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ORF10

Victor ID 3363
Gene Name ORF10
Sequence Strain (Species/Organism) Varicella-zoster virus
NCBI Gene ID 1487675
NCBI Protein GI 9625885
Locus Tag HHV3_gp12
Protein Accession NP_040133.1
Other Database IDs UniProtKB-ID: Q6QCP5_HHV3
UniRef100: UniRef100_P09265
UniRef90: UniRef90_P09265
UniRef50: UniRef50_P09265
UniParc: UPI0000126254
EMBL: AY548171
EMBL: AY548170
EMBL: DQ479953
EMBL: DQ479954
EMBL: DQ479955
EMBL: DQ479958
EMBL: DQ479959
EMBL: DQ479961
EMBL: DQ479962
EMBL: DQ479963
EMBL: DQ674250
EMBL: EU154348
EMBL-CDS: AAT07692.1
EMBL-CDS: AAT07768.1
EMBL-CDS: ABF21510.1
EMBL-CDS: ABF21583.1
EMBL-CDS: ABF21656.1
EMBL-CDS: ABF21875.1
EMBL-CDS: ABF21948.1
EMBL-CDS: ABF22094.1
EMBL-CDS: ABF22167.1
EM
Taxonomy ID 10335
Gene Starting Position 12159
Gene Ending Position 13420
Gene Strand (Orientation) +
Protein Name transactivates immediate early genes
DNA Sequence 
>gi|9625875:12159-13420 Human herpesvirus 3, complete genome
TATGGAGTGTAATTTAGGAACCGAACATCCTAGTACAGATACGTGGAATCGTAGTAAAACGGAACAAGCG
GTTGTGGACGCATTTGATGAATCGTTGTTTGGTGATGTAGCATCGGATATTGGATTTGAAACGTCGTTAT
ATTCACATGCAGTTAAAACTGCTCCGTCTCCGCCTTGGGTAGCTAGCCCTAAAATTTTATATCAACAGTT
AATACGGGATCTTGATTTTTCAGAAGGGCCGCGTTTACTATCATGTCTTGAAACCTGGAACGAGGATTTA
TTCTCATGTTTTCCTATTAATGAGGACCTATATTCCGATATGATGGTTTTATCCCCGGATCCAGATGACG
TTATCTCAACCGTTTCAACCAAAGACCATGTTGAAATGTTTAATTTAACAACCCGGGGTTCCGTTCGATT
GCCTAGTCCACCAAAGCAACCGACGGGGCTTCCAGCTTACGTTCAGGAGGTCCAGGATTCGTTTACCGTA
GAACTACGCGCCCGGGAAGAAGCATACACAAAACTACTAGTTACTTATTGTAAATCGATTATACGTTATC
TCCAAGGAACGGCGAAAAGGACGACAATAGGTCTTAATATACAAAACCCTGACCAGAAAGCTTACACGCA
ACTCAGGCAAAGTATTCTACTTAGATATTATCGTGAGGTGGCAAGTTTGGCGCGTCTTCTGTACCTACAT
TTATATTTAACCGTAACGCGTGAATTTTCCTGGCGTTTGTACGCCAGTCAATCTGCACACCCGGACGTGT
TTGCGGCTTTAAAATTCACCTGGACCGAACGTCGACAGTTCACGTGTGCGTTTCATCCTGTATTATGCAA
CCACGGCATTGTGTTATTAGAAGGGAAACCACTAACAGCGTCTGCCTTGAGGGAAATAAATTACCGCCGC
CGAGAACTGGGACTGCCTCTAGTTAGATGTGGTCTTGTTGAAGAAAACAAATCTCCGTTGGTTCAACAAC
CCTCATTTTCGGTTCATTTACCACGGTCGGTGGGTTTTCTTACCCACCACATTAAGCGTAAGTTAGACGC
ATATGCGGTCAAACATCCTCAAGAACCGAGACATGTACGAGCGGATCATCCTTACGCAAAAGTTGTTGAA
AATAGAAACTACGGTAGTAGCATCGAAGCTATGATTTTAGCACCTCCGTCCCCATCCGAGATCCTGCCGG
GGGACCCACCACGCCCACCCACGTGTGGGTTTTTAACGCGTTAAACGTCATTGGGGTAGAGGGTGTAAAT
AA
Protein Sequence 
>gi|9625885|ref|NP_040133.1| transactivating tegument protein VP16 [Human herpesvirus 3] MECNLGTEHPSTDTWNRSKTEQAVVDAFDESLFGDVASDIGFETSLYSHAVKTAPSPPWVASPKILYQQLIRDLDFSEGPRLLSCLETWNEDLFSCFPINEDLYSDMMVLSPDPDDVISTVSTKDHVEMFNLTTRGSVRLPSPPKQPTGLPAYVQEVQDSFTVELRAREEAYTKLLVTYCKSIIRYLQGTAKRTTIGLNIQNPDQKAYTQLRQSILLRYYREVASLARLLYLHLYLTVTREFSWRLYASQSAHPDVFAALKFTWTERRQFTCAFHPVLCNHGIVLLEGKPLTASALREINYRRRELGLPLVRCGLVEENKSPLVQQPSFSVHLPRSVGFLTHHIKRKLDAYAVKHPQEPRHVRADHPYAKVVENRNYGSSIEAMILAPPSPSEILPGDPPRPPTCGFLTR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: deletion of ORF10 reduced viral titers and the extent of cutaneous lesions significantly in SCIDhu skin xenografts in vivo (Che et al., 2006).
References
Che et al., 2006: Che X, Zerboni L, Sommer MH, Arvin AM. Varicella-zoster virus open reading frame 10 is a virulence determinant in skin cells but not in T cells in vivo. Journal of virology. 2006; 80(7); 3238-3248. [PubMed: 16537591].