Victors

UL39
Victor ID	5027
Gene Name	UL39
Sequence Strain (Species/Organism)	Human herpesvirus 1
NCBI Gene ID	2703361
NCBI Protein GI	9629420
Locus Tag	HHV1gp057
Genbank Accession	X14112
Protein Accession	NP_044641
Taxonomy ID	10298
Gene Starting Position	86216
Gene Ending Position	90987
Gene Strand (Orientation)	+
Protein Name	ribonucleotide reductase subunit 1
Protein pI	6.53
Protein Weight	116607.14
Protein Length	1137
Protein Note	1.17.4.1
DNA Sequence	>gi\|9629378:86216-90987 Human herpesvirus 1, complete genome TACCACAGGTGGGTGCTTTGGAAACTTGCCGGTCGCCGTGCTCCTGTGAGCTTGCGTCCCTCCCCGGTTT CCTTTGCGCTCCCGCCTTCCGGACCTGCTCTCGCCTACTCTTCTTTGGCTCTCGGTGCGATTCGTCAGGC AGCGGCCTTGTCGAATCTCGACCCCACCACTCGCCGGACCCGCCGACGTCCCCTCTCGAGCCCGCCGAAA CCCGCCGCGTCTGTTGAAATGGCCAGCCGCCCAGCCGCATCCTCTCCCGTCGAAGCGCGGGCCCCGGTTG GGGGACAGGAGGCCGGCGGCCCCAGCGCAGCCACCCAGGGGGAGGCCGCCGGGGCCCCTCTCGCCCACGG CCACCACGTGTACTGCCAGCGAGTCAATGGCGTGATGGTGCTTTCCGACAAGACGCCCGGGTCCGCGTCC TACCGCATCAGCGATAACAACTTTGTCCAATGTGGTTCCAACTGCACCATGATCATCGACGGAGACGTGG TGCGCGGGCGCCCCCAGGACCCGGGGGCCGCGGCATCCCCCGCTCCCTTCGTTGCGGTGACAAACATCGG AGCCGGCAGCGACGGCGGGACCGCCGTCGTGGCATTCGGGGGAACCCCACGTCGCTCGGCGGGGACGTCT ACCGGTACCCAGACGGCCGACGTCCCCACCGAGGCCCTTGGGGGCCCCCCTCCTCCTCCCCGCTTCACCC TGGGTGGCGGCTGTTGTTCCTGTCGCGACACACGGCGCCGCTCTGCGGTATTCGGGGGGGAGGGGGATCC AGTCGGCCCCGCGGAGTTCGTCTCGGACGACCGGTCGTCCGATTCCGACTCGGATGACTCGGAGGACACG GACTCGGAGACGCTGTCACACGCCTCCTCGGACGTGTCCGGCGGGGCCACGTACGACGACGCCCTTGACT CCGATTCGTCATCGGATGACTCCCTGCAGATAGATGGCCCCGTGTGTCGCCCGTGGAGCAATGACACCGC GCCCCTGGATGTTTGCCCCGGGACCCCCGGCCCGGGCGCCGACGCCGGTGGTCCCTCAGCGGTAGACCCA CACGCGCCGACGCCAGAGGCCGGCGCTGGTCTTGCGGCCGATCCCGCCGTGGCCCGGGACGACGCGGAGG GGCTTTCGGACCCCCGGCCACGTCTGGGAACGGGCACGGCCTACCCCGTCCCCCTGGAACTCACGCCCGA GAACGCGGAGGCCGTGGCGCGCTTTCTGGGAGATGCCGTGAACCGCGAACCCGCGCTCATGCTGGAGTAC TTTTGCCGGTGCGCCCGCGAGGAAACCAAGCGTGTCCCCCCCAGGACATTCGGCAGCCCCCCTCGCCTCA CGGAGGACGACTTTGGGCTTCTCAACTACGCGCTCGTGGAGATGCAGCGCCTGTGTCTGGACGTTCCTCC GGTCCCGCCGAACGCATACATGCCCTATTATCTCAGGGAGTATGTGACGCGGCTGGTCAACGGGTTCAAG CCGCTGGTGAGCCGGTCCGCTCGCCTTTACCGCATCCTGGGGGTTCTGGTGCACCTGCGGATCCGGACCC GGGAGGCCTCCTTTGAGGAGTGGCTGCGATCCAAGGAAGTGGCCCTGGATTTTGGCCTGACGGAAAGGCT TCGCGAGCACGAAGCCCAGCTGGTGATCCTGGCCCAGGCTCTGGACCATTACGACTGTCTGATCCACAGC ACACCGCACACGCTGGTCGAGCGGGGGCTGCAATCGGCCCTGAAGTATGAGGAGTTTTACCTAAAGCGTT TTGGCGGGCACTACATGGAGTCCGTCTTCCAGATGTACACCCGCATCGCCGGCTTTTTGGCCTGCCGGGC CACGCGCGGCATGCGCCACATCGCCCTGGGGCGAGAGGGGTCGTGGTGGGAAATGTTCAAGTTCTTTTTC CACCGCCTCTACGACCACCAGATCGTACCGTCGACCCCCGCCATGCTGAACCTGGGGACCCGCAACTACT ACACCTCCAGCTGCTACCTGGTAAACCCCCAGGCCACCACAAACAAGGCGACCCTGCGGGCCATCACCAG CAACGTCAGTGCCATCCTCGCCCGCAACGGGGGCATCGGGCTATGCGTGCAGGCGTTTAACGACTCCGGC CCCGGGACCGCCAGCGTCATGCCCGCCCTCAAGGTCCTTGACTCGCTGGTGGCGGCGCACAACAAAGAGA GCGCGCGTCCGACCGGCGCGTGCGTGTACCTGGAGCCGTGGCACACCGACGTGCGGGCCGTGCTCCGGAT GAAGGGGGTCCTCGCCGGCGAAGAGGCCCAGCGCTGCGACAATATCTTCAGCGCCCTCTGGATGCCAGAC CTGTTTTTCAAGCGCCTGATTCGCCACCTGGACGGCGAGAAGAACGTCACATGGACCCTGTTCGACCGGG ACACCAGCATGTCGCTCGCCGACTTTCACGGGGAGGAGTTCGAGAAGCTCTACCAGCACCTCGAGGTCAT GGGGTTCGGCGAGCAGATACCCATCCAGGAGCTGGCCTATGGCATTGTGCGCAGTGCGGCCACGACCGGG AGCCCCTTCGTCATGTTCAAAGACGCGGTGAACCGCCACTACATCTACGACACCCAGGGGGCGGCCATCG CCGGCTCCAACCTCTGCACCGAGATCGTCCATCCGGCCTCCAAGCGATCCAGTGGGGTCTGCAACCTGGG AAGCGTGAATCTGGCCCGATGCGTCTCCAGGCAGACGTTTGACTTTGGGCGGCTCCGCGACGCCGTGCAG GCGTGCGTGCTGATGGTGAACATCATGATCGACAGCACGCTACAACCCACGCCCCAGTGCACCCGCGGCA ACGACAACCTGCGGTCCATGGGAATCGGCATGCAGGGCCTGCACACGGCCTGCCTGAAGCTGGGGCTGGA TCTGGAGTCTGCCGAATTTCAGGACCTGAACAAACACATCGCCGAGGTGATGCTGCTGTCGGCGATGAAG ACCAGCAACGCGCTGTGCGTTCGCGGGGCCCGTCCCTTCAACCACTTTAAGCGCAGCATGTATCGCGCCG GCCGCTTTCACTGGGAGCGCTTTCCGGACGCCCGGCCGCGGTACGAGGGCGAGTGGGAGATGCTACGCCA GAGCATGATGAAACACGGCCTGCGCAACAGCCAGTTTGTCGCGCTGATGCCCACCGCCGCCTCGGCGCAG ATCTCGGACGTCAGCGAGGGCTTTGCCCCCCTGTTCACCAACCTGTTCAGCAAGGTGACCCGGGACGGCG AGACGCTGCGCCCCAACACGCTCCTGCTAAAGGAACTGGAACGCACGTTTAGCGGGAAGCGCCTCCTGGA GGTGATGGACAGTCTCGACGCCAAGCAGTGGTCCGTGGCGCAGGCGCTCCCGTGCCTGGAGCCCACCCAC CCCCTCCGGCGATTCAAGACCGCGTTTGACTACGACCAGAAGTTGCTGATCGACCTGTGTGCGGACCGCG CCCCCTACGTCGACCATAGCCAATCCATGACCCTGTATGTCACGGAGAAGGCGGACGGGACCCTCCCAGC CTCCACCCTGGTCCGCCTTCTGGTCCACGCATATAAGCGCGGACTAAAAACAGGGATGTACTACTGCAAG GTTCGCAAGGCGACCAACAGCGGGGTCTTTGGCGGCGACGACAACATTGTCTGCATGAGCTGCGCGCTGT GACCGACAAACCCCCTCCGCGCCAGGCCCGCCGCCACTGTCGTCGCCGTCCCACGCTCTCCCCTGCTGCC ATGGATTCCGCGGCCCCAGCCCTCTCCCCCGCTCTGACGGCCCTTACGGACCAGAGCGCGACGGCGGACC TGGCGATCCAGATTCCAAAGTGCCCCGACCCCGAGAGGTACTTCTACACCTCCCAGTGTCCCGACATTAA CCACCTGCGCTCCCTCAGCATCCTTAACCGCTGGCTGGAAACCGAGCTTGTTTTCGTGGGGGACGAGGAG GACGTCTCCAAGCTTTCCGAGGGCGAGCTCAGCTTTTACCGCTTCCTCTTCGCTTTCCTGTCGGCCGCCG ACGACCTGGTTACGGAAAACCTGGGCGGCCTCTCCGGCCTGTTTGAGCAGAAGGACATTCTCCACTACTA CGTGGAGCAGGAATGCATCGAAGTCGTACACTCGCGCGTGTACAACATCATCCAGCTGGTGCTTTTCCAC AACAACGACCAGGCGCGCCGCGAGTACGTGGCCGGTACCATCAACCACCCGGCCATCCGCGCCAAGGTGG ACTGGTTGGAAGCGCGGGTGCGGGAATGCGCCTCCGTTCCGGAAAAGTTCATTCTCATGATCCTCATCGA GGGCATCTTTTTTGCCGCCTCGTTTGCCGCCATCGCCTACCTTCGCACCAACAACCTTCTGCGGGTCACC TGCCAGTCAAACGACCTCATCAGCCGGGACGAGGCCGTGCACACGACGGCCTCGTGTTACATCTACAACA ACTACCTCGGCGGGCACGCCAAGCCCCCGCCCGACCGCGTGTACGGGCTGTTCCGCCAGGCGGTCGAGAT CGAGATCGGATTTATCCGATCCCAGGCGCCGACGGACAGCCATATCCTGAGCCCGGCGGCGCTGGCGGCC ATCGAAAACTACGTGCGATTCAGCGCGGATCGCCTGTTGGGCCTTATCCACATGAAGCCACTGTTTTCCG CCCCACCCCCCGACGCCAGCTTTCCGCTGAGCCTCATGTCCACCGACAAACACACCAATTTTTTCGAGTG TCGCAGCACCTCCTACGCCGGGGCGGTCGTCAACGATCTGTGAGTGTCGCGGCGCGCTTCTACCCGTGTT TGCCCATAATAA
Protein Sequence	>gi\|9629420\|ref\|NP_044641.1\| ribonucleotide reductase subunit 1 [Human herpesvirus 1] MASRPAASSPVEARAPVGGQEAGGPSAATQGEAAGAPLAHGHHVYCQRVNGVMVLSDKTPGSASYRISDN NFVQCGSNCTMIIDGDVVRGRPQDPGAAASPAPFVAVTNIGAGSDGGTAVVAFGGTPRRSAGTSTGTQTA DVPTEALGGPPPPPRFTLGGGCCSCRDTRRRSAVFGGEGDPVGPAEFVSDDRSSDSDSDDSEDTDSETLS HASSDVSGGATYDDALDSDSSSDDSLQIDGPVCRPWSNDTAPLDVCPGTPGPGADAGGPSAVDPHAPTPE AGAGLAADPAVARDDAEGLSDPRPRLGTGTAYPVPLELTPENAEAVARFLGDAVNREPALMLEYFCRCAR EETKRVPPRTFGSPPRLTEDDFGLLNYALVEMQRLCLDVPPVPPNAYMPYYLREYVTRLVNGFKPLVSRS ARLYRILGVLVHLRIRTREASFEEWLRSKEVALDFGLTERLREHEAQLVILAQALDHYDCLIHSTPHTLV ERGLQSALKYEEFYLKRFGGHYMESVFQMYTRIAGFLACRATRGMRHIALGREGSWWEMFKFFFHRLYDH QIVPSTPAMLNLGTRNYYTSSCYLVNPQATTNKATLRAITSNVSAILARNGGIGLCVQAFNDSGPGTASV MPALKVLDSLVAAHNKESARPTGACVYLEPWHTDVRAVLRMKGVLAGEEAQRCDNIFSALWMPDLFFKRL IRHLDGEKNVTWTLFDRDTSMSLADFHGEEFEKLYQHLEVMGFGEQIPIQELAYGIVRSAATTGSPFVMF KDAVNRHYIYDTQGAAIAGSNLCTEIVHPASKRSSGVCNLGSVNLARCVSRQTFDFGRLRDAVQACVLMV NIMIDSTLQPTPQCTRGNDNLRSMGIGMQGLHTACLKLGLDLESAEFQDLNKHIAEVMLLSAMKTSNALC VRGARPFNHFKRSMYRAGRFHWERFPDARPRYEGEWEMLRQSMMKHGLRNSQFVALMPTAASAQISDVSE GFAPLFTNLFSKVTRDGETLRPNTLLLKELERTFSGKRLLEVMDSLDAKQWSVAQALPCLEPTHPLRRFK TAFDYDQKLLIDLCADRAPYVDHSQSMTLYVTEKADGTLPASTLVRLLVHAYKRGLKTGMYYCKVRKATN SGVFGGDDNIVCMSCAL
Molecule Role	Virulence factor
Molecule Role Annotation	The RR mutant was extremely impaired in its ability to induce external vaginal lesions or to cause death in mice following intracerebral, intraperitoneal, or intravaginal inoculation, or in guinea pigs following intraperitoneal or intravaginal inoculation. The RR mutant replicated poorly in the vagina of mice and guinea pigs. (Idowu et al., 1992)
References	*Idowu et al., 1992:* Idowu AD, Fraser-Smith EB, Poffenberger KL, Herman RC. Deletion of the herpes simplex virus type 1 ribonucleotide reductase gene alters virulence and latency in vivo. Antiviral research. 1992; 17(2); 145-156. [PubMed: 1313220].


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UL39