| Victors ID |
Gene Name |
Sequence Strain (Species/Organism) |
NCBI Gene ID |
NCBI Nucleotide GI |
NCBI Protein GI |
Locus Tag |
Genbank Accession |
Protein Accession |
Protein Name |
Molecule Role |
Molecule Role Annotation |
PMID |
|
|
atxA from Bacillus anthracis str. A2012 |
Bacillus anthracis str. A2012 |
1158705
|
|
21392822
|
BXA0146 |
|
NP_652902.1 |
pXO1-119 |
Virulence factor |
MUTATION: atxA mutant is avirulent in mice [Ref6403:Koehler, 2002]. |
12224521
|
|
|
pagA from Bacillus anthracis str. A2012 |
Bacillus anthracis str. A2012 |
1158723
|
|
21392840
|
BXA0164 |
|
NP_652920.1 |
protective antigen |
Virulence factor |
MUTATION: pagA mutant is non-lethal in mice [Ref6404:Pezard et al., 1991]. |
1910002
|
|
|
lef from Bacillus anthracis str. A2012 |
Bacillus anthracis str. A2012 |
1158731
|
|
21392848
|
BXA0172 |
|
NP_652928.1 |
lethal factor |
Virulence factor |
MUTATION: lef mutants are non-lethal in mice [Ref6404:Pezard et al., 1991]. |
1910002
|
|
|
clpX from Bacillus anthracis str. Ames |
Bacillus anthracis str. Ames |
1083685
|
|
30264540
|
BA4704 |
|
NP_846917.1 |
ATP-dependent protease ATP-binding subunit |
Virulence factor |
MUTATION: clpX deletion mutant is attenuated in mice [Ref6428:McGillivray et al., 2009]. |
20375606
|
|
|
sodC from Bacillus anthracis str. Ames |
Bacillus anthracis str. Ames |
1084508
|
|
30264948
|
BA5139 |
|
NP_847325.1 |
superoxide dismutase, Cu-Zn |
Virulence factor |
MUTATION: A quadruple-knockout strain (Delta sod15 Delta sodA1 Delta sodC Delta sodA2) was attenuated more than 40-fold upon intranasal challenge of mice compared to the wild type [Ref6429:Cybulski et al., 2009]. |
18955476
|
|
|
codY from Bacillus anthracis str. Ames |
Bacillus anthracis str. Ames |
1086802
|
|
30263832
|
BA3966 |
|
NP_846209.1 |
transcriptional repressor CodY |
Virulence factor |
MUTATION: codY mutant is attenuated in mice [Ref6430:van et al., 2009]. |
19651859
|
|
|
sigB from Bacillus anthracis str. Ames |
Bacillus anthracis str. Ames |
1088960
|
|
30261116
|
BA0992 |
|
NP_843493.1 |
RNA polymerase sigma factor SigB |
Virulence factor |
MUTATION: sigB mutant is less virulent in mice than the parent strain [Ref6431:Fouet et al., 2000]. |
10960085
|
|
|
clpX from Bacillus anthracis str. Sterne |
Bacillus anthracis str. Sterne |
2851842
|
|
49187364
|
BAS4369 |
|
YP_030616.1 |
ATP-dependent protease ATP-binding subunit |
Virulence factor |
MUTATION: clpX deletion mutant is attenuated in mice [Ref6428:McGillivray et al., 2009]. |
20375606
|
|
|
BAS4929 |
Bacillus anthracis str. Sterne |
2852009
|
|
49187917
|
BAS4929 |
AE017225 |
YP_031170 |
hypothetical protein |
Virulence factor |
MUTATION: BAS4929 (ccpA) mutant is attenuated in mice [Ref6554:Chiang et al., 2011]. |
20971911
|
|
|
sigB from Bacillus anthracis str. 'Ames Ancestor' |
Bacillus anthracis str. 'Ames Ancestor' |
2814654
|
|
47526271
|
GBAA0992 |
|
YP_017620.1 |
RNA polymerase sigma factor SigB |
Virulence factor |
MUTATION: sigB mutant is less virulent in mice than the parental strain [Ref6431:Fouet et al., 2000]. |
10960085
|
|
|
GBAA4766 |
Bacillus anthracis str. 'Ames Ancestor' |
2815836
|
|
47530065
|
GBAA_4766 |
AE017334 |
YP_021414 |
iron compound ABC transporter iron compound-binding protein |
Virulence factor |
MUTATION: fpuA (GBAA4766) mutant is attenuated in mice [Ref6555:Carlson et al., 2010]. |
20487286
|
|
|
clpX from Bacillus anthracis str. 'Ames Ancestor' |
Bacillus anthracis str. 'Ames Ancestor' |
2816065
|
|
47530003
|
GBAA4704 |
|
YP_021352.1 |
ATP-dependent protease ATP-binding subunit |
Virulence factor |
MUTATION: clpX deletion mutant is attenuated in mice [Ref6428:McGillivray et al., 2009]. |
20375606
|
|
|
GBAA0552 |
Bacillus anthracis str. 'Ames Ancestor' |
2817231
|
|
47525825
|
GBAA_0552 |
AE017334 |
YP_017174 |
internalin |
Virulence factor |
MUTATION: GBAA0552 mutant is attenuated in mice [Ref6556:Carlson et al., 2009]. |
19768119
|
|
|
sodC from Bacillus anthracis str. 'Ames Ancestor' |
Bacillus anthracis str. 'Ames Ancestor' |
2819662
|
|
47530444
|
GBAA5139 |
|
YP_021793.1 |
superoxide dismutase, cu-zn |
Virulence factor |
MUTATION: A quadruple-knockout strain (Delta sod15 Delta sodA1 Delta sodC Delta sodA2) was attenuated more than 40-fold upon intranasal challenge of mice compared to the wild type [Ref6429:Cybulski et al., 2009]. |
18955476
|
|
|
phnX |
Bacillus anthracis str. 'Ames Ancestor' |
2819695
|
|
47526609
|
GBAA_1340 |
AE017334 |
YP_017958 |
phosphonoacetaldehyde hydrolase |
Virulence factor |
MUTATION: phnX (GBAA1340) mutant is attenuated in mice [Ref6556:Carlson et al., 2009]. |
19768119
|
|
|
codY from Bacillus anthracis str. 'Ames Ancestor' |
Bacillus anthracis str. 'Ames Ancestor' |
2820095
|
|
47529256
|
GBAA3966 |
|
YP_020605.1 |
transcriptional repressor CodY |
Virulence factor |
MUTATION: codY mutant is attenuated in mice [Ref6430:van et al., 2009]. |
19651859
|
|
|
lef from Bacillus anthracis str. 'Ames Ancestor' |
Bacillus anthracis str. 'Ames Ancestor' |
2820148
|
|
47566484
|
GBAA_pXO1_0172 |
|
YP_016503.2 |
lethal factor |
Virulence factor |
MUTATION: lef mutant is non-lethal in mice [Ref6404:Pezard et al., 1991]. |
1910002
|
|
|
pagA from Bacillus anthracis str. 'Ames Ancestor' |
Bacillus anthracis str. 'Ames Ancestor' |
2820165
|
|
47566476
|
GBAA_pXO1_0164 |
|
YP_016495.2 |
protective antigen |
Virulence factor |
MUTATION: pagA mutant is non-lethal in mice [Ref6404:Pezard et al., 1991]. |
1910002
|
|
|
atxA from Bacillus anthracis str. 'Ames Ancestor' |
Bacillus anthracis str. 'Ames Ancestor' |
2820309
|
|
47566458
|
GBAA_pXO1_0146 |
|
YP_016477.2 |
transcriptional activator atxa, (pxo1-119) |
Virulence factor |
MUTATION: atxA mutant is avirulent in mice [Ref6403:Koehler, 2002]. |
12224521
|
|
|
nos from Bacillus anthracis str. A0248 |
Bacillus anthracis str. A0248 |
7847881
|
|
229600939
|
BAA_5726 |
|
YP_002869655.1 |
nitric-oxide synthase, oxygenase subunit |
Virulence factor |
MUTATION: nos mutant is attenuated in mice [Ref6826:Shatalin et al., 2008]. |
18215992
|
|
|
mntA from Bacillus anthracis str. A0248 |
Bacillus anthracis str. A0248 |
7848141
|
|
229600559
|
BAA_3238 |
|
YP_002867390.1 |
manganese ABC transporter, manganese-binding protein |
Virulence factor |
MUTATION: mntA mutant is attenuated in guinea pigs [Ref6827:Gat et al., 2005]. |
16194238
|
|
|
asbA from Bacillus anthracis str. A0248 |
Bacillus anthracis str. A0248 |
7848168
|
|
229602755
|
BAA_2049 |
|
YP_002866379.1 |
petrobactin biosynthesis protein AsbA |
Virulence factor |
MUTATION: asbA mutant is attenuated in macrophages and mice [Ref6828:Cendrowski et al., 2004]. |
14756782
|
|
|
sodA2 from Bacillus anthracis str. A0248 |
Bacillus anthracis str. A0248 |
7848233
|
|
229600446
|
BAA_5727 |
|
YP_002869656.1 |
superoxide dismutase, Mn |
Virulence factor |
MUTATION: A quadruple-knockout strain (Delta sod15 Delta sodA1 Delta sodC Delta sodA2) was attenuated more than 40-fold upon intranasal challenge of mice compared to the wild type [Ref6429:Cybulski et al., 2009]. |
18955476
|
|
|
codY from Bacillus anthracis str. A0248 |
Bacillus anthracis str. A0248 |
7848783
|
|
229602839
|
BAA_3989 |
|
YP_002868066.1 |
transcriptional regulator CodY |
Virulence factor |
MUTATION: codY mutant is attenuated in mice [Ref6430:van et al., 2009]. |
19651859
|
|
|
sigB from Bacillus anthracis str. A0248 |
Bacillus anthracis str. A0248 |
7848794
|
|
229604478
|
BAA_1086 |
|
YP_002865547.1 |
RNA polymerase sigma-B factor |
Virulence factor |
MUTATION: sigB mutant is less virulent in mice than the parental strain [Ref6431:Fouet et al., 2000]. |
10960085
|
|
|
sodA1 from Bacillus anthracis str. A0248 |
Bacillus anthracis str. A0248 |
7850123
|
|
229603736
|
BAA_4518 |
|
YP_002868565.1 |
superoxide dismutase, Mn |
Virulence factor |
MUTATION: A quadruple-knockout strain (Delta sod15 Delta sodA1 Delta sodC Delta sodA2) was attenuated more than 40-fold upon intranasal challenge of mice compared to the wild type [Ref6429:Cybulski et al., 2009]. |
18955476
|
|
|
clpX from Bacillus anthracis str. A0248 |
Bacillus anthracis str. A0248 |
7851138
|
|
229600744
|
BAA_4722 |
|
YP_002868756.1 |
ATP-dependent Clp protease, ATP-binding subunit ClpX |
Virulence factor |
MUTATION: clpX deletion mutant is attenuated in mice [Ref6428:McGillivray et al., 2009]. |
20375606
|
|
|
alo from Bacillus anthracis str. A0248 |
Bacillus anthracis str. A0248 |
7851421
|
|
229604714
|
BAA_3389 |
|
YP_002867524.1 |
anthrolysin O |
Virulence factor |
MUTATION: alo mutant had diminished ability to grow in association with macrophages [Ref6829:Heffernan et al., 2007]. |
17419764
|
|
|
sodC from Bacillus anthracis str. A0248 |
Bacillus anthracis str. A0248 |
7853218
|
|
229602559
|
BAA_5175 |
|
YP_002869151.1 |
superoxide dismutase, Cu-Zn |
Virulence factor |
MUTATION: A quadruple-knockout strain (Delta sod15 Delta sodA1 Delta sodC Delta sodA2) was attenuated more than 40-fold upon intranasal challenge of mice compared to the wild type [Ref6429:Cybulski et al., 2009]. |
18955476
|
|
|
lef from Bacillus anthracis str. A0248 |
Bacillus anthracis str. A0248 |
7847664
|
|
229599780
|
BAA_A0173 |
|
YP_002860835.1 |
anthrax lethal factor endopeptidase |
Virulence factor |
MUTATION: lef mutant is non-lethal in mice [Ref6404:Pezard et al., 1991]. |
1910002
|
|
|
cya from Bacillus anthracis str. A0248 |
Bacillus anthracis str. A0248 |
7847735
|
|
229599815
|
BAA_A0144 |
|
YP_002860815.1 |
calmodulin-sensitive adenylate cyclase |
Virulence factor |
TOXIN: cya encodes EF protein, which with PA induces edema [Ref6404:Pezard et al., 1991]. |
1910002
|
|
|
pagA from Bacillus anthracis str. A0248 |
Bacillus anthracis str. A0248 |
7847827
|
|
229599856
|
BAA_A0168 |
|
YP_002860832.1 |
protective antigen |
Virulence factor |
MUTATION: pagA mutant is non-lethal in mice [Ref6404:Pezard et al., 1991]. |
1910002
|
|
|
atxA from Bacillus anthracis str. A0248 |
Bacillus anthracis str. A0248 |
7847839
|
|
229599851
|
BAA_A0151 |
|
YP_002860817.1 |
anthrax toxin expression trans-acting positive regulator |
Virulence factor |
MUTATION: atxA mutant is avirulent in mice [Ref6403:Koehler, 2002]. |
12224521
|
|
|
acpB from Bacillus anthracis str. A0248 |
Bacillus anthracis str. A0248 |
7847529
|
|
229599687
|
BAA_B0065 |
|
YP_002860667.1 |
capsule synthesis trans-acting positive regulator AcpB |
Virulence factor |
MUTATION: acpB mutant is attenuated in mice [Ref6830:Drysdale et al., 2005]. |
15616593
|
|
|
capD from Bacillus anthracis str. A0248 |
Bacillus anthracis str. A0248 |
7847571
|
|
229599667
|
BAA_B0068 |
|
YP_002860670.1 |
capsule anchoring protein CapD |
Virulence factor |
MUTATION: capD mutant is attenuated in mice [Ref6831:Candela and Fouet, 2005]. |
16045616
|
|
|
capE from Bacillus anthracis str. A0248 |
Bacillus anthracis str. A0248 |
7847606
|
|
229599639
|
BAA_B0067 |
|
YP_002860669.1 |
polyglutamate capsule biosynthesis protein CapE |
Virulence factor |
MUTATION: capE mutant is avirulent in mice [Ref6832:Candela et al., 2005]. |
16267300
|
|
|
alo from Bacillus anthracis str. CDC 684 |
Bacillus anthracis str. CDC 684 |
7782491
|
|
227813865
|
BAMEG_1271 |
|
YP_002813874.1 |
anthrolysin O |
Virulence factor |
MUTATION: alo mutant has diminished ability to grow in association of macrophages [Ref6829:Heffernan et al., 2007]. |
17419764
|
|
|
codY from Bacillus anthracis str. CDC 684 |
Bacillus anthracis str. CDC 684 |
7782752
|
|
227813264
|
BAMEG_0666 |
|
YP_002813273.1 |
transcriptional regulator CodY |
Virulence factor |
MUTATION: codY mutant is attenuated in mice [Ref6430:van et al., 2009]. |
19651859
|
|
|
asbA from Bacillus anthracis str. CDC 684 |
Bacillus anthracis str. CDC 684 |
7782926
|
|
227815199
|
BAMEG_2610 |
|
YP_002815208.1 |
petrobactin biosynthesis protein AsbA |
Virulence factor |
MUTATION: asbA mutant is attenuated in macrophages and mice [Ref6828:Cendrowski et al., 2004]. |
14756782
|
|
|
sigB from Bacillus anthracis str. CDC 684 |
Bacillus anthracis str. CDC 684 |
7782979
|
|
227816152
|
BAMEG_3579 |
|
YP_002816161.1 |
RNA polymerase sigma-B factor |
Virulence factor |
MUTATION: sigB mutant is less virulent in mice than the parent strain [Ref6431:Fouet et al., 2000]. |
10960085
|
|
|
sodC from Bacillus anthracis str. CDC 684 |
Bacillus anthracis str. CDC 684 |
7783063
|
|
227817676
|
BAMEG_5196 |
|
YP_002817685.1 |
superoxide dismutase, Cu-Zn |
Virulence factor |
MUTATION: A quadruple-knockout strain (Delta sod15 Delta sodA1 Delta sodC Delta sodA2) was attenuated more than 40-fold upon intranasal challenge of mice compared to the wild type [Ref6429:Cybulski et al., 2009]. |
18955476
|
|
|
mntA from Bacillus anthracis str. CDC 684 |
Bacillus anthracis str. CDC 684 |
7783280
|
|
227814016
|
BAMEG_1423 |
|
YP_002814025.1 |
manganese ABC transporter, manganese-binding protein |
Virulence factor |
MUTATION: mntA mutant is attenuated in guinea pigs [Ref6827:Gat et al., 2005]. |
16194238
|
|
|
nos from Bacillus anthracis str. CDC 684 |
Bacillus anthracis str. CDC 684 |
7783761
|
|
227818215
|
BAMEG_5743 |
|
YP_002818224.1 |
nitric-oxide synthase, oxygenase subunit |
Virulence factor |
MUTATION: nos mutant is attenuated in mice [Ref6826:Shatalin et al., 2008]. |
18215992
|
|
|
clpX from Bacillus anthracis str. CDC 684 |
Bacillus anthracis str. CDC 684 |
7784922
|
|
227817253
|
BAMEG_4740 |
|
YP_002817262.1 |
ATP-dependent Clp protease, ATP-binding subunit ClpX |
Virulence factor |
MUTATION: clpX deletion mutant is attenuated in mice [Ref6428:McGillivray et al., 2009]. |
20375606
|
|
|
sodA1 from Bacillus anthracis str. CDC 684 |
Bacillus anthracis str. CDC 684 |
7786419
|
|
227817051
|
BAMEG_4536 |
|
YP_002817060.1 |
superoxide dismutase, Mn |
Virulence factor |
MUTATION: A quadruple-knockout strain (Delta sod15 Delta sodA1 Delta sodC Delta sodA2) was attenuated more than 40-fold upon intranasal challenge of mice compared to the wild type [Ref6429:Cybulski et al., 2009]. |
18955476
|
|
|
sodA2 from Bacillus anthracis str. CDC 684 |
Bacillus anthracis str. CDC 684 |
7787415
|
|
227818216
|
BAMEG_5744 |
|
YP_002818225.1 |
superoxide dismutase, Mn |
Virulence factor |
MUTATION: A quadruple-knockout strain (Delta sod15 Delta sodA1 Delta sodC Delta sodA2) was attenuated more than 40-fold upon intranasal challenge of mice compared to the wild type [Ref6429:Cybulski et al., 2009]. |
18955476
|
|
|
pagA from Bacillus anthracis str. CDC 684 |
Bacillus anthracis str. CDC 684 |
7780695
|
|
227811585
|
BAMEG_A0160 |
|
YP_002811596.1 |
protective antigen |
Virulence factor |
MUTATION: pagA mutant is non-lethal in mice [Ref6404:Pezard et al., 1991]. |
1910002
|
|
|
cya from Bacillus anthracis str. CDC 684 |
Bacillus anthracis str. CDC 684 |
7780712
|
|
227811562
|
BAMEG_A0137 |
|
YP_002811573.1 |
calmodulin-sensitive adenylate cyclase |
Virulence factor |
TOXIN: cya encodes EF protein, which with PA induces edema [Ref6404:Pezard et al., 1991]. |
1910002
|
|
|
lef from Bacillus anthracis str. CDC 684 |
Bacillus anthracis str. CDC 684 |
7780718
|
|
227811590
|
BAMEG_A0165 |
|
YP_002811601.1 |
anthrax lethal factor endopeptidase |
Virulence factor |
MUTATION: lef mutant is non-lethal in mice [Ref6404:Pezard et al., 1991]. |
1910002
|
|
|
atxA from Bacillus anthracis str. CDC 684 |
Bacillus anthracis str. CDC 684 |
7780750
|
|
227811569
|
BAMEG_A0144 |
|
YP_002811580.1 |
anthrax toxin expression trans-acting positive regulator |
Virulence factor |
MUTATION: atxA mutant is avirulent in mice [Ref6403:Koehler, 2002]. |
12224521
|
|
|
acpB from Bacillus anthracis str. CDC 684 |
Bacillus anthracis str. CDC 684 |
7780535
|
|
227811374
|
BAMEG_B0065 |
|
YP_002808736.1 |
capsule synthesis trans-acting positive regulator AcpB |
Virulence factor |
MUTATION: acpB mutant is attenuated in mice [Ref6830:Drysdale et al., 2005]. |
15616593
|
|
|
capE from Bacillus anthracis str. CDC 684 |
Bacillus anthracis str. CDC 684 |
7780538
|
|
227811376
|
BAMEG_B0067 |
|
YP_002808738.1 |
polyglutamate capsule biosynthesis protein CapE |
Virulence factor |
MUTATION: capE mutant is avirulent in mice [Ref6832:Candela et al., 2005]. |
16267300
|
|
|
capD from Bacillus anthracis str. CDC 684 |
Bacillus anthracis str. CDC 684 |
7780572
|
|
227811377
|
BAMEG_B0068 |
|
YP_002808739.1 |
capsule anchoring protein CapD |
Virulence factor |
MUTATION: capD mutant is attenuated in mice [Ref6831:Candela and Fouet, 2005]. |
16045616
|
|
|
Low Molecular Weight Capsule |
Bacillus anthracis |
|
|
|
|
|
|
|
Virulence factor |
MUTATION:A dep null mutant Sm-1, which formed H-capsule but not L-capsule, was avirulent in mice [Ref7298:Makino et al., 2002]. |
12134259
|
