Victors

US3
Victor ID	5026
Gene Name	US3
Sequence Strain (Species/Organism)	Human herpesvirus 2
NCBI Gene ID	1487355
NCBI Protein GI	9629333
Locus Tag	HHV2gp66
Genbank Accession	Z86099
Protein Accession	NP_044533
Taxonomy ID	10310
Gene Starting Position	136324
Gene Ending Position	140054
Gene Strand (Orientation)	+
Protein Name	serine/threonine protein kinase US3
Protein pI	6.5
Protein Weight	50096.58
Protein Length	481
Protein Note	PK family
DNA Sequence	>gi\|9629267:136324-140054 Human herpesvirus 2, complete genome AATGGCCTGTCGTAAGTTCTGTGGGGTCTACCGTAGACCCGACAAGAGACAGGAGGCGTCCGTCCCGCCG GAGACAAACACGGCCCCGGCCTTCCCGGCGAGCACCTTTTATACCCCCGCGGAGGATGCGTACCTGGCCC CCGGGCCCCCGGAAACCATCCACCCTTCCCGCCCACCGTCCCCCGGCGAGGCTGCGCGCCTGTGTCAGCT GCAGGAGATCTTGGCCCAGATGCACAGCGACGAGGACTACCCCATCGTGGACGCCGCGGGTGCGGAGGAG GAAGACGAGGCCGACGATGACGCCCCGGATGACGTGGCCTACCCGGAGGACTACGCGGAGGGGCGTTTTC TGTCCATGGTTTCGGCCGCCCCCCTGCCCGGAGCCAGCGGCCATCCTCCTGTTCCGGGCCGCGCAGCCCC CCCCGACGTCCGGACCTGCGACACGGGTAAGGTGGGGGCCACGGGGTTCACCCCGGAAGAGCTCGACACC ATGGACCGGGAGGCACTTCGGGCCATCAGCCGCGGGTGCAAGCCCCCTTCGACCCTGGCAAAACTGGTGA CCGGGCTGGGATTCGCGATCCACGGAGCGCTCATCCCGGGGTCGGAGGGGTGTGTCTTTGATAGCAGCCA CCCGAACTACCCTCATCGGGTAATCGTCAAGGCGGGGTGGTACGCCAGCACGAGCCACGAGGCGCGGCTG CTGAGACGCCTGAACCACCCCGCGATCCTACCCCTCCTGGACCTGCACGTCGTTTCTGGGGTCACGTGTC TGGTCCTCCCCAAGTATCACTGCGACCTGTATACCTATCTGAGCAAGCGCCCGTCTCCGTTGGGCCACCT ACAGATAACCGCGGTCTCCCGGCAGCTCTTGAGCGCCATCGACTACGTCCACTGCAAAGGCATCATCCAC CGCGATATTAAGACCGAGAACATCTTCATCAACACCCCCGAGAACATCTGTCTGGGGGACTTTGGGGCGG CGTGCTTTGTGCGCGGGTGTCGATCGAGCCCCTTCCATTACGGGATCGCAGGCACCATCGATACAAACGC CCCCGAGGTCCTGGCCGGGGATCCGTACACCCAGGTAATCGACATCTGGAGCGCCGGCCTGGTGATCTTT GAGACCGCCGTCCACACCGCGTCCTTGTTCTCGGCCCCGCGCGACCCCGAAAGGCGGCCGTGCGACAACC AGATCGCGCGCATCATCCGACAGGCCCAGGTACACGTCGACGAGTTTCCGACGCACGCGGAATCGCGCCT CACCGCGCACTACCGCTCGCGGGCGGCCGGGAACAATCGTCCGGCGTGGACCCGACCGGCGTGGACCCGC TACTACAAGATCCACACAGACGTCGAATATCTCATATGCAAAGCCCTTACCTTTGACGCGGCGCTCCGCC CAAGCGCCGCGGAGTTGCTGCGCCTGCCGCTATTTCACCCTAAGTGACCCCGCTCCCCCCGGGGGGCGTG GAGGGGGGGGCTGGTTGGATGTTTTTGCACAAAAAGACGCGGCCCTCGGGCTTTGGTGTTTTTGGCACCT TGCCGCCCGGCGTCATGCACGCCATCGCTCCCAGGTTGCTTCTTCTTTTTGTTCTTTCTGGTCTTCCGGG GACACGCGGCGGGTCGGGTGTCCCCGGACCAATTAATCCCCCCAACAGCGATGTTGTTTTCCCGGGAGGT TCCCCCGTGGCTCAATATTGTTATGCCTATCCCCGGTTGGACGATCCCGGGCCCTTGGGTTCCGCGGACG CCGGGCGGCAAGACCTGCCCCGGCGCGTCGTCCGTCACGAGCCCCTGGGCCGCTCGTTCCTCACGGGGGG GCTGGTTTTGCTGGCGCCGCCGGTACGCGGATTTGGCGCACCCAACGCAACGTATGCGGCCCGTGTGACG TACTACCGGCTCACCCGCGCCTGCCGTCAGCCCATCCTCCTTCGGCAGTATGGAGGGTGTCGCGGCGGCG AGCCGCCGTCCCCAAAGACGTGCGGGTCGTACACGTACACGTACCAGGGCGGCGGGCCTCCGACCCGGTA CGCTCTCGTAAATGCTTCCCTGCTGGTGCCGATCTGGGACCGCGCCGCGGAGACATTCGAGTACCAGATC GAACTCGGCGGCGAGCTGCACGTGGGTCTGTTGTGGGTAGAGGTGGGCGGGGAGGGCCCCGGCCCCACCG CCCCCCCACAGGCGGCGCGTGCGGAGGGCGGCCCGTGCGTCCCCCCGGTCCCCGCGGGCCGCCCGTGGCG CTCGGTGCCCCCGGTATGGTATTCCGCCCCCAACCCCGGGTTTCGTGGCCTGCGTTTCCGGGAGCGCTGT CTGCCCCCACAGACGCCCGCCGCCCCCAGCGACCTACCACGCGTCGCTTTTGCTCCCCAGAGCCTGCTGG TGGGGATTACGGGCCGCACGTTTATTCGGATGGCACGACCCACGGAAGACGTCGGGGTCCTGCCGCCCCA TTGGGCCCCCGGGGCCCTAGATGACGGTCCGTACGCCCCCTTCCCACCCCGCCCGCGGTTTCGACGCGCC CTGCGGACAGACCCCGAGGGGGTCGACCCCGACGTTCGGGCCCCCCGAACCGGGCGGCGCCTCATGGCCT TGACCGAGGACACGTCCTCCGATTCGCCTACGTCCGCTCCGGAGAAGACGCCCCTCCCTGTGTCGGCCAC CGCCATGGCACCCTCAGTCGACCCAAGCGCGGAACCGACCGCCCCCGCAACCACTACTCCCCCCGACGAG ATGGCCACACAAGCCGCAACGGTCGCCGTTACGCCGGAGGAAACGGCAGTCGCCTCCCCGCCCGCGACTG CATCCGTGGAGTCGTCGCCACTCCCCGCCGCGGCGGCGGCAACGCCCGGGGCCGGGCACACGAACACCAG CAGCGCCTCCGCAGCGAAAACGCCCCCCACCACACCAGCCCCCACGACCCCCCCGCCCACGTCTACCCAC GCGACCCCCCGCCCCACGACTCCGGGGCCCCAAACAACCCCTCCCGGACCCGCAACCCCGGGTCCGGTGG GCGCCTCCGCCGCGCCCACGGCCGATTCCCCCCTCACCGCCTCGCCCCCCGCTACCGCGCCGGGGCCCTC GGCCGCCAACGTTTCGGTCGCCGCGACCACCGCCACGCCCGGAACCCGGGGCACCGCCCGTACCCCCCCA ACGGACCCAAAGACGCACCCACACGGACCCGCGGACGCTCCCCCCGGCTCGCCAGCCCCCCCACCCCCCG AACATCGCGGCGGACCCGAGGAGTTTGAGGGCGCCGGGGACGGCGAACCCCCCGAGGACGACGACAGCGC CACCGGCCTCGCCTTCCGAACTCCGAACCCCAACAAACCACCCCCCGCGCGCCCCGGGCCCATCCGCCCC ACGCTCCCGCCAGGAATTCTTGGGCCGCTCGCCCCCAACACGCCTCGCCCCCCCGCCCAAGCTCCCGCTA AGGACATGCCCTCGGGCCCCACACCCCAACACATCCCCCTGTTCTGGTTCCTAACGGCCTCCCCTGCTCT AGATATCCTCTTTATCATCAGCACCACCATCCACACGGCGGCGTTCGTTTGTCTGGTCGCCTTGGCAGCA CAACTTTGGCGCGGCCGGGCGGGGCGCAGGCGATACGCGCACCCGAGCGTGCGTTACGTATGTCTGCCAC CCGAGCGGGATTAGGGGGTGGGGGTGGGGGGCGAGAAACGATGAAGGACGGGAAAGGGAACAGCGACCAA ATGTCACGATAAGAACAATAA
Protein Sequence	>gi\|9629333\|ref\|NP_044533.1\| serine/threonine protein kinase US3 [Human herpesvirus 2] MACRKFCGVYRRPDKRQEASVPPETNTAPAFPASTFYTPAEDAYLAPGPPETIHPSRPPSPGEAARLCQL QEILAQMHSDEDYPIVDAAGAEEEDEADDDAPDDVAYPEDYAEGRFLSMVSAAPLPGASGHPPVPGRAAP PDVRTCDTGKVGATGFTPEELDTMDREALRAISRGCKPPSTLAKLVTGLGFAIHGALIPGSEGCVFDSSH PNYPHRVIVKAGWYASTSHEARLLRRLNHPAILPLLDLHVVSGVTCLVLPKYHCDLYTYLSKRPSPLGHL QITAVSRQLLSAIDYVHCKGIIHRDIKTENIFINTPENICLGDFGAACFVRGCRSSPFHYGIAGTIDTNA PEVLAGDPYTQVIDIWSAGLVIFETAVHTASLFSAPRDPERRPCDNQIARIIRQAQVHVDEFPTHAESRL TAHYRSRAAGNNRPAWTRPAWTRYYKIHTDVEYLICKALTFDAALRPSAAELLRLPLFHPK
Molecule Role	Virulence factor
Molecule Role Annotation	The mutant, L1BR1, could replicate in Vero cells as efficiently as the parental virus. L1BR1 were examined in mice by using four routes (footpad, intraperitoneal, corneal, and intracerebral) of infection, the mutant displayed the route-dependent reduction of virulence. After inoculation by footpad and intraperitoneal routes, the mutant was more than 10,000-fold less virulent than the parental virus. (Nishiyama et al., 1992)
References	*Nishiyama et al., 1992:* Nishiyama Y, Yamada Y, Kurachi R, Daikoku T. Construction of a US3 lacZ insertion mutant of herpes simplex virus type 2 and characterization of its phenotype in vitro and in vivo. Virology. 1992; 190(1); 256-268. [PubMed: 1326804].


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US3