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UL13

Victor ID 5061
Gene Name UL13
Sequence Strain (Species/Organism) Human herpesvirus 1
NCBI Gene ID 2703383
NCBI Protein GI 9629393
Locus Tag HHV1gp018
Genbank Accession AX164125
Protein Accession NP_044614
Taxonomy ID 10298
Gene Starting Position 24799
Gene Ending Position 28690
Gene Strand (Orientation) -
Protein Name tegument serine/threonine protein kinase
Protein pI 10.67
Protein Weight 53921.55
Protein Length 518
Protein Note PK family
DNA Sequence 
>gi|9629378:24799-28690 Human herpesvirus 1, complete genome
TTTTATTCGCTATCGGACATGGGGGGTGGAAACTGGGTGGCGGGGCAGGCGCCTCCGGGGGTCCGCCGGT
GAGTGTGGCGCGAGGGGGGGTCCGATGAACGCAGGCGCTGTCTCCCCGGGGCCCGCGTAACCCCGCGCAT
ATCCGGGGGCACGTAGAAATTACCTTCCTCTTCGGACTCGATATCCACGACGTCAAAGTCGTGGGCGGTC
AGCGAGACGACCTCCCCGTCGTCGGTGATGAGGACGTTGTTTCGGCAGCAGCAGGGCCGGGCCCCGGAGA
ACGAGAGGCCCATAGCTCGGCGAGCGTGTCGTCGAATGCCAGGCGGCTGCTTCGCTGGATGGCCTTATAG
ATCTCCGGATCGATGCGGACGGGGGTAATGATCAGGGCGATCGGAACGGCCTGGTTCGGGAGAATGGACG
CCTTGCTGGGTCCTGCGGCCCCGAGAGCCCCGGCGCCGTCCTCCAGGCGGAACGTTACGCCCTCCTCCGC
GCTGGTGCGGTGCCTGCCGATAAACGTCACCAGATGCGGGTGGGGGGGGCAGTCGGGGAAGTGGCTGTCG
AGCACGTAGCCCTGCACCAAGATCTGCTTAAAGTTCGGGTGACGGGGGTTCGCGAAGACGGGCTCGCGGC
GGACCAGATCCCCGGAGCTCCAGGACACGGGGGAGATGGTGTGGCGTCCGAGGTCGGGGGCGCCAAACAG
AAGCACCTCCGAGACAACGCCGCTATTTAACTCCACCAAGGCCCGATCCGCGGCGGAGCACCGCCTTTTT
TCGCCCGAGGCGTGGGCCTCTGACCAGGCCTGGTCTTGCGTGACGAGAGCCTCCTCCGGGCCGGGGACGC
GCCCGGGCGCGAAGTATCGCACGCTGGGCTTCGGGATCGACCGGATAAATGCCCGGAACGCCTCCGGGGA
CCGGTGTGCCATCAAGTCCTCGTACGCGGAGGCCGTGGGGTCGCTGGGGTCCATGGGGTCGAAAGCGTAC
TTGGCCCGGCATTTGACCTCGTAAAAGGCCAGGGGGGTCTTGGGGACTGGGGCCAGGTAGCCGTGAATGT
CCCGAGGACAGACGAGAATATCCAGGGACGCCCCGACCATCCCCGTGTGACCGTCCATGAGGACCCCACA
CGTATGCACGTTCTCTTCGGCGAGGTCGCTGGGTTCGTGGAAGATAAAGCGCCGCGTGTCGGCGCCGGCC
TCGCCGCCGTCGTCCGCGCGGCCCACGCAGTAGCGAAACAGCAGGCTTCGGGCCGTCGGCTCGTTCACCC
GCCCGAACATCACCGCCGAAGACTGTACATCCGGCCGCAGGCTGGCGTTGTGCTTCAGCCACTGGGGCGA
GAAACACGGACCCTGGGGGCCCCAGCGGAGGGTGGATGCGGTCGTGAGGCCCCGCCGGAGCAGGGCCCAT
AGCTGGCAGTCGGCCTGGTTTTGCGTGGCCGCCTCGTAAAACCCCATGAGGGGCCGGGGCGCCACGGCGT
CCGCGGCGGCCGGGGGCCCGCGGCGCGTCAGGCGCCATAGGTGCCGACCGAGTCCGCGGTCCACCATACC
CGCCTCCTCGAGGACCACGGCCAGGGAACACAGATAATCCAGGCGGGCCCAGAGGGGACCGATGGCCAGA
GGGGCGCGGACGCCGCGCAGCAACCCGCGCAGGTGGCGCTCGAACGTCTCGGCTAGTATATGGGAGGGCA
GCGCGTTGGGGATCACCGACGCCGACCACATAGAGTCAAGGTCCGGGGAGTCGGGATCGGCGTCCGGGTC
GCGGGCGTGGGTGCCCCCAGGAGATAGCGGAATGTCTGGGGTCGGAGGCCCTGAGGCGTCAGAAAGTGCC
GGCGACGCGGCCCGGGGCTTTTCGTCTGCGGTGTCGGTGGCGTGCTGATCACGTGGGGGGTTAACGGGCG
AATGGGAGCTCGGGTCCACAGCTGATGTCGTCTGGGGTGGGGGGGGCAGGGGACGGAAGGTGGTTGTCAG
CGGAAGACTGTTAGGGCGGGGGCGCTTGGGGGGGCTGTCGGGGCCACGAGGGGTGTCCTCGGCCAGGGCC
CAGGGACGCTTAGTCACGGTGCGTCCCGGCGGACATGCTGGGCCTACCGTGGACTCCATTTCCGAGACGA
CGTGGGGGGAGCGGTGGTTGAGCGCGCCGCCGGGTGAACGCTGATTCTCACGACAGCGCGTGCCGCGCGC
ACGGGTTGGTGTGACACAGGCGGGACACCAGCACCAGGAGAGGCTTAAGCTCGGGAGGCAGCGCCACCGA
CGACAGTATCGCCTTGTGTGTGTGCTGGTAATTTATACACCGATCCGTAAACGCGCGCCGAATCTTGGGA
TTGCGGAGGTGGCGCCGGATGCCCTCTGGGACGTCATACGCCAGGCCGTGGGTGTTGGTCTCGGCCGAGT
TGACAAACAGGGCTGGGTGCAGCACGCAGCGATAGGCGAGCAGGGCCAGGGCGAAGTCCGGCGACAGCTG
GTTGTTAAAATACTGGTAACCGGGAAACCGGGTCACGGGTACGCCCAGGCTCGGGGCGACGTACACGCTA
ACCACCAACTCCAGCAGCGTCTGGCCCAGGGCGTACAGGTCAACCGCTAACCCGACGTCGTGCTTCAGGC
GGTGGTTGGTAAATTCGGCCCGTTCGTTGTTAAGGTATTTCACCAACAGCTCCGGGGGCTGGTTATACCC
GTGACCCACCAGGGTGTGAAAGTTGGCTGTGGTTAGGGCGGTGGGCATGCCAAACATCCGGGGGGACTTG
AGGTCCGGCTCCTGGAGGCAAAACTGCCCCCGGGCGATCGTGGAGTTGGAGTTGAGGGTGACGAGGCTAA
AGTCGGCGAGGACGGCCCGCCGGAGCGAGACGGCGTCCGACCGCAGCATGACGAGGATGTTGGCGCACTT
GATATCCAGGTGGCTGATCCCGCAGGTGGTGTTTAAAAACACAACGGCGCGGGCCAGCTCCGTGAAGCAC
TGGTGGAGGGCCGTCGAGACCGAGGGGTTTGTTGTGCGCAGGGACGCCAGTTGGCCGATATACTTACCGA
GGTCCATGTCGTACGCGGGGAACACTATCTGTCGTTGTTGCAGCGAGAACCCGAGGGGCGCGATGAAGCC
GCGGATGTTGTGGGTGCGGCCGGCGCGTAGAACGCACTCCCCGACCAACAGGGTCGCGATGAGCTCAACG
GCAAACCACTCCTTTTCCTTTATGGTCTTAACGGCAAGCTTATGTTCGCGAATCAGTTGGACGTCACCGT
ATCCCCCAGACCCCCCGAAGCTTCGGGCCCCGGGGATCTCGAGGGTCGTGTAGTGTAGGGCGGGGTTGAT
GGCGAACACGGGGCTGCATAGCTTGCGGATGCGCGTGAGGGTGAGGATGTGCGAGGGGGACGAGGGGGGT
GCGGTTAACGCCGCCTGGGATCTGCGCAGGGGCGGGCGGTTCAGTTTGGCCGCCGTACCGGGCGTCTCGG
GGGACGCGCGGCGATGAGACGAGCGGCTCATTCGCCATCGGGATAGTCCCGCGCGAAGCCGCTCGCGGAG
GCCGGATCGGTGGCGGGACCCGTGGGAGGAGCGGGAGACGGCGGCGTCCTGGAGAGAGGGGCCGCTGGGG
CGCCCGGAGGCCCCGTGGGGGTTGGAGTGTACGTAGGATGCGAGCCAATCCTTGAAGGACCGTTGGCGTG
CACCTTGGGGGCTGAGGTTAGCTGCCACATGACCAGCAGGTCGCTGTCTGCGGGACTCATCCATCCTTCG
GCCAGGTCGCCGTCTCCCCACAGAGAAGCGTTGGTCGCTGCTTCCTCGAGTTGCTCCTCCTGGTCCGCAA
GACGATCGTCCACGGCGTCCAGGCGCTCACCAAGCGCCGGATCGAGGTACCGTCGGTGTGCGGTTAGAAA
GTCACGACGCGCCGCTTGCTCCTCCACGCGAATTTTAACACA
Protein Sequence 
>gi|9629393|ref|NP_044614.1| tegument serine/threonine protein kinase [Human herpesvirus 1]
MDESRRQRPAGHVAANLSPQGARQRSFKDWLASYVHSNPHGASGRPSGPSLQDAAVSRSSHGSRHRSGLR
ERLRAGLSRWRMSRSSHRRASPETPGTAAKLNRPPLRRSQAALTAPPSSPSHILTLTRIRKLCSPVFAIN
PALHYTTLEIPGARSFGGSGGYGDVQLIREHKLAVKTIKEKEWFAVELIATLLVGECVLRAGRTHNIRGF
IAPLGFSLQQRQIVFPAYDMDLGKYIGQLASLRTTNPSVSTALHQCFTELARAVVFLNTTCGISHLDIKC
ANILVMLRSDAVSLRRAVLADFSLVTLNSNSTIARGQFCLQEPDLKSPRMFGMPTALTTANFHTLVGHGY
NQPPELLVKYLNNERAEFTNHRLKHDVGLAVDLYALGQTLLELVVSVYVAPSLGVPVTRFPGYQYFNNQL
SPDFALALLAYRCVLHPALFVNSAETNTHGLAYDVPEGIRRHLRNPKIRRAFTDRCINYQHTHKAILSSV
ALPPELKPLLVLVSRLCHTNPCARHALS
Molecule Role Virulence factor
Molecule Role Annotation We isolated a UL13 gene-deleted mutant of the herpes simplex virus type 1 (HSV-1) strain VR3 (VRDelta13) and its revertant virus (VRDelta13R). VRDelta13 was cleared in the early period of intraperitoneal infection. VRDelta13 had a higher sensitivity to the mouse type I interferon (IFN) and showed a higher level of IFN induction in the study period of infection than did VR3 and VRDelta13R. These results suggest that a nonspecific antiviral response (i.e., the IFN system) may contribute to this rapid inhibition of viral replication in vivo. (Shibaki et al., 2001)
References
Shibaki et al., 2001: Shibaki T, Suzutani T, Yoshida I, Ogasawara M, Azuma M. Participation of type I interferon in the decreased virulence of the UL13 gene-deleted mutant of herpes simplex virus type 1. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 2001; 21(5); 279-285. [PubMed: 11429158].