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UL41

Victor ID 4529
Gene Name UL41
Sequence Strain (Species/Organism) Human herpesvirus 1
NCBI Gene ID 2703365
NCBI Protein GI 9629422
Locus Tag HHV1gp060
Genbank Accession X14112
Protein Accession NP_044643
Taxonomy ID 10298
Gene Starting Position 91115
Gene Ending Position 92739
Gene Strand (Orientation) -
Protein Name tegument host shutoff protein
Protein pI 7.75
Protein Weight 52138.35
Protein Length 489
DNA Sequence 
>gi|9629378:91115-92739 Human herpesvirus 1, complete genome
TTTTATTGGTGGGTCGTTTGTTCGGGGACAAGCGCGCTCGTCTGACGTTTGGGCTACTCGTCCCAGAATT
TGGCCAGGACGTCCTTGTAGAACGCGGGTGGGGGGGCCTGGGTCCGCAACTGCTCCAGAAACCTGTCGGC
GATATCAGGGGCCGTGATATGCCGGGTCACGATAGATCGCGCCAGGTTTTCGTCGCGGATGTCCTGGTAG
ATAGGCAGGCGTTTCAGAAGAGTCCACGGCCCCCGCTCCTTGGGGCCGATAAGCGATATGACGTACTTAA
TGTAGCGGTGTTCCACCAGCTCGGTGATGGTCATGGGATCGGGGAGCCAGTCCAGGGACTCTGGGGCGTC
GTGGATGACGTGGCGTCGCGGGTTGGCCACATAACTGCGGTGCTCTTCCAGCAGCTGCGCGTTCGGGACC
TGGACGAGCTCGGGCGGGGTGAGTATCTCCGAGGAGGACGACCTGGGGCCGGGGTGGCCCCCGGTAACGT
CCCGGGGATCCAGGGGGAGGTCCTCGTCGTCTTCGTATCCGCCGGCGATCTGTTGGGTTAGAATTTCGGT
CCACGAGACGCGCGTCTCGGTGCCGCCGGCGGCCGGCGGCAGAGGGGGCCTGGTTTCCGTGGAGCGCGAG
CTGGTGTGTTCCCGGCGGATGGCCCGCCGGGTCTGAGAGCGACTCGGGGGGGTCCAGTGACATTCGCGCA
GCACATCCTCCACGGAGGCGTAGGTGTTATTGGGATGGAGGTCGGTGTGGCAGCGGACAAAGAGGGCCAG
GAACTGGGGGTAGCTCATCTTAAAGTACTTTAGTATATCGCGACAGTTGATCGTGGGAATGTAGCAGGCG
CTAATATCCAACACAATATCACAGCCCATCAACAGGAGGTCAGTGTCCGTGGTGTACACGTACGCGACCG
TGTTGGTGTGATAGAGGTTGGCGCAGGCATCGTCCGCCTCCAGCTGACCCGAGTTAATGTAGGCGTACCC
CAGGGCCCGGAGAACGCGAATACAGAACAGATGCGCCAGACGCAGGGCCGGCTTCGAGGGCGCGGCGGAC
GGCAGCGCGGCTCCGGACCCGGCCGTCCCCCGGGTCCCCGAGGCCAGAGAGGTGCCGCGCCGGCGCATGT
TGGAAAAGGCAGAGCTGGGTCTGGAGTCGGTGATGGGGGAAGGCGGTGGAGAGGCGTCCACGTCACTGGC
CTCCTCGTCCGTCCGGCACTGGGCCGTCGTGCGGGCCAGGATGGCCTTGGCTCCAAACACAACCGGCTCC
ATACAATTGACCCCGCGATCGGTAACGAAGATGGGGAAAAGGGACTTTTGGGTAAACACCTTTAATAAGC
GACAGAGGCAGTGTAGCGTAATGGCCTCGCGGTCGTAACTGGGGTATCGGCGCTGATATTTGACCACCAA
CGTGTACATGACGTTCCACAGGTCCACGGCAATGGGGGTGAAGTACCCGGCCGGGGCCCCAAGGCCCCGG
CGCTTGACCAGATGGTGTGTGTGGGCAAACTTCATCATCCCGAACAAACCCATGTCAGGTCAATTGTAAC
TGCGGATCGGCCTAACTAAGGCGTGGTTGGTGCGACGGTCCGGGACACCCGAGCCTGTCTCTCTGTGTAT
GGTGACCCAGACAAC
Protein Sequence 
>gi|9629422|ref|NP_044643.1| tegument host shutoff protein [Human herpesvirus 1]
MGLFGMMKFAHTHHLVKRRGLGAPAGYFTPIAVDLWNVMYTLVVKYQRRYPSYDREAITLHCLCRLLKVF
TQKSLFPIFVTDRGVNCMEPVVFGAKAILARTTAQCRTDEEASDVDASPPPSPITDSRPSSAFSNMRRRG
TSLASGTRGTAGSGAALPSAAPSKPALRLAHLFCIRVLRALGYAYINSGQLEADDACANLYHTNTVAYVY
TTDTDLLLMGCDIVLDISACYIPTINCRDILKYFKMSYPQFLALFVRCHTDLHPNNTYASVEDVLRECHW
TPPSRSQTRRAIRREHTSSRSTETRPPLPPAAGGTETRVSWTEILTQQIAGGYEDDEDLPLDPRDVTGGH
PGPRSSSSEILTPPELVQVPNAQLLEEHRSYVANPRRHVIHDAPESLDWLPDPMTITELVEHRYIKYVIS
LIGPKERGPWTLLKRLPIYQDIRDENLARSIVTRHITAPDIADRFLEQLRTQAPPPAFYKDVLAKFWDE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Viruses lacking UL41 (vhs) are attenuated in mice (Smith et al., 2000).
References
Smith et al., 2000: Smith TJ, Ackland-Berglund CE, Leib DA. Herpes simplex virus virion host shutoff (vhs) activity alters periocular disease in mice. Journal of virology. 2000; 74(8); 3598-3604. [PubMed: 10729135].