| Victors ID |
Gene Name |
Sequence Strain (Species/Organism) |
NCBI Gene ID |
NCBI Nucleotide GI |
NCBI Protein GI |
Locus Tag |
Genbank Accession |
Protein Accession |
Protein Name |
Molecule Role |
Molecule Role Annotation |
PMID |
|
|
opb |
Leishmania major |
|
4581756
|
4581757
|
|
|
AAD24761.1 |
oligopeptidase B |
Virulence factor |
MUTATION: opb mutant is attenuated in murine macrophages [Ref7017:Munday et al., 2011]. |
20883728
|
|
|
LPG1 |
Leishmania major |
|
7239376
|
7239377
|
|
|
AAF43209.1 |
putative beta galactofuranosyl transferase |
Virulence factor |
MUTATION: lpg1 mutant are attenuated in mice and in macrophages [Ref7018:Späth et al., 2000].
|
10908670
|
|
|
LIT1 |
Leishmania major strain Friedlin |
5654245
|
|
157873579
|
LmjF31.3060 |
CT005268 |
XP_001685297 |
|
Virulence factor |
MUTATION: Inactivation of LIT1 gene results in attenuated virulence in murine footpad model of infection and reduced viability and replication in bone marrow macrophages [Ref7019:Marquis and Gros, 2007].
|
17257847
|
|
|
GP63 |
Leishmania major strain Friedlin |
5649648
|
|
157865343
|
LmjF10.0480 |
CT005249 |
XP_001681379 |
|
Virulence factor |
MUTATION: gp63 mutant is attenuated for survival in murine macrophages [Ref7021:McGwire and Chang, 1994].
|
7808483
|
|
|
PDI |
|
|
|
25990151
|
|
|
|
disulfide isomerase PDI |
Virulence factor |
Specific PDI inhibitors abolished the enzymatic activity of the recombinant protein and profoundly affected parasite growth. [Ref7552:Ben et al., 2002] |
12065498
|
|
|
LPG2 |
Leishmania major strain Friedlin |
5655087
|
|
157876111
|
LMJF_34_3120 |
FR796430 |
XP_001686416 |
|
Virulence factor |
the lpg2(-)REV revertant was unable to synthesize LPG2-dependent PGs in the promastigote stage and thus remained highly attenuated in the ability to induce infection. [Ref7553:Späth et al., 2004] |
15155672
|
|
|
DAT |
Leishmania major strain Friedlin |
5654871
|
|
157875635
|
LMJF_34_1090 |
FR796430 |
XP_001686202 |
|
Virulence factor |
LmDAT is the only dihydroxyacetone phosphate acyltransferase of the L. major localized in the peroxisome, important for growth and survival and essential for virulence.
[Ref7554:Zufferey and Ben, 2006] |
16423830
|
|
|
ATG4.2 |
Leishmania major strain Friedlin |
5653545
|
|
157872135
|
LMJF_30_0270 |
FR796426 |
XP_001684616 |
|
Virulence factor |
the low infectivity of Δatg4.2 demonstrates that autophagy is important for the virulence of the parasite. [Ref7556:Williams et al., 2013] |
23166325
|
|
|
APX |
Leishmania major strain Friedlin |
5654759
|
|
157875406
|
LMJF_34_0070 |
FR796430 |
XP_001686096 |
|
Virulence factor |
The null mutant cells exhibit hypervirulence after infection with macrophages as well as inoculation into BALB/c mice; in contrast, overexpressing cells show avirulence. LmAPX is an important factor for controlling parasite differentiation and survival within macrophages.[Ref7594:Pal et al., 2010]
|
20585663
|
|
|
PLA2 |
Leishmania major strain Friedlin |
3684469
|
|
72548599
|
LmjF35.3020 |
CP000081 |
XP_843407 |
|
Virulence factor |
Deletion of PLA2/PAF-AH in Leishmania Major is dramatically attenuated the virulence in BALB/c mice[Ref7606:Pawlowic and Zhang, 2012] |
22954769
|
|
|
GLF |
|
|
|
59859955
|
|
|
|
UDP-galactopyranose mutase |
Virulence factor |
glf(-) mutant is deficient in LPG backbone and expresses truncated glycoinositolphospholipids. These structural changes do not influence the in vitro growth of the parasite but lead to an attenuation of virulence comparable with that observed with a mutant exclusively deficient in LPG.[Ref7610:Kleczka et al., 2007]
|
17284446
|
