Victors

infected-cell protein (ICP34.5)
Victor ID	5059
Gene Name	infected-cell protein (ICP34.5)
NCBI Nucleotide GI	330116
NCBI Protein GI	330117
Protein Accession	AAA45791.1
Taxonomy ID	10298
Gene Strand (Orientation)	?
Protein Note	infected-cell protein 34.5
DNA Sequence	>gi\|330116\|gb\|M33700.1\|HS1ICP345B Herpes simplex virus type 1 infected-cell protein (ICP34.5) gene, complete cds TTTAAAGCACAGCGGCGGGCAGCCCGGGCCCCCCGCGGCCGAGACTAGCGAGTTAGACAGGCAAGCACTA CTCGCCTCTGCACGCACATGCTTGCCTGTCAAACTCTACCACCCCGGCACGCTCTCTGTCTCCATGGCCC GCCGCCGCCGCCGCCATCGCGGCCCCCGCCGCCCCCGGCCGCCCGGGCCCACGGGCGCGGTCCCAACCGC ACAGTCCCAGGTAACCTCCACGCCCAACTCGGAACCCGTGGTCAGGAGCGCGCCCGCGGCCGGTGGGCCC CCGCCTTCTTGTTCGCTGCTGCTGCGCCAGTGGCTCCACGTTCCCGAGTCCGCGTCCGACGACGACGATG ACGACGACTGGCCGGACAGCCCCCCGCCCGAGCCGGCGCCAGAGGCCCGGCCCACCGCCGCCGCCCCCCG CCCCCGGTCCCCACCGCCCGGCGCGGGCCCGGGGGGCGGGGCTAACCCCTCCCACCCCCCCTCACGCCCC TTCCGCCTTCCGCCGCGCCTCGCCCTCCGCCTGCGCGTCACCGCGGAGCACCTGGCGCGCCTGCGCCTGC GACGCGCGGGCGGGGAGGGGGCGCCGAAGCCCCCCGCGACCCCCGCGACCCCCGCGACCCCCGCGACCCC CGCGACCCCCGCGACCCCCGCGCGGGTGCGCTTCTCGCCCCACGTCCGGGTGCGCCACCTGGTGGTCTGG GCCTCGGCCGCCCGCCTGGCGCGCCGCGGCTCGTGGGCCCGCGAGCGGGCCGACCGGGCTCGGTTCCGGC GCCGGGTGGCGGAGGCCGAGGCGGTCATCGGGCCGTGCCTGGGGCCCGAGGCCCGTGCCCGGGCCCTGGC CCGCGGAGCCGGCCCGGCGAACTCGGTCTAACGTTACACCCGAGGCGGCCTGGGTCTTCCGCGGAGCTCC CGGGAGCTCCACACCAAGCCGCTCTCCGGAGAGACGATGGCAGGAGCCGCGCATATATACGCTGGGAGCC GGCCCGCCCCCGAGGCGGGCCCGCCCTCGGAGGGCGGGACTGGCCAATCGGCGGCCGCCAGCGCGGCGGG GCCCGGCCAACCAGCGTCCGCCGAGTCGTCGGGGCCCGGCCCACTGGGCGGTAACTCCCGCCCAGTGGGC CGGGCCGCCCACTTCCCGGTATGGTAATTAAAAACTTGCAAGAGGCCTTGTTCCGCTTCCCGGTATGGTA ATTAGAAACTCATTAATGGGCGGCCCCGGCCGCCCTTCCCGCTTCCGGCAATTCCCGCGGCCCTTAATGG GCAACCCCGGTATTCCCCGCCTCCCGCGCCGCGCGTAACCACTCCCTTGGGGTTCCGGGTTATGCTAATT GCTTTTTTGGCGGAAT
Molecule Role	Virulence factor
Molecule Role Annotation	All rabbits infected with the ICP34.5 mutant virus (d34.5) survived, even at challenge doses greater than 4 x 10(7) PFU per eye. In contrast, a 200-fold-lower challenge dose of 2 x 10(5) PFU per eye was lethal for approximately 50% of rabbits infected with either the wild-type McKrae parental virus or a rescued ICP34.5 mutant in which both copies of the ICP34.5 gene were restored. (Perng et al., 1995)
References	*Perng et al., 1995:* Perng GC, Thompson RL, Sawtell NM, Taylor WE, Slanina SM, Ghiasi H, Kaiwar R, Nesburn AB, Wechsler SL. An avirulent ICP34.5 deletion mutant of herpes simplex virus type 1 is capable of in vivo spontaneous reactivation. Journal of virology. 1995; 69(5); 3033-3041. [PubMed: 7707530].


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infected-cell protein (ICP34.5)