Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

RL1

Victor ID 5111
Gene Name RL1
Sequence Strain (Species/Organism) Human herpesvirus 1
NCBI Gene ID 2703396
NCBI Protein GI 9629440
Locus Tag HHV1gp083
Genbank Accession X14112
Protein Accession NP_044661
Taxonomy ID 10298
Gene Starting Position 124831
Gene Ending Position 125857
Gene Strand (Orientation) -
Protein Name neurovirulence protein ICP34.5
Protein pI 12.3
Protein Weight 24806.1
Protein Length 248
DNA Sequence 
>gi|9629378:124831-125857 Human herpesvirus 1, complete genome
TTTTAATTACCATACCGGGAAGTGGGCGGCCCGGCCCATTGGGCGGTAACTCCCGCCCAATGGGCCGGGC
CCCGAAGACTCGGCGGACGCTGGTTGGCCGGGCCCCGCCGCGCTGGCGGCCGCCGATTGGCCAGTCCCGC
CCCCGAGGCGGCCCGCCCTGTGAGGGCGGGCTGGCTCCAAGCGTATATATGCGCGGCTCCTGCCATCGTC
TCTCCGGAGAGCGGCTTGGTGCGGAGCTCCCGGGAGCTCCGCGGAAGACCCAGGCCGCCTCGGGTGTAAC
GTTAGACCGAGTTCGCCGGGCCGGCTCCGCGGGCCAGGGCCCGGGCACGGGCCTCGGGCCCCAGGCACGG
CCCGATGACCGCCTCGGCCTCCGCCACCCGGCGCCGGAACCGAGCCCGGTCGGCCCGCTCGCGGGCCCAC
GAGCCGCGGCGCGCCAGGCGGGCGGCCGAGGCCCAGACCACCAGGTGGCGCACCCGGACGTGGGGCGAGA
AGCGCACCCGCGCGGGGGTCGCGGGGGTCGCGGGGGTCGCGGGGGTCGCGGGGGTCGCGGGGGGCTCCGG
CGCCCCCTCCCCGCCCGCGCGTCGCAGGCGCAGGCGCGCCAGGTGCTCCGCGGTGACGCGCAGGCGGAGG
GCGAGGCGCGGCGGAAGGCGGAAGGGGCGCGAGGGGGGGTGGGAGGGGTCAGCCCCGCCCCCCGGGCCCA
CGCCGGGCGGTGGGGGCCGGGGCCGGGGGGCGGCGGCGGTGGGCCGGGCCTCTGGCGCCGGCTCGGGCGG
GGGGCTGTCCGGCCAGTCGTCGTCATCGTCGTCGTCGGACGCGGACTCGGGAACGTGGAGCCACTGGCGC
AGCAGCAGCGAACAAGAAGGCGGGGGCCCACCGGCGGGGGGCGGCGGCGGGGCGGCCGCGGGCGCGCTCC
TGACCGCGGGTTCCGAGTTGGGCGTGGAGGTTACCTGGGACTGTGCGGTTGGGACGGCGCCCGTGGGCCC
GGGCGGCCGGGGGCGGCGGGGGCCGCGATGGCGGCGGCGGCGGGCCA
Protein Sequence 
>gi|9629440|ref|NP_044661.1| neurovirulence protein ICP34.5 [Human herpesvirus 1]
MARRRRHRGPRRPRPPGPTGAVPTAQSQVTSTPNSEPAVRSAPAAAPPPPPAGGPPPSCSLLLRQWLHVP
ESASDDDDDDDWPDSPPPEPAPEARPTAAAPRPRPPPPGVGPGGGADPSHPPSRPFRLPPRLALRLRVTA
EHLARLRLRRAGGEGAPEPPATPATPATPATPATPARVRFSPHVRVRHLVVWASAARLARRGSWARERAD
RARFRRRVAEAEAVIGPCLGPEARARALARGAGPANSV
Molecule Role Virulence factor
Molecule Role Annotation Mutants exhibited a significantly reduced virulence (106 to 107 PFU/LD50), the LD50 of wild-type HSV-1(F) is 102 PFU.
(Meignier et al., 1988)
References
Meignier et al., 1988: Meignier B, Longnecker R, Mavromara-Nazos P, Sears AE, Roizman B. Virulence of and establishment of latency by genetically engineered deletion mutants of herpes simplex virus 1. Virology. 1988; 162(1); 251-254. [PubMed: 2827384].