| Victors ID |
Gene Name |
Sequence Strain (Species/Organism) |
NCBI Gene ID |
NCBI Nucleotide GI |
NCBI Protein GI |
Locus Tag |
Genbank Accession |
Protein Accession |
Protein Name |
Molecule Role |
Molecule Role Annotation |
PMID |
|
|
ace |
Enterococcus faecalis OG1RF |
|
10863204
|
10863205
|
|
|
AAG23931.1 |
collagen adhesin precursor |
Virulence factor |
MUTATION: an ace deletion mutant is significantly attenuated in a mixed infection rat endocarditis model [Ref7231:Singh et al., 2010].
|
20072611
|
|
|
EF3314 |
Enterococcus faecalis V583 |
1202157
|
|
29377755
|
EF3314 |
AE016830 |
NP_816909 |
cell wall surface anchor family protein |
Virulence factor |
MUTATION: EF3314 deletion mutant is attenuated in attachment to HeLa cells, survival within macrophages and in a C. elegans killing model [Ref7232:Creti et al., 2009].
|
19856273
|
|
|
ers |
Enterococcus faecalis |
|
72528353
|
72528354
|
|
|
AAZ73009.1 |
transcriptional regulator |
Virulence factor |
MUTATION: ers mutant is attenuated in mouse peritonitis model [Ref7233:Riboulet-Bisson et al., 2008].
|
18426870
|
|
|
srtC |
Enterococcus faecalis V583 |
1199996
|
|
29375670
|
EF1094 |
AE016830 |
NP_814824 |
sortase family protein |
Virulence factor |
MUTATION: bps (srtC) mutant is attenuated in mice [Ref7234:Kemp et al., 2007].
|
17785477
|
|
|
perR |
Enterococcus faecalis |
|
|
67043736
|
|
|
|
PerR |
Virulence factor |
MUTATION: perR mutant is attenuated in mice [Ref7235:Verneuil et al., 2005].
|
16339944
|
|
|
fsrA |
Enterococcus faecium |
|
226938234
|
226938235
|
|
|
ACO94083.1 |
FsrA |
Virulence factor |
MUTATION: fsrA mutant is attenuated for killing C. elegans [Ref7236:Sifri et al., 2002].
|
12228293
|
|
|
fsrB |
Enterococcus faecalis |
|
|
48428174
|
|
|
|
Protein FsrB |
Virulence factor |
MUTATION: fsrB mutant is attenuated for killing C. elegans [Ref7236:Sifri et al., 2002].
|
12228293
|
|
|
gelE |
Enterococcus faecalis |
|
148310
|
148311
|
|
|
AAA24778.1 |
gelatinase |
Virulence factor |
MUTATION: gelE mutant is attenuated for killing C. elegans [Ref7236:Sifri et al., 2002].
|
12228293
|
|
|
sprE |
Enterococcus faecalis |
|
43337
|
43338
|
|
|
CAA78168.1 |
Staphylococcal serine proteinase homologue |
Virulence factor |
MUTATION: sprE mutant is attenuated for killing C. elegans [Ref7236:Sifri et al., 2002].
|
12228293
|
|
|
scrB-1 |
Enterococcus faecalis V583 |
1200501
|
|
29376163
|
EF1603 |
AE016830 |
NP_815317 |
sucrose-6-phosphate dehydrogenase |
Virulence factor |
MUTATION: scrB mutant is avirulent in C. elegans and attenuated in mice [Ref7237:Garsin et al., 2001].
MUTATION: scrB-1 mutant is attenuated in killing C. elegans and is attenuated in mice [Ref7247:Maadani et al., 2007].
|
11535834
17307944
|
|
|
purL |
Enterococcus faecalis V583 |
1200671
|
|
29376329
|
EF1782 |
AE016830 |
NP_815483 |
phosphoribosylformylglycinamidine synthase II |
Virulence factor |
MUTATION: purL mutant is attenuated in mice [Ref7238:Singh et al., 1998].
|
9780263
|
|
|
cylR1 |
Enterococcus faecalis |
|
18139788
|
18139789
|
|
|
AAL60139.1 |
CylR1 |
Virulence factor |
MUTATION: nonhemolytic pAD1 plasmid (cylR1) insertions mutants were attenuated compared to strains with normal hemolytic phenotype in mice [Ref7239:Ike et al., 1984].
|
6086531
|
|
|
efaA |
Enterococcus faecalis |
|
|
306753329
|
|
|
|
endocarditis specific antigen |
Virulence factor |
MUTATION: efaA mutant is attenuated in mouse peritonitis model [Ref7240:Singh et al., 1998b].
|
9753005
|
|
|
esp |
Enterococcus faecalis |
|
|
111380585
|
|
|
|
surface protein Esp |
Virulence factor |
MUTATION: esp mutant is attenuated in murine model of urinary tract infection [Ref7241:Shankar et al., 2001].
|
11401975
|
|
|
asa1 |
Enterococcus faecalis V583 |
1202219
|
|
29377844
|
EFA0047 |
AE016833 |
NP_816972 |
aggregation substance Asa1 |
Virulence factor |
MUTATION: asa1 deletion mutant has reduced adherence to macrophages, and an AS negative strain had decreased survival in macrophages compared to a AS positive strain [Ref7242:Süssmuth et al., 2000].
|
10948103
|
|
|
glf |
Enterococcus faecalis V583 |
1201351
|
|
29376979
|
EF2487 |
AE016830 |
NP_816133 |
UDP-galactopyranose mutase |
Virulence factor |
MUTATION: cpsI mutant is rapidly cleared from murine cutaneous infection sites compared to the wild type [Ref7243:Hancock and Gilmore, 2002].
|
11830672
|
|
|
bopD |
Enterococcus faecalis V583 |
1199842
|
|
29375537
|
EF0954 |
AE016830 |
NP_814691 |
LacI family sugar-binding transcriptional regulator |
Virulence factor |
MUTATION: bopD mutant has delayed colonization in murine intestinal tract [Ref7244:Creti et al., 2006].
|
16834772
|
|
|
srtA |
Enterococcus faecalis V583 |
1201902
|
|
29377514
|
EF3056 |
AE016830 |
NP_816668 |
sortase family protein |
Virulence factor |
MUTATION: srtA mutant is attenuated in murine urinary tract infection model [Ref7245:Guiton et al., 2010].
|
20696830
|
|
|
prgB |
Enterococcus faecalis |
3267210
|
|
58616135
|
pCF10_16 |
AY855841 |
YP_195774 |
PrgB |
Virulence factor |
MUTATION: prgB mutant is attenuated in rabbit model of endocarditis [Ref7246:Chuang et al., 2009].
|
18955479
|
|
|
EF0382 |
Enterococcus faecalis V583 |
1199301
|
|
29375019
|
EF0382 |
AE016830 |
NP_814172 |
hypothetical protein |
Virulence factor |
MUTATION: EF0382 mutant is attenuated in killing C. elegans [Ref7247:Maadani et al., 2007].
|
17307944
|
|
|
EF1302 |
Enterococcus faecalis V583 |
1200199
|
|
29375870
|
EF1302 |
AE016830 |
NP_815024 |
transcriptional regulator, putative |
Virulence factor |
MUTATION: EF1302 mutant is attenuated in killing C. elegans [Ref7247:Maadani et al., 2007].
|
17307944
|
|
|
psr |
Enterococcus faecalis V583 |
1200469
|
|
29376132
|
EF1569 |
AE016830 |
NP_815286 |
transcriptional regulator, PSR protein |
Virulence factor |
MUTATION: psr mutant is attenuated in killing C. elegans [Ref7247:Maadani et al., 2007].
|
17307944
|
|
|
scrR-1 |
Enterococcus faecalis V583 |
1200502
|
|
29376164
|
EF1604 |
AE016830 |
NP_815318 |
sucrose operon repressor ScrR |
Virulence factor |
MUTATION: scrR-1 mutant is attenuated in killing C. elegans [Ref7247:Maadani et al., 2007].
|
17307944
|
|
|
agrBfs |
Enterococcus faecalis V583 |
1200706
|
|
29376364
|
EF1821 |
AE016830 |
NP_815518 |
agrBfs protein |
Virulence factor |
MUTATION: fsrB (agrBfs) mutant is attenuated in killing C. elegans and is attenuated in mice [Ref7247:Maadani et al., 2007].
|
17307944
|
|
|
brnQ |
Enterococcus faecalis V583 |
1199135
|
|
29374885
|
EF0243 |
AE016830 |
NP_814038 |
branched-chain amino acid transport system II carrier protein |
Virulence factor |
MUTATION: brnQ mutant is attenuated in killing C. elegans [Ref7247:Maadani et al., 2007].
|
17307944
|
|
|
EF1513 |
Enterococcus faecalis V583 |
1200416
|
|
29376080
|
EF1513 |
AE016830 |
NP_815234 |
pheromone binding protein |
Virulence factor |
MUTATION: EF1513 mutant is attenuated in killing C. elegans [Ref7247:Maadani et al., 2007].
|
17307944
|
|
|
EF2598 |
Enterococcus faecalis V583 |
1201458
|
|
29377084
|
EF2598 |
AE016830 |
NP_816238 |
PTS system, beta-glucoside-specific IIABC component |
Virulence factor |
MUTATION: EF2598 mutant is attenuated in killing C. elegans [Ref7247:Maadani et al., 2007].
|
17307944
|
|
|
recQ-1 |
Enterococcus faecalis V583 |
1200445
|
|
29376108
|
EF1545 |
AE016830 |
NP_815262 |
ATP-dependent DNA helicase RecQ |
Virulence factor |
MUTATION: recQ-1 mutant is attenuated in killing C. elegans and is attenuated in mice [Ref7247:Maadani et al., 2007].
|
17307944
|
|
|
phrB |
Enterococcus faecalis V583 |
1200497
|
|
29376159
|
EF1598 |
AE016830 |
NP_815313 |
deoxyribodipyrimidine photolyase |
Virulence factor |
MUTATION: phrB mutant is attenuated in killing C. elegans and is attenuated in mice [Ref7247:Maadani et al., 2007].
|
17307944
|
|
|
EF2591 |
Enterococcus faecalis V583 |
1201452
|
|
29377078
|
EF2591 |
AE016830 |
NP_816232 |
glyoxalase family protein |
Virulence factor |
MUTATION: EF2591 mutant is attenuated in killing C. elegans [Ref7247:Maadani et al., 2007].
|
17307944
|
|
|
EF0737 |
Enterococcus faecalis V583 |
1199634
|
|
29375331
|
EF0737 |
AE016830 |
NP_814485 |
amidase |
Virulence factor |
MUTATION: EF0737 mutant is attenuated in killing C. elegans [Ref7247:Maadani et al., 2007].
|
17307944
|
|
|
EF1623 |
Enterococcus faecalis V583 |
1200521
|
|
29376182
|
EF1623 |
AE016830 |
NP_815336 |
microcompartment protein |
Virulence factor |
MUTATION: EF1623 mutant is attenuated in killing C. elegans [Ref7247:Maadani et al., 2007].
|
17307944
|
|
|
thyA |
Enterococcus faecalis V583 |
1200476
|
|
29376139
|
EF1576 |
AE016830 |
NP_815293 |
thymidylate synthase |
Virulence factor |
MUTATION: thyA mutant is attenuated in killing C. elegans [Ref7247:Maadani et al., 2007].
|
17307944
|
|
|
map |
Enterococcus faecalis V583 |
1201076
|
|
29376708
|
EF2200 |
AE016830 |
NP_815862 |
methionine aminopeptidase |
Virulence factor |
MUTATION: map mutant is attenuated in killing C. elegans [Ref7247:Maadani et al., 2007].
|
17307944
|
|
|
EF0376 |
Enterococcus faecalis V583 |
1199295
|
|
29375014
|
EF0376 |
AE016830 |
NP_814167 |
hypothetical protein |
Virulence factor |
MUTATION: EF0376 mutant is attenuated in killing C. elegans [Ref7247:Maadani et al., 2007].
|
17307944
|
|
|
EF0861 |
Enterococcus faecalis V583 |
1199754
|
|
29375449
|
EF0861 |
AE016830 |
NP_814603 |
acetyltransferase |
Virulence factor |
MUTATION: EF0861 mutant is attenuated in killing C. elegans [Ref7247:Maadani et al., 2007].
|
17307944
|
|
|
EF1542 |
Enterococcus faecalis V583 |
1200442
|
|
29376105
|
EF1542 |
AE016830 |
NP_815259 |
hypothetical protein |
Virulence factor |
MUTATION: EF1542 mutant is attenuated in killing C. elegans [Ref7247:Maadani et al., 2007].
|
17307944
|
|
|
EF1590 |
Enterococcus faecalis V583 |
1200489
|
|
29376151
|
EF1590 |
AE016830 |
NP_815305 |
protease synthase and sporulation negative regulatory protein pai 1, putative |
Virulence factor |
MUTATION: EF1590 mutant is attenuated in killing C. elegans and is attenuated in mice [Ref7247:Maadani et al., 2007].
|
17307944
|
|
|
EF1792 |
Enterococcus faecalis V583 |
1200680
|
|
29376338
|
EF1792 |
AE016830 |
NP_815492 |
hypothetical protein |
Virulence factor |
MUTATION: EF1792 mutant is attenuated in killing C. elegans [Ref7247:Maadani et al., 2007].
|
17307944
|
|
|
EF2675 |
Enterococcus faecalis V583 |
1201532
|
|
29377157
|
EF2675 |
AE016830 |
NP_816311 |
competence protein, putative |
Virulence factor |
MUTATION: EF2675 mutant is attenuated in killing C. elegans [Ref7247:Maadani et al., 2007].
|
17307944
|
|
|
EF2957 |
Enterococcus faecalis V583 |
1201809
|
|
29377421
|
EF2957 |
HC905410 |
NP_816575 |
hexapeptide repeat-containing acetyltransferase |
Virulence factor |
MUTATION: EF2957 mutant is attenuated in killing C. elegans [Ref7247:Maadani et al., 2007].
|
17307944
|
|
|
acm |
Enterococcus faecium |
|
29134931
|
|
|
|
|
collagen adhesin precursor |
Virulence factor |
MUTATION: acm deletion mutant is attenuated in rat endocarditis model [Ref7248:Nallapareddy et al., 2008].
|
18591236
|
