Protegen ID	Gene Name	Sequence Strain (Species/Organism)	NCBI Gene ID	NCBI Nucleotide GI	NCBI Protein GI	Locus Tag	Genbank Accession	Protein Accession	Protein Name	Protein Annotation	Molecule Role	Molecule Role Annotation	COG	PMID
4479	opb	Leishmania major		4581756	4581757			AAD24761.1	oligopeptidase B		Virulence factor	MUTATION: opb mutant is  attenuated in murine macrophages [Ref7017:Munday et al., 2011].		20883728
4480	LPG1	Leishmania major		7239376	7239377			AAF43209.1	putative beta galactofuranosyl transferase		Virulence factor	MUTATION: lpg1 mutant are attenuated in mice and in macrophages [Ref7018:Späth et al., 2000].; 		10908670
4481	LIT1	Leishmania major strain Friedlin	5654245		157873579	LmjF31.3060	CT005268	XP_001685297			Virulence factor	MUTATION: Inactivation of LIT1 gene results in attenuated virulence in murine footpad model of infection and reduced viability and replication in bone marrow macrophages [Ref7019:Marquis and Gros, 2007].; 		17257847
4484	GP63	Leishmania major strain Friedlin	5649648		157865343	LmjF10.0480	CT005249	XP_001681379			Virulence factor	MUTATION: gp63 mutant is attenuated for survival in murine macrophages [Ref7021:McGwire and Chang, 1994].; 		7808483
5154	PDI				25990151				disulfide isomerase PDI		Virulence factor	Specific PDI inhibitors abolished the enzymatic activity of the recombinant protein and profoundly affected parasite growth.  [Ref7552:Ben et al., 2002]		12065498
5155	LPG2	Leishmania major strain Friedlin	5655087		157876111	LMJF_34_3120	FR796430	XP_001686416			Virulence factor	 the lpg2(-)REV revertant was unable to synthesize LPG2-dependent PGs in the promastigote stage and thus remained highly attenuated in the ability to induce infection.  [Ref7553:Späth et al., 2004]		15155672
5156	DAT	Leishmania major strain Friedlin	5654871		157875635	LMJF_34_1090	FR796430	XP_001686202			Virulence factor	LmDAT is the only dihydroxyacetone phosphate acyltransferase of the L. major localized in the peroxisome, important for growth and survival and essential for virulence.; [Ref7554:Zufferey and Ben, 2006]		16423830
5157	HSP100				1946209				100 kDa heat shock protein (Hsp100)		Virulence factor	[Ref7555:Reiling et al., 2010]		20345655
5158	ATG4.2	Leishmania major strain Friedlin	5653545		157872135	LMJF_30_0270	FR796426	XP_001684616			Virulence factor	the low infectivity of Δatg4.2 demonstrates that autophagy is important for the virulence of the parasite.  [Ref7556:Williams et al., 2013]		23166325
5196	APX	Leishmania major strain Friedlin	5654759		157875406	LMJF_34_0070	FR796430	XP_001686096			Virulence factor	The null mutant cells exhibit hypervirulence after infection with macrophages as well as inoculation into BALB/c mice; in contrast, overexpressing cells show avirulence. LmAPX is an important factor for controlling parasite differentiation and survival within macrophages.[Ref7594:Pal et al., 2010]; 		20585663
5208	PLA2/PAF-AH													
5209	PLA2	Leishmania major strain Friedlin	3684469		72548599	LmjF35.3020	CP000081	XP_843407			Virulence factor	Deletion of PLA2/PAF-AH in Leishmania Major is dramatically attenuated the virulence in BALB/c mice[Ref7606:Pawlowic and Zhang, 2012]		22954769
5215	GLF				59859955				UDP-galactopyranose mutase		Virulence factor	 glf(-) mutant is deficient in LPG backbone and expresses truncated glycoinositolphospholipids. These structural changes do not influence the in vitro growth of the parasite but lead to an attenuation of virulence comparable with that observed with a mutant exclusively deficient in LPG.[Ref7610:Kleczka et al., 2007]; 		17284446