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LAT-2

Victor ID 5062
Gene Name LAT-2
NCBI Nucleotide GI 330128
NCBI Protein GI 330129
Protein Accession AAA45796.1
Taxonomy ID 10298
Gene Strand (Orientation) ?
Protein Note latency associated transcript (LAT) ORF-1
DNA Sequence 
>gi|330128|gb|M17921.1|HS1LATA Herpes simplex virus type one (HSV-1) latency associated transcript (LAT)
GCATGCTATGCGCTGCGTTTTTTTTTTTTTTTTTTTTTTTTTTCTCGGTGTTCTGCCGGGCTCCGTCGCC
TTTCCTGTTCTCGCTTCTTCCCCCCCCCCCTTCACCCCCAGTACCCTCCTCCCTCCCTTCCTCCCCCGTT
ATCCCACTCGTCGAGGGCGCCCCGGTGTCGTTCAACAAAGACGCCGCGTTTCCAGGTAGGTTAGACACCT
GCTTCTCCCCAATAGAGGGGGGGGGACCCAAACGACAGGGGGCGCCCCAGAGGCTAAGGTCGGCCACGCC
ACTCGCGGGTGGGCTCGTGTTACAGCACACCAGCCCGTTATTTTCCCCCCCTCCCACCCTTAGTTAGACT
CTGTTACTTACCCGTCCGACCACCAACTGCCCCCTTATCTAAGGGCCGGCTGGAAGACCGCCAGGGGGTC
GGCCGGTGTCGCTGTAACCCCCCACGCCAATGACCCACGTACTCCAAGAAGGCATGTGTCCCACCCCGCC
TGTGTTTTTGTGCCTGGCTCTCTATGCTTGGGTCTTACTGCCTGGGGGGGGGAGTGCGGGGGAGGGGGGG
GGGTGTGGAAGGAAATGCACGGCGCGTGTGTACCCCCCCCTAAAGTTGTTCCTAAAGCGAGGATATGGAG
GAGTGGCGGGTGCCGGGGGACCGGGGTGATCTCTGGCACGCGGGGGTGGGAAGGGTCGGGGGAGGGGGGG
ATGGGGTACCGGCCCACCTGGCCGGCGCGGGTGCGCGTGCCTTTGCACACCAACCCCACGTCCCCCGGCG
GTCTCTAAGAAACACCGCCCCCCCTCCTTCATACCACCGAGCATGCCTGGGTGTGGGTTGGTAACCAACA
CGCCCATCCCCTCGTCTCCTGTGATTCTCTGGCTGCACCGCATTCTTCTTTTCTAACTATGTTCCTGTTT
CTGTCTCCCCCCCCACCCCTCCGCCCCACCCCCCAACACCCACGTCTGTGGTGTGGCCGACCCCCTTTTG
GGCGCCCCGTCCCGCCCCGCTACCCCTCCCATCCTTTGTTGCCCTATAGTGTAGTTAACCCCCCCCCCCC
CGCCCTTTGTGGCGGCCAGAGGCCAGGTCAGTCCGGGCGGGCAGGCGCTCGCGGAAACTTAACACCCACA
CCCAACCCACTGTGGTTCTGGCTCCATGCCAGTGGCAGGATGCTTTCGGGGATCGGTGGTCAGGCAGCCC
GGGCCGCGGCTCTGTGGTTAACACCAGAGCCTGCCCAACATGGCACCCCCACTCCCACGCACCCCCACTC
CCACGCACCCCCACTCCCACGCACCCCCACTCCCACGCACCCCCACTCCCACGCACCCCCACTCCCACGC
ACCCCCACTCCCACGCACCCCCACTCCCACGCACCCCCACTCCCACGCACCCCCACTCCCACGCACCCCC
ACTCCCACGCACCCCCACTCCCACGCACCCCCACTCCCACGCACCCCCACTCCCACGCACCCCCACTCCC
ACGCACCCCCGCGATACATCCAACACAGACAGGGAAAAGATACAAAAGTAAACCTTTATTTCCCAACAGA
CAGCAAAAATCCCCTGAGTTTTTTTTTATTAGGGCCAACACAAAAGACCCGCTGGTGTGTGGTGCCCGTG
TCTTTCACTTTCCACCTCCCCGACACGGATTGGCTGGTGTAGTGGGCGCGGCCAGAGACCACCCAGCGCC
CGACCCCCCCCTCCCCACAAACACGGGGGGCGTCCCTTATTGTTTTCCCTCGTCCCGGGTCGACGCCCCC
TGCTCCCCGGACCACGGGTGCCGAGACCGCAGGCTGCGGAAGTCCAGGGCGCCCACTAGGGTGCCCTGGT
CGAACAGCATGTTCCCCACGGGGGTCATCCAGAGGCTGTTCCACTCCGACGCGGGGGCCGTCGGGTACTC
GGGGGGCGTCACGTGGTTACCCGCGGTCTCGGGGAGCAGGGTGCGGCGGCTCCAGCCGGGGACCGCGGCC
CGCAGCCGGGTCGCCATGTTTCCCGTCTGGTCCACCAGGACCACGTACGCCCCGATGTTCCCCGTCTCCA
TGTCCAGGATGGGCAGGCAGTCCCCCGTGATCGTCTTGTTCACGTAAGGCGACAGGGCGACCACGCTAGA
GACCCCCGAGATGGGCAGGTAGCGCGTGAGGCCGCCCGCGGGGACGGCCCCGGAAGTCTCCGCGTGGCGC
GTCTTCCGGGCACACTTCCTCGGCCCCCGCGGCCCAGAAGCAGCGCGGGGGCCGAGGGAGGTTTCCTCTT
GTCTCCCTCCCAGGGCACCGACGGCCCCGCCCGAGGAGGCGGAAGCGGAGGAGGACGCGGCCCCGGTGGC
GGAAGAGGTGGCCCCCGCGGGAGTCGGGGCCGAGGAGGAAGAGGCGGAGGAGGAAGAGGCGGAGGCCGCC
GAGGACGTCAGGGGGGTCCCGGG
Molecule Role Virulence factor
Molecule Role Annotation dLAT1.5, a mutant with LAT nucleotides 76 to 1667 deleted. dLAT1.5 had similar or slightly reduced virulence in rabbits (based on survival following ocular infection). In contrast, in mice, dLAT1.5 had increased virulence (P < 0.0001). Thus, deletion of LAT nucleotides 76 to 1667 increased viral virulence in mice but not in rabbits. (Perng et al., 2001)
References
Perng et al., 2001: Perng GC, Esmaili D, Slanina SM, Yukht A, Ghiasi H, Osorio N, Mott KR, Maguen B, Jin L, Nesburn AB, Wechsler SL. Three herpes simplex virus type 1 latency-associated transcript mutants with distinct and asymmetric effects on virulence in mice compared with rabbits. Journal of virology. 2001; 75(19); 9018-9028. [PubMed: 11533165].