Protegen ID Gene Name Sequence Strain (Species/Organism) NCBI Gene ID NCBI Nucleotide GI NCBI Protein GI Locus Tag Genbank Accession Protein Accession Protein Name Protein Annotation Molecule Role Molecule Role Annotation COG PMID 799 atxA from Bacillus anthracis str. A2012 Bacillus anthracis str. A2012 1158705 21392822 BXA0146 NP_652902.1 pXO1-119 Virulence factor MUTATION: atxA mutant is avirulent in mice [Ref6403:Koehler, 2002]. 12224521 800 pagA from Bacillus anthracis str. A2012 Bacillus anthracis str. A2012 1158723 21392840 BXA0164 NP_652920.1 protective antigen Virulence factor MUTATION: pagA mutant is non-lethal in mice [Ref6404:Pezard et al., 1991]. 1910002 801 lef from Bacillus anthracis str. A2012 Bacillus anthracis str. A2012 1158731 21392848 BXA0172 NP_652928.1 lethal factor Virulence factor MUTATION: lef mutants are non-lethal in mice [Ref6404:Pezard et al., 1991]. 1910002 855 clpX from Bacillus anthracis str. Ames Bacillus anthracis str. Ames 1083685 30264540 BA4704 NP_846917.1 ATP-dependent protease ATP-binding subunit Virulence factor MUTATION: clpX deletion mutant is attenuated in mice [Ref6428:McGillivray et al., 2009]. COG1219O, under O: Posttranslational modification, protein turnover, chaperones 20375606 856 sodC from Bacillus anthracis str. Ames Bacillus anthracis str. Ames 1084508 30264948 BA5139 NP_847325.1 superoxide dismutase, Cu-Zn Virulence factor MUTATION: A quadruple-knockout strain (Delta sod15 Delta sodA1 Delta sodC Delta sodA2) was attenuated more than 40-fold upon intranasal challenge of mice compared to the wild type [Ref6429:Cybulski et al., 2009]. COG2032P, under P: Inorganic ion transport and metabolism 18955476 857 codY from Bacillus anthracis str. Ames Bacillus anthracis str. Ames 1086802 30263832 BA3966 NP_846209.1 transcriptional repressor CodY Virulence factor MUTATION: codY mutant is attenuated in mice [Ref6430:van et al., 2009]. COG4465K, under K: Transcription 19651859 858 sigB from Bacillus anthracis str. Ames Bacillus anthracis str. Ames 1088960 30261116 BA0992 NP_843493.1 RNA polymerase sigma factor SigB Virulence factor MUTATION: sigB mutant is less virulent in mice than the parent strain [Ref6431:Fouet et al., 2000]. COG1191K, under K: Transcription 10960085 1407 clpX from Bacillus anthracis str. Sterne Bacillus anthracis str. Sterne 2851842 49187364 BAS4369 YP_030616.1 ATP-dependent protease ATP-binding subunit Virulence factor MUTATION: clpX deletion mutant is attenuated in mice [Ref6428:McGillivray et al., 2009]. COG1219O, under O: Posttranslational modification, protein turnover, chaperones 20375606 1408 BAS4929 Bacillus anthracis str. Sterne 2852009 49187917 BAS4929 AE017225 YP_031170 hypothetical protein Virulence factor MUTATION: BAS4929 (ccpA) mutant is attenuated in mice [Ref6554:Chiang et al., 2011]. 20971911 1409 sigB from Bacillus anthracis str. 'Ames Ancestor' Bacillus anthracis str. 'Ames Ancestor' 2814654 47526271 GBAA0992 YP_017620.1 RNA polymerase sigma factor SigB Virulence factor MUTATION: sigB mutant is less virulent in mice than the parental strain [Ref6431:Fouet et al., 2000]. COG1191K, under K: Transcription 10960085 1410 GBAA4766 Bacillus anthracis str. 'Ames Ancestor' 2815836 47530065 GBAA_4766 AE017334 YP_021414 iron compound ABC transporter iron compound-binding protein Virulence factor MUTATION: fpuA (GBAA4766) mutant is attenuated in mice [Ref6555:Carlson et al., 2010]. COG4594P, under P: Inorganic ion transport and metabolism 20487286 1411 clpX from Bacillus anthracis str. 'Ames Ancestor' Bacillus anthracis str. 'Ames Ancestor' 2816065 47530003 GBAA4704 YP_021352.1 ATP-dependent protease ATP-binding subunit Virulence factor MUTATION: clpX deletion mutant is attenuated in mice [Ref6428:McGillivray et al., 2009]. COG1219O, under O: Posttranslational modification, protein turnover, chaperones 20375606 1412 GBAA0552 Bacillus anthracis str. 'Ames Ancestor' 2817231 47525825 GBAA_0552 AE017334 YP_017174 internalin Virulence factor MUTATION: GBAA0552 mutant is attenuated in mice [Ref6556:Carlson et al., 2009]. COG4886S, under S: Function unknown 19768119 1413 sodC from Bacillus anthracis str. 'Ames Ancestor' Bacillus anthracis str. 'Ames Ancestor' 2819662 47530444 GBAA5139 YP_021793.1 superoxide dismutase, cu-zn Virulence factor MUTATION: A quadruple-knockout strain (Delta sod15 Delta sodA1 Delta sodC Delta sodA2) was attenuated more than 40-fold upon intranasal challenge of mice compared to the wild type [Ref6429:Cybulski et al., 2009]. COG2032P, under P: Inorganic ion transport and metabolism 18955476 1414 phnX Bacillus anthracis str. 'Ames Ancestor' 2819695 47526609 GBAA_1340 AE017334 YP_017958 phosphonoacetaldehyde hydrolase Virulence factor MUTATION: phnX (GBAA1340) mutant is attenuated in mice [Ref6556:Carlson et al., 2009]. COG0637R, under R: General function prediction only 19768119 1415 codY from Bacillus anthracis str. 'Ames Ancestor' Bacillus anthracis str. 'Ames Ancestor' 2820095 47529256 GBAA3966 YP_020605.1 transcriptional repressor CodY Virulence factor MUTATION: codY mutant is attenuated in mice [Ref6430:van et al., 2009]. COG4465K, under K: Transcription 19651859 1416 lef from Bacillus anthracis str. 'Ames Ancestor' Bacillus anthracis str. 'Ames Ancestor' 2820148 47566484 GBAA_pXO1_0172 YP_016503.2 lethal factor Virulence factor MUTATION: lef mutant is non-lethal in mice [Ref6404:Pezard et al., 1991]. 1910002 1417 pagA from Bacillus anthracis str. 'Ames Ancestor' Bacillus anthracis str. 'Ames Ancestor' 2820165 47566476 GBAA_pXO1_0164 YP_016495.2 protective antigen Virulence factor MUTATION: pagA mutant is non-lethal in mice [Ref6404:Pezard et al., 1991]. 1910002 1418 atxA from Bacillus anthracis str. 'Ames Ancestor' Bacillus anthracis str. 'Ames Ancestor' 2820309 47566458 GBAA_pXO1_0146 YP_016477.2 transcriptional activator atxa, (pxo1-119) Virulence factor MUTATION: atxA mutant is avirulent in mice [Ref6403:Koehler, 2002]. COG3711K, under K: Transcription 12224521 3632 nos from Bacillus anthracis str. A0248 Bacillus anthracis str. A0248 7847881 229600939 BAA_5726 YP_002869655.1 nitric-oxide synthase, oxygenase subunit Virulence factor MUTATION: nos mutant is attenuated in mice [Ref6826:Shatalin et al., 2008]. COG4362PE, under P: Inorganic ion transport and metabolism; E: Amino acid transport and metabolism 18215992 3633 mntA from Bacillus anthracis str. A0248 Bacillus anthracis str. A0248 7848141 229600559 BAA_3238 YP_002867390.1 manganese ABC transporter, manganese-binding protein Virulence factor MUTATION: mntA mutant is attenuated in guinea pigs [Ref6827:Gat et al., 2005]. COG0803P, under P: Inorganic ion transport and metabolism 16194238 3634 asbA from Bacillus anthracis str. A0248 Bacillus anthracis str. A0248 7848168 229602755 BAA_2049 YP_002866379.1 petrobactin biosynthesis protein AsbA Virulence factor MUTATION: asbA mutant is attenuated in macrophages and mice [Ref6828:Cendrowski et al., 2004]. COG4264Q, under Q: Secondary metabolites biosynthesis, transport and catabolism 14756782 3635 sodA2 from Bacillus anthracis str. A0248 Bacillus anthracis str. A0248 7848233 229600446 BAA_5727 YP_002869656.1 superoxide dismutase, Mn Virulence factor MUTATION: A quadruple-knockout strain (Delta sod15 Delta sodA1 Delta sodC Delta sodA2) was attenuated more than 40-fold upon intranasal challenge of mice compared to the wild type [Ref6429:Cybulski et al., 2009]. COG0605P, under P: Inorganic ion transport and metabolism 18955476 3636 codY from Bacillus anthracis str. A0248 Bacillus anthracis str. A0248 7848783 229602839 BAA_3989 YP_002868066.1 transcriptional regulator CodY Virulence factor MUTATION: codY mutant is attenuated in mice [Ref6430:van et al., 2009]. COG4465K, under K: Transcription 19651859 3637 sigB from Bacillus anthracis str. A0248 Bacillus anthracis str. A0248 7848794 229604478 BAA_1086 YP_002865547.1 RNA polymerase sigma-B factor Virulence factor MUTATION: sigB mutant is less virulent in mice than the parental strain [Ref6431:Fouet et al., 2000]. COG1191K, under K: Transcription 10960085 3638 sodA1 from Bacillus anthracis str. A0248 Bacillus anthracis str. A0248 7850123 229603736 BAA_4518 YP_002868565.1 superoxide dismutase, Mn Virulence factor MUTATION: A quadruple-knockout strain (Delta sod15 Delta sodA1 Delta sodC Delta sodA2) was attenuated more than 40-fold upon intranasal challenge of mice compared to the wild type [Ref6429:Cybulski et al., 2009]. COG0605P, under P: Inorganic ion transport and metabolism 18955476 3639 clpX from Bacillus anthracis str. A0248 Bacillus anthracis str. A0248 7851138 229600744 BAA_4722 YP_002868756.1 ATP-dependent Clp protease, ATP-binding subunit ClpX Virulence factor MUTATION: clpX deletion mutant is attenuated in mice [Ref6428:McGillivray et al., 2009]. COG1219O, under O: Posttranslational modification, protein turnover, chaperones 20375606 3640 alo from Bacillus anthracis str. A0248 Bacillus anthracis str. A0248 7851421 229604714 BAA_3389 YP_002867524.1 anthrolysin O Virulence factor MUTATION: alo mutant had diminished ability to grow in association with macrophages [Ref6829:Heffernan et al., 2007]. 17419764 3641 sodC from Bacillus anthracis str. A0248 Bacillus anthracis str. A0248 7853218 229602559 BAA_5175 YP_002869151.1 superoxide dismutase, Cu-Zn Virulence factor MUTATION: A quadruple-knockout strain (Delta sod15 Delta sodA1 Delta sodC Delta sodA2) was attenuated more than 40-fold upon intranasal challenge of mice compared to the wild type [Ref6429:Cybulski et al., 2009]. COG2032P, under P: Inorganic ion transport and metabolism 18955476 3642 lef from Bacillus anthracis str. A0248 Bacillus anthracis str. A0248 7847664 229599780 BAA_A0173 YP_002860835.1 anthrax lethal factor endopeptidase Virulence factor MUTATION: lef mutant is non-lethal in mice [Ref6404:Pezard et al., 1991]. 1910002 3643 cya from Bacillus anthracis str. A0248 Bacillus anthracis str. A0248 7847735 229599815 BAA_A0144 YP_002860815.1 calmodulin-sensitive adenylate cyclase Virulence factor TOXIN: cya encodes EF protein, which with PA induces edema [Ref6404:Pezard et al., 1991]. 1910002 3644 pagA from Bacillus anthracis str. A0248 Bacillus anthracis str. A0248 7847827 229599856 BAA_A0168 YP_002860832.1 protective antigen Virulence factor MUTATION: pagA mutant is non-lethal in mice [Ref6404:Pezard et al., 1991]. 1910002 3645 atxA from Bacillus anthracis str. A0248 Bacillus anthracis str. A0248 7847839 229599851 BAA_A0151 YP_002860817.1 anthrax toxin expression trans-acting positive regulator Virulence factor MUTATION: atxA mutant is avirulent in mice [Ref6403:Koehler, 2002]. COG3711K, under K: Transcription 12224521 3646 acpB from Bacillus anthracis str. A0248 Bacillus anthracis str. A0248 7847529 229599687 BAA_B0065 YP_002860667.1 capsule synthesis trans-acting positive regulator AcpB Virulence factor MUTATION: acpB mutant is attenuated in mice [Ref6830:Drysdale et al., 2005]. COG3711K, under K: Transcription 15616593 3647 capD from Bacillus anthracis str. A0248 Bacillus anthracis str. A0248 7847571 229599667 BAA_B0068 YP_002860670.1 capsule anchoring protein CapD Virulence factor MUTATION: capD mutant is attenuated in mice [Ref6831:Candela and Fouet, 2005]. COG0405E, under E: Amino acid transport and metabolism 16045616 3648 capE from Bacillus anthracis str. A0248 Bacillus anthracis str. A0248 7847606 229599639 BAA_B0067 YP_002860669.1 polyglutamate capsule biosynthesis protein CapE Virulence factor MUTATION: capE mutant is avirulent in mice [Ref6832:Candela et al., 2005]. 16267300 3649 alo from Bacillus anthracis str. CDC 684 Bacillus anthracis str. CDC 684 7782491 227813865 BAMEG_1271 YP_002813874.1 anthrolysin O Virulence factor MUTATION: alo mutant has diminished ability to grow in association of macrophages [Ref6829:Heffernan et al., 2007]. 17419764 3650 codY from Bacillus anthracis str. CDC 684 Bacillus anthracis str. CDC 684 7782752 227813264 BAMEG_0666 YP_002813273.1 transcriptional regulator CodY Virulence factor MUTATION: codY mutant is attenuated in mice [Ref6430:van et al., 2009]. COG4465K, under K: Transcription 19651859 3651 asbA from Bacillus anthracis str. CDC 684 Bacillus anthracis str. CDC 684 7782926 227815199 BAMEG_2610 YP_002815208.1 petrobactin biosynthesis protein AsbA Virulence factor MUTATION: asbA mutant is attenuated in macrophages and mice [Ref6828:Cendrowski et al., 2004]. COG4264Q, under Q: Secondary metabolites biosynthesis, transport and catabolism 14756782 3652 sigB from Bacillus anthracis str. CDC 684 Bacillus anthracis str. CDC 684 7782979 227816152 BAMEG_3579 YP_002816161.1 RNA polymerase sigma-B factor Virulence factor MUTATION: sigB mutant is less virulent in mice than the parent strain [Ref6431:Fouet et al., 2000]. COG1191K, under K: Transcription 10960085 3653 sodC from Bacillus anthracis str. CDC 684 Bacillus anthracis str. CDC 684 7783063 227817676 BAMEG_5196 YP_002817685.1 superoxide dismutase, Cu-Zn Virulence factor MUTATION: A quadruple-knockout strain (Delta sod15 Delta sodA1 Delta sodC Delta sodA2) was attenuated more than 40-fold upon intranasal challenge of mice compared to the wild type [Ref6429:Cybulski et al., 2009]. COG2032P, under P: Inorganic ion transport and metabolism 18955476 3654 mntA from Bacillus anthracis str. CDC 684 Bacillus anthracis str. CDC 684 7783280 227814016 BAMEG_1423 YP_002814025.1 manganese ABC transporter, manganese-binding protein Virulence factor MUTATION: mntA mutant is attenuated in guinea pigs [Ref6827:Gat et al., 2005]. COG0803P, under P: Inorganic ion transport and metabolism 16194238 3655 nos from Bacillus anthracis str. CDC 684 Bacillus anthracis str. CDC 684 7783761 227818215 BAMEG_5743 YP_002818224.1 nitric-oxide synthase, oxygenase subunit Virulence factor MUTATION: nos mutant is attenuated in mice [Ref6826:Shatalin et al., 2008]. COG4362PE, under P: Inorganic ion transport and metabolism; E: Amino acid transport and metabolism 18215992 3656 clpX from Bacillus anthracis str. CDC 684 Bacillus anthracis str. CDC 684 7784922 227817253 BAMEG_4740 YP_002817262.1 ATP-dependent Clp protease, ATP-binding subunit ClpX Virulence factor MUTATION: clpX deletion mutant is attenuated in mice [Ref6428:McGillivray et al., 2009]. COG1219O, under O: Posttranslational modification, protein turnover, chaperones 20375606 3657 sodA1 from Bacillus anthracis str. CDC 684 Bacillus anthracis str. CDC 684 7786419 227817051 BAMEG_4536 YP_002817060.1 superoxide dismutase, Mn Virulence factor MUTATION: A quadruple-knockout strain (Delta sod15 Delta sodA1 Delta sodC Delta sodA2) was attenuated more than 40-fold upon intranasal challenge of mice compared to the wild type [Ref6429:Cybulski et al., 2009]. COG0605P, under P: Inorganic ion transport and metabolism 18955476 3658 sodA2 from Bacillus anthracis str. CDC 684 Bacillus anthracis str. CDC 684 7787415 227818216 BAMEG_5744 YP_002818225.1 superoxide dismutase, Mn Virulence factor MUTATION: A quadruple-knockout strain (Delta sod15 Delta sodA1 Delta sodC Delta sodA2) was attenuated more than 40-fold upon intranasal challenge of mice compared to the wild type [Ref6429:Cybulski et al., 2009]. COG0605P, under P: Inorganic ion transport and metabolism 18955476 3659 pagA from Bacillus anthracis str. CDC 684 Bacillus anthracis str. CDC 684 7780695 227811585 BAMEG_A0160 YP_002811596.1 protective antigen Virulence factor MUTATION: pagA mutant is non-lethal in mice [Ref6404:Pezard et al., 1991]. 1910002 3660 cya from Bacillus anthracis str. CDC 684 Bacillus anthracis str. CDC 684 7780712 227811562 BAMEG_A0137 YP_002811573.1 calmodulin-sensitive adenylate cyclase Virulence factor TOXIN: cya encodes EF protein, which with PA induces edema [Ref6404:Pezard et al., 1991]. 1910002 3661 lef from Bacillus anthracis str. CDC 684 Bacillus anthracis str. CDC 684 7780718 227811590 BAMEG_A0165 YP_002811601.1 anthrax lethal factor endopeptidase Virulence factor MUTATION: lef mutant is non-lethal in mice [Ref6404:Pezard et al., 1991]. 1910002 3662 atxA from Bacillus anthracis str. CDC 684 Bacillus anthracis str. CDC 684 7780750 227811569 BAMEG_A0144 YP_002811580.1 anthrax toxin expression trans-acting positive regulator Virulence factor MUTATION: atxA mutant is avirulent in mice [Ref6403:Koehler, 2002]. COG3711K, under K: Transcription 12224521 3663 acpB from Bacillus anthracis str. CDC 684 Bacillus anthracis str. CDC 684 7780535 227811374 BAMEG_B0065 YP_002808736.1 capsule synthesis trans-acting positive regulator AcpB Virulence factor MUTATION: acpB mutant is attenuated in mice [Ref6830:Drysdale et al., 2005]. COG3711K, under K: Transcription 15616593 3664 capE from Bacillus anthracis str. CDC 684 Bacillus anthracis str. CDC 684 7780538 227811376 BAMEG_B0067 YP_002808738.1 polyglutamate capsule biosynthesis protein CapE Virulence factor MUTATION: capE mutant is avirulent in mice [Ref6832:Candela et al., 2005]. 16267300 3665 capD from Bacillus anthracis str. CDC 684 Bacillus anthracis str. CDC 684 7780572 227811377 BAMEG_B0068 YP_002808739.1 capsule anchoring protein CapD Virulence factor MUTATION: capD mutant is attenuated in mice [Ref6831:Candela and Fouet, 2005]. COG0405E, under E: Amino acid transport and metabolism 16045616 4872 Low Molecular Weight Capsule Bacillus anthracis Virulence factor MUTATION:A dep null mutant Sm-1, which formed H-capsule but not L-capsule, was avirulent in mice [Ref7298:Makino et al., 2002]. 12134259