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US2

Victor ID 5108
Gene Name US2
Sequence Strain (Species/Organism) Human herpesvirus 1
NCBI Gene ID 2703399
NCBI Protein GI 9629443
Locus Tag HHV1gp087
Genbank Accession HM585513
Protein Accession NP_044664
Taxonomy ID 10298
Gene Starting Position 134022
Gene Ending Position 135332
Gene Strand (Orientation) -
Protein Name mRNA
Protein pI 8.42
Protein Weight 29891.12
Protein Length 291
DNA Sequence 
>gi|9629378:134022-135332 Human herpesvirus 1, complete genome
GGGGTGTTTGGGGGTTTATTGGCACCGGGGGCTAAAGGGTGGTAACCGGATAGCAGATGTGAGGAAGTCG
GGGCCGTTCGCCGCGAACGGCGATCAGAGGGTCAGTTTCTTGCGGACCACGGCCCGGCGATGTGGGTTGC
TCGTCTGGGACCTCGGGCATGCCCATACACGCACAACACGGACGCCGCACCGGATGGGACGTCGTAAGGG
GGCCTGGGGTAGCTGGGTGGGGTTTGTGCAGAGCAATCAGGGACCGCAGCCAGCGCATACAATCGCGCTC
CCGTCCGTTTGTCCCGGGCAGTACCACGCCGTACTGGTATTCGTACCGGCTGAGCAGGGTCTCCAGGGGG
TGGTTGGGGGCCGCGGGGAACGGGGTCCACGCCACGGTCCACTCGGGCAAAAACCGAGTCGGCACGGCCC
ACGGTTCTCCCACCCACGCGTCTGGGGTCTTGATGGCGATAAATCTTACCCCGAGCCGGATTTTTTGGGC
GTATTCGAGAAACGGCACACACAGATCCGCCGCGCCTACCACCCACAAGTGGTAGAGGCGAGGGGGGCTG
GGTTGGTCTCGGTGCAGCAGTCGGAAGCACGCCACGGCGTCCACGACCTCGGTGCTCTCCAAGGGGCTGT
CCTCCGCAAACAGGCCCGTGGTGGTGTTTGGGGGGCAGCGACAGGACCTAGTGCGCACGATCGGGCGGGT
GGGTTTGGGTAAGTCCATCAGCGGCTCGGCCAACCGTCGAAGGTTGGCCGGACGAACGACGACCGGGGTA
CCCAGGGGTTCTGATGCCAAAATGCGGCACTGCCTAAGCAGGAAGCTCCACAGGGCCGGGCTTGCGTCGA
CGGAAGTCCGGGGCAGGGCGTTGTTCTGGTCAAGGAGGGTCATTACGTTGACGACAACAACGCCCATGTT
GGTATATTACAGGCCCGTGTCCGATTTGGGGCACTTGCAGATTTGTAAGGCCACGCACGGCGGGGAGACA
GGCCGACGCGGGGGCTGCTCTAAAAATTTAAGGGCCCTACGGTCCACAGACCCGCCTTCCCGGGGGGGCC
CTTGGAGCGACCGGCAGCGGAGGCGTCCGGGGGAGGGGAGGGTGATTTACGGGGGGGTAGGTCAGGGGGT
GGGTCGTCAAACTGCCGCTCCTTAAAACCCCGGGGCCCGTCGTTCGGGGTGCTCGTTGGTTGGCACTCAC
GGTGCGGCGAATGGCCTGTCGTAAGTTTTGTCGCGTTTACGGGGGACAGGGCAGGAGGAAGGAGGAGGCC
GTCCCGCCGGAGACAAAGCCGTCCCGGGTGTTTCCTCATGGCCCCTTTTAT
Protein Sequence 
>gi|9629443|ref|NP_044664.1| virion protein US2 [Human herpesvirus 1]
MGVVVVNVMTLLDQNNALPRTSVDASPALWSFLLRQCRILASEPLGTPVVVRPANLRRLAEPLMDLPKPT
RPIVRTRSCRCPPNTTTGLFAEDSPLESTEVVDAVACFRLLHRDQPSPPRLYHLWVVGAADLCVPFLEYA
QKIRLGVRFIAIKTPDAWVGEPWAVPTRFLPEWTVAWTPFPAAPNHPLETLLSRYEYQYGVVLPGTNGRE
RDCMRWLRSLIALHKPHPATPGPLTTSHPVRRPCCACMGMPEVPDEQPTSPGRGPQETDPLIAVRGERPR
LPHICYPVTTL
Molecule Role Virulence factor
Molecule Role Annotation Mutants exhibited a significantly reduced virulence (106 to 107 PFU/LD50), the LD50 of wild-type HSV-1(F) is 102 PFU.
(Meignier et al., 1988)
References
Meignier et al., 1988: Meignier B, Longnecker R, Mavromara-Nazos P, Sears AE, Roizman B. Virulence of and establishment of latency by genetically engineered deletion mutants of herpes simplex virus 1. Virology. 1988; 162(1); 251-254. [PubMed: 2827384].