Victors

UL24
Victor ID	5063
Gene Name	UL24
Sequence Strain (Species/Organism)	Human herpesvirus 2
NCBI Gene ID	1487308
NCBI Protein GI	9629293
Locus Tag	HHV2gp26
Genbank Accession	Z86099
Protein Accession	NP_044493
Taxonomy ID	10310
Gene Starting Position	47901
Gene Ending Position	52998
Gene Strand (Orientation)	+
Protein Name	nuclear protein UL24
Protein pI	11.67
Protein Weight	28066.28
Protein Length	281
DNA Sequence	>gi\|9629267:47901-52998 Human herpesvirus 2, complete genome GATGGCTAGGACGGGACGCCGCGCGGCCGTCGGTAGGCCCGCTCGCACGAGCAGCCTGACCGAACGCAGG CGCGTGCTGTTGGCCGGCGTGAGAAGCCATACCCGCTTCTACAAGGCGTTCGCCCGAGAGGTGCGGGAGT TCAACGCCACCAGGATTTGTGGAACGCTGCTGACGCTGATGAGCGGGTCGCTGCAGGGTCGCTCGCTGTT CGAGGCCACGCGCGTCACCTTAATATGCGAAGTGGACCTCGGGCCGCGCCGCCCAGACTGCATCTGCGTG TTCGAATTCGCCAATGACAAAACGTTGGGAGGTGTGTGCGTCATCCTGGAGCTAAAGACATGCAAATCGA TTTCTTCCGGGGACACGGCCAGCAAACGCGAACAGCGGACCACGGGCATGAAGCAGCTGCGCCACTCCCT GAAGCTGCTGCAGTCGCTCGCGCCTCCGGGGGACAAGGTCGTCTACCTGTGTCCTATTTTGGTGTTTGTC GCGCAGCGTACGCTGCGCGTCAGCCGCGTGACCCGGCTCGTCCCGCAAAAGATCTCCGGCAACATCACCG CGGCCGTGCGGATGCTCCAAAGCCTGTCCACGTATGCCGTGCCGCCGGAACCGCAGACCCGGCGGTCGCG GCGCCGGGTCGCCGCGACCGCCAGACCGCAAAGGCCCCCCTCCCCGACACGTGACCCGGAAGGCACGGCG GGTCATCCGGCCCCACCAGAGAGCGACCCCCCCTCCCCAGGGGTCGTAGGCGTCGCTGCGGAGGGTGGGG GTGTGCTTCAGAAAATCGCGGCGCTTTTTTGCGTGCCGGTGGCCGCCAAGAGCAGACCCCGGACCAAAAC CGAGTGAGGTTCTGTGTGTTGTTTTTTTTTTTTTTTTTCCTCGTTTTGTTTTCTCTTCTTTCCCCCCCCC CTCCCCCGCTTCTGGCCAAGCATCCTCACCTGCTTAAGCGGAACCCGCGGGCGCGCGGGGACTCATTTGT CGCCGGCGACACCCACCCGACAACAGCCCCTGGGTGTCGACCGCTGTCGCCCCCGTCTGTCGCCTCTCCC TTTTTTCCCCCCCTCAAAGAACGTGGTGTTGGGCGCCGGCCAATTCTTCCCGGAGCGCCGTCGTCGCCCG CCCGCCGCCCTCGAACATGGACCCGTACTACCCTTTCGACGCGCTGGACGTTTGGGAACACAGGCGCTTC ATCGTCGCCGACTCCAGGAGCTTCATCACCCCCGAGTTCCCCCGGGACTTCTGGATGTTGCCCGTGTTCA ACATCCCCCGGGAGACGGCGGCGGAGCGGGCGGCAGTGCTGCAGGCCCAGCGCACCGCGGCCGCGGCGGC CCTGGAGAACGCCGCCCTCCAGGCCGCCGAGCTGCCCGTCGACATCGAGCGCCGGATACGCCCGATCGAG CAGCAGGTGCATCACATCGCCGACGCCCTGGAGGCGCTGGAGACCGCGGCGGCCGCGGCCGAAGAGGCGG ATGCCGCGCGGGACGCCGAGGCGAGGGGGGAGGGCGCTGCGGACGGGGCAGCGCCGTCGCCCACCGCGGG CCCCGCCGCCGCGGAGATGGAGGTTCAGATCGTACGCAACGACCCGCCGCTACGATACGATACCAACCTC CCCGTGGATCTGCTACACATGGTGTACGCGGGCCGCGGGGCCGCGGGTTCGTCGGGAGTCGTCTTTGGTA CCTGGTACCGCACGATCCAGGAACGCACCATCGCGGACTTCCCCCTGACCACCCGCAGCGCCGACTTTCG AGACGGGCGCATGTCCAAGACCTTCATGACCGCGCTGGTCCTGTCTCTGCAGTCGTGCGGCCGGCTGTAC GTGGGCCAGCGCCACTATTCCGCCTTCGAGTGCGCCGTGCTGTGTCTGTATCTGCTGTACCGAACCACCC ACGAGTCCTCCCCCGATCGCGATCGCGCTCCCGTTGCGTTCGGGGACCTGCTGGCCCGCCTGCCGCGCTA CCTGGCGCGTCTGGCCGCGGTAATCGGCGACGAGAGCGGACGCCCGCAGTACCGCTACCGCGACGACAAG CTGCCCAAAGCGCAGTTCGCGGCGGCCGGCGGCCGCTACGAGCACGGGGCCCTGGCCACCCACGTCGTGA TCGCCACGTTGGTGCGCCACGGGGTGCTACCGGCGGCCCCGGGCGACGTTCCCCGAGACACCAGCACCCG CGTGAACCCCGACGACGTGGCCCACCGCGACGACGTCAACCGCGCCGCCGCCGCGTTTTTGGCACGCGGC CACAACCTCTTCCTGTGGGAGGACCAGACGCTGCTGCGGGCGACCGCCAACACCATTACGGCCCTGGCCG TGCTTCGGCGGCTCCTCGCGAACGGCAACGTGTACGCGGACCGCCTCGACAACCGCCTGCAGCTGGGCAT GCTGATCCCGGGAGCCGTCCCGGCGGAGGCCATCGCTCGGGGGGCGTCCGGATTGGACTCGGGCGCCATA AAAAGCGGCGACAACAACCTGGAGGCGCTGTGCGTTAACTATGTACTTCCGCTGTATCAGGCAGACCCCA CGGTCGAGCTGACCCAGTTGTTTCCGGGGCTGGCCGCCCTGTGCCTGGACGCCCAGGCGGGGCGGCCACT GGCGTCGACGAGGCGCGTGGTGGATATGTCGTCGGGCGCCCGCCAGGCGGCGCTCGTGCGCCTCACCGCG CTGGAGCTCATCAACCGCACCCGCACAAACACCACCCCTGTGGGGGAGATTATTAACGCCCACGATGCCT TGGGGATACAATACGAACAGGGGCCTGGGCTGCTCGCCCAGCAGGCACGCATCGGCTTGGCGTCAAACAC CAAGCGATTCGCCACGTTCAACGTGGGCAGCGACTACGACCTGTTGTACTTTTTGTGTCTCGGGTTCATT CCCCAGTACCTGTCCGTGGCCTAGGGAAGGGTGGGGGTGGTGGTGGTGGGGTGTTTTTCTGTTGTTGTTT CTGGTCCGCCTGGTCACAAAAGGCACGGCGCCCCGAAACGCGGGCTTTAGTCCCGGCCCGGACGTCGGCG GACACGCAACAACGGCGGGCCCCGTGGGTGGGTAAGTTGGTTCGGGGGCATCGCTGTATTCCCTTGCCCG CTTCCACCCCCCCCCCCCTTCCCGTTTTGTTTGTTTGTGCGGGTGCCCATGGCGTCGGCGGAAATGCGCG AGCGGTTGGAGGCGCCTCTGCCCGACCGGGCGGTGCCCATCTACGTGGCCGGGTTTTTGGCCCTGTACGA CAGCGGGGACCCGGGCGAGCTGGCCCTGGACCCAGACACGGTGCGTGCGGCCCTGCCTCCGGAGAACCCC CTGCCGATCAACGTAGACCACCGCGCTCGGTGCGAGGTGGGCCGGGTGCTCGCCGTGGTCAACGACCCTC GGGGGCCGTTTTTTGTGGGGCTGATCGCGTGCGTGCAGCTGGAGCGCGTCCTCGAGACGGCCGCCAGCGC CGCTATTTTTGAGCGCCGCGGACCCGCGCTCTCCCGGGAGGAGCGTCTGCTGTACCTGATCACCAACTAC CTGCCATCGGTCTCGCTGTCCACAAAACGCCGGGGGGACGAGGTTCCGCCCGACCGCACCCTGTTTGCGC ACGTGGCCCTGTGCGCCATCGGGCGGCGCCTTGGAACCATCGTCACCTACGACACCAGCCTAGACGCGGC CATCGCTCCGTTTCGCCACCTGGACCCGGCGACGCGCGAGGGGGTGCGACGCGAGGCCGCCGAGGCCGAG CTCGCGCTGGCCGGGCGCACCTGGGCCCCCGGCGTGGAGGCGCTCACACACACGCTGCTCTCCACCGCCG TCAACAACATGATGCTGCGTGACCGCTGGAGCCTTGTGGCCGAGCGGCGGCGGCAGGCCGGGATCGCCGG ACACACGTACCTTCAGGCGAGCGAAAAATTTAAAATATGGGGGGCGGAGTCTGCCCCTGCGCCGGAGCGC GGGTATAAAACCGGCGCCCCGGGTGCCATGGACACATCCCCCGCCGCGAGCGTTCCCGCGCCGCAGGTCG CCGTCCGTGCGCGTCAAGTCGCGTCGTCGTCTTCTTCTTCTTCTTTTCCGGCACCGGCCGATATGAACCC CGTTTCGGCATCGGGCGCCCCGGCCCCTCCGCCGCCCGGCGACGGGAGTTATTTGTGGATCCCCGCCTCT CATTACAATCAGCTCGTCACCGGGCAATCCGCGCCCCGCCACCCGCCGCTGACCGCGTGCGGCCTGCCGG CCGCGGGGACGGTGGCCTACGGACACCCCGGCGCCGGCCCGTCCCCGCACTACCCGCCTCCTCCCGCCCA CCCGTACCCGGGTATGCTGTTCGCGGGCCCCAGTCCCCTGGAGGCCCAGATCGCCGCGCTGGTGGGGGCC ATCGCCGCCGACCGCCAGGCGGGTGGGCTTCCGGCGGCCGCCGGAGACCACGGGATCCGGGGGTCGGCGA AGCGCCGCCGACACGAGGTGGAGCAGCCGGAGTACGACTGCGGCCGTGACGAGCCGGACCGGGACTTCCC GTATTACCCGGGCGAGGCCCGCCCCGAGCCGCGCCCGGTCGACTCCCGGCGCGCCGCGCGCCAGGCTTCC GGGCCCCACGAAACCATCACGGCGCTGGTGGGGGCGGTGACGTCCCTGCAGCAGGAACTGGCGCACATGC GCGCGCGTACCCACGCCCCCTACGGGCCGTATCCGCCGGTGGGGCCCTACCACCACCCCCACGCAGACAC GGAGACCCCCGCCCAACCACCCCGCTACCCCGCCAAGGCCGTCTATCTGCCGCCGCCGCACATCGCCCCC CCGGGGCCTCCTCTATCCGGGGCGGTCCCCCCACCCTCGTATCCCCCAGTTGCGGTTACCCCCGGTCCCG CTCCCCCGCTACATCAGCCCTCCCCCGCACACGCCCACCCCCCTCCGCCGCCGCCGGGACCCACGCCTCC CCCCGCCGCGAGCTTACCCCAACCCGAGGCGCCCGGCGCGGAGGCCGGCGCCTTAGTTAACGCCAGCAGC GCGGCCCACGTGAACGTGGACACGGCCCGGGCCGCCGATCTGTTTGTGTCACAGATGATGGGGTCCCGCT AACTCGCCTCCAGGATCCGGACTTGGGGGGGGTGTGTGTTTTCATATATTTTAAATAA
Protein Sequence	>gi\|9629293\|ref\|NP_044493.1\| nuclear protein UL24 [Human herpesvirus 2] MARTGRRAAVGRPARTSSLTERRRVLLAGVRSHTRFYKAFAREVREFNATRICGTLLTLMSGSLQGRSLF EATRVTLICEVDLGPRRPDCICVFEFANDKTLGGVCVILELKTCKSISSGDTASKREQRTTGMKQLRHSL KLLQSLAPPGDKVVYLCPILVFVAQRTLRVSRVTRLVPQKISGNITAAVRMLQSLSTYAVPPEPQTRRSR RRVAATARPQRPPSPTRDPEGTAGHPAPPESDPPSPGVVGVAAEGGGVLQKIAALFCVPVAAKSRPRTKT E
Molecule Role	Virulence factor
Molecule Role Annotation	UL24-betagluc was not virulent after intravaginal inoculation of BALB/c mice in that all inoculated animals survived doses up to 400 times the 50% lethal dose (LD50) of the parental virus. Furthermore, few UL24-betagluc-inoculated mice developed any vaginal lesions. Although genital lesions developed in some UL24-betagluc-inoculated guinea pigs, both the overall number of lesions and the severity of disease were far less than that observed for animals infected with parental strain 186. (Blakeney et al., 2005)
References	*Blakeney et al., 2005:* Blakeney S, Kowalski J, Tummolo D, DeStefano J, Cooper D, Guo M, Gangolli S, Long D, Zamb T, Natuk RJ, Visalli RJ. Herpes simplex virus type 2 UL24 gene is a virulence determinant in murine and guinea pig disease models. Journal of virology. 2005; 79(16); 10498-10506. [PubMed: 16051842].


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UL24