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opb

Victor ID 4479
Gene Name opb
Sequence Strain (Species/Organism) Leishmania major
NCBI Nucleotide GI 4581756
NCBI Protein GI 4581757
Protein Accession AAD24761.1
Taxonomy ID 5664
Gene Strand (Orientation) ?
Protein Name oligopeptidase B
Protein Length 4066
Protein Note similar to prolyl oligopeptidases
DNA Sequence 
>gi|4581756|gb|AF109875.1| Leishmania major oligopeptidase B (opb) gene, complete cds
CGCGAGGATGCCAGGGGGTGGGGTTGTGTACGGAAGATGAAGGACAGGTGAGAGGGTAGAGGTGGTGTGG
GTACTGGTGTGATGAAGGCGGTGATCGACAGGTGGAGAGAGAGGTTGAGGGGCGTCGAGGAGCCTGCGCA
ATGACGATTTTGTCGAATAAGAGGCGAGAGAGACAGCAGGCGTCAGTCGGGCGAGAGATAGAGGAGAGAG
GAGAAGGGTCGTTGGCTGAGGTTGCTGTGGGATGTATCCAATGTGCCGTGATGTGTNCGTGTGCGCATGC
GTGTTGTTCTCGTGCGTAAGCGGTCGGCAGTGCGTTGGAGAAGGGGGGGGGGAGGTGAGGTGAGGCGAGG
GTACGTGTTGCCGTCAGGAGCGTCGTCGGGAGCAAGAAAAAGGATGCGAGCATTGCCGTTGTTGCCGCCA
CTCAAGCCCTCTCGCTGATTAGACCCACCCCTTTCCTTTAGGCCCTGTGACACCCTCCTCTCCACGACCC
TCCGGTGTCTTGGGGCGTATGGTGTCGGATGGTGGATGGAGGCATGCGGTGAAGGGCGACGGCGTCGCTG
CCTTTGCTTTTCTTCTCCGTTGGATGCGATGAGCGGCGCACGGCCCACTGCCTCGCGTACAGCGGCAGCC
TAAACATCACAGTCAGATACGAAGGGGAAGGGATATCACTGAGCTAACCAGGACATCGGTAGGGCGGAGC
AACACCTACACATAGATCTACAAGTGCCACCGAGAAGGAGAAAAGCAAGATCGAGAAGCTGAGATACCAC
GAGAACAACACGCATGCGCACACGNACACATCACGGCACATTGGATACATCCCACAGCAACCTCAGCCAA
CGACCCTTCTCCTCTCTCCTCTATCTCTCGCCCGACTGACGCCTGCTGTCTCTCTCGCCTCTTATTCGAC
AAAATCGTCATTGCGCAGGCTCCTCGACGCCCCTCAACCTCTCTCTCCACCTGTCGATCACCGCCTTCAT
CACACCAGTACCCACACCACCTCTACCCTCTCACCTGTCCTTCATCTTCCGTACACAACCCCACCCCCTG
GCATCCTCGCGCAGTTTCGCAGGGCACCACCCCCTCCCTCATTAGTGCACGCACACGTTTTAGCGAAGCG
GGTCGCACATACGTGGTACATGCGTGCCCAACGGAATACATATACATACATCTATTCATCTATATATGTA
CATCGATAGATATATCTACACATAGGTATACCGATCGATCTACGTGTGTGTGTGTGTGTGTGTGTTCTGT
AAGTCTTTGAAGACGCTGAGTTAACATCCCTTTCCTTTCTTTCGCTGATTTTCCCCACCTCCACCCGACC
GGATGTCGTCGGACAGCTCCGTCGCGGCCTCTGCGCAGCCGCCGATCGCCGCCAAGAAGCCGCACCGCGT
CAAGTTCGGGTACGTGGAGGGTGAGGACCGCGGCCCGAACCCGATGAACCCGCCGCGCTACCGCGAGGAC
CCGTATTTTTGGATGCGCGATGACGATCGTAAGGATCCGGCCGTGATTGAGCACCTCAACAAGGAGAAGG
TCTACTTCCAGGCGCGCAGCGCCGACATTGCGCAGCTGCGCGACGACATTTACGCAGAGCACATATCGCA
CATCAATGAGGACGACATGTCCGCGCCGTACGTGTACGGCAAGTACCGGTACTACACCCGCGAGGTGAAG
GGTAAGCCGTACAAGATTTACTGCCGCGTGTTCACGGACAAGGAGCCGGGCGACGTCGCGGCGGAAGAGG
TCATCATCGATGTCAACCAGGTCGCCGAGGGCAAAGCGTTCTGTGACGTGATGGAGGTGAAGCCGGCACC
GCCGGAGCATGACCTTGTAGCCTTTTCTGTGGACATGAGCGGTAACGAGGTGTACACGATCGAATTTAAA
AGGATTTCGGACCCGTCCCAAACCATCGCCGACAAGGTGAGTGGCACCAATGGCGAGATCGTGTGGGGCC
CGGACCACACCTCCTTATTCTACGTGACCAAAGACGAGACGCTGCGCGAAAACAAGGTGTGGCGCCACGT
GATGGGCAAGCTGCAGTCCGAGGACGTCTGCCTCTACGAGGAGCACAACCCGCTGTTCAGTGCCTTCATG
TACAAGGCCGCGGACACAAACACACTTTGCATCGGCTCGCAGTCACCGGAGACGGCGGAAGTGCACCTGC
TTGATCTGCGCAAGGGCAACGCCCACAATACGCTGGAAATTGTGCGGCCGCGCGAGAAGGGTGTGCGCTA
CGACGTGCAGATGCACGGCACCAGCCATCTTGTGATCCTCACCAACGAAGGTGGGGCGGTGAACCACAAG
CTTCTCATAGCGCCGCGTGGGCAGCCGAGCGACTGGTCGCATGTGCTGGTGGATCACAGCGAGGATGTGT
TTATGGAGAGCATCGCGGTGCGCTCGAACTACCTCGTCGTGGCAGGCCGCCGCGCCGGGCTGACGCGCAT
CTGGACGATGATGGCGGACTCGCAGGATGGTGTCTTCCAGGCTGGCACCGGGCTGCGCGAGGTGGTGATG
GAGGAGCCGATCTTCACGGTGCACCTCGTGGAGTCCCAGATGTTGGAGTACGAAGAGCCGACGTTCCGCA
TGGAGTACTCCTCCCTTGCCACGCCGAACACCTGGTTCGACGTCAGCCCGCAGGACACTCTCGCACCGCT
GGTGAAAGTGCGCGAGGTCGGCGGTGGCTTCGACGCCGCCAACTACAAGGTGGAGCGCCGCTTCGCTACC
GCACCGGACCAGACCAAGATCCCGCTCTCAGTTGTGTGCCACAAAGACCTCGACATGAGCCAGCCGCAGC
CGTGCATGCTGTACGGGTACGGCAGCTACGGCCTTAGCATGGACCCGCAGTTCAGTATTCAGCACCTGCC
ATACTGTGACCGCGGCATGATCTTCGCCATAGCCCACATCCGCGGCGGCAGTGAGCTGGGCCGTGCATGG
TACGAGATCGGCGCCAAGTACCTCACGAAGCGCAACACCTTTTCCGACTTCATCGCGGCAGCCGAATTCC
TGGTGAACGCGAAATTGACGACGCCGTCGCAGCTGGCCTGCGAGGGGCGTAGCGCCGGTGGCCTGCTGAT
GGGCGCCGTGCTGAACATGCGACCCGATCTCTTCAAGGTGGCGCTCGCCGGCGTACCGTTCGTGGATGTC
ATGACGACCATGTGCGACCCCAGCATTCCCTTGACGACGGGCGAGTGGGAGGAGTGGGGCAACCCGAACG
AGTACAAGTACTACGACTACATGCTGAGCTACAGCCCCATGGACAACGTCCGCGCGCAGGAGTACCCGAA
CATCATGGTCCAGTGCGGCCTGCACGACCCCCGCGTCGCCTATTGGGAGCCGGCCAAGTGGGTGAGCAAG
CTGCGTGAGTGCAAGACGGACAACAACGAAATTCTGCTGAACATAGACATGGAGAGCGGGCACTTCTCCG
CCAAGGATCGCTACAAGTTCTGGAAGGAGTCGGCTATCCAGCAAGCGTTCGTGTGCAAGCACCTGAAGAG
CACCGTGCGCCTGCTGGTTCGCAGGTAAGAGTCGTGAACATTAACTCCGGGGCACGATGGCACACTTCCA
CGTCTTCATAAGGGACGAAGGAGCTTGTCTGTCGATCTTTAGGTACGTCCGGGTGCATGCTGGGGTGCTT
GTTCGGTTGATTTCTTCTTGCATTATTGTACGTCTGCGCTTCTTGGTGCAGCAAGCCGTTATCGCCCTCT
TCCTCCCTCCACTGTGTGCAGCACCCCACCACCACCACCACCTTTTCGCCCTCGGCGGCGGAAAACATCT
TGCATTCGCACACACACACACACACACATATATATATATTTTTTCTTCCGTCTTTCGTTGTTTGCGTTTT
GCCGTGTATCGCTGTGCGCGTCTCTCGTGGGCACGGCAGCGCGGCAAGAGTTGGGGGAGGGGGGGGACGA
GCCTGTGTTCGCTGTCCGGTGGAAGCGCGATGTCTGGCATCCCGGTCAAGGTTCTTGTTAGGTGCCCCAT
TCTATTTGAGAAGCGGTCCTCGTGAAACGCTAGGCCCTTCTCTCTCCCGCTACCGCTAGTGCCCGTGCCT
CAAAAA
Protein Sequence 
>gi|4581757|gb|AAD24761.1|AF109875_1 oligopeptidase B [Leishmania major]
MSSDSSVAASAQPPIAAKKPHRVKFGYVEGEDRGPNPMNPPRYREDPYFWMRDDDRKDPAVIEHLNKEKV
YFQARSADIAQLRDDIYAEHISHINEDDMSAPYVYGKYRYYTREVKGKPYKIYCRVFTDKEPGDVAAEEV
IIDVNQVAEGKAFCDVMEVKPAPPEHDLVAFSVDMSGNEVYTIEFKRISDPSQTIADKVSGTNGEIVWGP
DHTSLFYVTKDETLRENKVWRHVMGKLQSEDVCLYEEHNPLFSAFMYKAADTNTLCIGSQSPETAEVHLL
DLRKGNAHNTLEIVRPREKGVRYDVQMHGTSHLVILTNEGGAVNHKLLIAPRGQPSDWSHVLVDHSEDVF
MESIAVRSNYLVVAGRRAGLTRIWTMMADSQDGVFQAGTGLREVVMEEPIFTVHLVESQMLEYEEPTFRM
EYSSLATPNTWFDVSPQDTLAPLVKVREVGGGFDAANYKVERRFATAPDQTKIPLSVVCHKDLDMSQPQP
CMLYGYGSYGLSMDPQFSIQHLPYCDRGMIFAIAHIRGGSELGRAWYEIGAKYLTKRNTFSDFIAAAEFL
VNAKLTTPSQLACEGRSAGGLLMGAVLNMRPDLFKVALAGVPFVDVMTTMCDPSIPLTTGEWEEWGNPNE
YKYYDYMLSYSPMDNVRAQEYPNIMVQCGLHDPRVAYWEPAKWVSKLRECKTDNNEILLNIDMESGHFSA
KDRYKFWKESAIQQAFVCKHLKSTVRLLVRR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: opb mutant is attenuated in murine macrophages (Munday et al., 2011).
References
Munday et al., 2011: Munday JC, McLuskey K, Brown E, Coombs GH, Mottram JC. Oligopeptidase B deficient mutants of Leishmania major. Molecular and biochemical parasitology. 2011; 175(1); 49-57. [PubMed: 20883728].