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ICP34.5

Victor ID 4528
Gene Name ICP34.5
Sequence Strain (Species/Organism) Human herpesvirus 1
NCBI Gene ID 2703396
NCBI Protein GI 9629440
Locus Tag HHV1gp083
Genbank Accession X14112
Protein Accession NP_044661
Taxonomy ID 10298
Gene Starting Position 124831
Gene Ending Position 125857
Gene Strand (Orientation) -
Protein Name neurovirulence protein ICP34.5
Protein pI 12.3
Protein Weight 24806.1
Protein Length 248
DNA Sequence 
>gi|9629378:124831-125857 Human herpesvirus 1, complete genome
TTTTAATTACCATACCGGGAAGTGGGCGGCCCGGCCCATTGGGCGGTAACTCCCGCCCAATGGGCCGGGC
CCCGAAGACTCGGCGGACGCTGGTTGGCCGGGCCCCGCCGCGCTGGCGGCCGCCGATTGGCCAGTCCCGC
CCCCGAGGCGGCCCGCCCTGTGAGGGCGGGCTGGCTCCAAGCGTATATATGCGCGGCTCCTGCCATCGTC
TCTCCGGAGAGCGGCTTGGTGCGGAGCTCCCGGGAGCTCCGCGGAAGACCCAGGCCGCCTCGGGTGTAAC
GTTAGACCGAGTTCGCCGGGCCGGCTCCGCGGGCCAGGGCCCGGGCACGGGCCTCGGGCCCCAGGCACGG
CCCGATGACCGCCTCGGCCTCCGCCACCCGGCGCCGGAACCGAGCCCGGTCGGCCCGCTCGCGGGCCCAC
GAGCCGCGGCGCGCCAGGCGGGCGGCCGAGGCCCAGACCACCAGGTGGCGCACCCGGACGTGGGGCGAGA
AGCGCACCCGCGCGGGGGTCGCGGGGGTCGCGGGGGTCGCGGGGGTCGCGGGGGTCGCGGGGGGCTCCGG
CGCCCCCTCCCCGCCCGCGCGTCGCAGGCGCAGGCGCGCCAGGTGCTCCGCGGTGACGCGCAGGCGGAGG
GCGAGGCGCGGCGGAAGGCGGAAGGGGCGCGAGGGGGGGTGGGAGGGGTCAGCCCCGCCCCCCGGGCCCA
CGCCGGGCGGTGGGGGCCGGGGCCGGGGGGCGGCGGCGGTGGGCCGGGCCTCTGGCGCCGGCTCGGGCGG
GGGGCTGTCCGGCCAGTCGTCGTCATCGTCGTCGTCGGACGCGGACTCGGGAACGTGGAGCCACTGGCGC
AGCAGCAGCGAACAAGAAGGCGGGGGCCCACCGGCGGGGGGCGGCGGCGGGGCGGCCGCGGGCGCGCTCC
TGACCGCGGGTTCCGAGTTGGGCGTGGAGGTTACCTGGGACTGTGCGGTTGGGACGGCGCCCGTGGGCCC
GGGCGGCCGGGGGCGGCGGGGGCCGCGATGGCGGCGGCGGCGGGCCA
Protein Sequence 
>gi|9629440|ref|NP_044661.1| neurovirulence protein ICP34.5 [Human herpesvirus 1]
MARRRRHRGPRRPRPPGPTGAVPTAQSQVTSTPNSEPAVRSAPAAAPPPPPAGGPPPSCSLLLRQWLHVP
ESASDDDDDDDWPDSPPPEPAPEARPTAAAPRPRPPPPGVGPGGGADPSHPPSRPFRLPPRLALRLRVTA
EHLARLRLRRAGGEGAPEPPATPATPATPATPATPARVRFSPHVRVRHLVVWASAARLARRGSWARERAD
RARFRRRVAEAEAVIGPCLGPEARARALARGAGPANSV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ICP34.5 mutant virus is avirulent in mice (Ward et al., 2003).
References
Ward et al., 2003: Ward SL, Scheuner D, Poppers J, Kaufman RJ, Mohr I, Leib DA. In vivo replication of an ICP34.5 second-site suppressor mutant following corneal infection correlates with in vitro regulation of eIF2 alpha phosphorylation. Journal of virology. 2003; 77(8); 4626-4634. [PubMed: 12663769].