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LIT1

Victor ID 4481
Gene Name LIT1
Sequence Strain (Species/Organism) Leishmania major strain Friedlin
NCBI Gene ID 5654245
NCBI Protein GI 157873579
Locus Tag LmjF31.3060
Genbank Accession CT005268
Protein Accession XP_001685297
Taxonomy ID 347515
Chromosome No 31
Gene Starting Position 1435790
Gene Ending Position 1437088
Gene Strand (Orientation) -
Protein pI 6.26
Protein Weight 41400.65
Protein Length 432
DNA Sequence 
>gi|157873612:1435790-1437088 Leishmania major strain Friedlin chromosome 31, complete sequence
CCTACAGCCAGTTGCCCACAAGCGCCATCAGCCCCATGCCCACCCACAGCGACACAAACAGGATGATCTT
CTTCGCCATGCGGTGCCTCTGCCCATCGCAGCAGTAGTGCTTCACATCCGCCACAAAGTCACCAAGCAGC
AGCGTGAAGGCGAGGTACAGCAGAATGCCGCCGCACAGCGTGTCCAGTACAGCAACGACAGTGGCGAAGA
CGCTGCCGGACATTGCAGACGGCGACACGGACACGGCAATCGCGGATGCTGCCATGCCAGCTGGCGCGCT
GAGGGAGAACACAAGGGCAAGGACAACATCAAGGGTGACCGAAAACTTGGCGTCCACGAGACGCGACCCA
ACCGCCATGCCCTCGAACAGCTGGTGGAACACAAGCGCCACAAGCAGCGGCTTCAGCTCACTGTCTTTCT
TGAGCCCGACATCCAGGCCAACAAACACGCTGTGCAGTGTCACACCGAACTCCAAGCACACGGCGGAGAT
CACGTAGCGGAGATAGCCCATGTCCCGTAGTGGCGCCACTGACAGATGCTGGTGCCCGTGAGCAGAGGGC
TCATCGCAGTGATGGTAGTGCTCCGGGTGCTTCGGCGACACCGCCACCAGCGGCACCTTACAGTCATCCA
ACGCAGCGGCGGGCACCGTCGTCTGTACATCGCTCTTCGAACTCGTGCTCTTACGTTCATCGATCAGAGG
CCCATCCGCCTGTGCTGGGCCCGTGGTGACGCCGACGTCCACATCAGGAGACAACCCGCAGCACTCGTCG
TTGCACTTGCTTTCCGCCTTGACCGCCTCTGTCTCTCTCTTCAGCTTGGCCTTCATCCAGCGCTCAGCGA
TGTCCGCCAGCTGCATGTCTAGCGCCTGCATCAGCAGCACAGCAATCAGGGCAAGCAAGAAGTACAGCGG
CCTGTAACTCTTCAGCACGGCGGGGATGCAATCCTCCGAGAAAGCCTCGGCGCCCTCGAAGATCAGGTGA
ATCGTCGACACAGACAGCAGCACGCCCGTTGCAGCGGACTTCGCCACGGAGAACACATACGGGTACCTCA
TGAGAGAAGGGATGCACTTGCCGAGAATCGGAATCGCAGTGCCGAGGAGCGACACGAAGAGAATCAGGAA
CAGCGCGCCGACATGCAGGCCAAGTGAGTAGGCCCCGGCGAAGCCCTTGCACAGCGAGTCCCCGGCCTCT
CCGGCGCTGGCAGCACTCGAGCCGTCGGCGTTGAGCGGCGCAGACACATGATACCCGAGCTCCATCAGAT
ACCTTGTGCTCGCCTCCACGCTCAGTTTCGCCGTCTCCA
Protein Sequence 
>gi|157873579|ref|XP_001685297.1| iron/zinc transporter protein-like protein [Leishmania major]
METAKLSVEASTRYLMELGYHVSAPLNADGSSAASAGEAGDSLCKGFAGAYSLGLHVGALFLILFVSLLG
TAIPILGKCIPSLMRYPYVFSVAKSAATGVLLSVSTIHLIFEGAEAFSEDCIPAVLKSYRPLYFLLALIA
VLLMQALDMQLADIAERWMKAKLKRETEAVKAESKCNDECCGLSPDVDVGVTTGPAQADGPLIDERKSTS
SKSDVQTTVPAAALDDCKVPLVAVSPKHPEHYHHCDEPSAHGHQHLSVAPLRDMGYLRYVISAVCLEFGV
TLHSVFVGLDVGLKKDSELKPLLVALVFHQLFEGMAVGSRLVDAKFSVTLDVVLALVFSLSAPAGMAASA
IAVSVSPSAMSGSVFATVVAVLDTLCGGILLYLAFTLLLGDFVADVKHYCCDGQRHRMAKKIILFVSLWV
GMGLMALVGNWL
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Inactivation of LIT1 gene results in attenuated virulence in murine footpad model of infection and reduced viability and replication in bone marrow macrophages (Marquis and Gros, 2007).
References
Marquis and Gros, 2007: Marquis JF, Gros P. Intracellular Leishmania: your iron or mine?. Trends in microbiology. 2007; 15(3); 93-95. [PubMed: 17257847].