGCCGCTGCTGTTGGTGGTGGTGTTGGTGTTACTGCTGCCGTGTGGCCCGATGGGCGC
CGAGGGGGGCGCTGTCCGAGCCGCGGCCGGCTGGGGGGCTGCGTGAGACGCCCCGCCCGTCACGGGGGGC
GCGGCGGCGCCTCTGCGTGGGGGGGCGCGGGGCGTCCGGCGGGGGGCGGGCGGTACGTAGTCTGCTGCAA
GAGACAACGGGGGGCGCGATCAGGTTACGCCCCCTCCCCGGCCCGCCCTTTCCTCGCCCGCCCGCCTATT
CCTCCCTCCCCCCCCCTCCTCCTCCTCCTCCCCCAGGGTCCTTGCCGCCCCCCGCCTCACCGTCGTCCAG
GTCGTCGTCATCCTCGTCCGTGGTGGGCTCCGGGTGGGTGGGCGACAGGGCCCTCACCGTGTGCCCCCCC
AGGGTCAGGTACCGCGGGGCGAACCGCTGATTGCCCGTCCAGATAAAGTCCACGGCCGTGCCCGCCCTGA
CGGCCTCCTCGGCCTCCATGCGGGTCTGGGGGTCGTTCACGATCGGGATGGTGCTGAACGACCCGCTGGG
CGTCACGCCCACTATCAGGTACACCAGCTTGGCGTTGCACAGCGGGCAGGTGTTGCGCAATTGCATCCAG
GTTTTCATGCACGGGATGCAGAAGCGGTGCATGCACGGGAAGGTGTCGCAGCGCAGGTGGGGCGCGATCT
CATCCGTGCACACGGCGCACACGTCGCCCTCGTCGCTCCCCCCGTCCTCTCGAGGGGGGGCGCCCCCGCA
ACTGCCGGGGTCTTCCTCGCGGGGGGGGCTCCCCCCCGAGACCGCCCCCCCATCCACGCCCTGCGGCCCC
AGCAGCCCCGTCTCGAACAGTTCCGTGTCCGTGCTGTCCGCCTCGGAGGCGGAGTCGTCGTCATGGTGGT
CGGCGTCCCCCCGCCCCCCCACTTCGGTCTCCGCCTCAGAGTCGCTGCTGTCCGGCAGGTCTCGGTCGCA
GGGAAACACCCAGACATCCGGGGCGGGCTAAGGGGAAAAAAGGGGGGCGGGTAAGAATGGGGGGGGATTT
CCCGCGTCAATCAGCACCCACGAGTTCCCCCTCTCCCCCCCCCGCCTCACAAAGTCCTGCCCCCCTGCTG
GCCTCGGAAGAGGGGGGAGAAAGGGGTCTGCAACCAAAGGTGGTCTGGGTCCGTCCTTTGGATCCCGACC
CCTCTTCTTCCCTCTTCTCCCGCCCTCCAGACGCACCGGAGTCGGGGGTCCCACGGCGTCCCCCAAATAT
GGCGGGCGGCTCCTCCCCACCCCCCTAGATGCGTGTGAGTAAGGGGGGCCTGCGTATGAGTCAGTGGGGA
CCACGCCCCCAACACGGCGACCCCGGTCCTTGTGTGTTTGTTGTGGGGGCGTGTCTCTGTGTATGAGTCA
GGGGGTCCCACGGCGACCCCGGGCCCTGCGTCTGAGTCAAAGGGGCCATGTGTATGTGTTGGGGGTCTGT
ATATATAAAGTCAGGGGGTCACATGGCGACCCCCAACAGGGCGACCCCGGTCCCTGTATATATAGGGTCA
GGGGGTTCCGCACCCCCTAACATGGCGCCCCCGGTCCCTGTATATATAGTGTCACGGGGTTCCACGCCCC
CTAACATGGCGCCCCAACATGGCGCCCGGCTCCCGTGTATGAGTGGGGGTCCCCCAACATGGCGGCCGGT
TCCAGTGTAAGGGTCGGGGGTCCCCCAACATGGCGCCCCCCAATATGGCGCCCCCCAATATGGCGCCCCA
GACATGGCGCCCGGCCCCTCACCTCGCGCTGGGGGCGGCCCTCAGGCCGGCGGGTACTCGCTCCGGGGCG
GGGCTCCATGGGGGTCGTATGCGGCTGGAGGGTCGCGGACGGAGGGTCCCTGGGGGTCGCAACGTAGGCG
GGGCTTCTGTGGTGATGCGGAGAGGGGGCGGCCCGAGTCTGCCTGGCTGCTGCGTCTCGCTCCGAGTGCC
GAGGTGCAAATGCGACCAGACTGTCGGGCCAGGGCTAACTTAT
Protein Sequence 
>gi|9629439|ref|NP_044660.1| ubiquitin E3 ligase ICP0 [Human herpesvirus 1]
MEPRPGASTRRPEGRPQREPAPDVWVFPCDRDLPDSSDSEAETEVGGRGDADHHDDDSASEADSTDTELF
ETGLLGPQGVDGGAVSGGSPPREEDPGSCGGAPPREDGGSDEGDVCAVCTDEIAPHLRCDTFPCMHRFCI
PCMKTWMQLRNTCPLCNAKLVYLIVGVTPSGSFSTIPIVNDPQTRMEAEEAVRAGTAVDFIWTGNQRFAP
RYLTLGGHTVRALSPTHPEPTTDEDDDDLDDADYVPPAPRRTPRAPPRRGAAAPPVTGGASHAAPQPAAA
RTAPPSAPIGPHGSSNTNTTTNSSGGGGSRQSRAAAPRGASGPSGGVGVGVGVVEAEAGRPRGRTGPLVN
RPAPLANNRDPIVISDSPPASPHRPPAAPMPGSAPRPGPPASAAASGPARPRAAVAPCVRAPPPGPGPRA
PAPGAEPAARPADARRVPQSHSSLAQAANQEQSLCRARATVARGSGGPGVEGGHGPSRGAAPSGAAPLPS
AASVEQEAAVRPRKRRGSGQENPSPQSTRPPLAPAGAKRAATHPPSDSGPGGRGQGGPGTPLTSSAASAS
SSSASSSSAPTPAGAASSAAGAASSSASASSGGAVGALGGRQEETSLGPRAASGPRGPRKCARKTRHAET
SGAVPAGGLTRYLPISGVSSVVALSPYVNKTITGDCLPILDMETGNIGAYVVLVDQTGNMATRLRAAVPG
WSRRTLLPETAGNHVMPPEYPTAPASEWNSLWMTPVGNMLFDQGTLVGALDFRSLRSRHPWSGEQGASTR
DEGKQ
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ICP0 null HSV-1 mutant is avirulent in mice (Halford et al., 2006).
References
Halford et al., 2006: Halford WP, Weisend C, Grace J, Soboleski M, Carr DJ, Balliet JW, Imai Y, Margolis TP, Gebhardt BM. ICP0 antagonizes Stat 1-dependent repression of herpes simplex virus: implications for the regulation of viral latency. Virology journal. 2006; 3; 44. [PubMed: 16764725].