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GP63

Victor ID 4484
Gene Name GP63
Sequence Strain (Species/Organism) Leishmania major strain Friedlin
NCBI Gene ID 5649648
NCBI Protein GI 157865343
Locus Tag LmjF10.0480
Genbank Accession CT005249
Protein Accession XP_001681379
Taxonomy ID 347515
Chromosome No 10
Gene Starting Position 223403
Gene Ending Position 225211
Gene Strand (Orientation) ?
Protein pI 6.74
Protein Weight 58187.1
Protein Length 602
DNA Sequence 
>gi|157865522:223403-225211 Leishmania major strain Friedlin chromosome 10, complete sequence
CATGTCCGTGGACAGCAGCAGCACGCACCGGCGCCGCTGCGTCGCCGCGCGCCTGGTGCGCCTCGCGGCT
GCCGGCGCCGCAGTCACCGTTGCTGTCGGCACCGCGGCCGCGTGGGCACACGCCGGTGCGCTGCAGCACC
GCTGCGTCCACGACGCGATGCAGGCACGCGTGCGGCAGTCGGTGGCGGACCACCACAAGGCCCCCGGCGC
GGTGTCCGCGGTGGGTCTGCCGTACGTTACTCTCGACGCCGCGCACACCGCGGCCGCCGCCGATCCCAGG
CCGGGCAGCGCGCGCAGCGTCGTGCGCGACGTGAACTGGGGCGCGCTGCGCATCGCCGTCTCCACCGAGG
ACCTCACCGACCCCGCCTACCACTGCGCTCGCGTCGGGCAGCATGTCAAAGACCACGCCGGCGCCATCGT
CACCTGCACCGCCGAGGACATCCTCACCAACGAGAAGCGCGACATCCTGGTCAAGCACCTCATCCCGCAG
GCGGTGCAGCTGCACACGGAGCGGCTGAAGGTGCAGCAGGTGCAGGGCAAGTGGAAGGTGACGGACATGG
TCGGCGAGATCTGTGGCGACTTCAAGGTGCCGCAGGCGCACATCACCGAGGGCTTCAGCAACACCGACTT
CGTGATGTACGTCGCCTCCGTGCCGAGTGAGGAGGGTGTGCTGGCGTGGGCCACGACCTGCCAGACGTTC
TCTGACGGCCATCCAGCCGTGGGCGTCATCAACATCCCCGCGGCGAACATTGCGTCGCGGTACGACCAGC
TCGTCACGCGTGTCGTCACGCACGAGATGGCGCACGCGCTCGGCTTCAGCGGCCCATTCTTCGAGGACGC
CCGCATCGTGGCGAGCGTTCCGAACGTTCGAGGCAAGAACTTCGATGTTCCCGTGATCAACAGCAGCACG
GCAGTGGCGAAGGCGCGCGAGCAGTACGGCTGCGACACTTTGGAGTATCTGGAGATGGAGGACCAAGGCA
GTGCGGGCTCCGCCGGGTCGCACATCAAGATGCGCAACGCGCAGGACGAGCTCATGGCGGCAGCCAGTGG
TGCCGGGTACTACACCGCCCTGACCATGGCCATCCTCCAGGACCTCGGCTTCTACCAGGCGGACTTCAGC
AAGGCCGAGGTGATGCCGTGGGGCCAGAACGCCGGCTGCGCCTTCCTCACCAACAAGTGCATGGAGCAGA
ACATCACGCAGTGGCCGGCGATGTTCTGCAATGAGAGCGAGGACGCCATCCGCTGCCCCACCAGTCGTCT
CAGCCTCGGTGCATGCGGTGTTACCCGTCACCCGGGCCTTCCGCCGTACTGGCAGTACTTCACGGACCCG
TCCCTCGCCGGCGTCTCCGCCTTCATGGACTACTGCCCTGTCGTGGTGCCCTACAGTGATATCAGCTGCA
CGCAGCGTGCCTCTGAGGCACATGCTTCGTTGCTGCCCTTCAACGTCTTCTCTGACGCGGCGCGCTGCAT
CGATGGTGCCTTCAGACCGAAGGCAACTAACGGCATAGTCAAGTCGTACGCCGGCCTGTGCGCCAACGTG
CAGTGTGACACGGCCACACGCACGTACAGCGTGCAGGTGCACGGCAGTAACGACTACACCAACTGCACGC
CGGGCCTCAGAGTTGAGCTGAGCACCGTGAGCAACGCCTTCGAGGGGGGCGGCTACATCACGTGCCCGCC
GTACGTGGAGGTGTGCCAGGGCAACGTGCAGGCTGCCAAGGACGGCGGCAACACGGCGGCTGGTCGTCGT
GGTCCGCGCGCCGCGGCGACGGCGCTGCTGGTGGCCGCGCTGCTGGCCGTGGCGCTCTA
Protein Sequence 
>gi|157865343|ref|XP_001681379.1| GP63, leishmanolysin; metallo-peptidase, Clan MA(M), Family M8 [Leishmania major]
MSVDSSSTHRRRCVAARLVRLAAAGAAVTVAVGTAAAWAHAGALQHRCVHDAMQARVRQSVADHHKAPGA
VSAVGLPYVTLDAAHTAAAADPRPGSARSVVRDVNWGALRIAVSTEDLTDPAYHCARVGQHVKDHAGAIV
TCTAEDILTNEKRDILVKHLIPQAVQLHTERLKVQQVQGKWKVTDMVGEICGDFKVPQAHITEGFSNTDF
VMYVASVPSEEGVLAWATTCQTFSDGHPAVGVINIPAANIASRYDQLVTRVVTHEMAHALGFSGPFFEDA
RIVASVPNVRGKNFDVPVINSSTAVAKAREQYGCDTLEYLEMEDQGSAGSAGSHIKMRNAQDELMAAASG
AGYYTALTMAILQDLGFYQADFSKAEVMPWGQNAGCAFLTNKCMEQNITQWPAMFCNESEDAIRCPTSRL
SLGACGVTRHPGLPPYWQYFTDPSLAGVSAFMDYCPVVVPYSDISCTQRASEAHASLLPFNVFSDAARCI
DGAFRPKATNGIVKSYAGLCANVQCDTATRTYSVQVHGSNDYTNCTPGLRVELSTVSNAFEGGGYITCPP
YVEVCQGNVQAAKDGGNTAAGRRGPRAAATALLVAALLAVAL
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: gp63 mutant is attenuated for survival in murine macrophages (McGwire and Chang, 1994).
References
McGwire and Chang, 1994: McGwire B, Chang KP. Genetic rescue of surface metalloproteinase (gp63)-deficiency in Leishmania amazonensis variants increases their infection of macrophages at the early phase. Molecular and biochemical parasitology. 1994; 66(2); 345-347. [PubMed: 7808483].