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DAT

Victor ID 5156
Gene Name DAT
Sequence Strain (Species/Organism) Leishmania major strain Friedlin
NCBI Gene ID 5654871
NCBI Protein GI 157875635
Locus Tag LMJF_34_1090
Genbank Accession FR796430
Protein Accession XP_001686202
Taxonomy ID 347515
Chromosome No 34
Gene Starting Position 489068
Gene Ending Position 493378
Gene Strand (Orientation) -
Protein pI 8.17
Protein Weight 142430.67
Protein Length 1436
DNA Sequence 
>gi|389595460:489068-493378 Leishmania major strain Friedlin complete genome, chromosome 34
CTCACATCTTGGATGGCTGTGTTAGCTCACGGTACACTGCCAGCACACGCTCTTGAATGGCTGCCTTGTC
GATCGTCACCCCCTCTGCTGCAGAGGGGTGCCACCACAGAGCCTTTATCTGTGTCGACAGCACCTCGAGG
CGAGCCAGCGCTGCCTCTTGCCCTAATAACCCGACCGTGTACGCAACGACTCCTCCGTTTACCTTCGACT
GGCCAGGCGTCGTTGTAATGGGCACGCGCTTTATCTGCAAGAGCGAGAGCGCGATGAGGCTCTCGTAGTA
GTGCTGCAGCGTCTCCTTGTTGGCCGCCACTATATAGCGCAGCTTGCGCTCCGCATACAGGATGTAACAC
GCTCGCTGCGTCGCCGTGACCACTTCGGCAGCCCCGAATGGCTTACCAGGGTACGCCGCCAGCAGTGCCG
ACGCAGCCGCCAGCACCGTGTAGAGCGCCTCCACGTGAGGGCAGATGAGTTGAAGGAGGAAGTAGTAGTA
CTGCGTAACGGGCAGGTGTACAATAGTGCCGCCGTGCGTGTCGGCGCCAGACAGTTGGGAGGACACGGTG
TGCTCCTCTACGCACTGCTGAAGTTGGCTTACAGTGCACTCCAGCCATGACGCGAAGCTCACCGGTGCTG
CTTCGGCGTAGTTAGGAAACTCAGCGGACAGCAGCCGCTGCAAAAGCTGCGTCTGGTTGCTCAGCACGTC
CGCTTTCACAGAGCGGACCCCGCACAGCATCGCCCCGTCAGCGCCGGATGGCGGACGGTGCGGCGTTGTG
ACGAAGCCGAACGCCTGCGCGACGACAGCGACGAGGGCCTCGTTCATACAAACGTGGATGAGCTGGTTGG
TGCTGATGTTGACTGCGAGTCTGGTGACAACGTTGTCGGGGTGGTATGTCACGCCTGACATCTCGTCCGT
GATGTGGATGTAGCGGTAGAGATTGGTCAGCGCCAGTGTCACGACCCCAGCAGGGTTCAACTTGGAGGCC
TCCGCCGAAAGCTGAGCGCCGCGCTCGCGCAAGCGCCCACGCAGCCATTCGACCCCCTGATGAACCTTTT
CTAACGGCATGGCGGCTGCTGCGGTCGGTGCCGCCGCGGTGGTGTCAATGCCCTCCTTCAACATTGTCGT
TGCTGTACAGTAGTAAGGGCCAAGACACTCGACTACAGCAGCCACCATCGATGCCGGGGTGATAACCGTG
TTACGCTGCAGTTTGTACACCAGGTGCCACGCGACGGTGCCGAGGAGAGGGATCGGGGTGATGGAGCTGC
CTTTGGCAATGGACGGCGTGGTATCGAGTGTCTTGCACACCGACGTGGTTGCGGCGGCTGGCGCGGCCGG
ATCTCGGAGTTGCTCGTCCTTAGGCTGGAGCGGCAGCGGGCACTGCCGCGGGTGCTGCTTGAGGGAGCGC
AGCGACACGGGCTCGCCAACGTGGATGTGGATGTTGCCGTGCATGCGCTCGAGTAGACTTCGGGCTTTGA
GCATGTTCGTCGGGTTCTCCTTCGGCTTCGGAACGCCCAAGAGCTCCTTGGCATGTGTAGTGGCCTCGAG
TACCTCGTCGTAGGAGAGGCTGACCGGAACAATGAGCACGTCGTCAAGCTCCTGCTGACCAGGCTCGTAG
AAGGTGTCGCAGACAAACTTGAGAAGGCCCAGCTTAGGCGCCATCGTCTTGCCGGTGCGACTCCGCGCTC
CCTCAATGAAGAACTCGAGAGGGCGGCGCGCACGCACCAGGTGCCGCACATATTCCTTCAACAGCGCAGC
GTACAGCGGGTCGTCGCGGAAGGAGCGGCGCATAAAGAGGGCGCCGCTGCCCCGCATCAGGGTCGCGAGG
ACACCCATACTAAGAAAGTTTTCTCCAGCCACGATGTGCGGCAGCGGCAACCGCATGAGCGCCAGCACCT
CGGAGAGAATGAGGAAGTCAATGTAAGAGCGGTGCAGCGGGGCGAAGACGACGGCCACGCGTGGCATGGC
GAAGTAGCGGTGGAGGCGCTCATAGGAGCCGTTGTTGACGTCGACGCGGCCGTAGATGCTGTGAAAGATC
GTGCGGATCATGAGACCCAGCGTGCGACAATGAACGTGATTCAGTGCATCGCCGCACTCCAGCAGAAGAC
GCTTTGCCCGGGCCTCCACGTCCTTTTTCGATGCGCCGTCTTTGGCAGCCAGAGCGGTCATGAGCCGCTG
GATGTTCGGCTGCGCGATGATTGAGGTGAGCACCTGCGGCGTCATGCCAGGTGTCATGTCACCGCGCCAG
CCGTTCGCCGTCATGCCGACACGATGAAGAAACACGAAGCAATCGAAGTACTTGTGCAGAAGGGACGGAA
ACGGCGGGATGCGCTCGGCACCGCGGTACACGAAGTCGTTGGTGAAGTAGCGCCGCGGCTCTGGAAAGGC
GAAAGGGGCTTCTGCGGCAGAAGCCGCCGCCTCCGGCTTGGTGGACGACGGCACCGCTGCACTCGCAGGC
GCCAGCTCGTCTGGGGCGCTGACGACAGGAGGACTGCGTACCACGCTGCCGATGTTCGCACTGTCGGCCA
CCGGCAGAGCATGGAAGCGACTCCGTACGTGCTGCAAGCCGGATGAAGACCGCAGAACACATCGTGCTAG
GTGCTCAAGCACTGCCCGTGCAATCACCGACACATACGCCTCCCAGTCGACCTCGACGAGCGCCACACAC
TGGTGATAGGGCATGAGTGTGTGGTGCGATGTCAGGCGACGCAGCAGCGAGTGATACAACGCCACGTTGA
AGTCATCGAGGCGGTATGGCGGAACTGAGAAGGACGAGGACGCTGTACGCCTGCGCGAGGCGGCGAAGGC
AGCGGATATCTTGTCTCGTGCTGCCGCCGCGCGTGCAGTACGCTCGATGTAGCGGACAACGCTGTCCATT
TGTGCCACATACGCCTTTAGCGCCTGCGCCGCCTCGGCATTGCCGACTTTCTCTTCCATGAGGCGCTGCC
GCTGCTGATACGCGCGCCATCCTTCCAGCGCGTAGGCAGCCGCGCGCGGCTCCGGCCCGAAGTTGACCCA
ATCCGCCACGCTAAACGGAAACTGCAGAATCGGTGCCTGCGTCAGCACGCCAGCCACGGGAAACGCCGCG
GAAATCTGGTCGGCAAATCGACCGTAATAACTCATGAGATACTCGCCCACCATGCCCCACACCAGTGACA
CCTCGCCAGGCTTGCGTGATTCGGCAACTGCGAAGGACCCCATACGGTGTCGCGTGACACACTGCGCCGG
CTGCGTTGGCATTGCCGTCGCCGTCTCGGCAGCGGCGGCGGCGTGCGAGGGCGCAGGCGAAAGGCCACAG
TACTGCATCTCCGCGGCACACTCTACACACTCTGGCAGCTCGCCATGGCACAGCCACACATATCCCAAGA
GGGCGGCATTCAGAGCGACGTCGACGGGCGTAATAGTGGCTGGCTCACCTCGGCTGACAGGGAAGTGCCG
GAGCACGCCGAGGGCGTTGGCGGCGCACAGCACTGGAAGCGTGCCGCCGAGTGAAATACCCGACGCGGCT
TGAACGGCGACCTCCGTCGCACCGAACTCCAGCGCCGGCGGGTCCATAGCGTATGCGTAGGCGAGGAGCA
CTACCCAGTCTACCGCCGTGGCGACCTCCTTCGCGATGCTAGACAGCATTGCACACGCAGCAGTGCGATA
GACGTCGTCAGCGAGAATGACAAGACTGCCGCGCACCCGCGTCTGTTGAGAAGCGGTCTCGGCGGCTTGC
GAAGGGCCGGCAGCACTCCAAAGACGGCGCAGAAGGATATCGTACGCCTTGAGCCCGCTTTCCGTGTCTG
GGCTCAGCGACTGCGCACTCAGCACCAGCACAAACACAGAATCCGCAACACGAGGTACACCACTGCTCCC
GCCAGATCCCGCAGTGACGTCTGTTGAGGATGCCGTGAAGTTCGTCTCGCCAAGTGCGCCGCTGCCGAGT
AGATGAATTCGATGCAGCATCGGCCCGATCTCCTCCGCCTTGGGTGACACCCCACCATAGTAGAACTGTG
TTATGTGTGTCACAGAAACGTCGCGGCGTGTGGCACGGCTCGCACGCAGTTTTGCCTCCACTCGCTGCAC
GGTGTTCATGAAGTCTCTCGCGGTGGCAGCGGATTCGGCGGAGCTGCACGCCATGTGGGGGCTATCGTTG
CCGGACGATGGGCTGCTGCTCTTCACTGCGATGCCGTCGACCAGCACGCGGCAGTTCAGCGGCACGAGCG
GGGACGTGGCGATCGCGCAAGCACATGCCGCAGTGAAGCCATCGATGGGCGCGACCAACACGACCTGCTT
GCACTCCTCTGGAAGCGCTAGCCGAGGTGGTGGGAAGCTCA
Protein Sequence 
>gi|157875635|ref|XP_001686202.1| dihydroxyacetonephosphate acyltransferase [Leishmania major strain Friedlin]
MSFPPPRLALPEECKQVVLVAPIDGFTAACACAIATSPLVPLNCRVLVDGIAVKSSSPSSGNDSPHMACS
SAESAATARDFMNTVQRVEAKLRASRATRRDVSVTHITQFYYGGVSPKAEEIGPMLHRIHLLGSGALGET
NFTASSTDVTAGSGGSSGVPRVADSVFVLVLSAQSLSPDTESGLKAYDILLRRLWSAAGPSQAAETASQQ
TRVRGSLVILADDVYRTAACAMLSSIAKEVATAVDWVVLLAYAYAMDPPALEFGATEVAVQAASGISLGG
TLPVLCAANALGVLRHFPVSRGEPATITPVDVALNAALLGYVWLCHGELPECVECAAEMQYCGLSPAPSH
AAAAAETATAMPTQPAQCVTRHRMGSFAVAESRKPGEVSLVWGMVGEYLMSYYGRFADQISAAFPVAGVL
TQAPILQFPFSVADWVNFGPEPRAAAYALEGWRAYQQRQRLMEEKVGNAEAAQALKAYVAQMDSVVRYIE
RTARAAAARDKISAAFAASRRRTASSSFSVPPYRLDDFNVALYHSLLRRLTSHHTLMPYHQCVALVEVDW
EAYVSVIARAVLEHLARCVLRSSSGLQHVRSRFHALPVADSANIGSVVRSPPVVSAPDELAPASAAVPSS
TKPEAAASAAEAPFAFPEPRRYFTNDFVYRGAERIPPFPSLLHKYFDCFVFLHRVGMTANGWRGDMTPGM
TPQVLTSIIAQPNIQRLMTALAAKDGASKKDVEARAKRLLLECGDALNHVHCRTLGLMIRTIFHSIYGRV
DVNNGSYERLHRYFAMPRVAVVFAPLHRSYIDFLILSEVLALMRLPLPHIVAGENFLSMGVLATLMRGSG
ALFMRRSFRDDPLYAALLKEYVRHLVRARRPLEFFIEGARSRTGKTMAPKLGLLKFVCDTFYEPGQQELD
DVLIVPVSLSYDEVLEATTHAKELLGVPKPKENPTNMLKARSLLERMHGNIHIHVGEPVSLRSLKQHPRQ
CPLPLQPKDEQLRDPAAPAAATTSVCKTLDTTPSIAKGSSITPIPLLGTVAWHLVYKLQRNTVITPASMV
AAVVECLGPYYCTATTMLKEGIDTTAAAPTAAAAMPLEKVHQGVEWLRGRLRERGAQLSAEASKLNPAGV
VTLALTNLYRYIHITDEMSGVTYHPDNVVTRLAVNISTNQLIHVCMNEALVAVVAQAFGFVTTPHRPPSG
ADGAMLCGVRSVKADVLSNQTQLLQRLLSAEFPNYAEAAPVSFASWLECTVSQLQQCVEEHTVSSQLSGA
DTHGGTIVHLPVTQYYYFLLQLICPHVEALYTVLAAASALLAAYPGKPFGAAEVVTATQRACYILYAERK
LRYIVAANKETLQHYYESLIALSLLQIKRVPITTTPGQSKVNGGVVAYTVGLLGQEAALARLEVLSTQIK
ALWWHPSAAEGVTIDKAAIQERVLAVYRELTQPSKM
Molecule Role Virulence factor
Molecule Role Annotation LmDAT is the only dihydroxyacetone phosphate acyltransferase of the L. major localized in the peroxisome, important for growth and survival and essential for virulence.
(Zufferey and Ben, 2006)
References