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APX

Victor ID 5196
Gene Name APX
Sequence Strain (Species/Organism) Leishmania major strain Friedlin
NCBI Gene ID 5654759
NCBI Protein GI 157875406
Locus Tag LMJF_34_0070
Genbank Accession FR796430
Protein Accession XP_001686096
Taxonomy ID 347515
Chromosome No 34
Gene Starting Position 22864
Gene Ending Position 23775
Gene Strand (Orientation) ?
Protein pI 6.85
Protein Weight 32383.33
Protein Length 303
DNA Sequence 
>gi|389595460:22864-23775 Leishmania major strain Friedlin complete genome, chromosome 34
CATGTCCGGCACCTCGCGGCGAGCGAAAGGCCTCTTTACCGGCATCGCTGTCGGCACCTTCGTGAGTGGT
GCCATGTTTGTTTCCTGCGCCAGTGCACGCGTGGAGGAGCCGCCGTTCGACATCAGGGCTCTCCGCGCCG
ACATTGAGGACATGATCTCTGAAAAGCTGGAACTCGGACCTTCGCTGATTCGCCTCGCATGGCACGAGGC
CGCCTCGTACGACTGCTTCAAGAAGGACGGCTCTCCGAACTCAGCGTCGATGCGCTTCAAACCGGAATGC
CTGTATGCGGGTAACAAAGGTCTCGATATCCCTCGCAAAGCGCTGGAGACGTTGAAGAAGAAGTACCCTC
AAATATCTTACGCTGATTTGTGGGTGCTCGCCGCCTACGTGGCCATCGAGTACATGGGTGGTCCCACGAT
TCCGTTCTGCTGGGGTCGTGTGGATGCCAAGGACGGCTCTGTGTGTGGACCTGACGGGCGCCTGCCGGAC
GGCTCAAAGACGCAAAGTCACGTGCGCGAGGTGTTCAGGCGTCTCGGGTTCAATGACCAGGAGACAGTGG
CGCTCATCGGTGCGCACACATGCGGTGAGTGCCACATCGAATTCTCCGGCTACCATGGGCCGTGGACACA
CGACAAGAACGGTTTTGACAACTCTTTCTTTACGCAGCTGCTCGATGAAGATTGGGTCTTGAATCCCAAG
GTCGAGCAGATGCAGCTGATGGACCGCGCGACGACAAAGCTGATGATGCTTCCCAGTGACGTTTGCCTCC
TCCTCGATCCCAGCTACCGCAAGTACGTGGAGCTGTACGCAAAGGACAACGACCGCTTCAACAAAGACTT
TGCGAATGCGTTCAAAAAGCTGACCGAGCTCGGCACCAGGAACCTTCACAAAGCACCCGCTTCGGAGAGC
TA
Protein Sequence 
>gi|157875406|ref|XP_001686096.1| ascorbate peroxidase [Leishmania major strain Friedlin]
MSGTSRRAKGLFTGIAVGTFVSGAMFVSCASARVEEPPFDIRALRADIEDMISEKLELGPSLIRLAWHEA
ASYDCFKKDGSPNSASMRFKPECLYAGNKGLDIPRKALETLKKKYPQISYADLWVLAAYVAIEYMGGPTI
PFCWGRVDAKDGSVCGPDGRLPDGSKTQSHVREVFRRLGFNDQETVALIGAHTCGECHIEFSGYHGPWTH
DKNGFDNSFFTQLLDEDWVLNPKVEQMQLMDRATTKLMMLPSDVCLLLDPSYRKYVELYAKDNDRFNKDF
ANAFKKLTELGTRNLHKAPASES
Molecule Role Virulence factor
Molecule Role Annotation The null mutant cells exhibit hypervirulence after infection with macrophages as well as inoculation into BALB/c mice; in contrast, overexpressing cells show avirulence. LmAPX is an important factor for controlling parasite differentiation and survival within macrophages.(Pal et al., 2010)
References